Clinical trials: sponsored by Indiana University
Asthma, Genotype
Evaluate Pharmacokinetics and Safety of Slow Release DHEA
This is a study to look at pharmacokinetic levels of different doses of slow release DHEA in subjects with asthma.
- Trial name
- DHEA (NCT05623059)
- Testing
- Slow Release DHEA
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Indiana University
Behavioral Health Client-centered Supervision
SuperAssist: Client-Centered Supervision Assist App for Mental Health Providers
The goal of this pilot study is to test a Supervision Assist App (SuperAssist) for implementing Client-Centered Supervision (CCS) to improve supervision practices for mental health providers (providers).
- Trial name
- SuperAssist (NCT07247045)
- Testing
- Client-centered supervision training and use of a mobile app
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Indiana University
Malaria, Asymptomatic Malaria
OPTIMAL LEAP: Optimizing Dihydroartemisinin-Piperaquine IPTsc Intervals to Advance Learning, Executive Function, Attendance, and Antimalarial Resistance Surveillance in Kenyan Schoolchildren
Malaria remains a major cause of illness among school-aged children in sub-Saharan Africa, many of whom carry asymptomatic Plasmodium falciparum infections that may contribute to anemia, inflammation, school absenteeism, and…
- Conditions
- Malaria, Asymptomatic Malaria, Intermittent Preventive Treatment
- Trial name
- Optimal LEAP (NCT07798583)
- Testing
- Monthly DP, Quarterly DP
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Indiana University
Autism Spectrum Disorder, Autism
Pepea Pamoja: Cluster-Randomized Trial for Caregivers of Children With Autism in Kenya
Pepea Pamoja is a ten-session, group-based caregiver intervention designed to improve caregiver well-being and strengthen caregivers' ability to support communication and positive behavior in children with autism.
- Conditions
- Autism Spectrum Disorder, Autism, ASD
- Trial name
- NCT07259044
- Testing
- Professionally-facilitated groups, Peer-facilitated groups
- Where
- Kenya
- Volunteers
- 240 people
- Sponsor
- Indiana University
Basic Science
Factors Affecting Sensory and Motor Learning
How participants perceive the position of their own hand in various contexts will be examined. This will include changing the visual display to suggest the hand is in a slightly different position, and asking participants to…
- Trial name
- NCT05374460
- Testing
- Explanatory diagram, Direct vision, Movement feedback, target hand
- Where
- United States
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Indiana University
HIV, Kaposi Sarcoma Herpesvirus -Associated Multicentric Castleman Disease
New Approaches for the Diagnosis of Lymphoma and Multicentric Castleman Disease
Persons living with HIV (PLWH) in sub-Saharan Africa (SSA), lymphadenopathy often portends one of a number of life-threatening diseases including tuberculosis, lymphoma, and multicentric Castleman disease (MCD).
- Conditions
- HIV, Kaposi Sarcoma Herpesvirus -Associated Multicentric Castleman Disease, Hodgkin Lymphoma, Non-Hodgkin Lymphoma
- Trial name
- NCT07793006
- Testing
- Lymph Node or Core Needle Biopsy, Fine Needle Aspiration, Tiny Isothermal Nucleic acid Amplification System (TINY)
- Where
- Malawi
- Volunteers
- 500 people
- Sponsor
- Indiana University
Caregiver Burden of People With Dementia
AIM 3 Focused Adaptation of a Mobile Caregiver Intervention for Dementia Caregivers
The goal of this clinical trial is to evaluate usability, feasibility and preliminary efficacy of a mobile telehealth supported behavioral intervention for caregivers of persons with dementia who identify as Hispanic.
- Trial name
- FAMILIA (NCT07792889)
- Testing
- Brain CareNotes Latino, Dementia Care app
- Volunteers
- 60 people
- Sponsor
- Indiana University
Stimulant Use, Substance Use Disorders
Enhancing Prospective Thinking in Early Recovery
The goal of this clinical trial is to use a novel virtual reality intervention to test for efficacy in reducing alcohol use and increasing abstinence, with concomitant increases in future self-identification, future time…
- Trial name
- NCT05835921
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Alcohol Use Disorder
Enhancing Prospective Thinking in Early Recovery (NERF)
The goal of this clinical trial is to test the prosocial effects of personally-relevant, high-intensity episodic future-thinking (EFT) cues in alcohol use disorder persons and related brain mechanisms.
- Trial name
- NERF (NCT06283446)
- Testing
- High-Intensity Cue, Low-Intensity Cue
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Indiana University
Anxiety, Well-Being
Supporting Families in the ICU
The overarching goal of our work is to test the effect of high-quality spiritual care for ICU family surrogates on outcomes of psychological and spiritual well-being and medical decision making.
