Clinical trials: sponsored by Indiana University
Postmenopausal Symptoms, Aging
Inspiratory Muscle Training in Postmenopausal Women
This study is being conducted by the Department of Kinesiology within the School of Public Health at Indiana University Bloomington.
- Conditions
- Postmenopausal Symptoms, Aging, Obesity
- Trial name
- MRS (NCT06459674)
- Testing
- PrO2 Fit (IMT Trainer)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy, Unconscious
External Nitric Oxide Measurement Through SNO Degradation
In this study, we aim to explore the feasibility of a novel, noninvasive SNO assay to acquire physiological SNO quantification from various parts of the human body and test this new method of analysis.
- Trial name
- NCT04903535
- Testing
- Alonefire SV003 10W 365nm UV Flashlight
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Indiana University
Neurologic Findings
Handheld Point of Care Electro-Diagnostic Device
There are currently several products offering POC EEG, intended to be deployed on each patient individually and continuously. The investigators propose studying a different approach by using a migrating POC electrodiagnostic…
- Trial name
- NCT07223827
- Testing
- POC EEG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Substance-Related Disorders, Opioid-Related Disorders
Fatal Overdose Review Teams - Research to Enhance Surveillance Systems
This project seeks to address the overdose epidemic by working with overdose fatality review (OFR) teams. Current OFR practices rely on a case review model where OFR teams assess one or two overdose cases to make policy and…
- Trial name
- FORTRESS (NCT06084221)
- Testing
- Data-Driven Decision Making (DDDM), Overdose-prevention strategies inventory
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Indiana University
Atrial Fibrillation
Ondansetron for the Management of Atrial Fibrillation
"Afib" is a common irregular heartbeat. Afib can cause stroke, blood clots, dementia and death. Medicines used to treat Afib often do not work well and can cause serious side effects.
- Trial name
- NCT05844501
- Testing
- Ondansetron 8mg
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Sickle Cell Disease
Zinc for Infection Prevention in Sickle Cell Anemia-2 (ZIPS-2)
A randomized double-blinded placebo-controlled trial of zinc to reduce the incidence of severe or invasive infections in Ugandan children with sickle cell anemia (SCA)
- Trial name
- ZIPS-2 (NCT06561061)
- Testing
- zinc sulfate
- Where
- Uganda
- Volunteers
- 100 people
- Sponsor
- Indiana University
Sickle Cell Disease
Imatinib for Pain in Sickle Cell Anemia
In this protocol, the investigators propose to evaluate the biochemical effects of imatinib on sickle red blood cells (RBCs). Patients will be administered imatinib mesylate orally following the guidelines previously established…
- Trial name
- IMPACT (NCT03997903)
- Testing
- Imatinib Mesylate
- Where
- 2 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Indiana University
Basic Science
Neural Basis of Sensory and Motor Learning: Functional Connections
The purpose of this study is to understand how the sensory and motor areas of the brain work together to keep a person's hand movements accurate (sensorimotor learning).
- Trial name
- NCT05124301
- Testing
- Perceptual learning
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Indiana University
Stroke
High vs Low-frequency of High-intensity Training in Chronic Stroke
The purpose of this pilot study is to investigate the potential role of training frequency on locomotor outcomes following high-intensity gait training and provision of a home walking program.
- Trial name
- F-ITT (NCT06612723)
- Testing
- high-intensity gait training, Physical activity coaching
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Diabetes Mellitus, Type 2, End Stage Renal Disease
Drug Interaction Potential of Pro-Inflammatory Conditions
Pro-inflammatory cytokines, which are elevated in pro-inflammatory disease states (e.g., type II diabetes mellitus [T2DM], irritable bowel diseases [IBD], and end stage renal disease [ESRD]) have been shown to inhibit hepatic…
- Conditions
- Diabetes Mellitus, Type 2, End Stage Renal Disease, Irritable Bowel Syndrome
- Trial name
- DIPPIC (NCT07360938)
- Testing
- None (Observational)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Cervical Cancer Prevention, Cervical Cancer
A Cervical Cancer Prevention Program in Kenya
Cervical cancer is caused by oncogenic, or "high-risk" (HR) human papillomavirus (HPV), and is the main cause of cancer-related death among Kenyan women.
