Clinical trials: open to volunteers, sponsored by Lund University
Finger Joint Deformities, Tendon Injuries
Conservative Treatment With Relative Motion Flexion Orthosis for Boutonniere Injuries in Fingers
Boutonnière injuries involve damage to the central slip of the extensor tendon over the proximal interphalangeal (PIP) joint (zone III) of the finger.
- Conditions
- Finger Joint Deformities, Tendon Injuries, Hand Injuries, Extensor Tendons of Finger Anomalies
- Trial name
- NCT07921927
- Testing
- Relative Motion Flexion (RMF) orthosis intervention group
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Lund University Hospital
Essential Tremor, Parkinsons Disease (PD)
Effects of Microelectrode-based Brain Stimulation in Humans
The currently available treatments of Parkinson's disease (PD) and Essential Tremor (ET) are inadequate and accompanied by adverse side effects making the treatment much less effective.
- Trial name
- HDBS (NCT07820189)
- Testing
- High Definition Brain Stimulation (HDBS)
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Lund University
Absenteeism, School Absenteeism
Early Absenteeism Guide for Lifelong Education
School absenteeism is a problem that can be caused by several different factors, such as difficulties within the family, problems in the school environment, or mental health difficulties.
- Trial name
- EAGLE (NCT07857603)
- Testing
- Intervention , EAGLE, Treatment as usual (TAU)
- Volunteers
- 90 people
- Sponsor
- Lund University
Atherosclerosis, Atherosclerotic Plaque
Atherosclerotic Plaque Imaging Project (CPIP)
The rupture or erosion of an atherosclerotic plaque with thrombosis or embolization often underlie heart attacks and strokes. The early identification of patients with atherosclerotic plaques prone to rupture or erosions…
- Trial name
- APIP (NCT05821894)
- Testing
- Observational study
- Where
- Sweden
- Volunteers
- 3,500 people
- Sponsor
- Lund University
Type 1 Diabetes Mellitus, Stage 2 Type 1 Diabetes
Information, Follow-up and Early Diagnosis of Children at Risk for Type 1 Diabetes
The aim is to investigate whether screening for islet autoantibodies, regular follow-up, and increased knowledge in families about the progression of the disease in children at high genetic risk or with single or multiple islet…
- Conditions
- Type 1 Diabetes Mellitus, Stage 2 Type 1 Diabetes, Stage 1 Type 1 Diabetes, Stage 3 Type 1 Diabetes
- Trial name
- iT1D (NCT06676566)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Lund University
POTS - Postural Orthostatic Tachycardia Syndrome
The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic…
- Trial name
- POTS (NCT05554107)
- Testing
- Training program
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lund University
Heart Rate Determination, Patient Participation
Promoting Children's Participation in Conventional X-ray Examinations
The goal of this explorative observational study is to map the procedure and child centered approach in the examination for children that undergo conventional X-ray examinations.
- Trial name
- NCT06322264
- Testing
- Measurement of variation in heart rate
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Lund University
Pregnancy Related, Tuberculosis Infection
Effects of Tuberculosis Infection on Development and Function of the Placenta
The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on…
- Conditions
- Pregnancy Related, Tuberculosis Infection, Placenta Diseases
- Trial name
- NCT06352970
- Testing
- TB infection
- Where
- Ethiopia
- Volunteers
- 500 people
- Sponsor
- Lund University
Breast Neoplasms
Sweden Cancerome Analysis Network - Breast : Genomic Profiling of Breast Cancer
This study evaluates the genomic profiles of breast cancer in a prospective and population-based manner. In the first phase, breast tumors are analyzed by whole transcriptome RNA-sequencing.
- Trial name
- SCAN-B (NCT02306096)
- Where
- 10 sites in Sweden
- Volunteers
- 20,000 people
- Sponsor
- Lund University
Mycosis Fungoides, Sezary Syndrome
Predictive and Prognostic Biomarkers in Patients With Mycosis Fungoides and Sézary Syndrome.
A translational study for identification of prognostic and treatment-predictive biomarkers in Mycosis fungoides and Sézary syndrome.
- Trial name
- BIO-MUSE (NCT04904146)
- Testing
- Blood tests and testing of analysis of the lymphoma microenvironment in skin, skin barrier and skin microbiology profile.
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lund University Hospital
Tonsil Cancer
Photon Therapy Versus Proton Therapy in Early Tonsil Cancer.
