Clinical trials: sponsored by Laval University
Trauma Injury
Reducing Low-value Care for Trauma Admissions
In Canada, injury leads to more potential years of life lost and to greater costs than heart and stroke diseases combined. Furthermore, more than 50% of patients hospitalised following injury do not receive optimal care, 20% of…
- Trial name
- NCT05744154
- Testing
- Audit & feedback with educational outreach and facilitation, Simple audit & feedback (usual practice)
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Laval University
Gastroesophageal Reflux, Sleeve Gastrectomy
The Use of EndoFlip as a Clinical Tool for the Prediction of Postoperative GERD After Sleeve Gastrectomy
This study aims to determine if preoperative EndoFlip measurement can effectively predict postoperative GERD-related quality of life and lower esophageal acid exposure.
- Conditions
- Gastroesophageal Reflux, Sleeve Gastrectomy, Bariatric Surgery Complication
- Trial name
- NCT05690022
- Testing
- sleeve gastrectomy
- Volunteers
- 100 people
- Sponsor
- Laval University
Post-Concussion Syndrome, Mild Traumatic Brain Injury
Cervico-vestibular Rehabilitation for Mild Traumatic Brain Injury
Neck pain, dizziness and headache are common symptoms following mild traumatic brain injury (mTBI). The efficacy of cervical spine and vestibular-ocular system impairments intervention need to be determined.
- Conditions
- Post-Concussion Syndrome, Mild Traumatic Brain Injury, Vestibular Disorder, Whiplash Injuries
- Trial name
- NCT03677661
- Testing
- Conventional approach, Personalized rehabilitation program
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Overweight, Microtia
Demonstration of the Prebiotic-like Effects of Camu-camu Consumption Against Obesity-related Disorders in Humans
Previous work of the investigators demonstrated the anti-obesity and anti-steatosis potential of the Amazonian fruit camu-camu (CC) in a mouse model of diet-induced obesity [1].
- Conditions
- Overweight, Microtia, Endotoxemia, Metabolic Syndrome
- Trial name
- NCT04130321
- Testing
- Camu camu
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Laval University
Incomplete Spinal Cord Injury
Powered Exoskeleton Combined With Functional Electrical Stimulation in Clinical Practice
After partial spinal cord injury, gait deficits may be present and often remain even after intensive rehabilitation. New robotic technologies have recently emerged to help augment the extent of rehabilitation.
- Trial name
- NCT04568928
- Testing
- OLTP/PE + FES
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Laval University
Thoracic Surgery, Video-Assisted
A Prospective Descriptive Study of the Individualized Capnography of Both Lungs During One-lung Ventilation With Double-lumen Tube
A prospective descriptive study of the use of an individualized capnography to each lung in the context of one-lung ventilation achieved with a double-lumen tube.
- Conditions
- Thoracic Surgery, Video-Assisted, Double-Lumen Tube, Capnography
- Trial name
- EtCO2-DLT (NCT04962581)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Metabolic Syndrome, Overweight
Systematic Review and Meta-analysis of the Differential Effects of DHA and EPA on Inflammation
According to the World Health Organization, cardiovascular diseases (CVDs) are the number 1 cause of death globally. Systemic and local tissue inflammation is now recognized as a key etiological process leading to CVD.
- Conditions
- Metabolic Syndrome, Overweight, Obesity, Chronic Inflammation
- Trial name
- NCT03520556
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Laval University
Hypertension
Effect of Polyphenols Combined to L-citrulline on Ambulatory Blood Pressure
The general objective of this project is to investigate the chronic effect of consuming supplements combining polyphenols from cranberry and grape seed extracts and L-citrulline (Nitric Oxide Ultra capsules, Pure Encapsulations…
- Trial name
- NCT03679195
- Testing
- NO Ultra
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Laval University
PreDiabetes, Insulin Resistance
Brown Seaweed Extract on Glycemic Control and Body Weight
The overall goal of this study is to investigate the effects of a daily dietary supplement of brown seaweed (2 capsules of InSea2®) on body weight, glycemic control and insulin secretion in overweight prediabetic men and women in…
- Trial name
- Algues (NCT03075943)
- Testing
- InSea2
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Laval University
Cerebral Palsy
Intensive Bimanual Intervention in Cerebral Palsy Children
Motor disorders related to cerebral palsy are often accompanied by sensory, cognitive, perceptive, communication and behavioural impairments.
- Trial name
- NCT05423171
- Testing
- Intensive bimanual therapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Gestational Diabetes
Human Milk: Understanding the Mechanisms Linked to the Prevention of Obesity and Diabetes in Children Exposed in Utero to Gestational Diabetes
Breastfeeding has been associated with decreased obesity. However, this relationship is not as clear in children who have been exposed to GDM and the mechanisms involved are little known.
