Clinical trials: sponsored by Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease
Investigation of the Benefits of Electrical Non-invasive Stimulation on Cognitive Symptoms in Parkinson's Disease
Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease. It is mostly characterized by the presence of motor difficulties.
- Trial name
- STIMPARK (NCT05808504)
- Testing
- Neuropsychological assessment, Neurological assessment, Cognitive task
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Multiple Sclerosis
Mechanisms of Disease Severity in Multiple Sclerosis: an Integrative Multimodal Study
This study will identify a combination of disease severity markers (genetic, immunology, epigenetic, imaging) associated with disease severity and progression in a cohort of patients with multiple sclerosis.
- Trial name
- SEP-BIO-PROG (NCT03369106)
- Testing
- Composite severity score calculation
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Respiratory Health
CRESPI - Respiratory Health of Children in Daycare
CRESPI - RESPIratory health of Children in daycare The CRESPI study, will be a cohort of 1500/2000 children attending daycare in Paris region, and will be initiated in November 2019.
- Trial name
- CRESPI (NCT04170881)
- Testing
- Exposed/non exposed - Epidemiology
- Where
- France
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Biliary Atresia
Molecular Characterization for Understanding Biliary Atresia
Although considered a rare disease, Biliary Atresia (BA) is the leading cause of neonatal cholestasis and liver transplantation in children. Little is known about the molecular mechanisms that drive BA.
- Trial name
- CAVB (NCT04272515)
- Testing
- blood sampling, skin biopsy sampling, explanted liver of BA patients sampling
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Liver Disease and Cirrhosis, Liver Cancer
"Constitution of a Biological Collection to Establish Preclinical Translational Models for the Study of Tumors and Chronic Liver Diseases".
Development of preclinical translational models for chronic liver tumors and diseases study, such as spheroids cultured in autologous medium and murine xenograft models to test the efficacy of new therapeutic strategies.
- Conditions
- Chronic Liver Disease and Cirrhosis, Liver Cancer, Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Steatohepatitis
- Trial name
- LivMOD (NCT04690972)
- Testing
- Blood sample during surgery, Taking an additional biopsy, Blood sample during diagnostic test
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Exposure
Intervention to Reduce Exposure to Environmental COntaminant (IRECO)
Main objective The intervention study IRECO aims to (1) modify habits of personal care product use for the participants and (2) evaluate the impact of those modification on urinary concentration for the following compounds…
- Trial name
- NCT04919434
- Testing
- IRECO
- Where
- France
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Non Invasive Diagnosis of Glioma
Non Invasive IDentification of Gliomas With IDH1 Mutation
The recurrent mutation IDH1Arg132His leads to the cellular accumulation of D-2-hydroxyglutarate (2-HG), thus representing a diagnostic marker (this change is almost specific for gliomas) and prognostic (mutated gliomas have…
- Trial name
- IDASPE (NCT01703962)
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stroke
The Role of Peripheral Afferents in Modulating Post-stroke Central Pain
Central post-stroke pain (CPP) is extremely difficult to relieve and responds very poorly to analgesics targeting neuropathic pain, probably because the mechanisms underlying this pain remain poorly understood.
- Trial name
- APEDOC (NCT06446960)
- Testing
- Lidocaine 20mg/ml, Levobupivacaine Hydrochloride 1.25 MG/ML, Sodium Chloride 0.9% Inj
- Where
- 2 sites in France
- Volunteers
- 33 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Intergenerational Trauma
Child Cognitive-Affective Resilience Following 13-11 Event : A Pluridisciplinary Study of Intergenerational Transmission of a Traumatic Event
CARE 13-11 study explores the transmission of trauma within families. Exposure to a traumatic event can have an impact on those directly exposed, but also on their family.
- Trial name
- CARE 13-11 (NCT07203443)
- Testing
- MRI, Psychological assessment, Cognitive assessment
- Where
- France
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Resistant Hypertension
Arterial Stiffness as a Tool to Investigate Adherence in Resistant Hypertension
According to WHO estimates, worldwide, 1.28 billion adults between the age of 30-79 years have hypertension. Furthermore, only 1 in 5 people with hypertension have it under control.
