Clinical trials: sponsored by Institut du Cancer de Montpellier - Val d'Aurelle
Metastatic Colorectal Cancer
Sorafenib With Irinotecan in Metastatic Colorectal Cancer (mCRC) and K-RAS Mutation
A multicentre two-part phase I/II study evaluating response and safety of SORAFENIB in combination with irinotecan in the second line treatment or more of metastatic colorectal cancer with K-RAS mutation.
- Trial name
- NEXIRI (NCT00989469)
- Testing
- Nexavar (Sorafenib) and irinotecan (Campto)
- Where
- 5 sites in France
- Volunteers
- 64 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Thyroid Cancer, Prostate Cancer
Clinico-biological Database in Patients Treated With Metabolic Radiotherapy in the Nuclear Medicine Department
Development of a clinico-biological database allowing the provision of clinical data and corresponding biological materials to the medical and scientific community.
- Conditions
- Thyroid Cancer, Prostate Cancer, Neuroendocrine Tumors, SSTR Positive Tumors
- Trial name
- BCB RIV (NCT04104529)
- Testing
- Biological collection, tumor collection
- Where
- 4 sites in France
- Volunteers
- 350 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Breast Cancer, Physiotherapy
Evaluation of the Impact of Pre-habilitation Using Physiotherapy and Mechanical Stimulation on Shoulder Pain and Mobility in Patients Undergoing Breast Reconstruction Using a Latissimus Dorsi Flap
Each year in France, nearly 59,000 new cases of breast cancer are diagnosed, and approximately 22,000 mastectomies are performed. Among these patients, 30% choose to undergo breast reconstruction.
- Conditions
- Breast Cancer, Physiotherapy, Breast Reconstruction, Latissimus Dorsi Flap
- Trial name
- PREHAB KINELGD (NCT07418060)
- Testing
- Prehabilitation with physiotherapy including mechanostimulation, No Prehabilitation with physiotherapy including mechanostimulation
- Where
- 2 sites in France
- Volunteers
- 96 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Anal Cancer, Sexuality
Assessment of Patients' Quality of Sexual Life After Anal Cancer Treatment
The purpose of this this study, to evaluate the quality of sexual life of patients treated for anal cancer treated by radiotherapy, during their treatment, then 3 months after treatment and, finally, 2 years after treatment.
- Conditions
- Anal Cancer, Sexuality, Psychologic Stress, HPV
- Trial name
- SEQUOIA (NCT05109468)
- Testing
- Quality of life questionnaire
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Cervical Cancer, Brachytherapy
Impact of an Educational Physiotherapy-Yoga Intervention on Perceived Stress in Women Treated With Brachytherapy for Cervical Cancer
Every year in France, nearly 3,000 women develop a cervical cancer. The average age of women diagnosed is 51. Uterovaginal brachytherapy is one of the reference treatments.
- Trial name
- KYOCOL (NCT06263283)
- Testing
- session of Kine-Yoga
- Where
- 3 sites in France
- Volunteers
- 98 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Rectal Cancer, Chemoradiotherapy
Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Treatment
Rectal cancer presents a significant global health challenge. Despite improvements in clinical outcomes, significant disparities persist across Europe.
- Conditions
- Rectal Cancer, Chemoradiotherapy, Mri
- Trial name
- RESTAGE (NCT07404228)
- Testing
- questionnaire completion
- Where
- France
- Volunteers
- 115 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Thyroid Cancer
Predictive Value of microRNA in Thyroid Cytologies of Undetermined Type
The aim is to validate a signature of microRNA (micro Ribonucleic acid) based in a first exploratory study allowing the stratification of the cytologies of indeterminate type and to study and select others.
- Trial name
- PREDICYTHY (NCT04285476)
- Testing
- Signature of microRNA for patients with bethesda classification 3, 4 or 5
- Where
- 3 sites in France
- Volunteers
- 71 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Rectal Cancer, Colon Cancer
Contribution of Preserving the Superior Left Colic Artery to the Vascularization of the Descending Colon Prior to Colorectal Anastomosis During Left-Sided or Rectal Resections for Colorectal or Ovarian Cancer. (Revascularisation Colique)
Colorectal cancers and ovarian cancers are respectively the 2nd and 5th cause of cancer mortality in France. Surgical resection is a crucial step in the therapeutic management of colorectal cancers.
- Conditions
- Rectal Cancer, Colon Cancer, Ovarian Cancer
- Trial name
- NCT07098182
- Testing
- Clamping and restauration of arterial blood of the inferior mesenteric artery
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Locally Advanced Malignant Neoplasm, Rectal Carcinoma
Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma
Locally advanced rectal carcinoma raise the issue of both the oncological control, local and general, and the therapeutic morbidity.
- Trial name
- GRECCAR14 (NCT04749108)
- Testing
- Induction chemotherapy - modified FOLFIRINOX regimen, Early tumor response evaluation by MRI volumetry, Radiochemotherapy Cap 50
- Where
- 30 sites in France
- Volunteers
- 1,075 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Cancer Survivors, Peripheral Neuropathic Pain
Evaluating Laser Photobiomodulation for the Treatment of Neuropathic Pain in Chemotherapy-induced Peripheral Neuropathy in Cancer Patients
Chemotherapy-induced peripheral neuropathy (CIPN) (including taxanes, platinum, al pervenche from Madagascar alkaloids...), is a frequent secondary effect of treatments: 68% at 1-month post-chemotherapy, 60% at 3 months and 30%…
- Trial name
- NEUROdoux (NCT06834685)
- Testing
- Photobiomodulation sessions
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Breast Cancer, Biopsy Wound
Pain Monitoring After Breast Biopsy: Benefit of E-health
Each year, approximately 1500 breast biopsies (1000 microbiopsies and 500 macrobiopsies) are performed in the radiologic department of the Montpellier Cancer Institute (ICM).
