Clinical trials: sponsored by Kaiser Permanente
Mental Health
Novel Methods for Implementing Measurement-Based Care for Youth in Low-resource Environments
This study will visit 4 community mental health clinics in Washington state and work with clinic staff to find out if staff are regularly evaluating clinical outcomes using questionnaires (which is also called measurement-based…
- Trial name
- NIMBLE (NCT05644756)
- Testing
- IMPACT Methods to Identify and Prioritize Determinants (Challenge I), Challenge and Match strategies to Prioritized Determinants (Challenge II)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Depression
Bright Start Study
The Bright Start study is a randomized trial to compare three approaches, or "arms", for delivering Bright Light Therapy (BLT) to real-world patients.
- Trial name
- NCT05356130
- Testing
- Written Educational Material on BLT, Enhanced BLT Encouragement and Adherence Promotion
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Kaiser Permanente
Human Papillomavirus
Provider Recommendation and HPV Vaccination
In the United State, there are millions of US teens who are not vaccinated against the human papillomavirus (HPV) putting them at risk of getting HPV-related cancers.
- Trial name
- HPVV (NCT05365048)
- Testing
- Local Tailoring implementation strategy, Prescribed Strategy
- Where
- United States
- Volunteers
- 301,201 people
- Sponsor
- Kaiser Permanente
Dementia, Med: Dementia
Can Value Champions Reduce Inappropriate Prescribing for People With Dementia?
The primary objective is to assess the effectiveness of training a clinician to be a 'value champion' within clinical settings to decrease the use of three classes of potentially inappropriate prescription medications (PIMs)…
- Trial name
- NCT05359679
- Testing
- Value Champion Training Program, No Intervention
- Where
- United States
- Volunteers
- 3,300 people
- Sponsor
- Kaiser Permanente
Cardiovascular Diseases, Influenza
Kaiser Permanente VACCination Improvement With Nudge-based CardiovAscular Targeted Engagement
In randomized clinical trials and observational studies, influenza vaccination is effective in reducing influenza-related illness and hospitalizations and potentially cardiovascular (CV) events and mortality in select…
- Conditions
- Cardiovascular Diseases, Influenza, Behavior, Social
- Trial name
- KP-VACCINATE (NCT06571747)
- Testing
- Cardiovascular-Focused Nudge Communication
- Where
- 2 sites in United States
- Volunteers
- 3,668,428 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Severe Hypoglycemia
Comparing the Effectiveness of Two Approaches to Preventing Severe Hypoglycemia in Patients With Type 2 Diabetes (PHT2)
Severe hypoglycemia is the most feared complication of medications used to lower blood glucose levels in patients with diabetes.
- Trial name
- PHT2 (NCT04863872)
- Testing
- Proactive Care Management, MyHC-T2D education program
- Where
- United States
- Volunteers
- 259 people
- Sponsor
- Kaiser Permanente
Alcohol Use Disorder, Unhealthy Alcohol Use
Systematic Implementation of Patient-centered Care for Alcohol Use Trial: Beyond Referral to Treatment
The Systematic Implementation of Patient-centered Care for Alcohol Use Trial is a pragmatic, cluster-randomized, effectiveness-implementation trial testing two interventions in Kaiser Permanente Washington to systematically…
- Trial name
- NCT06318026
- Testing
- Centralized Intervention, Primary Care Intervention
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Kaiser Permanente
Diet, Healthy, Overweight and Obesity
Food Prescriptions to Promote Affordable Diets
This is an Randomized controlled trial (RCT) to assess the impact of meal planning and affordable grocery delivery on weight loss, dietary quality and health on members of multigenerational Latino households.
- Trial name
- FoodRx (NCT05309395)
- Testing
- FoodRx
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Distress, Cancer
POEM (Practice Of Embracing Each Moment) STUDY
A cancer diagnosis is extremely stressful, emotionally challenging, and often life-altering for both patients and their loved ones.
- Conditions
- Distress, Cancer, Chemotherapy Effect
- Trial name
- POEM (NCT03078608)
- Testing
- Mindfulness meditation program (administered via mobile app), Progressive muscle relaxation (via mobile app)
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Prostate Cancer, Prostate Cancer Stage I
Randomized Trial of HIFU vs. Cryo for Prostate Cancer
HIFU has been FDA approved and is widely utilized across the United States and Europe for the treatment of prostate cancer. Despite this, HIFU has not been offered within SCPMG until now due to growing patient demand.
- Conditions
- Prostate Cancer, Prostate Cancer Stage I, Prostate Cancer Stage II, High Intensity Focused Ultrasound
- Trial name
- KPFT (NCT06929065)
- Testing
- HIFU vs Cryoablation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Influenza, Pneumonia
Flublok v. Standard Dose Vaccine Effectiveness Among Kaiser Permanente Northern California Adults 18-64 Years
The overall objective of this study is to describe the effectiveness of Flublok Quadrivalent vaccine compared to standard dose inactivated influenza vaccine (SD-IIV) in adults 18 through 64 years of age.
