Clinical trials: sponsored by IRCCS San Raffaele
Interstitial Lung Diseases
Advanced Mutidimensional and Ultra High Resolution Computed Tomography to Inspect Cardiopulmonary Involvement in Progressive Fibrosing Interstitial Lung Diseases
Interstitial lung diseases (ILDs) are common chronic disease characterized by high mortality and morbidity, also linked to cardiovascular implication.
- Trial name
- AMICI-ILD (NCT06537934)
- Where
- Italy
- Volunteers
- 123 people
- Sponsor
- IRCCS San Raffaele
Mitral Valve Prolapse Syndrome, Arrhythmogenic Bileaflet Mitral Prolapse
Mitro-annular Disjunction in Cardiac Magnetic Resonance
Mitral annular disjunction (MAD) is an abnormal atrial displacement of the mitral valve leaflet hinge point. MAD is gaining clinical importance for several studies reporting its association to mitral valve prolapse (MVP), complex…
- Conditions
- Mitral Valve Prolapse Syndrome, Arrhythmogenic Bileaflet Mitral Prolapse, Mitral Valve Disorder
- Trial name
- NCT06436573
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- IRCCS San Raffaele
Coronary Artery Disease
Peri-luminal COROnary CTa AI-driven radiOMICS to Identify Vulnerable Patients (CORO-CTAIOMICS)
CAD is a leading cause of mortality in Europe. cCTA is recommended to rule out obstructive CAD, but, in most patients, it shows non-obstructive CAD.
- Trial name
- CORO-CTAIOMICS (NCT06029777)
- Where
- Italy
- Volunteers
- 2,190 people
- Sponsor
- IRCCS San Raffaele
Neuroendocrine Tumors, GEP-NET
Influence of Tumour and Patient's Related Factors on the Response to Medical Treatments in Well Differentiated GEP-NENs
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) represent the most common NeuroEndocrin Neoplasms (NEN) site, comprising 55-70% of all NENs, and they are extremely heterogeneous diseases in terms of clinical…
- Trial name
- FARINET (NCT06356467)
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- IRCCS San Raffaele
Cardiovascular Diseases
CT-based Myocardial Characterization (CTMyoC)
The identification of myocardial fibrosis in term of myocardial scar and extracellular matrix remodelling assessed respectively with the technique of Late Gadolinium Enhancement (LGE) and with the quantification of the…
- Trial name
- CTMyoC (NCT06029400)
- Where
- Italy
- Volunteers
- 2,200 people
- Sponsor
- IRCCS San Raffaele
Oncologic Disorders, Neurologic Disorder
Advanced Imaging Holistic Omics Biobank
Imaging methods today represent the pillar of prevention, diagnosis, patients monitoring and treatment. Improvement in technology led the development of increasingly high-performance scanners whose potential has not yet been…
- Conditions
- Oncologic Disorders, Neurologic Disorder, Pulmonary Disease, Cardiovascular Diseases
- Trial name
- NCT06523270
- Testing
- Computed Tomography (CT) using Photon Counting CT scanner (Neaotom Alpha, Siemens) and Magnetic Resonance (MRI)
- Where
- Italy
- Volunteers
- 50,000 people
- Sponsor
- IRCCS San Raffaele
Pancreatic Cancer
Pancreatic Cancer Evolution Upon Treatment
This project aims at evaluating the different subtypes of pancreatic cancer on EUS-tissue acquisition of pancreatic cancer patients, and their possible modifications throughout time.
- Trial name
- NCT05195281
- Testing
- Fine Needle Biopsy or Aspiration
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS San Raffaele
Aortic Dissection
Registry of Patients With Acute/Subacute Type B Aortic Dissection Treated by Means of the STABILISE Technique (STABILISE)
The aim of the study is to evaluate results of patients treated with the STABILISE technique for acute/subacute aortic dissection.
- Trial name
- STABILISE (NCT03707743)
- Where
- 34 sites in United States, Australia and 12 more
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Gastric Outlet Obstruction, Pancreatic Cancer
Management of Malignant Gastric Outlet Obstruction Between Surgery and Endoscopy
The aim of this observational study is to compare the outcomes of three different procedures performed for the management of malignant Gastric Outlet Obstruction due to Pancreatic Cancer.
- Trial name
- GOOSE (NCT06071507)
- Where
- 5 sites in France, Italy and 2 more
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Coronary Artery Disease
Artificial Intelligence for Preventing Heart Disease (AiPHD): Observational, Single Center, Prospective and Retrospective Study
Coronary artery disease (CAD) is a leading cause of mortality in western countries. Coronary computed tomography angiography (cCTA) is the first-line imaging test in patients with suspected obstructive CAD.
- Trial name
- AiPHD (NCT06029387)
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- IRCCS San Raffaele
Ulcerative Colitis
Development of Novel Imaging and Molecular Biomarkers of Fibrosis in Patient With Ulcerative Colitis
Prospective multicenter interventional non-randomized cross-sectional study. Ultrasound operators will be blinded to clinical and endoscopic findings and the endoscopist will be blinded of the clinical and ultrasound findings.
- Trial name
- NCT06516237
- Testing
- to determine molecular and epigenetic biomarkers
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Colorectal Cancer
Role of Photon Counting CT in Detecting Liver Metastatis From Colorectal Cancer
Colorectal cancer is the first leading cause of cancer death in men and second in women. Its incidence rates also increased by 1%-2% annually in young adults (ages <55 years).
- Trial name
- PCDCRC-D34H (NCT06753903)
- Testing
- PCD-CT
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
EGFR, Non Small Cell Lung Cancer
The HER Project: HRD in EGFR-mutated NSCLC
This observational retrospective-prospective study aims to evaluate the prevalence of homologous recombination deficiency (HRD) in metastatic EGFR mutated NSCLC and to assess its correlation with clinical and molecular features.
- Conditions
- EGFR, Non Small Cell Lung Cancer, Homologous Recombination Deficiency, PARP Inhibitor
- Trial name
- HER (NCT07303218)
- Testing
- No Intervention: Observational Cohort
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS San Raffaele
Age - Related Macular Degeneration (AMD), Diabetic Macular Edema
Wide Field OCTA in Ocular Diseases
The main retinal diseases, whether or not associated with specific mutations genetic, cause progressive degeneration of vascular retinal structures and not vascular, resulting in decreased visual function.
- Conditions
- Age - Related Macular Degeneration (AMD), Diabetic Macular Edema, Diabetic Retinopathy, Myopia
- Trial name
- WOOD-2025 (NCT07298174)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Orthodontic Appliance, Debonding
Comparison of Two Orthodontic Clean-Up Protocols
Orthodontic clean-up following debonding remains a technically demanding procedure, with documented risks of enamel roughening, microdefects, discoloration, and increased plaque retention.
- Conditions
- Orthodontic Appliance, Debonding, Case-control Study
- Trial name
- NCT07304310
- Testing
- Two-step ultrasonic protocol, One-step clean-up protocol
- Where
- Italy
- Volunteers
- 142 people
- Sponsor
- IRCCS San Raffaele
Moral Development, Moral Dilemma
Moral Reasoning Intervention on Moral Justification Abilities
The primary aim of this study is to evaluate the short (immediate) and mid-term (one month) impact of moral (vs non-moral) reasoning interventions on the moral justification abilities in non-expert subjects.
- Conditions
- Moral Development, Moral Dilemma, Healthy Controls, Moral Justification
- Trial name
- NCT06735989
- Testing
- Lecture on moral reasoning, Lecture on logical reasoning
- Where
- Italy
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Celiac Disease in Children, Eating Behaviors
Eating Behaviors in Children and Adolescents With/Without Celiac Disease
This observational study investigates the prevalence and severity of disordered eating behaviors in adolescents aged 11-17 years with celiac disease.
- Trial name
- NCT07285512
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Overactive Bladder (OAB), Incontinence, Urge
Efficacy and Safety of 7 Millimeters Vaginal Radiofrequency in Overactive Bladder
The investigator hypothesizes that controlled delivery of low heat (45-50 Centigrade) to the sub-detrusor and detrusor muscle can ablate the autonomic nerve endings and control overactive bladder symptoms without causing…
- Trial name
- HYPNOS (NCT07279142)
- Testing
- Radiofrequency
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- IRCCS San Raffaele
Multiple Sclerosis
Home-based Action Observation Treatment With Virtual-reality for Arm Rehabilitation in People With Multiple Sclerosis
Action Observation Treatment (AOT) is a rehabilitative strategy which has been proposed as a promising approach to improve motor performance in neurological conditions, including multiple sclerosis (MS).
- Trial name
- NCT05713890
- Testing
- Home-based Action Observation Treatment with virtual-reality for upper limb rehabilitation, Home-based landscape observation with virtual-reality for upper limb rehabilitation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Raffaele
Gynecological Disorders, Male Infertility
Biobank Aimed to Study Gynecological Pathologies, of Male and Female Infertility and Pregnancy Pathologies
The REPRO-Biobank has been established at San Raffaele Hospital in Milan for the purpose of collecting and preserving human biological samples and associated data.
- Conditions
- Gynecological Disorders, Male Infertility, Female Infertility, Pregnancy
- Trial name
- NCT07265908
- Testing
- Blood sampling
- Where
- Italy
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele