Clinical trials: sponsored by Indiana University
HIV
Effects of Switching Efavirenz to Raltegravir on Vascular Function and Bone Markers in HIV-infected Patients
Efavirenz, a commonly used HIV medication, may cause worsening vascular function and bone problems. The purpose of this study is to determine if switching efavirenz to raltegravir, a newer HIV medication, will improve vascular…
- Trial name
- NCT01270802
- Testing
- Tenofovir/emtricitabine, Tenofovir/emtricitabine/efavirenz, Raltegravir
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Parkinson Disease
PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)
The PROGENI Family Study is part of a larger consortium that is studying a gene shown to be important in Parkinson's disease, called LRRK2. People who have a defect in the LRRK2 gene will often develop Parkinson's disease.
- Trial name
- PROGENI (NCT01536821)
- Where
- 10 sites in United States, Canada
- Volunteers
- 81 people
- Sponsor
- Indiana University
Lung Cancer
Lung Cancer Location: a Repository
The purpose of this repository is to prospectively examine subjects with known or suspected lung cancer to determine the extent of mediastinal lymph node involvement with respect to primary lung cancer location.
- Trial name
- NCT00578084
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Obesity, Insulin Resistance
Treating the Endothelium to Restore Insulin Sensitivity
A study of 12 weeks' treatment with losartan or placebo, to test the hypothesis that RAS inhibition will improve insulin' vascular actions and therefore improve insulin sensitivity in skeletal muscle.
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance, Pre-diabetes
- Trial name
- NCT00402194
- Testing
- Losartan
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Depression, Pain
Telemedicine or Standard Care in Treating Patients With Depression and/or Pain Caused By Cancer
RATIONALE: Telemedicine may help in the treatment of depression and/or pain caused by cancer. It is not yet known whether telemedicine is more effective than standard care in treating depression and/or pain caused by cancer.
- Conditions
- Depression, Pain, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00313573
- Testing
- management of therapy complications, pain therapy, psychosocial assessment and care
- Where
- 17 sites in United States
- Volunteers
- 480 people
- Sponsor
- Indiana University
Atrial Fibrillation
Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery
The investigators hypothesize that the medication amiodarone decreases the incidence of atrial fibrillation (AF) following non-cardiac open-chest surgery.
- Trial name
- NCT00127712
- Testing
- Amiodarone
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Indiana University
Atrial Fibrillation, Esophagectomy
Prevention of Atrial Fibrillation Following Esophagectomy
The investigators hypothesize that the medication amiodarone decreases the incidence of atrial fibrillation (AF) following esophagectomy surgery.
- Trial name
- NCT00420017
- Testing
- Amiodarone, Control
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Colorectal Cancer
Interactive Computer Program or Brochure in Increasing Colorectal Cancer Screening Among African Americans
RATIONALE: An interactive computer program may be more effective than a brochure in increasing colorectal cancer screening among African Americans.
- Trial name
- PACT (NCT00672828)
- Testing
- Non-tailored CRC screening brochure, Interactive computer intervention
- Where
- United States
- Volunteers
- 693 people
- Sponsor
- Indiana University
HIV
HIV Testing & Womens Attitudes on HIV Vaccine Trials
The purpose of this study is to test the effects of different persuasive informational messages on rates of rapid HIV testing and willingness to participate in a HIV vaccine clinical trial.
- Trial name
- NCT00771537
- Testing
- Message Sidedness
- Where
- United States
- Volunteers
- 2,031 people, healthy volunteers welcome
- Sponsor
- Indiana University
Acute Low Back Pain
Psychosocial Treatment for Acute Low Back Pain
Acute low back pain (severe pain that comes on suddenly and lasts a relatively short time) is very common in the United States, and accounts for substantial illness, functional limitations, pain, and health care costs.
- Trial name
- NCT00000418
- Testing
- Psychosocial intervention
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- Indiana University
Chronic Kidney Disease
The Effect of Paricalcitol on Creatinine Filtration, Secretion and Glomerular Filtration Rate
The purpose of this study is to study the effects of Paricalcitol (Zemplar) on kidney functioning. The investigators hypothesize that the increase in serum creatinine observed in recent paricalcitol trials is a function of…
- Trial name
- Paricalcitol (NCT01163162)
- Testing
- Paricalcitol
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Indiana University
Osteoarthritis
Effects of Comprehensive Care for Knee OA
We will study 300 people with knee osteoarthritis (OA) who receive their medical care from a large health maintenance organization (HMO) in Indianapolis.
- Trial name
- NCT00000404
- Testing
- Patient education in self-care of knee OA
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Osteoarthritis, Knee
Effects of Strength Training on Knee Osteoarthritis
To understand the effects of leg strengthening exercise, we will study the effects of strength training of the legs in four groups of people: (1) osteoarthritis (OA) with knee pain; (2) OA without knee pain; (3) no OA but elderly…
- Trial name
- NCT00000406
- Testing
- Progressive resistance exercise
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Indiana University
Colonic Neoplasms
Trial of a Computer-Based Presentation of Quantitative Information About Colorectal Cancer Screening
Fifty thousand people die from colorectal cancer (CRC) every year, making it the second leading cause of death from cancer in the United States.
- Trial name
- NCT01415479
- Testing
- Control, Quantitative, Default
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- Indiana University
Osteoarthritis
Doxycycline and OA Progression
This study will determine whether doxycycline decreases the severity or rate of progression of osteoarthritis (OA) in the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most popular agents used to treat OA, but…
- Trial name
- NCT00000403
- Testing
- Doxycycline
- Where
- 6 sites in United States
- Volunteers
- 432 people
- Sponsor
- Indiana University
Asthma, Eczema
Risk of Asthma in Infants With Atopic Dermatitis
Infants will be enrolled in this study if they have never been diagnosed with asthma or wheezing and have been diagnosed with atopic dermatitis or eczema.
- Conditions
- Asthma, Eczema, Dermatitis, Atopic
- Trial name
- NCT00459576
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cataract
Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs
Based on previous results with eyes without filtering blebs, the aqueous concentrations of ofloxacin and levofloxacin will exceed the concentration of ciprofloxacin after either topical or topical plus oral administration.
- Trial name
- NCT00392275
- Testing
- Ofloxacin 0.3%, Ciprofloxacin 0.3%, Levofloxacin 0.5%
- Where
- 3 sites in United States
- Volunteers
- 48 people
- Sponsor
- Indiana University
HIV Infections
Nutrition Intervention in Drug Naive HIV-infected Kenyan Women and Their Children
Many of the 28 million people with immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) estimated to be living in sub-Saharan Africa also suffer from malnutrition.
- Trial name
- HNP (NCT00562874)
- Testing
- Meat Biscuit, Soy Biscuit, Wheat Biscuit
- Where
- Kenya
- Volunteers
- 808 people, healthy volunteers welcome
- Sponsor
- Indiana University
Traumatic Brain Injury
Osmotic Therapy for Treatment of Intracranial Hypertension for Traumatic Brain Injury
Osmotic therapy is a mainstay in the treatment of intracranial hypertension after traumatic brain injury.This study proposes to compare two hypertonic saline agents in patients with traumatic brain injury.
- Trial name
- NCT01215019
- Testing
- Mannitol, NaCl
- Where
- United States
- Sponsor
- Indiana University
Obesity
Remote Information Counseling for Elders
The purpose of this study is to provide testing methods of delivering nutrition and physical activity services for weight loss.
- Trial name
- RICE (NCT01203995)
- Testing
- Nutrition information, Nutrition education and exercise training
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Indiana University
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