Clinical trials: sponsored by Loma Linda University
Menstruation Disorders, Menstrual Cramps
Impact of Seed Cycling on Menstrual Regularity, Dysmenorrhea, and Premenstrual Symptoms
The purpose of this research is to investigate the impact of seed cycling on menstrual regularity, cramps, and pre-menstrual symptoms in women with an irregular menstrual cycle and/or dysmenorrhea.
- Conditions
- Menstruation Disorders, Menstrual Cramps, Menstruation
- Trial name
- NCT07052500
- Testing
- Seed Cycling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Loma Linda University
Pelvic Organ Prolapse, Cystocele
SCP vs HUSLS for Pelvic Organ Prolapse Repair
The purpose of this study is to compare the effectiveness of R-SCP versus HUSLS for treatment of pelvic organ prolapse.
- Conditions
- Pelvic Organ Prolapse, Cystocele, Rectocele, Enterocele
- Trial name
- NCT02800512
- Testing
- Robotic sacrocolpopexy, high uterosacral ligament suspension
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Loma Linda University
Hypersensitivity Reactions
Conventional Prophylactic Oral Dexamethasone vs Short-course IV Dexamethasone in Paclitaxel Hypersensitivity
This study is a single center, prospective, randomized, open-label study aimed at determining the most effective means of preventing hypersensitivity reactions in gynecologic oncology patients receiving paclitaxel infusions.
- Trial name
- NCT03598426
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Loma Linda University
Adverse Childhood Experiences
Building Resilient Families
Prior research suggests that it is possible to improve health outcomes in children with ACEs through multi-component interventions.
- Trial name
- NCT05388864
- Testing
- Three-Tier Model
- Where
- United States
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Cesarean Section Complications, Cesarean Section; Infection
Wound Irrigation With Saline Versus Hypodilute-chlorhexidine After Cesarean Section (WISHES Study)
This investigator-initiated, open-label, randomized controlled trial will explore the effects of two treatment arms, comparing standard treatment with normal saline against Irrisept, a jet lavage solution containing a low…
- Trial name
- NCT06339203
- Testing
- Irrisept, Normal Saline
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Loma Linda University
Obesity, Body Weight Changes
Does Personality Predict Patient Adherence, Health Behaviors, and Weight Loss Outcomes During the Latino Crossover Semaglutide Study (LCSS)? (Story-LCSS Project)
The goal of this observational study is to learn about the personality attributes and values of people living with obesity that are part of the Latino community, and how these personality attributes and values can help to predict…
- Trial name
- StoryLCSS (NCT05622045)
- Testing
- Voice data
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Loma Linda University
Tobacco Use, Tobacco Use Cessation
Integrating CHWs Into Prenatal Care for Maternal Smoking Cessation
This develops a novel behavioral tobacco cessation program for pregnant smokers in San Bernardino County.
- Conditions
- Tobacco Use, Tobacco Use Cessation, Tobacco Use in Childbirth
- Trial name
- SFHOPE (NCT06438549)
- Testing
- HCP-CHW Integration into Prenatal Care for Smoking Cessation, Control Arm
- Where
- 2 sites in United States
- Volunteers
- 105 people
- Sponsor
- Loma Linda University
Esophagus Cancer
Proton Therapy for Esophageal Cancer
The goal of this phase II study is to investigate the feasibility, toxicity and efficacy of a regimen incorporating a proven systemic regimen, carboplatin /paclitaxel, with conformal proton modality, followed by definitive…
- Trial name
- NCT01684904
- Testing
- Proton radiation
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Loma Linda University
Amyotrophic Lateral Sclerosis
Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone
This study is being conducted to help the investigators better understand how the new FDA approved medication Edaravone (also known as Radicava) works in subsets of patients with ALS.
- Trial name
- NCT04097158
- Testing
- Sample Collection
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Loma Linda University
Liver Metastases
Proton Therapy in the Treatment of Liver Metastases
Local control of hepatic metastases appears to be a major determinant of overall survival. However, many patients are not suitable for resection due to medical or surgical reasons.
- Trial name
- NCT01697371
- Testing
- Proton, Proton Radiation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Loma Linda University
Anesthesia
Assessment of Diagnostic Adequacy of AI-assisted Point-of-Care Echocardiography Among Anesthesiology Trainees
This pilot study serves to assess the diagnostic adequacy of Artificial Intelligence (AI)-guided point-of-care. Focused echocardiography examinations will be obtained by Anesthesiology trainees and assessed by an expert…
- Trial name
- NCT06548373
- Testing
- Artificial Intelligence-assisted Point-of-Care Echocardiography
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Cancer
Radiation Medicine Patient Registry, Loma Linda University Medical Center
For most cancers, long-term follow-up is the best measure of treatment effectiveness. The Department of Radiation Medicine at Loma Linda University Medical Center operates the James M.
- Trial name
- NCT02436941
- Testing
- Proton or Photon
- Volunteers
- 75,000 people
- Sponsor
- Loma Linda University
Healthy
Intermittent Fasting on Body Fat and Quality of Life
The purpose of this investigator-initiated study to check the feasibility that intermittent fasting has on body fat loss and quality of life.
- Trial name
- NCT06307275
- Testing
- Fasting, non fasting
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Low Back Pain, Mechanical, Piriformis Syndrome
Strain-Counterstrain Treatment of Piriformis Pain
The purpose of this investigator-initiated study is to provide an efficient and non-invasive treatment option for pain caused by the piriformis muscle.
- Conditions
- Low Back Pain, Mechanical, Piriformis Syndrome, Somatic Dysfunction of Sacral Region (Finding)
- Trial name
- NCT05023005
- Testing
- Strain-Counterstrain treatment of piriformis muscle
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Intraoperative Neurophysiological Monitoring, Magnesium Sulfate
Effect of Magnesium Sulfate Bolus on Intraoperative Neuromonitoring
Magnesium Sulfate(MgSo4) is increasingly being used as part of the multimodal pain regimen in the perioperative period. The intraoperative neurophysiological monitoring (IONM) is utilized in complex spine and cranial surgeries to…
- Trial name
- NCT04938765
- Testing
- Magnesium sulfate, Normal Saline
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Loma Linda University
Cannabis Use Disorder, Stimulant Use Disorder
Emotional Brain Training for Addiction Medicine Treatment - A Pilot Study
The goal of this clinical trial is to determine whether Emotional Brain Training (EBT), a behavioral modification method, can help manage stress and health problems related to addiction.
- Conditions
- Cannabis Use Disorder, Stimulant Use Disorder, Opioid Use Disorder, Tobacco Use Disorder
- Trial name
- NCT07001371
- Testing
- Emotional Brain Training, Standard addiction counseling and medical therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Loma Linda University
Renal Colic, Kidney Stones, Urolithiasis, Hypocitraturia
Relief Efficacy of Lidocaine Versus Morphine for Acute Renal Colic in the Emergency Department
The opioid epidemic continues to be a major public health crisis in the United States. According to the Center for Disease Control, approximately 8 million Americans reported misusing prescription opioids in 2023, with over 5…
- Conditions
- Renal Colic, Kidney Stones, Urolithiasis, Hypocitraturia, Opioid Use During Medical Care
- Trial name
- RELIEF-RC (NCT07536594)
- Testing
- Lidocaine, Morphine 0,1 mg/kg
- Volunteers
- 250 people
- Sponsor
- Loma Linda University
Postoperative Pain, Patient Satisfaction
Post Operative Analgesia and Patient Satisfaction
To understand how patients perceive the quality of care they receive when given different post-operative analgesic medications. Specifically the investigators want to assess whether patients who receive non-opioid analgesia…
- Conditions
- Postoperative Pain, Patient Satisfaction, Analgesia
- Trial name
- NCT04976387
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Radiation Exposure, Overactive Bladder
Fluoroscopy Radiation Reduction During Sacral Neuromodulation Lead Placement
Fluoroscopy is performed when placing a lead during a sacral neuromodulation procedure. During lead placement, subjects will receive either conventional or experimental fluoroscopic settings.
- Conditions
- Radiation Exposure, Overactive Bladder, Urge Incontinence, Urgency-frequency Syndrome
- Trial name
- NCT04527445
- Testing
- Reduced radiation fluoroscopy, Conventional fluoroscopy
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Loma Linda University
HIV Infections, Inpatient Facility Diagnoses
Teamwork Makes the Dream Work
Exploring the effect of team-based ARTAS intervention in an inpatient setting on HIV linkage to care and hospital readmission rates.
- Trial name
- ARTAS (NCT05866523)
- Testing
- Team Based Inpatient ARTAS, Standard of Care
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Loma Linda University