- Trial name
- LAIT-M (NCT04263675)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laval University
Dietary Modification, Weight Loss
Feasibility of a Postpartum Lifestyle Intervention on the Cardiometabolic Risk Profile of GDM Women
The goal of the study is to investigate the effect of a lifestyle intervention program (adoption of exclusive breastfeeding, healthy diet and regular physical activity) on minimizing postpartum weight retention among women with…
- Conditions
- Dietary Modification, Weight Loss, Physical Activity, Breastfeeding
- Trial name
- DEPART (NCT02872402)
- Testing
- Lifestyle intervention, Active control lifestyle intervention
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laval University
Chronic Heart Failure, Central Sleep Apnea
Nocturnal Oxygen Needs and Central Sleep Apnea in Patients With Chronic Heart Failure.
The aims of this study are to 1) determine the optimal levels of O2 flow which prevent nocturnal O2 desaturation while minimizing periods of hyperoxia during the course of nocturnal oxygen therapy (NOXT) in heart failure patients…
- Trial name
- HO2F (NCT03254212)
- Testing
- Titration of nocturnal oxygen needs to prevent desaturations
- Where
- 2 sites in Canada
- Volunteers
- 14 people
- Sponsor
- Laval University
Gestational Diabetes, Type 2 Diabetes
Relationship Between Gestational Diabetes and Type 2 Diabetes
The overall objective of this research project is to study the impact of preventive practices on the T2D-related risk profile among women with and without prior GDM and their children exposed and unexposed to GDM.
- Trial name
- GDM (NCT01340924)
- Where
- Canada
- Volunteers
- 450 people
- Sponsor
- Laval University
Sleep Apnea, Post Menopausal
Impact of Estrogen + Estradiol Receptor Alpha Modulator Therapy on Oxidative Stress in Post-menopausal Women With and Without Sleep Apnea
One of the most likely mechanisms explaining the sleep apnea (SA)-induced increase in metabolic syndrome is the oxidative stress (OS) induced by intermittent hypoxia (IH).
- Conditions
- Sleep Apnea, Post Menopausal, Oxidative Stress
- Trial name
- Alpha MenoX (NCT03981341)
- Testing
- Duavive (0.45 estrogens mg and 20 mg bazedoxifene)
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- Laval University
Insomnia Disorder
Optimization of Insomnia Treatment in Primary Care
The primary objective of this pragmatic clinical trial is to evaluate the efficacy, feasibility, and adaptability of pharmacological and non-pharmacological treatments for insomnia disorder, delivered in primary care clinics.
- Trial name
- NCT03633305
- Testing
- Hypnotics, Online CBT, Face-to-face CBT
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Laval University
Dyspnea, Lung Diseases
Effects of Automated Oxygen Titration Alone or With High Flow Nasal Therapy on Dyspnea and Exercise Tolerance
The main purpose of this study is to evaluate the effects of automated oxygen administration (FreeO2 system) alone or with high-flow oxygen on dyspnea and exercise tolerance in people with desaturating chronic lung disease…
- Conditions
- Dyspnea, Lung Diseases, Pulmonary Hypertension, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT05267418
- Testing
- Automated nasal O2 titration with FreeO2
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Musculoskeletal Pain, Low Back Pain
Group-based Exercise Training Programs for Military Members With Musculoskeletal Conditions
This randomized controlled trial will compare the mid- and long-term effects of group-based training programs with usual individual physiotherapy care for the treatment of musculoskeletal disorders in military.
- Conditions
- Musculoskeletal Pain, Low Back Pain, Rotator Cuff Tendinitis, Patellofemoral Pain Syndrome
- Trial name
- NCT05235152
- Testing
- Usual individual physiotherapy care, Group-supervised physiotherapy training programs
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Laval University
COVID-19, Hypoxemia
Clinical Impact of Automated Oxygen Administration on Confirmed or Suspected COVID-19 in the Emergency Department.
The aim of this study is to evaluate the impact of the FreeO2 system on the quality of the oxygen therapy in confirmed or suspected SARS-CoV-2 patients in the emergency department.
- Conditions
- COVID-19, Hypoxemia, Hyperoxia, Hypoxia
- Trial name
- NCT05235386
- Testing
- Automated oxygen titration
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Laval University
Low Back Pain
Quebec Low Back Pain Study: Core Dataset
Persistent back pain is the leading cause of years lived with disability worldwide. Current therapeutic interventions are often either not effective or are associated with undesired consequences.
- Trial name
- QLBPS (NCT04791891)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- Laval University