Clinical trials: sponsored by KU Leuven
Antibiotic Allergy
Support Tool for Antibiotic Allergy deLabeling
Antibiotic allergy labels (AAL) are reported in 7% of inpatient's charts, especially for beta-lactams (86% of AAL, i.e., prevalence of 6%).
- Trial name
- STAAL (NCT06771440)
- Testing
- EPR search
- Where
- Belgium
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Multimorbidity, Older Adults (65 Years and Older)
Integrated Care for Older Adults With Major Depression and Physical Multimorbidity - The I-CONNECT
The goal of this clinical trial is to learn if I-CONNECT (Integrated Care for Older Adults with Major Depression and Physical Multimorbidity) can improve the health and well-being of older adults with depression or bipolar…
- Conditions
- Multimorbidity, Older Adults (65 Years and Older), Mood Disorders, Depression - Major Depressive Disorder
- Trial name
- I-CONNECT (NCT07211750)
- Testing
- integrated care intervention tailored to the needs of older adults leaving at home with mood disorders and multimorbidity in Leuven
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- KU Leuven
Validation Study
Validation of the Experience Sampling Dietary Assessment Method
A new dietary assessment method was developed based on the Experience Sampling Methodology. In order to use this newly developed Experience Sampling Dietary Assessment Method (ESDAM) in research and clinical practice as a valid…
- Trial name
- YONAS (NCT06485960)
- Testing
- ESDAM validation
- Where
- Belgium
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Personality Disorders
Benchmarking and Change Mechanisms in Personality Disorder Treatment
Personality disorders (PDs) are severe mental disorders characterized by pathological personality traits as well as problems in identity and interpersonal relationships (American Psychiatric Association, 2013).
- Trial name
- NCT06804369
- Testing
- Intensive psychodynamic therapy (PDT)
- Where
- Belgium
- Volunteers
- 91 people
- Sponsor
- KU Leuven
Vitamin D, Vitamin D and Calcium Homeostasis
Free Vitamin D and Steroid Metabolism in Endocrine Disorders
This clinical study aims to gain a better understanding of how different forms of vitamin D are processed in the body in healthy individuals, pregnant women, and patients with various hormonal (endocrine) and kidney (renal)…
- Trial name
- FREEDOM (NCT07268742)
- Testing
- Blood draw for the laboratory assessment
- Where
- Belgium
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lymphedema, Ketogenic Dieting
Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients?
Lymphedema is a debilitating disorder that severely impairs the quality of life of the patients and requires life-long attention. Treatment for lymphatic dysfunction remains largely symptomatic, without real cure.
- Conditions
- Lymphedema, Ketogenic Dieting, Ketone Ester Supplement
- Trial name
- KETOLYMPH (NCT03991897)
- Testing
- Ketogenic diet, Isocaloric diet, Ketone ester supplementation
- Where
- Belgium
- Volunteers
- 81 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Implantable Cardioverter Defibrillator (ICD)
In-depth Interviews of Patients With ICDs
Although ICDs are effective in preventing sudden cardiac death, they can also profoundly affect patients' and partner/caregivers' emotional well-being, social relationships, and daily functioning.
- Trial name
- QoLICD-INSIGHT (NCT07258602)
- Testing
- semi-structured interview
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Implantable Cardioverter Defibrillator (ICD)
Patient-Reported Quality of Life in Patients With an Implantable-Cardioverter Defibrillator - A Cross-Sectional Observational Study
Patients at risk for life-threatening arrhythmias are eligible for the implantation of an implantable cardioverter-defibrillator (ICD), which has repeatedly shown improved survival.
- Trial name
- QoL-ICD I (NCT06654232)
- Testing
- quality of life questionnaires
- Where
- Belgium
- Volunteers
- 731 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Heart Failure, Non-ischemic Cardiomyopathy
Cardiac RadiothErapy For hEart faiLure
Preliminary data suggests that patients suffering from advanced refractory heart failure (HF) could benefit from single low dose whole heart external beam radiotherapy (EBRT).
- Conditions
- Heart Failure, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy
- Trial name
- CREFEL (NCT06661876)
- Testing
- 5 Gray Whole Heart external beam radiotherapy
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Implantable Cardioverter Defibrillator (ICD)
Patient-Reported Quality of Life in Patients With an Implantable-Cardioverter Defibrillator - A Longitudinal Observational Study
Patients at risk for life-threatening arrhythmias are eligible for the implantation of an implantable cardioverter-defibrillator (ICD), which has repeatedly shown improved survival.
- Trial name
- QoL-ICD II (NCT06654284)
- Testing
- quality of life questionnaires
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Hearing Disability
Assistant for LIstening and Communication Enhancement
As we get older, our hearing deteriorates and an age-related hearing loss can develop. Having a hearing loss can make it more difficult for people to understand conversations.
- Trial name
- ALICE (NCT05329922)
- Testing
- ALICE: Audiological rehabilitation
- Where
- Belgium
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ulcerative Colitis
Drug Repurposing - Statins as Microbiota Modulating Agents in Ulcerative Colitis
Evaluation of the microbiota modulation away from inflammation associated microbiota profile Bacteroides2 (Bact2) Evaluation of the effect of microbiota modulation on disease activity in ulcerative colitis and Crohn's disease…
- Trial name
- ReMiDy (NCT04883840)
- Testing
- Rosuvastatin 10mg
- Where
- 3 sites in Belgium
- Volunteers
- 177 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lymphedema Lower Extremity
Psychometric Properties of a Lymphedema-specific Quality of Life Questionnaire in Lower Limb Lymphedema
The goal of this observational study is to cross-validate the Lymphedema Functioning, Disability and Health Questionnaire for Lower Limb Lymphedema (Lymph-ICF-LL) in French and to investigate the responsiveness of the original…
- Trial name
- NCT07075549
- Testing
- Maintenance phase of Decongestive Lymphatic Therapy, Intensive phase of Decongestive Lymphatic Therapy
- Where
- 3 sites in Belgium, France
- Volunteers
- 451 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dyspnea, Chronic Obstructive Pulmonary Disease
Menthol for Dyspnea Relief in Health and COPD
Menthol inhalation (MI) is a novel and promising treatment option for acute relief of dyspnea, however, the underlying ventilatory and/or neural related mechanisms for this relief in symptoms remain unknown.
- Trial name
- MENTHODYSC (NCT05785026)
- Testing
- Menthol inhalation, Strawberry scent, Menthol inhalation and facial airflow
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Physiological Responses
The Role of TRP Channels in DPN
The study aims to characterize the vascular response upon topical application of cinnamaldehyde, allyl isothiocyanate and capsaicin on feet skin in healthy volunteers.
- Trial name
- NCT07237022
- Testing
- Cinnamaldehyde, Allyl isothiocyanate (AITC), Capsaicin
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Disability Physical
Recovery From Disability After Geriatric-home Rehabilitation Versus Standard of Care: Pilot Study
At discharge after a hospitalization, many older people are not as able as before their hospital stay and have difficulty performing their daily activities at home.
- Trial name
- RECOVER@HOME (NCT06404138)
- Testing
- The Geriatric Activation Program (GAPP) Home version, Standard of care
- Where
- 2 sites in Belgium
- Volunteers
- 15 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
ADPKD, Pain
Somatosensory Phenotyping of ADPKD
Over 60% of patients with ADPKD suffer from pain, mostly in the abdomen, flank and back, often leading to the diagnosis. It is challenging to manage and cure the pain; approximately 39% of patients are not satisfied with their…
- Trial name
- NCT06970028
- Testing
- Quantitative Sensory Testing, Questionnaires regarding pain and quality of life
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
IBD - Inflammatory Bowel Disease
Trial Comparing Multiport RObotic and Laparoscopic Surgery for Elective Colorectal Resections in IBD Patients (ACRO-IBD)
The aim of this study is to better understand whether robotic surgery leads to better outcomes than laparoscopy in terms of complications, recovery and quality of life.
- Trial name
- ACRO-IBD (NCT07230262)
- Testing
- Robotic colorectal surgery, Laparoscopic colorectal surgery
- Where
- Belgium
- Volunteers
- 110 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Influenza With Pneumonia, Invasive Pulmonary Aspergillosis
Influenza Associated Aspergillosis In-depth Investigation
This trial is aimed to study the immunological and pathological characteristics of influenza versus non-influenza severe community-acquired pneumonia patients in ICU.
- Trial name
- PIAS (NCT03748069)
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Asthma (Diagnosis)
The Effect of a Cold Air Eucapnic Hyperventilation Test on Lower Respiratory Airways in Healthy Volunteers and Patients With Asthma
In this study, we want to evaluate the feasibility and safety of a CAEH test in healthy volunteers and patients with asthma. We want to develop a CAEH test to differentiate patients with different types of asthma and…
- Trial name
- CLARINET (NCT07220928)
- Testing
- Cold air challenge
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven
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