Clinical trials: sponsored by Indiana University
Delirium in Old Age
Using EMR Data and AI to Develop a Passive Digital Marker to Predict Postoperative Delirium
This study will be a pilot randomized controlled trial that will determine the effect of an indicator of delirium risk, which will be delivered either via a paper form or via the electronic medical record, on (1)postoperative…
- Trial name
- NCT06216483
- Testing
- PDM Alert
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Colon Polyp, Colon Adenoma
Cold Snare Piecemeal Resection vs Cold Snare Endoscopic Mucosal Resection
The study will compare the use of cold snare piecemeal resection (CSPR) vs cold endoscopic mucosal resection (Cold EMR). The study will include two cohorts: one cohort for conventional adenomas 10-19mm in size and one cohort for…
- Conditions
- Colon Polyp, Colon Adenoma, Serrated Polyp
- Trial name
- CARDINAL (NCT06462521)
- Testing
- Cold Snare Piecemeal Resection (CSPR), Cold Snare Endoscopic Mucosal Resection (Cold EMR)
- Where
- 9 sites in United States, Canada
- Volunteers
- 570 people
- Sponsor
- Indiana University
Colon Polyp, Adenoma
Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection
The study will compare the use of a 6-month follow-up vs a 12-month follow-up after the removal of a large non-pedunculated polyp 20-50mm in size and without high grade dysplasia.
- Conditions
- Colon Polyp, Adenoma, Serrated Polyp, Recurrence, Local Neoplasm
- Trial name
- STARLING (NCT07198945)
- Testing
- 6-month follow-up, 12-month follow-up
- Where
- 10 sites in United States, Canada and 1 more
- Volunteers
- 546 people
- Sponsor
- Indiana University
Obesity & Overweight
Supplementation of Gut-brain Axis (GLP-1)-Activating Carbohydrates for Increasing Satiety in Adolescents With Obesity
Glucagon-like peptide (GLP1) drugs have quickly become a standard treatment for the adults with obesity. These drugs target the appetite control center of the brain, which clows the rate of stomach emptying, and makes a person…
- Trial name
- GUT BOOST (NCT07823452)
- Testing
- gut-brain axis (GLP-1)-activating food carbohydrate
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Indiana University
Long QT Syndrome, Abnormalities, Drug-Induced
Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening
This research will determine if: 1) Oral progesterone attenuates drug-induced QT interval, J-Tpeak and Tpeak-Tend lengthening in postmenopausal women 50 years of age or older, and 2) Transdermal testosterone attenuates…
- Trial name
- NCT04675788
- Testing
- Progesterone, Ibutilide, Testosterone
- Where
- 3 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Indiana University
Attention-Deficit/Hyperactivity Disorder (ADHD)
Developing Virtual Reality Programs to Address Social Skills Deficits in Youth With ADHD
Researchers at OpenMindXR, in collaboration with Indiana University, are conducting a paid research study evaluating an innovative virtual reality (VR)-based intervention designed to support social and emotional skill development…
- Trial name
- NCT07882823
- Testing
- VIP Suite
- Volunteers
- 48 people
- Sponsor
- Indiana University
Type 2 Diabetes
Effects of Adding a Registered Dietitian to Rural Community Healthy Behavior Support Services for Management of Type 2 Diabetes
Rural communities experience health care shortages of diabetes services provided by a registered dietitian nutritionist (RDN). This pilot study tested the feasibility of using rural community health screenings to recruit adults…
- Trial name
- NCT07883343
- Testing
- Medical Nutrition Therapy Intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Indiana University
Healthy Subjects
ABVN Phase 1 - Vagal Maneuvers
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope to be able to measure the activity of the vagus nerve when it is stimulated through simple physical techniques.
- Trial name
- ABVN1 (NCT07881276)
- Testing
- Vagal Maneuvers, Multi-Electrode Array (MEA) Recording
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gastroparesis
ABVN Phase 2 - Vagal Maneuvers
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators want to evaluate the effects of noninvasive stimulation of the auricular branch of the vagal nerve (ABVN) on vagal nerve…
- Trial name
- ABVN2 (NCT07881289)
- Testing
- Vagal Maneuvers
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Indiana University
Type 1 Diabetes
Safety and Efficacy of Adjunct Therapies in Adults With Type 1 Diabetes: Multicenter, Registry Study
This will be a multicenter registry-based study to evaluate safety and efficacy of GLP-1RA and SGLTi therapies in adjunct to insulin in adults with type 1 diabetes (T1D) over 1 year.
