Clinical trials: sponsored by Kaiser Permanente
Migraine, Headache
Migraine Headache Mitigation Utilizing Avulux
This will be a randomized double blind cross over interventional trial to determine if Avulux lenses are able to reduce headache symptoms in patients
- Conditions
- Migraine, Headache, Photophobia
- Trial name
- NCT06149000
- Testing
- Avulux Lenses
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Anterior Vaginal Wall Prolapse, Cystocele
Anterior Colporrhaphy Versus Cystocele Repair Using Polypropylene Mesh or Porcine Dermis
The purpose of this study is to evaluate the success rate of cystocele repair using polypropylene mesh or porcine dermis compared to that of anterior colporrhaphy in a prospective randomized fashion.
- Conditions
- Anterior Vaginal Wall Prolapse, Cystocele, Pelvic Organ Prolapse
- Trial name
- OARS (NCT01393171)
- Testing
- Polypropylene mesh (Polyform by Boston Scientific), Porcine Dermis (Pelvicol by CRBard), Anterior Colporrhaphy
- Where
- 2 sites in United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Urge Incontinence, Overactive Bladder
Transcutaneous Tibial Nerve Stimulation for Urgency Urinary Incontinence
This is a single-center, double-blinded, randomized controlled trial evaluating the efficacy of TTNS versus a sham intervention. Both interventions will be performed by participants in their homes after standardized instruction.
- Trial name
- TTeNS (NCT04936464)
- Testing
- transcutaneous tibial nerve stimulation (TTNS), transcutaneous electrical stimulation (TENS)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Kaiser Permanente
Perinatal Depression
Accelerating Implementation of Mindful Mood Balance for Moms
The Mindful Mood Balance for Moms (MMBFM) study examines whether using an internet program called Mindful Mood Balance for Moms to deliver Mindfulness Based Cognitive Therapy (MBCT) over an 8-week time period, is effective for…
- Trial name
- MMB4Moms (NCT04846504)
- Testing
- MMBFM program with clinician coach support, MMBFM program with peer coach support, Patient facing strategy intervention arm
- Where
- 4 sites in United States
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Dementia, Alzheimer Disease
Systematic Multi-domain Alzheimer's Risk Reduction Trial
The primary goal of this randomized controlled trial (RCT) is to pilot-test a personalized, pragmatic, multi-domain Alzheimer's disease risk reduction intervention in a U.S. integrated healthcare delivery system.
- Trial name
- SMARRT (NCT03683394)
- Testing
- SMARRT Intervention, Health Education Intervention
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Kaiser Permanente
Uterine Cervical Neoplasm, Uterine Neoplasms
Self-Testing Options in the Era of Primary HPV Screening for Cervical Cancer Trial
The Self-Testing options in the Era of Primary HPV screening for cervical cancer (STEP) trial will evaluate effectiveness of home-based HPV kits for improving cervical cancer screening uptake and its cost-effectiveness.
- Conditions
- Uterine Cervical Neoplasm, Uterine Neoplasms, Genital Neoplasms, Female, Urogenital Neoplasms
- Trial name
- STEP (NCT04679675)
- Testing
- Usual Care, Education, Direct Mail
- Where
- United States
- Volunteers
- 32,771 people
- Sponsor
- Kaiser Permanente
Polyp of Colon
De-implementation of Outdated Colonoscopy Surveillance Interval Recommendations Among Patients With Low-risk Adenomas
The purpose of this study is to compare the effectiveness of three standard of care outreach approaches (i.e., mailed letter, secure message, and telephone call) on patient adoption of the new 10-year colonoscopy surveillance…
- Trial name
- DESIRE (NCT05389397)
- Testing
- Outreach
- Where
- United States
- Volunteers
- 604 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Chronic Non-malignant Pain
Pain Program for Active Coping & Training
The overall aim of this study is to adopt an integrative rehabilitation approach for helping patients adopt self-management skills for managing chronic pain, limiting use of opioid medications, and identifying exacerbating…
- Trial name
- PPACT (NCT02113592)
- Testing
- Interdisciplinary pain program
- Where
- 3 sites in United States
- Volunteers
- 850 people
- Sponsor
- Kaiser Permanente
Opioid Abuse, Overdose
Impact of Direct Outreach to Expand Access to Naloxone in the Context of Standing Orders
In the setting of naloxone standing orders, this study will assess if direct outreach with a web-based "Naloxone Navigator 1.0" to patients prescribed chronic opioid therapy (COT) changes opioid risk behaviors, increases naloxone…
- Conditions
- Opioid Abuse, Overdose, Risk Behavior
- Trial name
- NCT03241771
- Testing
- Naloxone Navigator 1.0
- Where
- United States
- Volunteers
- 325 people
- Sponsor
- Kaiser Permanente
Pre-Exposure Prophylaxis
Leveraging Electronic Health Record Data in a Risk Prediction Model to Increase HIV PrEP Intake in Primary Care
Kaiser Permanente Northern California (KPNC) has been a national leader in implementation of HIV preexposure prophylaxis (PrEP), a daily antiretroviral pill that is more than 99% effective in preventing HIV acquisition.
- Trial name
- NCT05991869
- Testing
- Point-of-care decision support intervention
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Diabetes Mellitus
Encouraging Mail Order Pharmacy Use to Improve Outcomes and Reduce Disparities
The investigators propose a randomized encouragement trial to encourage use of the existing mail order pharmacy services among diabetes patients with poor adherence to CVD risk factor medications in 3 health care systems: Kaiser…
- Trial name
- NCT02621476
- Testing
- Standardized intervention, Usual care
- Where
- United States
- Volunteers
- 63,012 people
- Sponsor
- Kaiser Permanente
Gestational Diabetes, Obesity
Randomizing Two Gestational Diabetes Screening Methods in a Diverse HMO
This project randomizes two different screening strategies for diabetes in pregnancy, among a study population of over 17,500 pregnant women and their babies (over 35,000 total) in a large diverse health maintenance organization…
- Conditions
- Gestational Diabetes, Obesity, Pregnancy
- Trial name
- NCT02266758
- Testing
- GDM Screening Methods
- Volunteers
- 23,792 people
- Sponsor
- Kaiser Permanente
Substance Related Disorders
Screening for Youth Alcohol and Drug Use: A Study of Primary Care Providers
This study evaluates the implementation and effectiveness of two modalities of Screening, Brief Intervention and Referral to Treatment (SBIRT) to reduce adolescent alcohol and other drug (AOD) use in a large pediatrics clinic.
- Trial name
- NCT02408952
- Testing
- Primary Care Physician, Behavioral Medicine Specialist
- Where
- United States
- Volunteers
- 9,084 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Covid19, Atherosclerosis
A Pragmatic Randomized Trial of Icosapent Ethyl for High-Cardiovascular Risk Adults
MITIGATE is a prospective, open-label, parallel-group, randomized, pragmatic clinical trial. The MITIGATE Study has been designed to evaluate the real-world clinical effectiveness of pre-treatment with icosapent ethyl (IPE), also…
- Conditions
- Covid19, Atherosclerosis, Cardiovascular Diseases, Upper Respiratory Tract Infections
- Trial name
- MITIGATE (NCT04505098)
- Testing
- Icosapent ethyl
- Where
- United States
- Volunteers
- 39,600 people
- Sponsor
- Kaiser Permanente
Heart Failure
The Heart Failure Readmission Intervention by Variable Early Follow-up (THRIVE) Study
This study is a pragmatic randomized clinical trial to determine the effectiveness of two strategies of early follow-up in adults after hospitalization for heart failure: telephone follow-up with a heart failure care manager vs.
- Trial name
- THRIVE (NCT03524534)
- Testing
- Telephone Call, In-Person Primary Care Clinical Follow-Up Visit
- Volunteers
- 2,091 people
- Sponsor
- Kaiser Permanente
Preventive Health Services, Health Communication
Patients Engaged in Prevention: Enhancing Outreach to Increase Patient Engagement in Diabetes Prevention
This study examines whether a health message that includes a self-affirmation intervention (where people reflect on values that are important to them) increases acceptance of the message and encourages people to take steps to…
- Trial name
- PEP (NCT03550066)
- Testing
- Values affirmation, No affirmation
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Alcohol, Drinking
Michigan SPARC Trial
Unhealthy alcohol use is a major contributor to morbidity and mortality in the US. Although effective prevention for unhealthy alcohol use and medication treatment for alcohol use disorders (AUDs) can be provided in primary care…
- Conditions
- Alcohol, Drinking, Alcohol Use Disorder (AUD)
- Trial name
- MI-SPARC (NCT04861792)
- Testing
- Michigan SPARC Quality Improvement Intervention
- Where
- United States
- Volunteers
- 9,590 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Physical Activity, Mental Health Wellness 1
Park Rx and Physical Activity Among Low-income Children
This study is a randomized controlled trial to evaluate ParkRx, a clinic-based counseling intervention in which health care providers prescribe park visits at a specific frequency, duration, and includes instructions for physical…
- Trial name
- ParkRx (NCT04114734)
- Testing
- Park Rx
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Kaiser Permanente
Overdose, Risk Behavior
The Impact of Co-Dispensing Naloxone to Patients Prescribed Chronic Opioid Therapy
In the setting of naloxone standing orders, this study will assess if co-dispensing naloxone with opioids to patients prescribed chronic opioid therapy changes opioid risk behaviors, increases naloxone uptake, and increases…
- Trial name
- NCT03337100
- Testing
- Co-Dispensing
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Kaiser Permanente
Depression, Anxiety
Evaluation of the Achieving Depression and Anxiety Patient Centered Treatment (ADAPT) Program
Depression and anxiety are increasingly common conditions for which primary care providers (PCPs) serve as the initial healthcare contact for most patients.
- Trial name
- ADAPT (NCT04839718)
- Testing
- ADAPT
- Where
- United States
- Sponsor
- Kaiser Permanente