Clinical trials: sponsored by IRCCS San Raffaele
Gastroparesis, Gastroparesis Postoperative
Safety and Efficacy of GPOEM in the Treatment of Gastroparesis
The purpose of this study is to assess the clinical efficacy and safety in the treatment of gastroparesis.
- Conditions
- Gastroparesis, Gastroparesis Postoperative, Gastroparesis With Diabetes Mellitus
- Trial name
- NCT04349670
- Testing
- GPOEM - gastric per-oral endoscopic myotomy
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele
COPD
Cognitive Impairment in COPD Patients
Prior researches suggest the presence of impaired lung function may be linked to cognitive impairment (CI). A recent study shows that lung disease, and specifically Chronic obstructive pulmonary disease (COPD) are associated to a…
- Trial name
- RESCOG (NCT04394299)
- Where
- Italy
- Volunteers
- 1,476 people
- Sponsor
- IRCCS San Raffaele
Aneurysm, Aneurysm Abdominal
Totally Percutaneous Approach to Endovascular Treatment of Aortic Aneurysms (PEVAR-PRO)
Purpose of the study is the evaluation of the applicability of the percutaneous technique through double Proglide and Pre-Close Technique to the treatment of complex aortic aneurysms with thoracic endoprosthesis (TEVAR)…
- Conditions
- Aneurysm, Aneurysm Abdominal, Aneurysm Thoracic, Aneurysm, Thoracoabdominal Aortic
- Trial name
- PEVAR-PRO (NCT03484013)
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- IRCCS San Raffaele
Ventricular Tachycardias
Does Timing of VT Ablation Affect Prognosis in Patients With an Implantable Cardioverter-defibrillator?
The purpose of this study is to assess whether the burden of untreated non-sustained ventricular tachycardias (VTs), or episodes treated with anti-tachycardia pacing, correlates with appropriate implantable cardiac defibrillator…
- Trial name
- PARTITA (NCT01547208)
- Testing
- Immediate radiofrequency ablation of ventricular tachycardia, Radiofrequency ablation of ventricular tachycardia
- Where
- 21 sites in Belgium, Czechia and 5 more
- Volunteers
- 590 people
- Sponsor
- IRCCS San Raffaele
Low Back Pain, Healthy Volunteers
Locating Nociceptive Stimuli on Digital Body Chart
Digital body charts are used to assess the pain experience in people with pain. People are asked to report their pain by shading a human body template on a digital tablet.
- Trial name
- NCT03463109
- Testing
- Electrocutaneous stimulation, Assessment + Electrocutaneous stimulation
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Thoracoabdominal Aneurysms and Para-renal Aortic Aneurysms
Anatomical Feasibility of Multibranched Off-the-shelf Endografts for Thoracoabdominal and Para-renal Aortic Aneurysms (TAMBE Study)
Since the development of multibranched endografts a novel therapeutic option for the management of thoracoabdominal and para-renal aortic aneurysms was made accessible.
- Trial name
- TAMBE (NCT03213795)
- Where
- Italy
- Volunteers
- 562 people
- Sponsor
- IRCCS San Raffaele
Kidney Cancer
Protocol Active Surveillance Small Renal Masses (SRMs)
Prospective study of active surveillance, non-randomized, multicentric, in asymptomatic patients over the age of 50 years, not affected by other tumors, with occasional diagnosis of single monolateral solid renal mass equal to or…
- Trial name
- NCT03804320
- Testing
- Active Surveillance
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- IRCCS San Raffaele
Colon Lesion, Colon Polyp
INtegrated Colonoscopy Improvement Program in Italy
The Italian Society of Digestive Endoscopy (SIED) and the Italian Association of Gastroenterologists and Hospital Digestive Endoscopists (AIGO) want to develop an effective training program for endoscopists to improve the quality…
- Trial name
- incipit (NCT03661099)
- Testing
- colonoscopy
- Where
- Italy
- Volunteers
- 21,250 people
- Sponsor
- IRCCS San Raffaele
Suspected Damage to Fetus From Biologic Agents
Study on the Safety for the Newborn of the Use of Biologics During Pregnancy by Mothers Affected by Autoimmune Diseases
The goal of the study is to evaluate the effects on the offspring and therefore the safety of using biologic agents during pregnancy and their eventual consequences on children.
- Trial name
- BIOGN1 (NCT04197232)
- Testing
- clinical evaluation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Hypertension,Essential
Association Between Coronary Flow Reserve and BH4 Levels in High CV Risk
To determine if there is a relationship between coronary flow reserve (CFR) and platelet/plasma BH2 and BH4 levels in patients with high cardiovascular risk .
