Clinical trials: open to volunteers, sponsored by Institut National de la Santé Et de la Recherche Médicale, France
- Lead sponsor (exact) Institut National de la Santé Et de la Recherche Médicale, France
- Status Open to volunteers
General Population, no Specific Condition
Heat Waves, Urban Heat Islands, and Wellbeing and Health: a Mobile Sensing Approach
The first objective of H3Sensing is to investigate outdoor environmental, building, dwelling, situational, and behavioral determinants of objectively assessed personal heat stress over daily movements during warm periods.
- Trial name
- H3Sensing (NCT06850025)
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Gut Microbiome
Nutrition, Gut Microbiota and Health : Feces Sample Collection in NutriNet-Santé Participants
The gut microbiota is currently attracting increasing attention from the scientific community and also from the general public, as evidence of its role in human physiology has been highlighted.
- Trial name
- NUTRIGUT (NCT06941090)
- Testing
- sampling stool
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Kidney Disease, Hypertension (HTN)
Investigating Vascular Properties of HEMI and SPG Signals in Individuals With or at Risk for Chronic Kidney Disease
This prospective, single-center clinical investigation conducted in France will evaluate two non-invasive investigational devices (HEMI and SPG-NINOX) designed to assess microcirculation in adults.
- Conditions
- Chronic Kidney Disease, Hypertension (HTN), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- STIMULUS-CKD (NCT07604922)
- Testing
- HEMI device, SPG-NINOX device
- Where
- France
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Childhood Solid Tumor
French Childhood Cancer Survivor Study
The FCCSS is a multicentric national large-scale collaborative population-based study of children treated for a solid tumor before 2000 in France and before the age of 19 years.
- Trial name
- FCCSS (NCT01620372)
- Where
- 36 sites in France
- Volunteers
- 18,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Congenital Heart Disease, Cyanotic Congenital Heart Disease
Prenatal Maternal Mental Health and Neurodevelopment in Congenital Heart Disease
Congenital heart disease (CHD) is the leading cause of congenital malformations, representing 1% of live births. Progress in surgical care have led to the dramatic increase in the population of children and adults living with…
- Conditions
- Congenital Heart Disease, Cyanotic Congenital Heart Disease, d-Transposition of the Great Arteries, Hypoplastic Left Heart Syndrome
- Trial name
- Neuro-Moms (NCT06711666)
- Where
- 5 sites in France
- Volunteers
- 174 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Infectious Disease, Cardiovascular Diseases
Metabolic and Infectious Diseases in La Réunion (the REUNION Population-based Study)
The aim of the present study is to determine the prevalence of cardiometabolic and infectious disease in La Reunion (french oversea department and region of France).
- Conditions
- Infectious Disease, Cardiovascular Diseases, General Population, Metabolic Disease
- Trial name
- NCT05400824
- Testing
- Blood, DNA, feces, urine, hair and skin microbiota collection
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Glioma
MRS of Glioma Genomics
In France, about 5000 new people with a primary malignant brain tumor are diagnosed each year. The most common primary tumors are gliomas, originating from glial cells (astrocytomas and oligodendrogliomas).
- Trial name
- GLIOMRS (NCT05700071)
- Testing
- MRI
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson's Disease
Subthalamic Nucleus, Akinesia and Parkinson's Disease
This program aims to understand the role of the subthalamic nucleus in the control of the movement in healthy humans and patients with Parkinson's disease, how the STN dysfunction contributes to akinesia and how the STN…
- Trial name
- GB-MOV (NCT01682668)
- Testing
- Bilateral subthalamic stimulation
- Where
- 2 sites in France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Choroidal Neovascularization, Mineralocorticoid Excess
Biomarkers and Choroidal Neovascularization
The aim of the study is to find biomarkers in the blood and aqueous humor of patients with type 1 choroidal neovascularization and correlate them with the response to anti-VEGF treatment.