- Conditions
- Anxiety, Well-Being, Satisfaction
- Trial name
- SF-ICU (NCT07228299)
- Testing
- Spiritual Care Assessment and Intervention (SCAI) Framework, ICU Guide
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Indiana University
Skull Base Neoplasms, Cerebrospinal Fluid Leakage
Role of Novel RADA16 Hydrogel in Endoscopic Skull Base Surgery
The purpose of this study is to specifically evaluate the effectiveness of PuraGel, a RADA16 polypeptide hydrogel, in expediting post-operative healing and re-mucosalization of the nasoseptal flap harvest site during endoscopic…
- Conditions
- Skull Base Neoplasms, Cerebrospinal Fluid Leakage, Nasal; Hypertrophy, Mucous Membrane (Septum)
- Trial name
- NCT05898074
- Testing
- Non-Absorbable Packing (Silastic Splint), PuraGel (RADA16) Hydrogel
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Fluid Overload, POCUS
Concordance and Discordance in the Assessment of Volume Status in Home Dialysis Patients: A Comparison of Modified Medical Research Council Dyspnea Scale, Physical Exam, and Point of Care Ultrasound (POCUS)
Fluid overload (when the body has too much fluid), is one of the reasons why people on home dialysis need to go to the hospital. Fluid overload commonly presents as trouble breathing and leg swelling.
- Conditions
- Fluid Overload, POCUS, Lung Ultrasound, Volume Status
- Trial name
- NCT07178470
- Testing
- point-of-care ultrasound (POCUS), specifically lung ultrasound (LUS), Modified Medical Research Council (mMRC) Dyspnea scale, Physical Exam
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Indiana University
Gestational Diabetes, Pregnancy Complications
Lifestyle Interventions to Improve Glycemic Parameters and Reduce Gestational Diabetes in High-risk Pregnant Individuals
The goal of this study is assess the impact of a higher intensity dietary and activity counseling program to improve blood sugar control and reduce the chance of developing gestational diabetes (GDM) as compared to the current…
- Trial name
- NCT06445270
- Testing
- GDM Prevention Program
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Glaucoma
Smart Soft Contact Lenses for Monitoring Glaucoma
This study is exploring the effectiveness and safety of soft contact lenses with embedded sensors, called smart contact lenses. Smart contact lenses are used to measure the pressure inside the eye.
- Trial name
- NCT07224542
- Testing
- Bare Contact Lens, Experimental Smart Contact Lens, Commercially available smart contact lens
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Indiana University
Diplopia, Monocular
VisionApp - Ghosting
Recent Android mobile device technology is available which allows user-measured refractive error and reading add power. This technology could be quite useful to the clinical and research community.
- Trial name
- NCT07571538
- Testing
- Proclear 1 Day Contact Lens, MyDay Contact Lens, NaturalVue Contact Lens
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
HIV/AIDS, Pregnancy Related
Measuring Adverse Pregnancy and Newborn Congenital Outcomes
The purpose of this study is to develop a pharmacovigilance (PV) surveillance program to monitor adverse pregnancy and infant outcomes, including the presence of congenital abnormalities, among HIV-positive and HIV-negative women…
- Conditions
- HIV/AIDS, Pregnancy Related, Congenital Disorders, Newborn Morbidity
- Trial name
- MANGO (NCT04405700)
- Testing
- Pharmacovigilance surveillance program
- Where
- Kenya
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Indiana University
Immobility Syndrome, Deep Venous Thrombosis
Bedside Bike Early Mobilization Program for Inpatients
Hospital immobility leads to serious complications including muscle loss, weakness, delirium, pressure ulcers, and blood clots. Despite being medically stable, hospitalized patients spend over 90% of their time in bed due to…
- Conditions
- Immobility Syndrome, Deep Venous Thrombosis, Delirium, Hospital Acquired Condition
- Trial name
- BB-STEP (NCT07281638)
- Testing
- Bedside Bike
- Volunteers
- healthy volunteers welcome
- Sponsor
- Indiana University
Snoring, Obstructive Sleep Apnea
Smart Pillows for Enhancing Sleep Quality
The purpose of this study is to examine the impact of smart pillows on the sleep quality of individuals who experience a snoring issue and/or obstructive sleep apnea (OSA), as well as their sleep partners.
- Trial name
- NCT06594627
- Testing
- Smart pillow
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Indiana University
HIV, Depression in Adults
The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV
The goal of this clinical trial is to learn if depression treatment improves insulin resistance, or how the body uses insulin to lower blood sugar, in people with HIV on HIV treatment.
- Conditions
- HIV, Depression in Adults, Insulin Resistance, Cognitive Behavior Therapy
- Trial name
- NCT07226128
- Testing
- Internet cognitive behavioral therapy (iCBT-D), Active Control (AC)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Drug-Drug Interaction
Interaction of CYP2B6 Genotype and Efavirenz With Methadone and Tizanidine PK
The main goal of this clinical study is to test how CYP2B6 genetic variations and efavirenz (cornerstone in HIV-1 therapy) dictate the disposition (PK) of CYP2B6 substrate (methadone) and PK and effect (PD) of CYP1A2 substrate…
- Trial name
- NCT05789173
- Testing
- Methadone and Tizanidine, Efavirenz, Methadone and Tizanidine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Indiana University
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