- Trial name
- INSIDE-RH (NCT07207226)
- Testing
- Laser doppler vibrometry
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Gilles de la Tourette Syndrome, Tics
Repetitive Transcranial Magnetic Stimulation of the Posterior Parietal Cortex in Patients Suffering From Gilles de la Tourette Syndrome
Repetitive transcranial stimulation (rTMS) of the posterior parietal cortex will be applied daily over five days in adult Gilles de la Tourette patients.
- Trial name
- rTMSPPCGT (NCT01043549)
- Testing
- rTMS
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Influenza A Virus, H1N1 Subtype
Study of Immune Responses After Vaccination Against Seasonal Influenza Virus and Against Influenza H1N1-v Pandemic Virus in a Medical Staff.
This project may help to answer several fundamental questions related to public health regarding vaccination against influenza viruses and regarding the influenza A(H1N1)v pandemy: What is the immunologic efficacy in terms of…
- Trial name
- FLU-HOP (NCT01063608)
- Testing
- Anti-H1N1v Vaccine
- Where
- 2 sites in France
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Post-Traumatic Stress Disorder
Resilience and Modification of Brain Control Network Following November 13
This is a multiwave longitudinal neuroimaging study in a cohort of direct survivors of 11/13 Paris terrorist attacks. Both structural and functional brain imaging data will be collected at 8-12 months, 3 years, and 6 years after…
- Trial name
- REMEMBER (NCT02810197)
- Testing
- Psychopathological assessment, Neuropsychological assessment, Functional magnetic resonance imaging (fMRI)
- Where
- France
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Menstruation
Evolution of Menstruation
This study examines gene expression and gene regulation in the uterine lining during menses in women, for evolutionary comparison with other primates which do or do not menstruate.
- Trial name
- EVOMENS (NCT04085835)
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Idiopathic Intracranial Hypertension
MR Lymphatic Imaging in Idiopathic Intracranial Hypertention
In the brain and its borders, blood vessels coexist with lymphatic vessels exclusively in the dura mater, the outermost layer of meninges.
- Trial name
- LYMPHIMAGIIH (NCT05762367)
- Testing
- 3T MRI with Gadobutrol injection
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Heart Failure
Impact of Heart Failure on Calcium Homeostasis and Mitochondrial Function in Human Skeletal Muscle
The aim of this project is to investigate the impact of heart failure (HF) on calcium homeostasis, mitochondrial function and oxidative stress in human skeletal muscle, before and after exercise training.
- Trial name
- Calcicard (NCT01014611)
- Where
- France
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Hepatitis C
A Pilot Study Evaluating Safety of Sitagliptin Combined With Peg-IFN Alfa-2a + Ribavirin in Chronic Hepatitis C Patients
Hepatitis C infection is a major public health problem with nearly 175 million infected individuals worldwide. Although cure is possible, only 20-40% of patients spontaneously resolve infection and 40-80% of chronically infected…
- Trial name
- NCT01567540
- Testing
- Sitagliptin
- Where
- 4 sites in France
- Volunteers
- 3 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Stroke, Cognitive Impairment
Cognitive Rehabilitation and Galantamine for Post Stroke Cognitive Impairment
The investigators would like to conduct a double blind placebo-controlled prospective study to show the impact of a treatment combining a specific cognitive rehabilitation program and acetylcholinesterase inhibitors on executive…
- Trial name
- COGICRehab (NCT01508494)
- Testing
- Galantamine
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Hepato Carcinoma
A Pilot Study to Evaluate the Safety of a 3 Weeks Sitagliptin Treatment in HCC Patients Undergoing Liver Resection
Boosting of tumor cell killing by cytotoxic lymphocytes may be a promising means to enhance anti-tumor immunity. Prior studies demonstrated that tumor infiltration by cytotoxic lymphocytes correlates with control of tumor growth…
- Trial name
- HCC-DPPIV (NCT02650427)
- Testing
- Sitagliptin
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cerebellar Ataxias, Spastic Paraplegias
SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
Cerebellar ataxias (CA) and spastic paraplegias (SP) are genetically and clinically very heterogeneous. More than 40 loci are already known but the number of phenotypes is even greater suggesting further genetic heterogeneity.
- Trial name
- Spatax (NCT00140829)
- Where
- 27 sites in Algeria, Belgium and 13 more
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France