Clinical trials: sponsored by KU Leuven
Femoroacetabular Impingement
Investigating the Reliability of Highly Dynamic 3D Motion Analysis Protocol in Adolescence and Adult Males
Femoroacetabular impingement is an orthopedic condition that is primarily characterized by the presence of anatomic bony abnormalities in the femoral head and/or the acetabulum resulting in an abnormal contact between the two…
- Trial name
- CAM-FAI relia (NCT04822571)
- Testing
- Reliability of 3D motion analysis protocol
- Where
- Belgium
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Coxarthrosis, Avascular Necrosis of Hip
Effect of Peri-operative Glucocorticoids on Short-term Functional Outcome After THA
This randomized, single surgeon, placebo controlled, double blind study will be conducted in order to investigate whether or not peri-operative high doses of intravenous glucocorticoids improve short-term functional outcome after…
- Trial name
- DEXA (NCT04317872)
- Testing
- High dose of peri-operative intravenous dexamethasone, Low dose of peri-operative intravenous dexamethasone
- Where
- Belgium
- Volunteers
- 71 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Palsy
Eye-tracking Working Memory Training in Children and Youth With Severe Cerebral Palsy
People with severe cerebral palsy (CP) who are nonverbal and unable to control conventional computer interfaces due to the severe limitations in hand control benefit from eye-tracking technology as access method to Augmentative…
- Trial name
- NCT06918379
- Testing
- Cogmed Working Memory Training (CWMT)
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- KU Leuven
Femoro Acetabular Impingement, CAM
Longitudinal Follow-up of Male Soccer Players Prone to Developing CAM Hip Deformity
Femoroacetabular impingement (FAI) is a clinical problem in which abnormal contact occurs between the thighbone and the hip socket.
- Trial name
- CAM-FAI (NCT04418596)
- Testing
- bi-planer radiography (EOS), Conventional radiography (Hip+pelvis)
- Where
- Belgium
- Volunteers
- 27 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Aspergillosis; Pulmonary, Invasive (Etiology)
Posaconazole for the Prevention of Influenza-associated Aspergillosis in Critically Ill Patients
The objective of this study is to deliver proof of concept that antifungal prophylaxis can reduce the incidence of Influenza Associated Aspergillosis (IAA) in ICU (intensive care unit) patients with severe influenza.
- Trial name
- POSA-FLU (NCT03378479)
- Testing
- SOC +Posaconazole 18 MG/ML (milligram/milliliter), standard of care (SOC)
- Where
- 12 sites in Belgium, France and 1 more
- Volunteers
- 88 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Congenital Heart Disease, Neurodevelopmental Disorders
Predictive Value of Neurovascular Coupling in Infants With COngenital Heart Disease
Infants with congenital heart disease (CHD) are at increased risk for delayed neurodevelopment. Multiple etiological explanations have been proposed, as there seems to be a multifactorial interplay of both prenatal and…
- Conditions
- Congenital Heart Disease, Neurodevelopmental Disorders, Electroencephalography, Near-Infrared Spectroscopy
- Trial name
- NICO (NCT06190210)
- Testing
- electroencephalography, Near-Infrared Spectroscopy, neuronal cell-free DNA
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glioma of Brain
Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients
Gliomas are the most common primary intracranial tumors, representing at least 75% of all primary malignant brain tumors. Histopathologically, gliomas are classified into different subgroups including astrocytomas (60-70%)…
- Trial name
- Glioma2015 (NCT03849430)
- Where
- Belgium
- Volunteers
- 750 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Prostate Cancer, Radiotherapy
Observational Study on Extreme Hypofractionation for Localized Prostate Cancer
Radiotherapy (RT) is an established treatment option for localized prostate cancer (PCa), with cure rates similar to those of radical prostatectomy.
- Conditions
- Prostate Cancer, Radiotherapy, SBRT
- Trial name
- OBELIX PCa (NCT05344235)
- Testing
- SBRT
- Where
- Belgium
- Volunteers
- 246 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Polymyalgia Rheumatica
Validation of the PMR Activity Score and Evolution of Patient-reported Outcomes in Patients With Polymyalgia Rheumatica
Polymyalgia rheumatica (PMR) is a systemic inflammatory disease that affects elderly people. It is characterized by pain and morning stiffness in the shoulders, pelvic girdles and neck.
- Trial name
- NCT05542316
- Where
- Belgium
- Volunteers
- 133 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
A Study to Evaluate Non-invasive Measurements of the Inflammatory Status in Patients with IBD
Patients with IBD, including both Crohn's disease and ulcerative colitis, require accurate monitoring of intestinal inflammation for optimal follow-up and treatment.
