Clinical trials: sponsored by IRCCS San Raffaele
Alzheimer
Telerehabilitation in Alzheimer's Disease
Telemedicine has developed rapidly during the COVID-19 pandemic and is now integrated into the clinical practice of many hospitals.
- Trial name
- VRTAD (NCT07722169)
- Testing
- Online cognitive telerehabilitation, VRRS tablet
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
TOLerogenic Potential of Hematopoietic Stem and Progenitor Cells and Inflammatory Bowel Disease
Pediatric refractory Inflammatory Bowel Disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract, not responsive to current treatments.
- Trial name
- TOL-IBD (NCT07740499)
- Testing
- biological sample collection: an additional volume of peripheral blood (3-10 ml), biological sample collection: small fragment (1-5 mm) of intestinal tissue - residual or leftover material, biological sample collection: leftover peripheral blood samples from healthy subjects
- Where
- 2 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Parkinson's Disease (PD)
Parkinson's Research In Metagenomic Early Stage Biomarkers
This 2x2 factorial, randomized, controlled pilot study aims to identify a specific microbiota pattern, which could constitute a biomarker of Parkinson's disease, and to evaluate whether specific pathotypes can be associated with…
- Trial name
- PRIME_2025 (NCT07097103)
- Testing
- Mediterranean Diet Intervention, Intensive Physical Activity Intervention, Control
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS San Raffaele Roma
Idiopathic REM Sleep Behavior Disorder, Parkinson Disease
Predicting Parkinson's Disease Before It Strikes: A Brain Imaging Study in At-Risk Individual
This study aims to characterize neurodegeneration progression in patients with polysomnography (PSG)-confirmed longstanding idiopathic REM sleep behavior disorder (iRBD) and to develop a prognostic model for clinical evolution…
- Conditions
- Idiopathic REM Sleep Behavior Disorder, Parkinson Disease, Neurodegeneration, Prodromal Parkinson Disease
- Trial name
- iRBD (NCT07729748)
- Testing
- Multiparametric clinical, neuropsychological, PSG and MRI assessment
- Where
- 2 sites in Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis, Alzheimer Disease
Optical Coherence Tomography in Neurological Practice: Utility and Applicability Across Neurological Diseases (OCt.IN.N)
OCt.IN.N is a national, monocentric, prospective, observational cohort study evaluating the utility and applicability of Optical Coherence Tomography (OCT) in the diagnostic workup and longitudinal monitoring of neurological…
- Conditions
- Multiple Sclerosis, Alzheimer Disease, Parkinson Disease, Migraine
- Trial name
- OCT (NCT07720765)
- Testing
- Optical Coherence Tomography (OCT) - Heidelberg SPECTRALIS HRA+OCT
- Where
- Italy
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Alzheimer Disease, Mild Cognitive Impairment
Blood Tests for Alzheimer's Disease: Can Plasma Biomarkers Diagnose and Predict Disease Progression
BLAD is a prospective, monocentric, observational epidemiological study with an additional procedure (annual blood draw) evaluating the diagnostic and prognostic performance of plasma biomarkers for Alzheimer's disease (AD) in a…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Subjective Cognitive Decline, Dementia
- Trial name
- BLAD (NCT07717567)
- Testing
- Annual blood draw for plasma biomarker measurement
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- IRCCS San Raffaele
Liver and Intrahepatic Biliary Tract Cancer
San Raffaele Registry on Liver Cancer
This is a Retrospective and Prospective Observational Single-Center Study. The purpose is to collect all data to generate a registry of primary liver cancer (hepatocellular carcinoma and biliary tract carcinoma) of patients…
- Trial name
- NCT07704489
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis
Validation and Standardization of Paramagnetic Rim Lesion (PRL) Identification in Multiple Sclerosis Across MAGNIMS Centers
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system. Paramagnetic rim lesions (PRLs) are a subtype of chronic active MS lesions showing an iron-laden inflammatory rim on…
- Trial name
- NCT07705581
- Where
- 15 sites in Austria, Czechia and 9 more
- Volunteers
- 1,402 people
- Sponsor
- IRCCS San Raffaele
Neurotrophic Keratopathy, Exposure Keratopathy
Clinical Predictors of Visual Outcome in Patients Affected With Ocular Surface Diseases
This retrospective-prospective study aims to identify the diagnostic parameters most predictive of BSCVA in patients with OSD. Clinical, structural, and biochemical data will be collected from standard-of-care examinations and…
- Conditions
- Neurotrophic Keratopathy, Exposure Keratopathy, Limbal Stem Cell Deficiency (LSCD), Cornea Abnormality
- Trial name
- OSD (NCT07694817)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Type 1 Diabetes, Autoimmunity
Targeting GLUT1 to Control Autoimmunity in Type 1 Diabetes
Type 1 Diabetes is an autoimmune disease in which immune cells contribute to the destruction of insulin-producing pancreatic beta cells.
- Trial name
- GLUT1D (NCT07695727)
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS San Raffaele
Prostate Biopsy
Use of a Virtual Reality Headset During Prostate Biopsy Under Local Anesthesia to Improve the Patient's Experience
This is a post-market clinical investigation evaluating the effect of immersive virtual reality (VR) as an adjunct to standard local anesthesia during transperineal prostate biopsy.
- Trial name
- NCT07701421
- Testing
- Standard Local Anesthesia, Immersive Virtual Reality (VR) Headset
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
HPV Infection, HPV Integration
Effect of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on HPV DNA Integration
This interventional, single-center, open-label randomized clinical study evaluates the efficacy of an oral dietary supplement (Pervistop®) in women with persistent Human Papillomavirus (HPV) infection.
- Conditions
- HPV Infection, HPV Integration, HPV Disease, HPV Genital Infection
- Trial name
- NCT07697196
- Testing
- Epigallocatechin gallate (EGCG), Folic Acid (FA), Vitamin B12 (B12), and Hyaluronic Acid (HA)
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- IRCCS San Raffaele
Ulcerative Colitis (UC)
Effectiveness and Safety of Mirikizumab in Patients With Moderate-to-severe Ulcerative Colitis: a Real-life Retrospective Multicenter Study
This is a real-life, multicenter, retrospective observational study with the aim to evaluate effectiveness and safety of Mirikizumab in a real life setting from the baseline up to manteinance at 12, 24 and 52 weeks.
- Trial name
- MIRI REAL (NCT07695636)
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- IRCCS San Raffaele
Gait Disorders
Quantifying Gait Disorders With Wearable Sensors
This is a single-centre, cross-sectional observational study with adjunctive procedure for the healthy voluteers at IRCCS Ospedale San Raffaele's Rehabilitation Department.
- Trial name
- NCT07473141
- Testing
- Gait assessment
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Periodontitis
Sterify Gel as an Adjunct to Non-Surgical Periodontal Therapy in Periodontitis
This retrospective observational study will evaluate the clinical response to Sterify Gel, a sterile mucoadhesive polymeric hydrogel, when used as an adjunct to non-surgical periodontal therapy in adult patients with stage II…
- Trial name
- Sterify (NCT07672665)
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Type 1 Diabetes
M1no-Study - Early Identification of Infants With High Type 1 Diabetes Risk for Participation in Primary Prevention Trials
The goal of this observational study is to identify newborns at increased genetic risk of developing type 1 diabetes-specific beta-cell autoantibodies in order to determine eligibility for participation in primary prevention…
- Trial name
- M1N0 (NCT07670143)
- Where
- 5 sites in Italy
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
B-cell Lymphomas With MYC Rearrangement
Safety and Efficacy of Intensified Chemotherapy Regimens in Aggressive B-cell Lymphomas With MYC Rearrangement
A multicenter, retrospective, observational drug study using anonymized data from adult patients with aggressive B-cell lymphoma treated with the CARMEN regimen.
- Trial name
- OSR-CARMEN (NCT07663175)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele
HGF, Fibroblast
Effects of Chlorhexidine on Human Gingival Fibroblasts
This prospective in vitro study aims to evaluate the effects of two chlorhexidine-based mouthwash formulations on the survival and function of human gingival fibroblasts (hGFs).
- Conditions
- HGF, Fibroblast, Chlorhexidine, Cytotoxicity
- Trial name
- NCT07669636
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
CRC (Colorectal Cancer)
Monocentric Retrospective and Prospective Observational Study of Patients With Colorectal Cancer
Monocentric retrospective and prospective observational study of patients with colorectal cancer
- Trial name
- CRC-R (NCT07663162)
- Volunteers
- 2,000 people
- Sponsor
- IRCCS San Raffaele
Preimplantation Genetic Testing (PGT), Frozen Embryo Transfer Cycle
Effects of Trophectoderm (TE) Biopsy on the Health and Development of Children Born After Preimplantation Genetic Testing (PGT) Cycles.
This study aims to investigate the effects of trophectoderm (TE) biopsy on the health and development of children born after preimplantation genetic testing (PGT) cycles.
- Conditions
- Preimplantation Genetic Testing (PGT), Frozen Embryo Transfer Cycle, Assisted Reproduction Technologies, Postnatal Health
- Trial name
- NCT07349966
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele