Clinical trials: sponsored by Mahidol University
Renal Insufficiency, Tenofovir
TDF Dose Adjustment VS. Switching to TAF in TDF-experienced CHB Patients With Renal Impairment
Tenofovir is a nucleotide analog drug that works against both Human immunodeficiency virus (HIV) and HBV. TDF and TAF are prodrug of Tenofovir.
- Trial name
- NCT04391608
- Testing
- Switching to Tenofovir Alafenamide
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Carpal Tunnel Syndrome
Efficacy of Focused Shockwave Therapy in Patients With CTS
Carpal tunnel syndrome (CTS) is the most common entrapment of upper extremity. Patients with CTS will experience symptoms of pain, numbness of tingling sensation along the median nerve distribution.
- Trial name
- NCT05253729
- Testing
- Focused ESWT, Control
- Where
- Thailand
- Volunteers
- 24 people
- Sponsor
- Mahidol University
Tuberculosis, Pulmonary
Efficacy of Metformin for Sputum Conversion in Patients With Active Pulmonary Tuberculosis
This study was a randomized controlled trial studying about acid-fast bacillus sputum conversion ratio from positive to negative of pulmonary tuberculosis patients between metformin with pulmonary tuberculosis standard treatment…
- Trial name
- NCT05215990
- Testing
- MetFORMIN 500 Mg Oral Tablet
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
The iNPH Patients Scheduled for VP or LP Shunt Procedures
Factors Associated With Post-induction Hypotension in iNPH Patient Undergoing VP and LP Shunt
This study is a retrospective work involving the review of patients who were scheduled for VP or LP shunt in Siriraj Hospital, Mahidol University, Thailand.
- Trial name
- NCT05183061
- Testing
- Ehedrine Norepineprine
- Where
- Thailand
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Pertussis
5-year Follow-up After a Single Dose Acellular Pertussis Vaccination
In July 2015-November 2016, a phase II/III randomized, observer-blind,controlled study of two acellular Pertussis vaccines (aP standalone and TdaP combined vaccines) manufactured by BioNet-Asia Co., Ltd.
- Trial name
- NCT04529720
- Testing
- Biological/Vaccine: Pertagen (aP BioNet), Biological/Vaccine: Boostagen (TdaP BioNet), Biological/Vaccine: Adacel
- Where
- Thailand
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Mahidol University
HIV Infections, Inflammatory Markers
Efficacy and Safety of Low-Dose Colchicine on Surrogate Markers of Cardiovascular Events in People Living With HIV Receiving Antiretroviral Therapy
In a double-blind, randomized controlled trial, we assigned PLWH receiving ART without a history of cardiovascular events to received colchicine 0.6 mg once daily or placebo.
- Conditions
- HIV Infections, Inflammatory Markers, Colchicine Adverse Reaction
- Trial name
- NCT05168137
- Testing
- Low-dose colchicine
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Mahidol University
Dental Implant
Treatment Time Comparing Digital & Conventional Workflows
This randomized controlled trial (RCT) analyzed monolithic single-unit implant restorations out of lithium disilicate (LS2) or polymer-infiltrated ceramic networks (PICN) in a chairside digital workflow (Test) and a conventional…
- Trial name
- NCT05165563
- Testing
- Treatment of implant single crown
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Diabetic Foot Ulcer
Low-level Laser Therapy for the Treatment of Diabetic Foot Ulcer
The study evaluates the efficacy of Low-level laser therapy on ulcer healing in patients with diabetic foot ulcer. Half the patients are randomized to receive Low-level laser therapy and a half to recieve the placebo (LED).
- Trial name
- NCT03788642
- Testing
- Control LED shoe arm, Laser Shoe arm
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Mahidol University
Venous Leg Ulcer
Early Glue Saphenous Vein Ablation With Compression Versus Compression Alone in the Healing of the Venous Ulcer
The study evaluates the effects of early endovenous glue ablation on ulcer healing in patients with chronic venous ulceration. Half the patients are randomized to receive early endovenous ablation (within 2 weeks) and a half to…
- Trial name
- NCT03666754
- Testing
- Standard therapy arm, Early endovenous glue embolization arm
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Intermittent Claudication, PAD
Treatment of Intermittent Claudication by G-CSF-mobilized PB-MNC
This study will investigate the efficacy of G-CSF mobilized mononuclear cell injection of patients with PAD who presented with intermittent claudication.
- Conditions
- Intermittent Claudication, PAD, Atherosclerotic Ischemic Disease
- Trial name
- NCT03683628
- Testing
- PB-MNC therapy, No PB-MNC therapy
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
PAD, Critical Limb Ischemia
Treatment of No-option CLI by G-CSF-mobilized PB-MNC
This study will investigate the efficacy of G-CSF mobilized mononuclear cell injection of patients with PAD who presented with no-option CLI.