- Trial name
- NCT03841383
- Testing
- Echo stress dipyridamole
- Where
- 2 sites in Italy
- Volunteers
- 55 people
- Sponsor
- IRCCS San Raffaele
Beta-Thalassemia
Gene Therapy for Transfusion Dependent Beta-thalassemia
This is a phase I/II study evaluating safety and efficacy of autologous hematopoietic stem cells genetically modified with GLOBE lentiviral vector encoding for the human beta-globin gene for the treatment of patients affected by…
- Trial name
- TIGET-BTHAL (NCT02453477)
- Testing
- Autologous hematopoietic stem cells genetically modified with GLOBE lentiviral vector encoding for the human beta-globin gene
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- IRCCS San Raffaele
Acquired Brain Injury
Virtual Reality Rehabilitation in Patients With Acquired Brain Injury
The aim of the study is to investigate the effectiveness of motor and cognitive virtual environment rehabilitation on upper limb function in sub-acute patients after an acquired brain injury.
- Trial name
- NCT03402360
- Testing
- Virtual Reality rehabilitation group, Control group rehabilitation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- IRCCS San Raffaele
Blood Loss, Surgical
Tranexamic Acid in Major Vascular Surgery
The purpose of this study is to determine whether tranexamic acid is effective in reducing intraoperative blood loss and necessity for haemotransfusion in patients undergoing open abdominal aortic aneurysm repair
- Trial name
- NCT02335359
- Testing
- tranexamic acid diluted in 100 ml of saline solution (loading dose), tranexamic acid undiluted (continous infusion)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Analgesia
Acute Post-operative Pain in Colon Resections
Objective of the study is to compare three different analgesic techniques in patients undergoing laparoscopic colon resections: peridural catheter, patient controlled analgesia of endovenous morphine and patient controlled…
- Trial name
- ERAS-PO (NCT03403842)
- Testing
- Sublingual sufentanil tablet system, Peridural catheter, PCA Morphine
- Where
- Italy
- Volunteers
- 159 people
- Sponsor
- IRCCS San Raffaele
Rectal Cancer
Transanal Versus Laparoscopic Total Mesorectal Excision for Rectal Cancer.
This study is designed as a prospective, multi-center, randomized, open-labelled, parallel group, non-inferiority trial. The aim of this study is to evaluate the TaTME technique compared with conventional laparoscopic rectal…
- Trial name
- taTME (NCT03413904)
- Testing
- transanal TME, laparoscopic TME
- Where
- Italy
- Volunteers
- 184 people
- Sponsor
- IRCCS San Raffaele
Benign Prostatic Hyperplasia
Outcomes and Complications of Holmium Laser Enucleation of the Prostate in Expert Hands
The efficacy and safety of holmium laser enucleation of the prostate (HoLEP) for the treatment of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) have been comprehensively assessed.
- Trial name
- ExpHo (NCT03583034)
- Testing
- Holmium laser enucleation of the prostate (HoLEP)
- Where
- Italy
- Volunteers
- 275 people
- Sponsor
- IRCCS San Raffaele
Breast Cancer, Mastectomy
Kinesio Tex Tape in Reducing Edema and Seroma After Complex Reconstructive Breast Surgery
Over the last two decades in the field of oncology, the prevention, diagnosis, treatment and rehabilitation have reached a remarkable development, improving healing rates and reducing the number of deaths from cancer.
- Conditions
- Breast Cancer, Mastectomy, Breast Implantation, Edema
- Trial name
- BREASTAPE (NCT03477565)
- Testing
- Kinesio tape lymphatic drainage technique application
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Hypovolemia
Hemodynamic Changes Induced by Alveolar Recruitment Maneuver With Respect to Volemic State in Colon Surgery
Intraoperative hemodynamic management is important, since even mild variations in circulatory volume can be extremely damaging for patients.
- Trial name
- RecruVol (NCT03468764)
- Testing
- Vigileo monitoring during lung recruitment maneuver
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele
Sedative Adverse Reaction
Effect of Sedation on Pulmonary Aeration in Children
Pediatric sedation is an anesthesiological technique with a good safety profile, but various complications might ensure, especially from the respiratory point of view.
- Trial name
- LunSed (NCT03392012)
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- IRCCS San Raffaele
Overactive Bladder Syndrome, Multiple Sclerosis
Efficacy of Lower Limb Exercises on Overactive Bladder Symptoms in Patients With Multiple Sclerosis
The aim of the study (OVERACT_V1) is to verify if the isometric contraction of ankle plantarflexor and Hamstring muscles, induces a significant reduction of overactive bladder symptoms in patients with Multiple sclerosis.
- Conditions
- Overactive Bladder Syndrome, Multiple Sclerosis, Muscle Strain
- Trial name
- NCT03322748
- Testing
- Usual physical therapy+ strengthening of lower limbs muscles, Usual physical therapy
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS San Raffaele