- Trial name
- Merck-3 (NCT06411938)
- Testing
- High Risk HPV DNA Testing, Visual Inspection with acetic acid (VIA) and possible cervical biopsy, Gardisil-9
- Where
- Kenya
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- Indiana University
Spinal Cord Injuries
High Intensity Exercise in Incomplete SCI
The goal of this study is to identify the comparative efficacy of high-intensity walking training in individuals with chronic, motor incomplete spinal cord injury as compared to lower-intensity walking exercise.
- Trial name
- NCT03714997
- Testing
- Walking training
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Indiana University
Cervical Dysplasia
The Mother-Daughter Project: Merck-4
This project serves to continue a community-based initiative, known as the Kenya Mother-Daughter Cervical Cancer Eradication Project, or the Mother-Daughter Project (MDP), in the Webuye region of Western Kenya.
- Trial name
- Merck-4 (NCT07240220)
- Testing
- Gardisil-9, High Risk HPV DNA Testing, Visual Inspection with acetic acid (VIA) and possible cervical biopsy
- Where
- Kenya
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Indiana University
Melanoma, Gastrointestinal Neoplasms
Pilot Study to Determine Pro-Inflammatory Cytokine Kinetics During Immune Checkpoint Inhibitor Therapy
This research aims to identify clinical strategies to manage adverse events during immune checkpoint inhibitor therapy by (1) determining the impact of checkpoint inhibitors on metabolism through major CYP enzymes and (2)…
- Conditions
- Melanoma, Gastrointestinal Neoplasms, Genitourinary Cancer, Thoracic Cancer
- Trial name
- ICI-PICK (NCT05707286)
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Indiana University
Traumatic Brain Injury, Alzheimer Disease
The Aging Brain ANSWERS Program
This study will test the effectiveness of an intervention for Veterans diagnosed with Alzheimer's Disease (AD) or Traumatic Brain Injury (TBI) and the burden on their informal (family/friend) caregiver.
- Conditions
- Traumatic Brain Injury, Alzheimer Disease, Veterans, Family Caregivers
- Trial name
- ABC ANSWERS (NCT03397667)
- Testing
- ABC ANSWERS, Control
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- Indiana University
Schizophrenia, Schizoaffective Disorder
Academic-Community EPINET (AC-EPINET)
The investigators propose to examine the effects of CSC services delivered via TH (CSC-TH) versus the standard clinic-based CSC model (CSC-SD) on engagement and outcomes in a 12-month, randomized trial.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorders, Major Depression With Psychotic Features
- Trial name
- AC-EPINET (NCT04497857)
- Testing
- Coordinated Specialty Care (CSC)
- Where
- 6 sites in United States
- Volunteers
- 74 people
- Sponsor
- Indiana University
Sodium Excess, Racial Disparities
Vascular Effects of Acute Sodium (VEAS) Study
This IRB will cover a current clinical trial (NCT04244604) that was started at Auburn University (AU IRB#19-390), the Principal Investigator's prior institution, and is supported by his NIH Career Development Award (NHLBI…
- Conditions
- Sodium Excess, Racial Disparities, Blood Pressure, Cardiovascular Risk Factor
- Trial name
- NCT04244604
- Testing
- Low Sodium Meal (140 mg sodium chloride), High Sodium Meal (2500 mg sodium chloride)
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Indiana University
HIV (Human Immunodeficiency Virus), Geriatric
Promoting Aging and Thriving With HIV
The pilot is an intervention of a geriatric assessment and management tool (PATH) in outpatient HIV clinics.
- Conditions
- HIV (Human Immunodeficiency Virus), Geriatric, Geriatric Assessment, HIV
- Trial name
- PATH (NCT07192419)
- Testing
- Promoting Aging and Thriving with HIV (PATH)-Implementation of a Tailored Geriatric Assessment and Management Strategy for HIV Care Settings
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Primary Ciliary Dyskinesia, Healthy
Examining Bronchial Hyperresponsiveness in Primary Ciliary Dyskinesia
The purpose of this study is to look at children with PCD and see if they have another condition called "bronchial hyperresponsiveness".
- Trial name
- BHR (NCT07288827)
- Testing
- Lung Function Testing, Phlebotomy, Allergy skin prick testing
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Depression, Cognitive Decline
Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)
Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD).
- Trial name
- ADEPT-ICU (NCT06627894)
- Testing
- Therapist-Assisted Internet Cognitive-Behavioral Therapy for Depression, Active Control
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
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