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), Crohn Disease (CD)
- Trial name
- VERSATILE (NCT06900738)
- Testing
- Inflammometer
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tooth, Impacted
Effect of Interceptive Strategies on the Clinical Outcome of Maxillary Impacted Canines
This study aims to investigate the effect of 3 randomly applied interceptive measures (slow maxillary expansion, extraction of deciduous canines and no intervention) on maxillary canine impaction in patients with early mixed…
- Trial name
- NCT05629312
- Testing
- Maxillary expansion, Extraction of deciduous upper canines
- Where
- Belgium
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Weight Regain Post Bariatric Surgery, Obesity (Disorder)
Naltrexone/Bupropion With or Without Very Low Calorie Ketogenic Diet for Weight Regain After Bariatric Surgery
The goal of this clinical trial is to evaluate the superiority of combined VLCKD, intensive lifestyle intervention and naltrexone/bupropion (N/B) versus standard of care with naltrexone/bupropion on weight loss for people with…
- Trial name
- Relay (NCT06881485)
- Testing
- Very Low Calorie Diet
- Where
- 2 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Cerebral Visual Impairment
A Computerized, Adaptive Therapeutic Gaming Approach Training Visual Perceptual Skills in Children With CVI
This clinical trial aims to compare the effectiveness of our adaptive, therapeutic game to the effectiveness of the same game, without the adaptive component.
- Trial name
- iVision2_WP3 (NCT05014503)
- Testing
- Adaptive Therapeutic gaming, Non-adaptive Therapeutic gaming
- Where
- Belgium
- Volunteers
- 73 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Fibroid Uterus
Temporary Artery Clipping for Robotically-assisted Myomectomy, a Multicentric Randomized Controlled Trial
This study aims to investigate the efficacy of temporary clipping of the uterine artery and utero-ovarian ligament during robotically assisted myomectomy (RAM) for uterine fibroids.
- Trial name
- TACROM (NCT06269809)
- Testing
- Temporary clipping of the uterine arteries and the utero-ovarian ligmants., No temporary clipping of the uterine arteries and the utero-ovarian ligmants.
- Where
- 4 sites in Belgium, France and 1 more
- Volunteers
- 82 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Tooth Impaction, Canine Teeth
Effect of Interceptive Strategies on the Clinical Outcome of Impacted Maxillary Permanent Canines
Canine impaction is a sign of abnormal dental development with potentially far-reaching consequences (such as significant root resorption and loss of lateral incisors.
- Trial name
- RCTcanines2 (NCT06374329)
- Testing
- Interceptive Slow Maxillary Expansion with removable plates
- Where
- 3 sites in Belgium, Czechia and 1 more
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
IBD, Crohn's Diseases
Psychological Intervention for Fatigue in Inflammatory Bowel Diseases
The investigators would like to evaluate the effect of a multicomponent psychological treatment on fatigue as a symptom of patients with inflammatory bowel diseases (IBD).
- Conditions
- IBD, Crohn's Diseases, Ulcerative Colitis (UC)
- Trial name
- PEARL (NCT06860009)
- Testing
- Multicomponent psychological intervention, Early start, Late start (after 28 weeks)
- Volunteers
- 155 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Zinc Absorption
Zinc Absorption in Flakes Derived from Sprouted or Hydrothermally Processed Wheat
The aim of this project is to investigate whether the increased zinc bio-accessibility values in sprouted or hydrothermally processed wheat is reflected in an increased zinc absorption in human subjects after consuming breakfast…
- Trial name
- Wheatflakes (NCT06236620)
- Testing
- Processing of wheat
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Dementia
Effect of Improved Indoor Lighting on Residents of Residential Care Homes with Dementia
Elderly with dementia living in residential care homes often have limited access to adequate lighting (daylight). Light can however positively impact the individual on a number of factors, including sleep quality and mental…
- Trial name
- NCT06205654
- Where
- Belgium
- Volunteers
- 98 people
- Sponsor
- KU Leuven
Parkinson Disease
Predicting Motor Learning of an Upper Limb Task Based on Behavioral and Disease-specific Characteristics in Patients With Parkinson's Disease
Manual dexterity deficits and loss of motor automaticity are commonly seen in patients with Parkinson's disease (PD). Amongst these problems, using a touchscreen is becoming increasingly burdensome.
- Trial name
- NCT06738290
- Testing
- Targeted home-based touchscreen training
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- KU Leuven
Obesity and Overweight, Bariatric Surgery (Gastric Bypass)
Protein Requirements After Bariatric Surgery
The study investigates protein requirements at least 1 year after gastric bypass surgery in adult males, to investigate whether protein requirements are elevated compared to protein requiremens for the general populaiotn.
- Conditions
- Obesity and Overweight, Bariatric Surgery (Gastric Bypass), Protein Requirement
- Trial name
- PROXY (NCT06853652)
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
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