Clinical trials: sponsored by Lund University
Temporomandibular Disorders (TMD), Temporomandibular Joint Ankylosis
Virtual Planning of Total Temporomandibular Joint Replacement
A total TMJ replacement surgery is currently planned based on the X-ray appearance of the facial X-ray. It is now possible to use either an individually designed TMJ prosthesis or a prosthesis with a standard appearance.
- Trial name
- NCT07373184
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Lund University Hospital
Liver Metastases, Liver Cancer
Perioperative Intravenous Lidocaine in Liver Surgery
This is a randomized double blinded placebo-controlled study, conducted in Lund, Sweden. Patients will be randomized in two groups, with a ratio of 1:1.
- Conditions
- Liver Metastases, Liver Cancer, Postoperative Pain, Opioid Use
- Trial name
- NCT05153785
- Testing
- Lidocaine, Normal saline
- Where
- Sweden
- Volunteers
- 124 people
- Sponsor
- Lund University Hospital
Sleep Quality, Well-being
Light in Healthcare Environment (Ljus i sjukhusmiljö)
The goal of this clinical trial is to learn if light can enhance the feeling of well-being and sleep quality in Radiographers. It will also find out if there is an optimal recipe for light.
- Conditions
- Sleep Quality, Well-being, Melatonin, Cortisol
- Trial name
- LIS (NCT06687304)
- Testing
- Light enhancement
- Where
- 3 sites in Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University
Lymphedema of Face, Neoplasms
Manual Lymph Drainage for External Lymphedema
This study will evaluate the feasibility of a randomized controlled trial. The future randomized controlled trial will compare two groups following different intensities of manual lymphatic drainage for external head- and neck…
- Conditions
- Lymphedema of Face, Neoplasms, Radiotherapy Side Effect, Lymphedema Due to Radiation
- Trial name
- MLD-HN (NCT07215169)
- Testing
- HIT, LIT
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Lund University
Cancer of Head and Neck
Lymphoedema Among Persons With Head- and Neck Cancer
Lymphedema in the head and neck area is common after treatment for head and neck cancer. The aim of the research project is: to assess the prevalence of lymphedema in patients with head and neck cancer (HNC) by measuring the…
- Trial name
- NCT05316974
- Testing
- Prevalence of lymphoedema
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Lund University
Prostate Cancer
Personalized Radiotherapy for Biochemical Recurrence of Prostate Cancer After Prostatectomy.
A randomized phase III trial to study the effect of adding lymph node irradiation in patients with poor prostate-specific antigen (PSA) response during salvage radiotherapy for biochemical recurrence (0.15 ≤ PSA <0.70 ng/ml)…
- Trial name
- PROPER2 (NCT04858880)
- Testing
- Radiation to the prostate bed with or without addition of radiation of lymph node irradiation.
- Where
- 3 sites in Sweden
- Volunteers
- 374 people
- Sponsor
- Lund University Hospital
Metastatic Breast Cancer
Sweden Cancerome Analysis Network - Breast Recurrence (SCAN-B-rec)
Prospective multicenter observational study to assess molecular drivers of metastatic breast cancer and disease evolution upon therapeutic pressure.
- Trial name
- NCT03758976
- Testing
- Biopsies, blood
- Where
- 2 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Lund University Hospital
Breast Cancer, Triple Negative Breast Neoplasms
NordicTrip, a Translational Study of Preoperative Chemotherapy in TNBC
Primary aim: To compare the effect on pathologic complete response (pCR) rate of adding capecitabine to carboplatin based preoperative chemotherapy in early ER-negative and HER2-negative breast cancer.
- Trial name
- NCT04335669
- Testing
- epirubicin, cyclophosphamide, paclitaxel, carboplatin, pembrolizumab, epirubicin, cyclophosphamide, capecitabine, paclitaxel, carboplatin, pembrolizumab
- Where
- 24 sites in Denmark, Sweden
- Volunteers
- 325 people
- Sponsor
- Lund University Hospital
Tumor in Upper Gastrointestinal Canal or Patients With Colorectal Cancer
Observational Study of Early Contact With Palliative Care Unit for Patients Receiving First Line Palliative Chemotherapy With Cancer in Upper Gastrointestinal Canal, or Second Line Palliative Chemotherapy in Patients With Colorectal Cancer - an Open, Randomised Investigator Initiated Trial.
In this trial, patients with cancer in the upper gastrointestinal canal who are going to receive first line palliative chemotherapy and patients with colorectal cancer who are going to receive second line palliative chemotherapy…
- Trial name
- ALLAN (NCT02246725)
- Testing
- Contact with palliative care unit.
- Where
- Sweden
- Volunteers
- 108 people
- Sponsor
- Lund University Hospital
Atrial Fibrillation
The Use of Flecainide for Treatment of Atrial Fibrillation
This prospective observational study will include patients with atrial fibrillation that has indication for treatement with flecainide. Included patients are followed during a 12 month period.
- Trial name
- NCT05084495
- Testing
- Global peak atrial longitudinal strain and ECG
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Lund University
Neuroendocrine Tumors
Systemic Targeted Adaptive RadioTherapy of NeuroEndocrine Tumors.
There are several ways of personalizing PRRT (peptide receptor radionuclide treatment) in NEN (neuroendocrine neoplasia). Nevertheless, the current treatment regimen is not personalized.
- Trial name
- START-NET (NCT05387603)
- Testing
- 177Lu-DOTATOC, Capecitabine
- Where
- 4 sites in Sweden
- Volunteers
- 300 people
- Sponsor
- Lund University Hospital
Breast Cancer
A Clinical Trial to Compare Efficacy and Tolerability of Atorvastatin in Addition to Endocrine Treatment With Focus on Mechanisms of Resistance to Endocrine Treatment (Fulvestrant/Aromatase Inhibitors) in Patients With Advanced Breast Cancer
A Clinical Trial to Compare Efficacy and Tolerability of Atorvastatin in Addition to Endocrine Treatment with Focus on Mechanisms of Resistance to Endocrine Treatment (fulvestrant/aromatase inhibitors) in Patients With Advanced…
- Trial name
- ABC-SE (NCT02958852)
- Testing
- Letrozole, Letrozole and atorvastatin, Fulvestrant
- Where
- Sweden
- Volunteers
- 126 people
- Sponsor
- Lund University Hospital
Resectable Gastric and Gastroesophageal Junction Adenocarcinoma
Irinotecan-based Triplet (FOLFOXIRI) as Perioperative Treatment in Resectable Gastric and Gastroesophageal Junction Adenocarcinoma.
In this clinical trial, patients with gastric and gastroesophageal junction adenocarcinoma will be included. Treatment with curative intent will be given with chemotherapy for 4 cycles with fluorouracil, oxaliplatin and…
- Trial name
- INTENSE (NCT03773367)
- Testing
- Fluorouracil, Oxaliplatin, Irinotecan
- Where
- 4 sites in Norway, Sweden
- Volunteers
- 60 people
- Sponsor
- Lund University Hospital
Periampullary Adenocarcinoma, Periampullary Cancer
Chemotherapy, Host Response and Molecular Dynamics in Periampullary Cancer
The CHAMP (Chemotherapy, Host response And Molecular dynamics in Periampullary cancer) study is a prospective, single-arm observational study that started Sept 1 2018.
- Conditions
- Periampullary Adenocarcinoma, Periampullary Cancer, Pancreatic Cancer
- Trial name
- CHAMP (NCT03724994)
- Testing
- Gemcitabine
- Where
- Sweden
- Volunteers
- 201 people
- Sponsor
- Lund University
Persistent Pain, Pain Management
Self-monitoring and Remote Monitoring of Chronic Pain in Primary Care - Using a Digital Tool to Improve Quality of Life
Chronic pain impacts individuals, their families, and society significantly, yet specialist care resources are limited, with most patients managed in primary care.
- Conditions
- Persistent Pain, Pain Management, Remote Monitoring
- Trial name
- NCT07141108
- Testing
- Paindrainer Care system
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Lund University
Microbiota Analysis in Healthy Subjects
Analysis of the Gut Microbiota Composition After Consumption of Probiotic Bacteria
The goal of this intervention study is to evaluate the beneficial effect of the probiotic bacterium Bacillus coagulans in healthy volunteers.
- Trial name
- NCT07046897
- Testing
- Consumption of probiotics strain 5, Consumption of probiotics strain 6
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lund University
Children With Cerebral Palsy Who Are Ambulant, Cerebral Palsy GMFCS-ER I-II
Exercise Training Among Children With Cerebral Palsy to Increase Health and Well-being - A Feasibility Study
The use of eHealth in children with cerebral palsy (CP) holds promise to increase participation in exercise. eHealth, has shown to increase accessibility to appropriate healthcare professionals as well as reduces time- and energy…
- Trial name
- HOME-EX (NCT07025694)
- Testing
- A eHealth application on a computer tablet contected to a secure severer with an interface on a computer to deliver exercise interventions., A eHealth application on a computer tablet contected to a secure severer with an interface on a computer to deliver exercise interventions, Moderate Intensity Continues Training
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Chronic Cancer-related Pain
An N-of-1 Trial of an Internet-delivered CBT Program Based on the Psychological Flexibility Model of Chronic Pain for Cancer-related Difficulties
Chronic pain is a commonly occurring complication of cancer and can have negatively impact day-to-day functioning and well-being. The recommended treatment for all forms of chronic pain is cognitive behavioral therapy (CBT).
- Trial name
- NCT06749964
- Testing
- Internet-delivered, therapist-assisted, pain-focused CBT based on the psychological flexibility model for chronic pain
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Lund University
Depressive Disorder, Major
Aerobic Versus Leisure Group for Adolescents With Depression
The aim is to evaluate aerobic group exercise versus leisure group activities in adolescents with mild to moderate depression. Primary outcome is Children's Depression Rating Scale - Revised (CDRS-R).
- Trial name
- NCT05076214
- Testing
- Aerobic exercise in group, Leisure activities in group
- Where
- 4 sites in Sweden
- Volunteers
- 122 people
- Sponsor
- Lund University Hospital
Female Infertility
Hormone Evaluation in Artificial Reproductive Technology
The aim is to be able to predict the hormonal response according to gonadotropin receptor genotype and hormone type used for treatment of women undergoing in vitro fertilization or egg donation.
- Trial name
- HEART (NCT03737253)
- Testing
- Follitropin alpha, Menotropin
- Where
- 2 sites in Poland, Sweden
- Volunteers
- 810 people
- Sponsor
- Lund University