Clinical trials: sponsored by Indiana University
Cholestasis of Parenteral Nutrition
Comparison of Smoflipid to Soy-based Lipid Reduction for Cholestasis Prevention in Surgical Neonates
Intestinal failure associated liver disease is a cholestatic liver disease associated with prolonged need for parenteral nutrition that can lead to such significant complications as liver failure.
- Trial name
- NCT03387579
- Testing
- Smoflipid 20% Lipid Emulsion for Injection, Intralipid, 20% Intravenous Emulsion
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Indiana University
Unspecified Behavioral and Emotional Disorders With Onset Usually Occurring in Childhood and Adolescence, Mental Disorder First Evident in Infancy, Childhood, or Adolescence
Assessing Implementation of Delivering Community-based, Peer-led Interventions for Mental Health Problems Among Youth in Eldoret, Kenya
Introduction: Mental health disorders are a leading cause of disability among youth globally, and this has been worsened by the COVID-19 pandemic.
- Conditions
- Unspecified Behavioral and Emotional Disorders With Onset Usually Occurring in Childhood and Adolescence, Mental Disorder First Evident in Infancy, Childhood, or Adolescence, Mental Disorder of Infancy, Childhood, or Adolescence (Diagnosis)
- Trial name
- Husisha (NCT06132373)
- Testing
- Peer delivered problem solving therapy
- Where
- Kenya
- Volunteers
- 182 people
- Sponsor
- Indiana University
Healthy, Achilles Tendon Length and Thickness
Does Instrument-assisted Mobilization Influence Healthy, Short Achilles Tendons?
The goal of this clinical trial is to learn if instrumented-assisted soft tissue mobilization (i.e., massage using specialized metal instruments) of the lower leg and Achilles tendon region changes the properties of the tendon…
- Trial name
- NCT07075172
- Testing
- Instrumented-assisted soft tissue mobilization
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Indiana University
CVD, Cardiovascular Diseases
Hoosier Sport: Refining and Implementing a Sustainable Campus-Community Partnership in Rural Indiana
Hoosier Sport is a sport-based youth development program that uses the power of sport to teach children and adolescents sport and leadership skills while promoting health education.
- Trial name
- NCT06602596
- Testing
- Hoosier Sport
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Indiana University
Anemia, Iron Deficiency, Melanoma
Intravenous Iron in Combination With Standard of Care Immunotherapy in Melanoma
Anemia is a common complication among cancer patients and is negatively associated with overall prognosis and therapeutic outcomes.
- Trial name
- NCT06508827
- Testing
- Iron dextran 1000 mg IV
- Sponsor
- Indiana University
Kidney Calculi
MOSES Lithotripsy Technology Applied to Stone Fragmentation During Ureteroscopy
To determine if the effects of MOSES laser modulation technology can improve the safety and efficiency to laser fragmentation resulting in decreased total laser time, reduced potential for injury to the patient, and total OR time…
- Trial name
- NCT03995758
- Testing
- MOSES
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Indiana University
Resting Energy Expenditure, Thermogenesis
MIrabegron and Physiological Function in Cold Environments
Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal…
- Conditions
- Resting Energy Expenditure, Thermogenesis, Brown Adipose Tissue
- Trial name
- NCT05990387
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Fatigue
Treatment for Persistently Fatigued Cancer Survivors: A Randomized Controlled Trial With Biomarker Response
The purpose of this study is to compare the effects of Mindfulness-Based Stress Reduction (MBSR) to an attention control psycho-educational support group in treating cancer-related fatigue (CRF) in early-stage (0-III)…
- Trial name
- NCT01919853
- Testing
- Mindfulness-Based Stress Reduction, Attention Control
- Where
- 4 sites in United States
- Volunteers
- 107 people
- Sponsor
- Indiana University
Long QT Syndrome, Abnormalities, Drug-Induced
Reducing the Risk of Drug-Induced QT Interval Lengthening in Women
This research will determine if oral progesterone attenuates drug-induced QT interval lengthening in a) Postmenopausal women 50 years of age or older, and b) Premenopausal women studied during the ovulation phase of the menstrual…
- Trial name
- NCT03834883
- Testing
- Progesterone, Ibutilide
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Indiana University
Acute Heart Failure
Pre-Hospital Lung Ultrasound Impact on Diagnosis
Acute heart failure (AHF) is a major reason patients seek emergency care and is a significant public health burden. The ability to differentiate AHF from other etiologies of dyspnea remains a challenge as symptoms and physical…
- Trial name
- NCT05461547
- Testing
- Lung Ultrasound, Usual Care
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Indiana University
Sleep
Assessment of the Safety and Efficacy of Weighted Wearable Blankets in Healthy Infants During Sleep
The goal of this clinical trial is to assess the risk of an infant overheating and/or experiencing lowered respiration via measurement of vital signs in a controlled clinical environment while wearing a weighted wearable blanket…
- Trial name
- NCT06422364
- Testing
- Weighted Wearable Blanket provided by Dreamland Baby Co.
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Indiana University
Nicotine Use Disorder, Substance Use Disorders
Temporal Interference Neurostimulation and Addiction
This project aims to develop a line of research using new non-invasive neurostimulation technology to treat adults with opioid use disorders (OUDs).
- Trial name
- NCT04432064
- Testing
- Active TI-NDBS, tDCS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indiana University
Caries
In Situ Comparison of the Remineralization Potential of Optimized Fluoride Dentifrice With Control Fluoride Dentifrice
The purpose of this study is to compare the remineralization potential of an optimized fluoride dentifrice to a control fluoride dentifrice in an in situ caries model.
- Trial name
- NCT06010732
- Testing
- 1100 ppm F as sodium fluoride (positive control), 1100 ppm F as sodium fluoride Test Product
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gingivitis, Supragingival Plaque
Evaluation of the Efficacy and Safety of a Loop Stretchable Dental Floss
This will be a single-blind, single-center, parallel, randomized controlled clinical trial to evaluate the efficacy and safety of Floss Loops stretchable floss for the control of gingivitis and supragingival plaque removal…
- Trial name
- NCT06515483
- Testing
- Brushing and Flossing of teeth, Brushing Only
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Indiana University
Speech, Hearing Loss, Sensorineural
Effects of Nonlinear Signal Processing Algorithms on Speech Perception
The purpose of this study is to investigate the effect of nonlinear signal processing algorithms on speech perception.
- Conditions
- Speech, Hearing Loss, Sensorineural, Hearing Aids
- Trial name
- NCT05954520
- Testing
- Tympan
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Squamous Cell Carcinoma, Nonmelanoma Skin Cancer
Sentinel Lymph Node Biopsy for Cutaneous Squamous Cell Carcinoma of the Head and Neck
The purpose of this study is to research if a type of biopsy known as sentinel lymph node biopsy (SLNB) can help in determining the rate of tumor deposits that are hard to detect and identify in node-negative cutaneous squamous…
- Conditions
- Squamous Cell Carcinoma, Nonmelanoma Skin Cancer, Cutaneous Squamous Cell Carcinoma
- Trial name
- NCT05108090
- Testing
- sentinel lymph node biopsy (SLNB)
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Indiana University
Chronic Pain, Depression
Equity Using Interventions for Pain and Depression - Pilot Study
This project is part of the NIH Helping to End Addiction Long-term (HEAL) initiative (https://heal.nih.gov/). This pilot randomized controlled trial (RCT) is part of phase 1 of a two-phase, 5-year project with the overarching…
- Conditions
- Chronic Pain, Depression, Health Equity
- Trial name
- EQUIPD-Pilot (NCT05695209)
- Testing
- Coaching and Decision Aid
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Intrauterine Device (IUD), Abnormal Uterine Bleeding
Suction Cervical Stabilizer Compared to Standard Tenaculum for Intrauterine Procedures
To evaluate patient-reported pain, bleeding, and device efficiency along with provider satisfaction and ease of use between intrauterine procedures employing a suction cervical stabilizer (new device, FDA approved, atraumatic) or…
- Trial name
- NCT06193590
- Testing
- Carevix, Tenaculum
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Indiana University
Hiv, Insomnia
HIV-related Insomnia and Inflammation
This randomized trial will determine the effects of internet cognitive behavioral therapy on measures of systemic inflammation in HIV-positive people receiving antiretroviral therapy.
- Trial name
- NCT04721067
- Testing
- SHUTi, Sleep Education/Hygiene
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Symptomatic Irreversible Pulpitis
Combination of Buffered Anesthetic to Treat Mandibular Molars
The purpose of this study is to determine whether a combination of anesthetics (numbing medicine) will adequately anesthetize teeth over a different combination.
- Trial name
- NCT06047366
- Testing
- Sodium bicarbonate, Lidocaine w/ epi, Articaine w/ epi
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
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