In this trial, patients with early squamous cell carcinoma of the tonsil with clinical stage T1-2 (p16-positive or p16-negative) N0-1 (p16-positive)/N0-N2b (p16-negative) according to American Joint Committee on Cancer (AJCC) 8th…
- Trial name
- ARTSCAN V (NCT03829033)
- Testing
- Radiotherapy
- Where
- 12 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Lund University Hospital
Dedifferentiated Liposarcoma
A Phase 2, Open Label Study of PEmigatinib and REtifanlimab in Advanced Dedifferentiated LIposarcoma (PERELI)
Dedifferentiated liposarcomas (DDLPS) are aggressive soft tissue sarcomas with no effective medical treatment options. Immunotherapy with checkpoint inhibitors, so-called PD-1 inhibitors, have shown some effect in DDLPS in…
- Trial name
- PERELI (NCT06389799)
- Testing
- Pemigatinib, Retifanlimab
- Where
- 4 sites in Norway, Sweden
- Volunteers
- 33 people
- Sponsor
- Lund University Hospital
Cesarean Birth
The Cesarean Study: Optimizing Cesarean Sections and Improving Patient-Healthcare Provider Trust Using Evidence Informed Recommendations
Cesarean section (CS) rates have rapidly increased worldwide, with projections suggesting that by 2030, one in every three births will be by CS (1).
- Trial name
- CS (NCT07759622)
- Testing
- Cesarean Bundle
- Where
- Sweden
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Lund University
Healthy Tissue, Muscles
Deep Optical Imaging of Tissue (DOIT)
In medical imaging, X-ray-based methods are widely used, which means that patients are exposed to ionizing radiation. In addition, invasive tissue samples often need to be taken with biopsy needles to, for example, safely…
- Conditions
- Healthy Tissue, Muscles, Extremity, Breast
- Trial name
- DOIT (NCT07754500)
- Testing
- Mk1
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lund University
Plant-based Milk, Gastrointestinal Microbiome
Study the Effect of Plant-based Beverage Consumption on the Gut Microbiome in Healthy Adults
The goal of this intervention study is to analyse the microbiota composition after the plant-based beverage consumption. The main questions are to evaluate if the plant-based beverage can have a beneficial effect on the gut…
- Trial name
- NCT07730229
- Testing
- plant-based beverage
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lund University
Type 1 Diabetes, Autoimmune Diabetes
Intensive Dietary and Activity Counselling (IDAC)
The aim of this intervention study is to investigate if a intensive dietary and physical activity counselling during the first two years of life in children with increased (genetically) risk for Type 1 Diabetes (T1D) can promote…
- Trial name
- IDAC (NCT06670625)
- Testing
- IDAC+
- Where
- Sweden
- Volunteers
- 1,244 people
- Sponsor
- Lund University
URTI - Viral Upper Respiratory Tract Infection
Evaluation Viral RNA and Virus Infectivity in Exhaled Air Before and After Use of One Dose With ColdZyme Mouth Spray
Many respiratory diseases spread through aerosols. ColdZyme is a mouth spray that protects against upper respiratory tract viruses causing common cold and flu-like symptoms.
- Trial name
- NCT07041671
- Testing
- ColdZyme
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lund University
Hip Pain Chronic, Femoro Acetabular Impingement
Education and Exercise for Patients With Longstanding Hip and Groin Pain
Longstanding hip and groin pain (LHGP) is a common and debilitating problem in young to middle aged individuals. These patients often get referred to orthopedic departments.
- Conditions
- Hip Pain Chronic, Femoro Acetabular Impingement, Groin Injury
- Trial name
- HIPSTER (NCT05853640)
- Testing
- Usual care, HIPSTER
- Where
- Sweden
- Volunteers
- 122 people
- Sponsor
- Lund University
Mental Illness
UPSIDES - Recovery Through Peer Support
Research problem and specific questions Peer support (PS) is a well-established intervention within community mental health services (CMHS) internationally, involving a person recovering from serious mental health problems (SMHP)…
- Trial name
- NCT07407842
- Testing
- UPSIDES-Swe
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Lund University
ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), Specific Phobia
Internet-Delivered Cognitive Behavioral Intervention for Youths With Anxiety Disorders
The goal of this study is to develop a new internet-delivered cognitive behavioral therapy (ICBT) intervention for youths with anxiety disorders based on the best current knowledge about effective cognitive behavioral therapy for…
- Conditions
- ANXIETY DISORDERS (or Anxiety and Phobic Neuroses), Specific Phobia, Social Anxiety Disorder, Separation Anxiety Disorder
- Trial name
- NCT06661460
- Testing
- Internet-Delivered Cognitive Behavioral Therapy
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Lund University