Clinical trials: sponsored by Istituto Auxologico Italiano
Hypertension, Old Age
Study on Blood Pressure Variability and Frailty in the Older People
Observational prospective single-center, non-profit study. Primary objective of the study: To determine if the hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) <90 mmHg (or two episodes of…
- Trial name
- HypoPHrail (NCT06868069)
- Testing
- Diagnostic tests and questionnaires
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- Istituto Auxologico Italiano
Hypercortisolism
Effects of Metyrapone in Patients With Hypercortisolism
The aims of the present study are to evaluate in patients with mild hypercortisolism the effect of metyrapone treatment on glycometabolic control, blood pressure, thrombotic risk parameters, lipid profile, bone turnover markers…
- Trial name
- CEM (NCT05255900)
- Testing
- Metyrapone Capsules
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
Amyotrophic Lateral Sclerosis
Needs of ALS Patients With C9orf72 Mutation and Their Caregivers
Individuals with Amyotrophic Lateral Sclerosis (ALS) carrying the C9orf72 HRE mutation (C9Pos) often exhibit different phenotypic traits compared to other patients (C9Neg), presenting a more aggressive form of the disease, with…
- Trial name
- C9survALS (NCT07302321)
- Testing
- Survey for ALS patients, Survey for Caregivers
- Where
- 3 sites in Italy
- Volunteers
- 208 people
- Sponsor
- Istituto Auxologico Italiano
Homonymous Hemianopsia, Stroke
Neuromodulation Through Multisensory Stimulation for Visual Field Deficits in the Subacute Stage of Disease
Homonymous visual field defects (HVFDs) after acquired brain injuries affect daily life by impairing reading, navigation, and social activities, often impacting anxiety and depression. Spontaneous recovery is rare.
- Trial name
- MULTICAMPO (NCT07358832)
- Testing
- tDCS, Audio-visual training
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Istituto Auxologico Italiano
Amyotrophic Lateral Sclerosis
LONgitudinal and Integrated Evaluation of Biomarkers in reLation to phenotYpe in ALS
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons, leading to paralysis and death.
- Trial name
- LONELYALS (NCT07312240)
- Testing
- Lumbar Puncture for analysis of Cerebrospinal Fluid, Deep Phenotyping, Routine blood chemistry analysis and genetic analysis
- Where
- Italy
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Goiter, Thyroid Disease
Dysphagia After Thyroidectomy
The goal of this observational study is to develop a questionnaire for measuring swallowing and throat discomfort symptoms in patients with goiter or thyroidectomy, which complies with the model of Rasch and which satisfies the…
- Trial name
- DYSPHATHYR (NCT06296420)
- Where
- Italy
- Volunteers
- 420 people
- Sponsor
- Istituto Auxologico Italiano
Anterior Cruciate Ligament Injuries
Deficit in Quadriceps Voluntary Activation After Anterior Cruciate Ligament Reconstruction: Roles of the "Learned Non-use" Paradigm and the Interhemispheric Inhibition
Anterior cruciate ligament (ACL) tear is mainly caused by sport injuries. 40% of injuries are attributed to noncontact mechanisms involving pivoting.
- Trial name
- AQUARIUS (NCT04837417)
- Testing
- Pathologic group
- Where
- 2 sites in Italy
- Volunteers
- 10 people
- Sponsor
- Istituto Auxologico Italiano
Multiple Sclerosis, Poststroke/CVA Hemiparesis
Mechanical Determinants of Upper Limbs Oscillation During Gait
It is unclear why humans typically swing their arms during gait. To date, the debate on how to arm swing comes about (i.e. whether it is caused by accelerations of the shoulder girdle or muscular activity) is still going on.
- Conditions
- Multiple Sclerosis, Poststroke/CVA Hemiparesis, Parkinson Disease, Cerebral Palsy
- Trial name
- CLAPENDAS (NCT05778474)
- Testing
- Healthy subjects, Pathologic group
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Istituto Auxologico Italiano
Stroke, Hemiparesis
Mechanism of Action of Focal Extracorporeal Shock Waves as a Treatment of Upper Limb Stroke Spasticity: a Pilot Study
Spasticity, common after a stroke, aggravates the patient's motor impairment causing pain and limitation in daily activities such as eating, dressing and walking.
- Conditions
- Stroke, Hemiparesis, Hemiplegia, Spasticity as Sequela of Stroke
- Trial name
- SASHA (NCT06311526)
- Testing
- Extracorporeal Shockwave Therapy
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Istituto Auxologico Italiano
Cardiovascular Diseases, Lifestyle
Relationship Between Lifestyle Indicators and Cardiovascular Clinical Parameters
The goal of the study is to build a Register accruing data derived from the compilation of the questionnaire about LifeStyle for a population both of adults and of young boys and girls.
- Conditions
- Cardiovascular Diseases, Lifestyle, Nutrition, Healthy, Physical Inactivity
- Trial name
- RICH (NCT06283069)
- Testing
- compilation of a questionnaire about LifeStyle
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Amyotrophic Lateral Sclerosis
Perception of Unpleasant Sensations During Study Procedures in ALS Patients
Diagnosis of Amyotrophic Lateral Sclerosis (ALS) is considered a traumatic life event for both the patient and their next-of-kin/carers, due to the lack of treatment.
- Trial name
- PESALS (NCT06325865)
- Testing
- Interview
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Auxologico Italiano
Obesity
Abnormal Eating and Taste Perception in Subjects With Obesity
The identification of safe and effective strategies for weight loss and long-term maintenance is critical to reduce the alarming prevalence of obesity worldwide and mitigate obesity-associated health risks.
- Trial name
- TASTEOB (NCT05772052)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Istituto Auxologico Italiano
Obesity, Morbid
Bariatric Surgery and Modulation of Perceived Satiety
Bariatric surgery is the ideal therapeutic strategy for patients with severe obesity when lifestyle interventions have failed. Unfortunately, weight recovery after surgery affects one third of patients and is due to several…
- Trial name
- BAR_SAZ (NCT05777928)
- Testing
- Sleeve gastrectomy, OverStitch™ Endoscopic Suturing System
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Auxologico Italiano
Obesity, Morbid Obesity
Long Term Effect of Very-low-calories Ketogenic Diet on Weight Control and Cardiovascular Brisk Factors (KETOHEART)
The growing obesity pandemic has a major impact on global cardiovascular (CVD)-related morbidity and premature mortality, severely compromising the quality of life of those affected and significantly increasing costs for the…
- Trial name
- KETOHEART (NCT05781269)
- Testing
- VLCKD, r-MedDiet
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Plummer Disease, Multinodular Goiter
Prospective, Observational Study on the Carotid Intima-media Thickness in Patients Undergoing Thyroid Surgery
The evaluation of carotid intima-media thickness (cIMT) has become a possible predictor of the future risk of cardiovascular diseases (CVD).
- Conditions
- Plummer Disease, Multinodular Goiter, Graves Disease, Hyperthyroidism
- Trial name
- TIROVASC (NCT05774535)
- Testing
- Experimental
- Where
- Italy
- Sponsor
- Istituto Auxologico Italiano
Stroke, Hemiparesis
Novel Non-invasive Brain Stimulation Techniques in Neurological Rehabilitation
Paired associative stimulation (PAS) is a non-invasive brain stimulation protocol, where two stimuli (a peripheral and a cortical one, the latter delivered with transcranial magnetic stimulation - TMS) are repeatedly associated…
- Conditions
- Stroke, Hemiparesis, Phantom Limb Pain
- Trial name
- StimNeuro (NCT05766059)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Istituto Auxologico Italiano
Cognitive Impairment, Dementia
Advances in Neuropsychological Diagnostics
This project is aimed at advancing neuropsychological diagnostics, enriching and modernizing the panorama of both clinical and forensic psychometric testing.
- Conditions
- Cognitive Impairment, Dementia, Psychiatric Disorder
- Trial name
- NeuroPsiD (NCT05794061)
- Testing
- Neuropsychological instruments
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Obstructive Sleep Apnea, Sleep Disorder
Multidimensional Evaluation of Patients' Affected by Obstructive Apnea Syndrome (OSAS) Before and After Ventilotherapy
This observational study aims to evaluate multiple dimensions of health in patients with Obstructive Sleep Apnea Syndrome (OSAS), before and after three weeks of ventilotherapy.
- Conditions
- Obstructive Sleep Apnea, Sleep Disorder, Well-Being, Psychological, Cognitive Impairment
- Trial name
- MULTI-OSAS (NCT06312956)
- Testing
- Continuous Positive Airway Pressure Ventilotherapy
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Istituto Auxologico Italiano
Reflex Syncope
Implantable Loop Recorder and Cardioneuroblation
The study aims to determine which method of vagal ganglia ablation is most effective in preventing recurrences of reflex asystole syncope.
- Trial name
- ILR-CNA (NCT07162740)
- Testing
- Right atrial ablation, Bi-atrial ablation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Auxologico Italiano
Obesity
Auditory Sensory Attenuation in Obesity
The goal of this observational cross-sectional study is to test the sensory attenuation effect with auditory stimuli comparing women with obesity and healthy-weight women.
- Trial name
- Ud_SA_OB (NCT06298539)
- Where
- Italy
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano