Clinical trials: sponsored by Istituto Clinico Humanitas
Knee Prosthesis, Knee Prosthesis Infection
Microbiota as Early Diagnostic and predictivE Factor for Osteoarthritic Degeneration and Microbial Contamination
The patient(s) will participate in a clinical study that aims to investigate how the gut microbiota may influence the proper functioning of joints in the body and how it may affect the development of early osteoarthritis (OA)…
- Conditions
- Knee Prosthesis, Knee Prosthesis Infection, Disbiosis
- Trial name
- MILESTONE (NCT06944288)
- Testing
- total knee replacement
- Volunteers
- 170 people
- Sponsor
- Istituto Clinico Humanitas
Oligometastatic Disease
Prospective Observational Basket Study of Stereotactic Body Radiation Therapy for OligoMetastatic Patients From Rare Tumors
This prospective observational study aims to investigate the effectiveness and safety of SBRT in the management of oligometastases from rare tumors.
- Trial name
- PROMPT (NCT05903261)
- Testing
- SBRT
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Clinico Humanitas
Infertility (IVF Patients), Oocyte Retrieval
Impact of the Operator Performing Oocyte Retrieval on the Cumulative Live Birth Rate
This is a monocentric retrospective observational study. The study investigates the impact of the operator performing the oocyte retrieval on the cumulative live birth rate (CLBR).
- Trial name
- OPU-CLBR (NCT06933901)
- Testing
- Oocyte retrieval
- Volunteers
- 19,500 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Brain Metastases, Adult
Prospective Double Arm Randomized Trial: WBRT Alone and WBRT Plus Silibinin
The occurrence of brain metastases (BMs) is increasing given the availability of a more accurate radiological imaging such as MRI for detecting also small brain lesions and the most effective systemic therapy able to control…
- Trial name
- NCT05793489
- Testing
- Silibinin
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Istituto Clinico Humanitas
Oligorecurrent and Oligoprogressive Prostate Cancer Patients
Immune Response Evaluation in Oligorecurrent and Oligoprogressive Prostate Cancer Patients Treated With SBRT
At the moment there is a lack of data in the setting of oligometastatic PC in particular regarding the interaction between ablative SBRT, ADT and patient's immune system response.
- Trial name
- IOSCAR (NCT04624828)
- Testing
- Radiotherapy, androgen deprivation therapy (ADT), immune evaluation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Clinico Humanitas
Diffuse Large B-Cell Lymphoma, High-grade B-cell Lymphoma (HGBCL)
Study of Loncastuximab Tesirine in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) or High-Grade B-Cell Lymphoma (HGBCL) Following CAR-T Therapy Failure
The goal of this clinical trial is to evaluate whether the drug Loncastuximab Tesirine can treat patients with relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL) or High-Grade B-Cell Lymphoma (HGBCL) who have not…
- Conditions
- Diffuse Large B-Cell Lymphoma, High-grade B-cell Lymphoma (HGBCL), B-Cell Lymphoma Treatment, Relapsed or Refractory Lymphoma
- Trial name
- LORELY (NCT06918912)
- Testing
- Loncastuximab Tesirine (Anti-CD19 Antibody-Drug Conjugate)
- Where
- 7 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Clinico Humanitas
Meniscopathy
Prevention of Post mEniscectomy Osteoarthritis: From New Animal Model to Patient pRofiLing
Data collection from patients included in the observational clinical study will be achieved by the following activities: A total of 100 patients with degenerative meniscal tears will be enrolled in the observational study and…
- Trial name
- PEARL (NCT06906094)
- Testing
- Selective meniscectomy
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Clinico Humanitas
Gastrointestinal Diseases, Endoscopic Surgery
A Randomized Comparison of UnderwateR Versus Regular Coagulation in Endoscopic Submucosal DissectioN and Third Space Endoscopy
What the investigatorpropose in this protocol is a technique already used in clinical practice. It prevents the risk of bleeding and make third space endoscopy easier, quicker, safer and cheaper.
- Trial name
- NCT05804266
- Testing
- Coventional coagulation, Underwater coagulation
- Where
- Italy
- Volunteers
- 73 people
- Sponsor
- Istituto Clinico Humanitas
Acute Myeloid Leukaemia, MDS (Myelodysplastic Syndrome)
Anti-NKG2A Monoclonal Antibody for AML or MDS Patients Undergoing Haploidentical Transplantation
The goal of this clinical trial is to evaluate the effectiveness and safety of the anti-NKG2A monoclonal antibody (Monalizumab) in patients undergoing haploidentical stem cell transplantation (Haplo-SCT) with post-transplantation…
- Conditions
- Acute Myeloid Leukaemia, MDS (Myelodysplastic Syndrome), MPN (Myeloproliferative Neoplasms)
- Trial name
- NCT06892223
- Testing
- Monalizumab (anti-NKG2A monoclonal antibody)
- Where
- 2 sites in Italy
- Volunteers
- 42 people
- Sponsor
- Istituto Clinico Humanitas
Biomarkers, Neurodevelopmental Disorders
Predictive BioMArkers of AlTERed NeurologicAL Trajectories Consequent to PrenataL InflammatorY Insults
Inflammation during pregnancy represents an important risk factor for the development of neuropsychiatric disorders in the offspring.
- Conditions
- Biomarkers, Neurodevelopmental Disorders, Inflammation, Brain
- Trial name
- MATERNALLY (NCT06852703)
- Testing
- Infection during pregnancy
- Where
- Italy
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Parkinson Disease
Effects of Action Observation Training and Motor Imagery Delivered by Telerehabilitation in Patients with Parkinson's Disease
The goal of this clinical trial is to investigate the efficacy on motor and postural tasks of Action Observation Training (AOT) and Action Observation combined with Motor Imagery (AOMI) delivered by telerehabilitation in patients…
- Trial name
- TeleAOTPD (NCT06814782)
- Testing
- Action Observation Training, Action Observation and Motor Imagery, Exercise
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Breast Cancer
PBI for Breast in Situ Carcinoma of Intermediate Low Risk As Local Adjuvant Treatment
Screening and advances in breast imaging led to a continuous increase of Ductal Carcinoma in situ (DCIS) diagnosis. Whole breast radiotherapy was reported to be effective in reducing the risk of local recurrence in all analyzed…
- Trial name
- PRISCILLA (NCT05663294)
- Testing
- external beams radiotherapy, brachytherapy
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Clinico Humanitas
Glioblastoma
Imaging and Biological Markers for Prediction and Identification of Glioblastoma Pseudoprogression: a Prospective Study.
The goal of this interventional study is the development and validation of imaging markers, MRI and PET, plasma biomarkers, and/or cell markers that could support clinicians and researchers in differentiating pseudoprogression…
- Trial name
- NCT06113705
- Testing
- 18F-GE-180 PET, Advanced MRI, Collection of hematopoietic stem cells
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Istituto Clinico Humanitas
Spondylolisthesis
Effects of a Single Session of Physiotherapy on Patients Operated for Lumbar Spondylolisthesis
The goal of this clinical trial is to investigate whether a meeting with physiotherapist before hospital discharge can improve the post-operative outcomes in patients who have undergone lumbar fusion surgery for…
- Trial name
- NCT06799975
- Testing
- Education, Usual Care
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Clinico Humanitas
Neuroendocrine (NE) Tumors, Liver Metastasis
The Role of Intraoperative Hepatic Ultrasonography in Gastrointestinal or Pancreatic Neuroendocrine Tumor
Background: Liver metastases are common in patients with neuroendocrine neoplasms, but often underestimated by preoperative imaging.
- Trial name
- ECHO-NET (NCT06779708)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- Istituto Clinico Humanitas
Liver Metastases From Colorectal Cancer (mCRC)
Radiomics of Colorectal Liver Metastases: Identification of New Prognostic Biomarkers.
Background: Liver metastases (CLM) affect about half of patients with colorectal cancer and dictate patients' prognosis. Prediction of prognosis is of paramount importance for patients allocation to the most adequate treatment…
- Trial name
- NCT06779734
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Istituto Clinico Humanitas
COVID 19
Impact of Cryopreservation Methods on Post-Thaw SARS-CoV-2 in Semen Samples
Cryopreservation of seminal fluid or spermatozoa from epididymary and testicular retrieval represents a crucial tool in managing conditions of permanent or temporary infertility, as well as in cases of secretory and excretory…
- Trial name
- SEM-COV-19 (NCT06703723)
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Surgery, Perioperative Complication
BRAIN-targeted Goal-directed Therapy in High-risk Patients undeRgOing Major electIve SurgEry: the BRAIN-PROMISE Study
The aim of the study is to further understand whether the use of non-invasive monitoring NIRS (Near Infrared Spectroscopy) is useful in reducing postoperative complications in high-risk patients undergoing elective surgery.
- Trial name
- BRAINPROMISE (NCT04266574)
- Testing
- Near Infrared Spectroscopy (NIRS), Standard Care
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Clinico Humanitas
Colon Neoplasm
A Novel Adaptive Anastomotic Technique for Left-sided Colonic Resection
The goal of this pilot clinical trial is provide preminary evidence of the effectiveness of the C-REX device, developed by CarpoNovum AB, in preventing anastomotic leak and improving anastomosis healing after sigmoid or high…
- Trial name
- NOVA (NCT06615583)
- Testing
- Surgical device
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
Ulcerative Colitis
Utility of Low Intensity Pulsed Ultrasound Stimulation (LIPUS) to Modulate the Release of Mediators Capable of Reflecting the Inflammatory State in the Affected Colonic Tract of Ulcerative Colitis Patients
The goal of this clinical trial is to learn whether Low Intensity Pulsed Ultrasound (LIPUS) is capable of promoting the release of extracellular vesicles from the gut into the bloodstream of Ulcerative Colitis (UC) patients…
- Trial name
- LIPUSinVIVO (NCT06569888)
- Testing
- LIPUS stimulation
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas