Clinical trials: sponsored by Laval University
Obesity; Drug, Obesity, Morbid
Improving Efficacity of Sleeve Gastrectomy With Naltrexone/Bupropion Extended-release Tablet
The goal of this clinical trial is to assess the impact of combination therapy with Naltrexone-Bupropion (NB) in the post-operative period of sleeve gastrectomy (SG).
- Trial name
- NCT06620562
- Testing
- Naltrexone/Bupropion
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Laval University
Obesity, Obesity, Morbid
Impact of Wearing a Support Garment Following Parietal Gastrectomy
Custom-made orthopedic support equipment and abdominal-lumbar support belts offer promising potential for several aspects affecting the health and well-being of people with obesity who choose a surgical weight loss option.
- Trial name
- NCT04938310
- Testing
- sleeve gastrectomy, support garment
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Laval University
Thoracic, Surgery
Frequency and Severity of Respiratory Acidosis During One-lung Ventilation, a Retrospective Pilot Study to Compare Clinician Settings and Those Proposed by the VentilO Application
One-lung ventilation is a mechanical ventilation method frequently used during several thoracic surgeries. One-lung ventilation requires the use of protective ventilation to limit ventilator-induced injury and reduce…
- Conditions
- Thoracic, Surgery, Mechanical Ventilation, Hypercapnia
- Trial name
- NCT07099963
- Testing
- one lung ventilation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Laval University
Diabetes
A Comparison of Different Units for Blood Glucose (mmol/L and mg/dl) and Hemoglobin A1c (% and mmol/Mol) Results.
A comparison of people's reactions to hypothetical test results using different units.
- Trial name
- NCT07102498
- Testing
- BG mmol/L, BG mg/dl, A1c percent
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Laval University
Attitudes
A Comparison of People's Responses to the Labels "Natural Immunity" Versus "Disease-induced Immunity".
A comparison of how people respond to the terms "natural immunity" versus "disease-induced immunity".
- Trial name
- NCT07102485
- Testing
- disease-induced immunity, natural immunity
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Laval University
Attitudes
An Experiment Comparing Public Reactions to the Labels "Community Immunity" Versus "Herd Immunity".
Participants are shown a scenario consisting of static images from a previous study ("herdimm") showing a visualization of how herd immunity works.
- Trial name
- NCT07102472
- Testing
- Using the term "community immunity" instead of "herd immunity", Herd immunity
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Laval University
Thoracic Aortic Aneurysm
Effects of Exercise on Thoracic Aneurysms
Thoracic aneurysm incidence is estimated to 4.5 cases per 100 000. The manifestation as well as natural history of thoracic aneurysm depend on many factors such as its localisation, its diameter, presence of collagen disease and…
- Trial name
- EXTRA (NCT04197648)
- Testing
- Exercise group
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Obesity, Abdominal, Diabete Type 2
Production of Gut Microbiota-Derived Metabolites in Response to Different Fatty Acid Profiles
The proposed project mainly aims to investigate the microbial processes leading to dietary metabolites production, independently of long-term microbiota adaptation to the diet, by measuring the microbiota-derived metabolite…
- Trial name
- METAc (NCT05917132)
- Testing
- Nutritionnal intervention
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Laval University
Gambling Disorder, Psychotic Disorders
Prospective Multicenter Cohort Study Evaluating the Incidence and Risk Factors for Problem Gambling Among Young Adults With First-episode Psychosis
The aims of this propsective cohort study are to get a better understanding of the association between problem gambling and psychotic disorders among young adults with first-episode psychosis.
- Trial name
- ANTE-UP (NCT05686772)
- Testing
- Antipsychotic use, Psychiatric comorbidities, Sociodemographics/socioeconomic status
- Where
- 2 sites in Canada
- Volunteers
- 520 people
- Sponsor
- Laval University
Rotator Cuff-related Shoulder Pain, Shoulder Osteoarthritis
Could a Feedback Device Help Manage Work-related Shoulder Disorders?
Work-related shoulder pain is a common problem with significant socio-economic repercussions. The impact of these disorders on workers is considerable, particularly in terms of pain, disability and reduced quality of life.
- Conditions
- Rotator Cuff-related Shoulder Pain, Shoulder Osteoarthritis, Rheumatoid Arthritis (RA)
- Trial name
- NCT06693479
- Testing
- Shoulder watch load (SWL) feedback, Education
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Laval University
Insomnia Disorder
Efficacy of CBT-I and Lemborexant Medication for Different Subtypes of Chronic Insomnia
The primary aims of this study is to contrast the effectiveness of CBT-I and pharmacotherapy (lemborexant) compared to placebo on sleep and mental health outcomes in people with insomnia disorder and anxiety/depressive symptoms.
- Trial name
- NCT06779149
- Testing
- Cognitive Behavioral Treatment for Insomnia (CBT-I), Lemborexant
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Laval University
Peritoneal Carcinomatosis, Peritoneal Metastases
Diagnostic Value of Diffusion-weighted Magnetic Resonance in High-risk Colorectal and Appendiceal Neoplasms
Diffusion-weighted magnetic resonance imaging (DWI/MRI) has been described in recent literature as a highly sensitive and specific modality for the detection of peritoneal metastases PM.
- Conditions
- Peritoneal Carcinomatosis, Peritoneal Metastases, Appendix Cancer, Appendix Neoplasm
- Trial name
- DWI-HighRisk (NCT05623787)
- Testing
- Whole-body diffusion-weighted magnetic resonance imaging
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Pancreas Cancer, Duct Cell Adenocarcinoma, Pancreas Adenocarcinoma
Diagnostic Value of DWI-MRI for Detection of Peritoneal Metastases in High-risk Pancreatic Ductal Adenocarcinoma.
Diffusion-weighted magnetic resonance imaging (DWI/MRI) has been described in recent literature as a highly sensitive and specific modality for the detection of peritoneal metastases (PM).
- Conditions
- Pancreas Cancer, Duct Cell Adenocarcinoma, Pancreas Adenocarcinoma, Peritoneal Metastases, Peritoneal Carcinomatosis
- Trial name
- DWI-PDAC (NCT05340569)
- Testing
- Whole-body diffusion-weighted magnetic resonance imaging
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Laval University
Coronary Artery Disease, Stable Angina
Physiology as Guidance to Evaluate the Direct Impact of Coronary Lesion Treatment: The PREDICT Study
The purpose of this study is to assess whether the use of physiology parameters as guidance post-percutaneous coronary interventions (PCI) is associated with less risks of target vessel failure (TVF) and angina-related events…
- Conditions
- Coronary Artery Disease, Stable Angina, Unstable Angina, Ischemic Heart Disease
- Trial name
- EASY-PREDICT (NCT04929496)
- Testing
- post-PCI FFR
- Where
- Canada
- Volunteers
- 221 people
- Sponsor
- Laval University
Type 2 Diabetes
Dissecting Host-microbiome Modifiers of Type 2 Diabetes Risk
It is now well documented that changes in gut microbiota composition accompany obesity and type 2 diabetes (T2D) and contribute to low-grade inflammation, insulin resistance,and glucose intolerance.
- Trial name
- DBBIOTE (NCT04579900)
- Testing
- Endoscopy and duodenal biopsy and sampling
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Laval University
Metabolic Syndrome
Salmon Peptide Fraction: Safety and Cardiometabolic Health
The overall goal of this study is to verify the safety of 15g of salmon peptide fraction (SPF), and to test the effects on metabolic syndrome risk factors of two doses of SPF (7.5g and 15g) in overweight-obese men and women.
- Trial name
- SPF1 (NCT05025462)
- Testing
- Supplement dose 15g/d, Supplement dose 7.5g/d
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Laval University
Diabetes Mellitus, Type 2, Physical Activity
Portable Monitoring Device, Physical Activity Motivation and Patients with Type 2 Diabetes
The intervention proposed for this project aims to improve the practice of physical activity (PA) for people with type 2 diabetes by increasing their motivation using a portable device to monitor PA (FitBit).
- Conditions
- Diabetes Mellitus, Type 2, Physical Activity, Motivation
- Trial name
- DBFitbit (NCT03709966)
- Testing
- Portable monitoring device, Routine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Radial Artery Occlusion
Radial Artery Occlusion and Dual Artery Hemostasis After Transradial Approach.
Improving patient comfort and implementing the protocols required to minimize the risk of RAO must be part of quality control. Several procedural parameters are related to the risk of RAO but hemostasis is a critical period.
- Trial name
- NCT04933136
- Testing
- Terry2 Band
- Where
- 5 sites in Canada
- Volunteers
- 500 people
- Sponsor
- Laval University
Low Back Pain, Neck Pain
Which Model of Care is the Most Cost-effective in the Treatment of Musculoskeletal Disorders?
As musculoskeletal disorders (MSKDs) reach epidemic proportions in Canada, access to the public health system for those who suffer from them is increasingly difficult.
- Conditions
- Low Back Pain, Neck Pain, Anterior Knee Pain Syndrome, Rotator-cuff Related Shoulder Pain
- Trial name
- Edu1st (NCT06832852)
- Testing
- Stepped care, Rehabilitation Care, Medical Care
- Where
- Canada
- Volunteers
- 369 people
- Sponsor
- Laval University
Gynecologic Cancers, Breast Cancer Female
Pelvic Health Rehabilitation After Breast and Gynecologic Cancer
The GYVE study aims at testing an online program (eModule) to help people who have had breast or gynecologic cancer and are experiencing pelvic health issues like urinary incontinence and pain during sex.
- Conditions
- Gynecologic Cancers, Breast Cancer Female, Incontinence, Incontinence Bowel
- Trial name
- GYVE (NCT06822582)
- Testing
- Pelvic Health Module
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Laval University