- Trial name
- BioNéoRet (NCT04439708)
- Testing
- Blood and aqueous humor biomarker of treatment response
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stroke, Hemiparesis
Neuroplasticity After Proprioceptive Rehabiliation
Sequences of muscle tendon vibrations allow to reproduce the sensory feedback during movement like locomotion and kinaesthesia. It is known that such a treatment promotes motor recovery after stroke assuming that it enhances…
- Conditions
- Stroke, Hemiparesis, Traumatic Brain Injury
- Trial name
- VibraLCA (NCT05277519)
- Testing
- Vibrations
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Alzheimer Disease, Memory Complaint
Investigation of AlzHeimer's Predictors in Subjective Memory Complainers - Extension Study
A regional, single-center, prospective, observational academic cohort will follow subjects who previously participated in the INSIGHT study and who agree an extension of their follow-up in the INSIGHT-2 research for additional…
- Conditions
- Alzheimer Disease, Memory Complaint, Memory Disorders
- Trial name
- INSIGHT-2 (NCT05806697)
- Testing
- Electroencephalogram (EEG), Oculomotor tests, MRI
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cystinosis
European Cystinosis Cohort
Cystinosis is a generalized lysosomal storage disease with a reported incidence of about 1:180,000 live births. There are estimated 110-140 cases in France (approximately 500 in Western Europe).
- Trial name
- RaDiCo-ECYSCO (NCT05901077)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Anophthalmia, Microphthalmia
National Cohort on Congenital Defects of the Eye
Congenital malformations of the eye comprise various developmental defects including microphthalmia, anophthalmia, aniridia, and anterior segment anomalies (such as Peters and Axenfeld-Rieger anomalies).
- Conditions
- Anophthalmia, Microphthalmia, Aniridia, Anterior Segment Dysgenesis 6, Peters Anomaly Subtype
- Trial name
- RaDiCoACOEIL (NCT05954403)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Infectious Disease
Genetic Susceptibility to Severe Infections
Only a fraction of individuals infected with microbes develop clinical disease. This observation raises fundamental questions about the pathogenesis of infectious diseases.
- Trial name
- PREDISPOSITI (NCT06102070)
- Testing
- Blood samples drawing, Skin biopsy
- Where
- France
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Developmental Language Disorder
MOLECULAR BASIS OF LANGUAGE DEVELOPMENT AND ASSOCIATED DISORDERS
Developmental Language Disorder (DLD) refers to children who present with language difficulties that are not due to a known biomedical condition or associated with autism spectrum disorder (ASD) or intellectual disability.
- Trial name
- TSLO (NCT06660108)
- Testing
- blood draw
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Rare Diseases, Ophthalmology
Identification of Cellular Biomarkers of Rare Eye Diseases in Adults
The cornea is the outermost transparent 'window' of the eye allowing light to enter and serving as the first-line immune and mechanical barrier.
- Trial name
- REVIBIO (NCT07063719)
- Testing
- Ophthalmological visit, Questionnaires, Blood sample collection
- Where
- 2 sites in France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Healthy Participants, Magnetic Stimulation
Study of the Correlation Between Cortical Excitability and Cytoarchitectonics of Prefrontal Cortex in Healthy Adult Participants, Using Transcranial Magnetic Stimulation Coupled to EEG and High-field MRI
Repeated transcranial magnetic stimulation (rTMS) is mainly used to treat mood disorders by addressing differences in brain function, particularly in the dorsolateral prefrontal cortex (DLPFC), which affects emotions and…
- Conditions
- Healthy Participants, Magnetic Stimulation, MRI, EEG
- Trial name
- FrontalProbe (NCT07071259)
- Testing
- TMS Stimulation
- Where
- France
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Amyotrophic Lateral Sclerosis (ALS)
Identification of Early Markers for ALS
Although several molecules have been proposed as biomarker candidates, a clinically established signature for an early or even premotor diagnosis of ALS is not available.
- Trial name
- PremodiALS (NCT07213440)
- Testing
- lumbar puncture
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Mental Health (Depression), Mental Health
Precarity and Reduction of Its Impact on the Mental Health of Health Students
Student financial insecurity has become a major public health and societal issue affecting a growing proportion of young adults in higher education, exacerbated by the COVID-19 pandemic and more recently by inflation.
- Conditions
- Mental Health (Depression), Mental Health, Quality of Lifte
- Trial name
- PRISMES (NCT07539207)
- Testing
- Targeted Mental Health and Well-being Support for Financially Vulnerable Health Student
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Paroxysmal Dyskinesia
Neural Correlates of Movement Disorders Associated With PRRT2 Related Paroxysmal Kinesigenic Dyskinesia - an Ancillary Study of AMEDYST Research
The main objective of this study is to investigate in real-time the neuronal correlates of paroxysmal dyskinesia episodes related to the PRRT2 mutation within this subgroup of patients (who can control paroxysmal dyskinesia…
- Trial name
- TRIGGER (NCT06701851)
- Testing
- Voluntary and involuntary conditions
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France