- Trial name
- BIO-PSY (NCT04456920)
- Testing
- phone consultation, e-PRO self-completed via connected objects (tablet/phone), visit
- Where
- France
- Volunteers
- 193 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Prostate Cancer
Evaluation of Late Toxicity Following Intensity-Modulated Radiotherapy and Two Image-Guided Strategies With Corresponding Treatment Margins.
The Calypso® System (Varian Medical Systems, Inc., Palo Alto, CA) is a recent technology using electromagnetic transponders implanted within the prostate.
- Trial name
- RCMIGI (NCT03254420)
- Testing
- Calypso beacon implant, moderate hypofractionation Radiotherapy
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Invasive Breast Cancer, Breast-conserving Surgery
Observational Study of Intra-operative Partial Irradiation of Invasive Ductal Breast Carcinomas With a Good Prognosis
Due to screening, T1N0 early-stage breast cancer now accounts for more than 50% of the tumors diagnosed in France. The prognosis of these tumors is good, even excellent in women ≥ 65 years of age, with specific survival of 98% at…
- Trial name
- INTRA-OBS (NCT04414202)
- Testing
- tumorectomy with axillary dissection (sentinel lymph node), per-operative partial irradiation
- Where
- France
- Volunteers
- 519 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Pediatric Oncology, Radiotherapy
Effect of the MIROKI Companion Robot on Anxiety in Pediatric Radiotherapy
Pediatric radiotherapy is an anxiety-provoking situation that can, on one hand, impair the child's cooperation and require sedation, and on the other hand,burden the care pathway by generating significant anxiety in both the…
- Conditions
- Pediatric Oncology, Radiotherapy, Parent
- Trial name
- KOKORO01 (NCT07645950)
- Where
- France
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Glioma
Using the Epitranscriptome to Diagnose and Treat Gliomas
Diffuse gliomas are among the most common tumors of the central nervous system, with high morbidity and mortality and very limited therapeutic possibilities.
- Trial name
- EPIGLIO (NCT06575452)
- Testing
- Blood, urine and tumoral tissue samples, Tumoral tissue samples
- Where
- 2 sites in France
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Neuroendocrine Tumors, Intestinal Well Differentiated Endocrine Tumor
Assessment of Retreatment With Lutathera® in Patients With New Progression of Intestinal Well-differenciated NET
In France, since the reimbursement of Lutathera®, this treatment is allowed for retreatment if patients still fulfill the criteria of its indication and 4 news cycles could be proposed.
- Conditions
- Neuroendocrine Tumors, Intestinal Well Differentiated Endocrine Tumor, Progressive Disease
- Trial name
- ReLUTH (NCT04954820)
- Testing
- Lutathera
- Where
- 28 sites in France
- Volunteers
- 146 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Breast Cancer
Evaluation of the Efficacy of a Physical Therapy-yoga-patient Educational Program for Breast Cancer Patients With Pain Due to Hormonal Therapy Treatment.
As much as 50% of patients treated with hormonotherapy (HT) for breast cancer (BC) suffer from osteoarticular pain during treatment.
- Trial name
- SKYPE2 (NCT04457895)
- Testing
- educational yoga program, no intervention
- Where
- 7 sites in France
- Volunteers
- 108 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Glioblastoma, Glioma
Memory Perception Assessment in Central/Non-central Nervous System Cancers
Prospective memory (PM) is the ability to implement intended actions in the future. It allows maintaining and retrieving future plans, goals, and activities (i.e., remember to remember).
- Conditions
- Glioblastoma, Glioma, Breast Cancer, Healthy
- Trial name
- PROMESSE (NCT03975959)
- Testing
- QMRP questionnaire
- Where
- 6 sites in France
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Metastatic Pancreatic Cancer
Efficacy of Gembrax Followed by Folfirinox Versus Folfirinox Alone in First Metastatic Line Pancreatic Cancer Patients
The aim of this study is to evaluate the efficacy of sequential treatment (Gabrinox) comprising Gembrax regimen (Gemcitabine -Abraxane) followed by the Folfirinox regimen (5FU, Oxaliplatin and Irinotecan) compared to folfirinox…
- Trial name
- GABRINOX2 (NCT05065801)
- Testing
- GEMBRAX/FOLFIRINOX Arm A, FOLFIRINOX Arm B
- Where
- 8 sites in France
- Volunteers
- 162 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Pelvic Cancer, Anal Cancer
Assessment of Sexual Quality of Life Following Local Treatment (Radiotherapy With or Without Surgery) in Patients With HPV-positive Pelvic Cancer: a Descriptive Longitudinal Study
In patients with cancer associated with human papillomavirus (HPV), the physical effects of treatment, combined with the psychosexual impact linked to HPV status, can further impair the quality of sexual life.
- Conditions
- Pelvic Cancer, Anal Cancer, Vaginal Cancer
- Trial name
- SAPPHIRE (NCT07523152)
- Testing
- Assessment of sexual quality of life
- Volunteers
- 42 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle