Clinical trials: sponsored by Istituto Auxologico Italiano
Ventral Hernia Repair
ORION Study: Mesh Position and Risk During Subsequent Minimally Invasive Abdominal Surgery
Ventral hernia repair is one of the most commonly performed abdominal surgical procedures worldwide, increasingly carried out using minimally invasive techniques.
- Trial name
- ORION (NCT07384962)
- Where
- Italy
- Volunteers
- 790 people
- Sponsor
- Istituto Auxologico Italiano
Migraine
Evaluation of the Performance of the Doraldo-Castelletti Scale in Supporting the Neurologist's Decision to Refer Migraine Patients to Physiotherapy
Migraine is the leading cause of disability worldwide among people aged 15 to 49. Although therapies targeting the CGRP pathway have improved the management of the condition, there are large groups of patients who do not respond…
- Trial name
- MIGSKA (NCT07626307)
- Testing
- Doraldo-Castelletti scale
- Where
- Italy
- Volunteers
- 439 people
- Sponsor
- Istituto Auxologico Italiano
Multiple Sclerosis (MS) - Relapsing-remitting
Behavioral and Electrophysiological Evidence of the Modulation of Fatigue in RR-MS
To furnish behavioral and electrophysiological evidence of the possible modulation of fatigue in Multiple Sclerosis - relapsing remitting form, through a verbal placebo.
- Trial name
- Fatigue_SM (NCT07624812)
- Testing
- TENS therapy
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Istituto Auxologico Italiano
Osteoporosis, Menopause
MicroRNA and Markers and Therapeutic Response to Romosozumab and Abaloparatide in Postmenopausal Osteoporosis
Osteoporosis is a systemic skeletal disorder affecting approximately 10% of individuals over 50 years of age. It is characterised by an increased risk of fragility fractures, which constitute a major source of morbidity…
- Trial name
- ROMIRNA (NCT07616401)
- Testing
- miRNA typing
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- Istituto Auxologico Italiano
Obesity, Sarcopenic Obesity
Effects of Obesity on Physical Abilities and Daily Living Activities in Elderly Adults
Obesity is a significant health problem whose prevalence has tripled worldwide in the last fifty years, also involving older people.
- Trial name
- CAPFISOBEANZ (NCT07614464)
- Testing
- Fitness tests and questionnaires
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Cardiac Magnetic Resonance
Assessment of Left Atrial Size and Function by Cardiac Magnetic Resonance
Left atrial (LA) size and function are powerful prognostic markers in a variety of clinical conditions. Cardiac magnetic resonance (CMR) is considered the gold-standard to assess the volumes of heart chambers by contouring cavity…
- Trial name
- ALATRIUM (NCT07561151)
- Testing
- CMR scan
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Auxologico Italiano
Obesity Morbid, Weight Loss
Metabolic Effects of a Diet Replaced With Essential Amino Acids
The effectiveness of low-protein diets supplemented with essential aminoacid (EAA) formulas in genetic disorders of amino acid (AA) catabolism, such as maple syrup urine disease (MSUD), is widely recognized (Blackburn PR et al.
- Trial name
- AMINOB (NCT06309563)
- Testing
- Aminoacid supplementation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Auxologico Italiano
Hypercortisolism
Effects of Metyrapone in Patients With Hypercortisolism
The aims of the present study are to evaluate in patients with mild hypercortisolism the effect of metyrapone treatment on glycometabolic control, blood pressure, thrombotic risk parameters, lipid profile, bone turnover markers…
- Trial name
- CEM (NCT05255900)
- Testing
- Metyrapone Capsules
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
Obesity
Whole Body Vibration Effects on Energy Expenditure in Obese Adolescents
The main aim of the present study is to evaluate in a group of adolescents with obesity, hospitalized for a period of integrated metabolic rehabilitation (calorie restriction, aerobic physical activity, psychological counseling…
- Trial name
- VIBRAREEOB (NCT06800872)
- Testing
- Multidisciplinary metabolic rehabilitation, Multidisciplinary metabolic rehabilitation + training with WBVE
- Where
- Italy
- Volunteers
- 28 people
- Sponsor
- Istituto Auxologico Italiano
Hypertension, Old Age
Study on Blood Pressure Variability and Frailty in the Older People
Observational prospective single-center, non-profit study. Primary objective of the study: To determine if the hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) <90 mmHg (or two episodes of…
- Trial name
- HypoPHrail (NCT06868069)
- Testing
- Diagnostic tests and questionnaires
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Istituto Auxologico Italiano
Anorexia Nervosa
Orexin Gene in Anorexia Nervosa
The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate…
- Trial name
- ORESSANNE (NCT06800898)
- Testing
- Blood samples and Questionnaires
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Masked Hypertension
MASked-unconTrolled hypERtension Management Based on Office BP or on Out-of-office (Ambulatory) BP Measurement
MASTER study is a 4-year prospective, randomized, open-label, blinded-endpoint study (PROBE) comparing 2 management strategies 1) office BP as a guide to treatment, or 2) 24-hour ABP as a guide to treatment.
- Trial name
- MASTER (NCT02804074)
- Testing
- Optimization of antihypertensive treatment based on office BP, Optimization of antihypertensive treatment based on 24-hour ABPM
- Where
- 2 sites in Italy, Venezuela
- Volunteers
- 1,240 people
- Sponsor
- Istituto Auxologico Italiano
Anorexia Nervosa
Body Composition in Adolescents With Anorexia Nervosa
Body Mass Index (BMI) is currently the most widely recommended parameter for identifying underweight subjects. Among eating disorder diseases, anorexia nervosa (AN) is the one with the highest mortality rate and with relapses…
- Trial name
- COCOMETANNER (NCT06800742)
- Testing
- Collection of anthropometric and biochemical parameters
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Auxologico Italiano
Anorexia Nervosa
Posture and Spinal Mobility in Anorexia Nervosa
The primary objective of the study is to compare the results of the postural and mobility analysis obtained with the use of the Idiag M360 instrument in adult women with anorexia nervosa and in a control group represented by…
- Trial name
- SPINALAN (NCT06800924)
- Testing
- Postural and mobility analysis
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Feeding and Eating Disorders
Metacognitive Beliefs in Adolescents With Eating and Nutrition Disorders
The present study aims to study the presence of metacognitive beliefs in adolescent subjects with eating and nutrition disorders (END) compared with a control group composed of subjects of the same sex and age belonging to the…
- Trial name
- METAED (NCT06800807)
- Testing
- Observation of several factors involved in eating and nutrition disorders
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- Istituto Auxologico Italiano
Anorexia Nervosa
Sphingolipidomic Profile in Anorexia Nervosa
: The objective of this research project will be to determine the sphingolipidomic profile in a group of women (> 18 years) affected by Anorexia Nervosa (AN), phenotypically characterized (restricting [AN-R] vs binge-eating…
- Trial name
- SFINGOANNER (NCT06800937)
- Testing
- Determination of sphingolipidomic profile
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Auxologico Italiano
Amyotrophic Lateral Sclerosis
Needs of ALS Patients With C9orf72 Mutation and Their Caregivers
Individuals with Amyotrophic Lateral Sclerosis (ALS) carrying the C9orf72 HRE mutation (C9Pos) often exhibit different phenotypic traits compared to other patients (C9Neg), presenting a more aggressive form of the disease, with…
- Trial name
- C9survALS (NCT07302321)
- Testing
- Survey for ALS patients, Survey for Caregivers
- Where
- 3 sites in Italy
- Volunteers
- 208 people
- Sponsor
- Istituto Auxologico Italiano
Homonymous Hemianopsia, Stroke
Neuromodulation Through Multisensory Stimulation for Visual Field Deficits in the Subacute Stage of Disease
Homonymous visual field defects (HVFDs) after acquired brain injuries affect daily life by impairing reading, navigation, and social activities, often impacting anxiety and depression. Spontaneous recovery is rare.
- Trial name
- MULTICAMPO (NCT07358832)
- Testing
- tDCS, Audio-visual training
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Istituto Auxologico Italiano
Amyotrophic Lateral Sclerosis
LONgitudinal and Integrated Evaluation of Biomarkers in reLation to phenotYpe in ALS
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons, leading to paralysis and death.
- Trial name
- LONELYALS (NCT07312240)
- Testing
- Lumbar Puncture for analysis of Cerebrospinal Fluid, Deep Phenotyping, Routine blood chemistry analysis and genetic analysis
- Where
- Italy
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Eating Disorders, Anorexia Nervosa
Sleep and Activity For Eating Disorders
The SAFE (i.e., Sleep and Activity For Eating disorders) study aims to investigate the characteristics of sleep, daytime activity, and circadian rhythms in a sample of patients with eating disorders-specifically anorexia nervosa…
- Conditions
- Eating Disorders, Anorexia Nervosa, Bulimia Nervosa, Binge Eating Disorder
- Trial name
- SAFE (NCT07295470)
- Testing
- Actigraphy, Collection of biological parameters, Psychological testing
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Istituto Auxologico Italiano