- Trial name
- ATT1D (NCT07676565)
- Where
- 17 sites in United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Gestational Diabetes, Pregnancy, High Risk
Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes
This is a multicenter randomized clinical trial of 828 overweight and obese individuals with gestational diabetes designed to compare standard to intensive glycemic targets.
- Conditions
- Gestational Diabetes, Pregnancy, High Risk, Overweight and Obesity
- Trial name
- iGDM (NCT05124808)
- Testing
- Intensive glycemic targets, Standard glycemic targets
- Where
- 5 sites in United States
- Volunteers
- 828 people
- Sponsor
- Indiana University
Gastroesophageal Reflux Disease
Transoral Incisionless Fundoplication Database Repository (TIF)
Collect data on individuals who have a transoral incisionless fundoplication (TIF) performed by physicians at Indiana University for the treatment of gastroesophageal reflux disease.
- Trial name
- TIF (NCT04306380)
- Testing
- no intervention, database study
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Indiana University
Delayed Onset Muscle Soreness
Effects of Kinesio Tape on Delayed Onset Muscle Soreness
The purpose of this study is to determine the effect of Kinesio tape on delayed onset muscle soreness of the biceps muscle of your arm following strenuous exercise of the bicep muscle.
- Trial name
- NCT04128670
- Testing
- Kinesiotape
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy Subjects
ABVN Phase 1 - Ear Stimulation
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve.
- Trial name
- ABVN1 (NCT04206540)
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gastroparesis, Healthy Subjects
ABVN Phase 2 - Ear Stimulation
The vagus nerve is a nerve that controls many bodily functions, including stomach function. Investigators hope that electrically stimulating the nerve around the external ear will also stimulate the internal vagus nerve.
- Trial name
- ABVN2 (NCT06491758)
- Testing
- ML1101 Stimulus Isolator
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Indiana University
Older People, Pain
Exploring the Acute and Dynamic Relationships Between Movement and Pain in Older Adults With Musculoskeletal Pain
The purpose of this research study is to evaluate the effect of brief bouts of intermittent walking on bodily pain, pain during movement, and how the body adapts to musculoskeletal pain in older adults.
- Trial name
- NCT06886906
- Testing
- Intermittent light walking, uninterrupted sitting
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Indiana University
Stroke
Overground Virtual Reality (VR) Gait Rehabilitation for Stroke
The purpose of this study is to evaluate a new virtual reality (VR)-based rehabilitation program designed to help stroke survivors improve their walking abilities in real-world settings.
- Trial name
- NCT07676578
- Testing
- Walk-over-Ground, C-Mill VR+ by Motek
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Traumatic Brain Injury
Overground Virtual Reality (VR) Gait Rehabilitation for Traumatic Brain Injury (TBI)
The purpose of this study is to evaluate a new virtual reality (VR)-based rehabilitation program designed to help individuals with traumatic brain injury (TBI) improve their walking abilities in real-world settings.
- Trial name
- NCT07038889
- Testing
- C-Mill VR+ by Motek, Walk-over-Ground
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Healthy Volunteers
Temporal Interference Methods for Non-invasive Deep Brain Stimulation, Study 1.2
In its totality, this grant aims to develop a line of research using temporal interference (TI) electrical neurostimulation technology to understand the causal role of deep brain structures in cognition.
- Trial name
- NCT07339072
- Testing
- Temporal Interference (TI) Electrical Stimulation - NAcc 5 Hz TI Active, Temporal Interference (TI) Electrical Stimulation - NAcc 10 Hz TI Active
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Vagus Nerve Stimulation
Recording Cutaneous Vagal Nerve Activity With Multi-Electrode Array (MEA) in Patients Undergoing VNS Therapy
The overall purpose of the ABVN Phase 2 grant is to expand on previous work evaluating vagal nerve function. This will be accomplished through several independent, but related, studies.
- Trial name
- NCT06827548
- Testing
- Multi-Electrode Array (MEA) Recording
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Indiana University
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