- Conditions
- PAD, Critical Limb Ischemia, Atherosclerotic Ischemic Disease
- Trial name
- NCT03686228
- Testing
- PB-MNC therapy, No-PB-MNC therapy
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Septic Shock, Cytokine Storm
CLinical Efficacy of Hemoperfusion With a Cytokine Adsorber in Norepinephrine-Resistant SEptic Shock
Sepsis and septic shock are major causes of ICU admission worldwide. Despite recent advances in treatment, including targeted resuscitation and timely use of antimicrobial agents, mortality of ICU patients with septic shock…
- Trial name
- CLEANSE (NCT05136183)
- Testing
- HA-330 Disposable Hemoperfusion Cartridge (Jafron, China)
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Mahidol University
Periodontal Diseases, Malnutrition
The Association Between Periodontal Disease and Malnutrition in a Group of Elderly People in Thailand.
This study will be determine the association between periodontitis and malnutrition status in older adult.
- Trial name
- NCT05129826
- Testing
- the association between periodontitis and malnutrition status
- Where
- Thailand
- Volunteers
- 78 people
- Sponsor
- Mahidol University
ESRD, Influenza Vaccine
Efficacy of Different Doses of Influenza Vaccine in Chronic Hemodialysis Patients
This study was a randomized controlled trial to investigate the immune response of influenza vaccines when doses were increased.
- Conditions
- ESRD, Influenza Vaccine, Seroprotection
- Trial name
- Enhance (NCT05070494)
- Testing
- Egg-derived standard dose trivalent influenza vaccine (surface antigen, inactivated)
- Where
- Thailand
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Morality, Lung Cancer
Incidence of Mortality and Complications After Lung Surgery, Open Thoracic Aortic Repair, TEVAR, EVAR.
Lung surgery, open aortic surgery, TEVAR, and EVAR are major operations that carry a higher incidence of perioperative mortality and complications compare to other surgery.
- Conditions
- Morality, Lung Cancer, Aortic Aneurysm, Aortic Dissection
- Trial name
- NCT05073991
- Testing
- Lung surgery, Open aortic surgery, TEVAR
- Where
- Thailand
- Volunteers
- 2,224 people
- Sponsor
- Mahidol University
Shock, Septic Shock
LV Diastolic Function vs IVC Diameter Variation as Predictor of Fluid Responsiveness in Shock
Fluid responsive is defined as increasing in Cardiac output or Stroke volume by 10-15% after fluid challenge. Left ventricular diastolic dysfunction is associated with lower left ventricular end-diastolic volume (LVEDV) resulting…
- Trial name
- NCT05066256
- Testing
- Left ventricular diastolic function, Inferior vena cava variation
- Where
- Thailand
- Volunteers
- 80 people
- Sponsor
- Mahidol University
Pediatric Surgery
Effect of Using Dextrose-containing Intraoperative Fluid in Children
The glucose-containing fluid was preferred for maintenance fluid in pediatric surgery to prevent hypoglycemic events. This practice can lead to intraoperative hyperglycemia which can induce osmotic diuresis and consequently…
- Trial name
- NCT05061836
- Testing
- Ringer acetate, 1.25%Dextrose equivalence, 2.5%Dextrose equivalence
- Where
- Thailand
- Volunteers
- 68 people
- Sponsor
- Mahidol University
Osteoporosis
Efficacy and Safety of Brand Versus Generic Alendronate for Osteoporosis Treatment
Osteoporosis is a common disease defined as a decrease in bone mass and strength which increases risk of fragility fractures. This disorder may affecting health in many adults which causing disability, morbidity, and mortality.
- Trial name
- NCT02371252
- Testing
- Generic alendronate
- Where
- Thailand
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Non-dermatophyte Onychomycosis
Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte Onychomycosis
This study aims to compare the efficacy and safety of amorolfine, long-pulsed Nd:YAG laser and the combination between amorolfine and long-pulsed Nd:YAG in treating the non-dermatophyte and mixed-infection onychomycosis.
- Trial name
- NCT02812043
- Testing
- 1,064nm Long-pulsed Nd:YAG, Amorolfine
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Fungal Infection, Onychomycosis
Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis
The randomized control trial study aimed to evaluate effectiveness and safety of amphotericin B in 30% DMSO solution comparing with 30% DMSO solution in NDMs onychomycosis treatment.
- Conditions
- Fungal Infection, Onychomycosis, Fungus, Nail
- Trial name
- amphotericin (NCT03814343)
- Testing
- amphotericin B in 30% DMSO, 30% DMSO
- Where
- Thailand
- Volunteers
- 19 people
- Sponsor
- Mahidol University