- Conditions
- Influenza, Pneumonia, Lower Respiratory Tract Infection, Acute Myocardial Infarction
- Trial name
- NCT03694392
- Testing
- Flublok Quadrivalent, Standard Dose Inactivated Influenza Vaccine (SD-IIV)
- Where
- United States
- Volunteers
- 2,776,278 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Type 2 Diabetes, Type 2 Diabetes Mellitus (T2DM)
Population Health Management for KPNC Members With Newly Diagnosed Diabetes: A Randomized Trial of a Proactive and Augmented Initial Care Strategy
This study is a 2-arm randomized trial of Augmented Initial Type 2 Diabetes (T2D) Care vs. Usual Initial T2D Care among adults (18-74 years) with newly diagnosed T2D who have risk factors (defined by age and diagnosis HbA1c…
- Conditions
- Type 2 Diabetes, Type 2 Diabetes Mellitus (T2DM), Type 2 Diabetes (T2D)
- Trial name
- NCT06906653
- Testing
- Augmented Initial Type 2 Diabetes Care
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Kaiser Permanente
Diabetes Mellitus, Type 2
Food As Medicine Study
The investigators are conducting a pre-randomized controlled trial to assess the effect of a 6 month Produce Prescription intervention for patients enrolled in Medicaid who experience consistently uncontrolled Hemoglobin A1c…
- Trial name
- NCT05407376
- Testing
- Produce prescription (weekly produce delivery)
- Where
- United States
- Volunteers
- 460 people
- Sponsor
- Kaiser Permanente
Foot Ulcer, Diabetic
Impact of Remote Foot Temperature Monitoring
One of the only evidence-based practices for the prevention of diabetic foot ulcer recurrence is once-daily foot temperature monitoring, which is recommended by multiple clinical practice guidelines for high-risk patients…
- Trial name
- NCT04345016
- Testing
- Once-daily remote foot temperature monitoring
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Kaiser Permanente
PreDiabetes, Diabetes
Randomized Trial of Exercise Promotion in Primary Care
Millions of Americans have diabetes or prediabetes, for which regular physical activity can reduce risks of unfavorable outcomes of these conditions.
- Conditions
- PreDiabetes, Diabetes, Sedentary Behavior
- Trial name
- EPPC (NCT04445168)
- Testing
- Telephone-based motivational interviews
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Kaiser Permanente
Type 2 Diabetes Treated With Insulin, Hypoglycemia
Reducing Treatment Risk in Older Adults With Diabetes
This study will evaluate the impact of academic detailing (evidence-based provider education) with or without patient pre-visit preparation (elicitation of values and preferences) on safe insulin de-prescribing among older…
- Conditions
- Type 2 Diabetes Treated With Insulin, Hypoglycemia, Primary Health Care, Polypharmacy
- Trial name
- RETRO-DM (NCT04585191)
- Testing
- Conversation Aid, Attention Control Educational Handout
- Where
- 4 sites in United States
- Volunteers
- 450 people
- Sponsor
- Kaiser Permanente
Lung Cancer
Evaluation of a Patient 'nudge' on Engagement in Lung Cancer Screening
The purpose of this quality improvement project is to conduct and evaluate the effect of sending an electronic reminder message to patients who qualify for lung cancer screening, haven't had a screening previously, and who have…
- Trial name
- NCT06474611
- Testing
- Patient nudge
- Where
- United States
- Volunteers
- 894 people
- Sponsor
- Kaiser Permanente
Heart Attack, Stroke
CV Wizard: Does a Clinical Decision Support Tool Improve CVD Risk Factor Control in Safety Net Clinics?
This project aims to reduce disparities in cardiovascular disease (CVD) risk factor control and in rates of heart attacks and strokes among the low-income, racially / ethnically diverse Americans who receive primary care at…
- Conditions
- Heart Attack, Stroke, Cardiovascular Diseases
- Trial name
- CV_WIZARD (NCT03001713)
- Testing
- CV WIZARD
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Alzheimer Disease, Dementia
STAR Caregivers - Virtual Training and Follow-up
This study evaluates the effectiveness of a caregiver outreach, training, and support program for caregivers of people with dementia who are using antipsychotic medication to manage agitation/aggression.
- Conditions
- Alzheimer Disease, Dementia, Caregiver Burnout
- Trial name
- STAR-C-VTF (NCT04271046)
- Testing
- STAR-C-VTF, Control
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Kaiser Permanente
Hypertension, Diabetes Mellitus, Type 2
COHERE - COntextualized Care in cHcs' Electronic Health REcords
This study was designed to develop and test clinical decision support (CDS) tools that present clinical care team members with a given patient's social risk information and recommend care plan adaptations based on those risks.
- Trial name
- COHERE (NCT05022316)
- Testing
- CDS Tool Access
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Kaiser Permanente