Clinical trials: sponsored by IRCCS San Raffaele
Pancreatic Cancer
Gemcitabine, Cisplatin, Epirubicin, and Capecitabine in Treating Patients With Stage I-II Resectable Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride, cisplatin, epirubicin hydrochloride, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping…
- Trial name
- PACT-15 (NCT01150630)
- Testing
- capecitabine, cisplatin, epirubicin
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer
A Phase I-II Study of PAXG in Stage III-IV Pancreatic Adenocarcinoma
Four-drug combo yielded a statistically significant improvement in progression-free survival and overall survival compared to gemcitabine in patients with advanced pancreatic adenocarcinoma.
- Trial name
- PACT-19 (NCT01730222)
- Testing
- cisplatin, capecitabine, gemcitabine
- Where
- Italy
- Volunteers
- 137 people
- Sponsor
- IRCCS San Raffaele
Chronic Heart Failure, Lung; Congestive
Usefulness of Lung Ultrasound in Ambulatory Management of Patients With Chronic Heart Failure
Purpose. The aim of this study is to evaluate whether lung ultrasound, in addition to physical examination, leads to a reduction of the admission rate for acute decompensated heart failure of patients with chronic heart failure…
- Conditions
- Chronic Heart Failure, Lung; Congestive, Acute Decompensated Heart Failure
- Trial name
- NCT03262571
- Testing
- Lung ultrasound
- Where
- Italy
- Volunteers
- 244 people
- Sponsor
- IRCCS San Raffaele
Tracheal Intubation Morbidity
Preoperative Fibroscopy as a Predictor of the Difficulty of Laryngoscopy and Intubation
The aim of this study is the evaluation of preoperative transnasal fiberoscopy, as a possible predictor of difficult laryngoscopy and intubation during elective general anesthesia in an adult population.
- Trial name
- TubeDiff (NCT02671877)
- Testing
- Transnasal fiberoscopy
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Healthy
Safety of Ginkgo Biloba Leaf Extract
Primary objective: The primary objective of this study is to assess the effect of Ginkgo biloba L. leaf extract (IDN 5933) in comparison to placebo in human subjects treated at therapeutic doses for 6 months on the level of DNA…
- Trial name
- GiBiEx (NCT03004508)
- Testing
- Gingko Biloba Extract
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- IRCCS San Raffaele
Nervous System Neoplasms
Protective Ventilation in Neurosurgery, a Pilot Study
The purpose of this study is to assess the effect size and variability of dural tension measured as intracranial pressure (ICP) below the dura of the surgical field in patients undergoing elective supra-tentorial surgery for…
- Trial name
- NeuroVentOR (NCT02450019)
- Testing
- Traditional to protective ventilation, Protective to traditional ventilation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS San Raffaele
Biliary Tract Cancer
Second Line Therapy in Advanced Biliary Tract Cancer
The purpose of this study is to assess the therapeutic activity of capecitabine alone or in combination with mitomycin C as second-line therapy in patients with advanced/metastatic biliary adenocarcinoma in progression after…
- Trial name
- BIT-2 (NCT01530503)
- Testing
- capecitabine and mitomycin, Capecitabine
- Where
- 16 sites in Italy
- Volunteers
- 52 people
- Sponsor
- IRCCS San Raffaele
Urinary Tract Infection, Pelvic Organ Prolapse
L-methionine, Hibiscus Sabdariffa and Boswellia Leaf Extract to Prevent Postoperative Urinary Tract Infection.
This study will include women who will undergo pelvic reconstructive surgery and/or anti-incontinence sling procedures. Patients will be randomized to the combination of L-methionine, Hibiscus Sabdariffa and Boswellia Leaf…
- Conditions
- Urinary Tract Infection, Pelvic Organ Prolapse, Urinary Incontinence
- Trial name
- NCT02216253
- Testing
- L-methionine, Hibiscus Sabdariffa and Boswellia Leaf Extract
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer
Combination Chemotherapy With or Without Metformin Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- PACT-17 (NCT01167738)
- Testing
- capecitabine, cisplatin, epirubicin
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Heart Failure
Heart Rate Reduction in Heart Failure
Patients with heart failure (HF) have a limited exercise tolerance,few pharmacological interventions have been proven effective in improving exercise capacity.
- Trial name
- CARVIVA-HF (NCT01178528)
- Testing
- ivabradine, "Drug:Carvedilol" and "Drug:Ivabradine", Carvedilol
- Where
- 2 sites in Italy
- Volunteers
- 121 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer
Trabectedin in Treating Patients With Metastatic Pancreatic Cancer After First-Line Chemotherapy
RATIONALE: Drugs used in chemotherapy, such as trabectedin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- PACT-18 (NCT01339754)
- Testing
- trabectedin
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS San Raffaele
Platelet Dysfunction
Evaluation of Platelet Function After Statin Loading Dose in Patients Before Percutaneous Coronary Intervention
The purpose of this study is to evaluate the effect of a loading dose of two different statins on platelet reactivity (atorvastatin, metabolized by CYP3A4, and rosuvastatin, which is rather independent of this enzyme)in patients…
- Trial name
- STATIPLAT (NCT01526460)
- Testing
- Atorvastatin, Rosuvastatin
- Where
- Italy
- Volunteers
- 146 people
- Sponsor
- IRCCS San Raffaele
Type 2 Diabetes Mellitus, Peripheral Vascular Disease
Normalization of Fasting Glucose and the Incidence of Restenosis After Peripheral Angioplasty
Primary objective of the study is to test whether an intensified insulin therapy incorporating the target of normal fasting glucose (<5.5 mmol/L) and glycated hemoglobin <6.5% is able to halve the incidence of angiographic…
- Trial name
- LIMBISCH (NCT01150617)
- Testing
- Insulin glargine plus insulin analogues
- Where
- Italy
- Volunteers
- 46 people
- Sponsor
- IRCCS San Raffaele
Acute Coronary Syndrome
Activity of Platelets After Inhibition and Cardiovascular Events Optical Coherence Tomography Study
It is an exploratory study evaluating a biological effect (stent strut coverage) using a novel technology such as OCT without any clinical implication.
- Trial name
- APICE-OCT (NCT01239654)
- Testing
- stent implantation
- Where
- 4 sites in Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Refractory Angina
Intramyocardial Delivery of Autologous Bone Marrow
A randomized study to assess the safety, feasibility and effectiveness of direct intramyocardial percutaneous delivery of autologous bone marrow-derived total mononuclear cells or selected CD34+ cells in patients with refractory…
- Trial name
- NCT00820586
- Testing
- Mononuclear bone marrow derived cells
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer
Mitomycin C and Ifosfamide in Treating Patients With Metastatic Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as mitomycin C and ifosfamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- PACT-11 (NCT00967291)
- Testing
- ifosfamide, mitomycin C
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer
Cisplatin, Capecitabine, Gemcitabine and Epirubicin or Docetaxel for Patients With Stage III or IV Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin, capecitabine, gemcitabine hydrochloride, epirubicin hydrochloride, and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or…
- Trial name
- PACT-9 (NCT00966706)
- Testing
- capecitabine, cisplatin, docetaxel
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer
Maintenance Therapy With Sunitinib or Observation in Metastatic Pancreatic Cancer
RATIONALE: Sunitinib malate may stop the growth of tumor cells by blocking some of the tyrosine kinases needed for angiogenesis and cell growth.
- Trial name
- PACT-12 (NCT00967603)
- Testing
- sunitinib
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer
Gemcitabine or Combination Chemotherapy Followed by Chemoradiation for Stage IB, II, or III Pancreatic Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine hydrochloride, cisplatin, epirubicin hydrochloride, fluorouracil, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells…
- Trial name
- PACT-7 (NCT00960284)
- Testing
- capecitabine, cisplatin, epirubicin hydrochloride
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- IRCCS San Raffaele
Migraine
Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms.
Triptans are first choice drugs in the acute treatment of migraine and cluster headache. However, while in cluster headache the response rate to subcutaneous sumatriptan is 96%, around 30% of patients fail to respond to a…
- Trial name
- NCT00753311
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS San Raffaele