Clinical trials: sponsored by Mahidol University
Septic Shock, Refractory Shock
Terlipressin for Refractory Septic Shock
Norepinephrine was recommended as the first vasopressor for septic shock resuscitation. For the patient who did not response to high dose norepinephrine, epinephrine was recommended.
- Conditions
- Septic Shock, Refractory Shock, Norepinephrine Adverse Reaction
- Trial name
- TERESEP (NCT04339868)
- Testing
- Terlipressin
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Mahidol University
on Invasive Mechanical Ventilation, ARDS
Comparison Between Limited Driving Pressure Ventilation and Conventional Mechanical Ventilation Strategies in Medical Intensive Care Patients With Acute Respiratory Failure
Background An appropriated mechanical ventilator setting for acute respiratory failure results of ventilator associated lung injury.
- Conditions
- on Invasive Mechanical Ventilation, ARDS, Respiratory Failure
- Trial name
- NCT04035915
- Testing
- Limited driving pressure, Conventional mechanical ventilation strategies
- Where
- Thailand
- Volunteers
- 126 people
- Sponsor
- Mahidol University
Postoperative Pain, Root Canal
Gutta-percha Solvent on Postoperative Pain After Root Canal Retreatment
The process of non-surgical retreatment includes removing the previous root canal filling materials, disinfecting and sealing the root canal system to prevent re-infection.
- Conditions
- Postoperative Pain, Root Canal, Retreatment
- Trial name
- NCT04326998
- Testing
- solvent, non-solvent
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Postoperative Delirium
Postoperative Delirium After Total Knee Arthroplasty Under Regional Anesthesia
Postoperative delirium after total knee replacement surgery has been related to significant morbidity and mortality among high risk patients. Anesthetic care might play a role in the development of postoperative delirium.
- Trial name
- NCT03120442
- Testing
- Propofol, Dexmedetomidine, Fentanyl
- Where
- Thailand
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Covid19
Andrographis Paniculata vs Boesenbergia Rotunda vs Control in Asymptomatic COVID-19
The purpose of this study is to examine the effect of Andrographis Extract, Boesenbergia Extract compared to standard treatment in asymptomatic COVID patients.
- Trial name
- NCT05019326
- Testing
- Andrographis Paniculata, Boesenbergia, Standard supportive treatment
- Where
- Thailand
- Volunteers
- 3,060 people
- Sponsor
- Mahidol University
Inguinal Herniorrhaphy, Pain, Postoperative
Post-Operative Analgesic Effects of Local Wound Infiltration With Ketorolac After Inguinal Herniorrhaphy
Inguinal hernia is one of the most common diseases worldwide, including Thailand. Patients who underwent treatment of inguinal hernia (herniorrhaphy) found surgical site pain.There are many procedures to relieve pain after…
- Trial name
- NCT03534505
- Testing
- Ketorolac group, Bupivacaine group
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Mahidol University
Pain, Postoperative Period
Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study
Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills.
- Trial name
- NCT02570230
- Testing
- NSS, Ketamine
- Where
- Thailand
- Volunteers
- 32 people
- Sponsor
- Mahidol University
Retinitis Pigmentosa
Intravitreal Injection of MSCs in Retinitis Pigmentosa
The purpose of this study is to determine the feasibility and safety of adult human bone marrow-derived mesenchymal stem cells by intravitreal injection in patients with retinitis pigmentosa.
- Trial name
- NCT01531348
- Testing
- BM-MSC
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Mahidol University
Incompatible Blood Transfusion, Immune Defect
Immunomodulation Effect of Blood Transfusion
An increasing number of publications have demonstrated that homologous (allogeneic) blood transfusion impairs outcome in cancer and non-cancer patients.
- Conditions
- Incompatible Blood Transfusion, Immune Defect, Surgery
- Trial name
- NCT02140216
- Testing
- No blood transfusion, Day 0 blood transfusion, Day 1 or 2 blood transfusion
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Laparoscopic Colorectal Surgery, Colorectal Cancer
Local Wound Infiltration With 0.5% Levobupivacaine for Postoperative Pain After Laparoscopic Colorectal Surgery.
The study design is a prospective randomized, double-blind, controlled trial of patients who are due to have elective laparoscopic colorectal surgery in Ramathibodhi Hospital.
- Trial name
- NCT03433014
- Testing
- 0.5% Levobupivacaine, Control
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Digestive System Cancer
Association Between Perioperative Nutritional Status and Surgical Outcome in Digestive System Cancer Patients
Malnutrition is a common problem in cancer patients. It negatively influences patients' prognosis and quality of life. In gastrointestinal patients, it is also caused by insufficient food intake due to dysphagia, lack of appetite…
- Trial name
- NCT03763526
- Where
- Thailand
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Colorectal Cancer, Bowel Ileus
Efficacy of Mosapride on Recovery of Intestinal Motility After Elective Colorectal Cancer Surgery
Postoperative ileus (POI) is one of the most common causes of prolonged hospital stays after abdominal surgery. The pathophysiology of POI is multifactorial and complex.It is known to be associated with sympathetic neural…
- Trial name
- NCT04905147
- Testing
- Mosapride
- Where
- Thailand
- Volunteers
- 44 people
- Sponsor
- Mahidol University
Abdominal Pain
Effectiveness of Prokinetic Agents in Improving Abdominal Discomfort at Colonoscopy
colonoscopy has been a preferred modality for colorectal screening which efficiently reduce in morbidity and mortality of the disaese.
- Trial name
- NCT04104867
- Testing
- Itopride, Domperidone
- Where
- Thailand
- Volunteers
- 525 people
- Sponsor
- Mahidol University
Pain
Intravenous Propofol and Fentanyl vs Propofol for Sedation in TRUS Biopsy
Nowadays, TRUS biopsy become one of the most popular tests for diagnosis of prostate cancer. This procedure causes pain to the patients who does not received the sedative drugs or analgesic drugs.
- Trial name
- NCT02733705
- Testing
- Control, Fentanyl, propofol
- Where
- Thailand
- Volunteers
- 124 people
- Sponsor
- Mahidol University
Pain, Agitation on Recovery From Sedation
Assessment and Management of Pain, Agitation, Delirium and Sleep Deprivation (PADS) in ICU by PADS Protocol, Thailand
The investigators proposed that pain, agitation, delirium and sleep deprivation protocol (PADS) will help improve the patients' outcomes (shortening ICU length of stay, improving ventilator free days, increasing delirium free…
- Conditions
- Pain, Agitation on Recovery From Sedation, Delirium
- Trial name
- NCT04270331
- Testing
- PADS protocol
- Where
- Thailand
- Volunteers
- 509 people
- Sponsor
- Mahidol University
Protamine Adverse Reaction
Effect of Anti-histamine in Prevention Systolic Hypotension After Protamine
Protamine remains the anticoagulant of choice for cardiopulmonary bypass (CPB). The process of protamine neutralization of heparin came with the side effects sometimes; it can be life threatening or fetal reaction.
- Trial name
- NCT03583567
- Testing
- Chlorpheniramine and ranitidine, 0.9% Normal Saline
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Stroke
The Outcomes of Seamless ADL Training Between Occupational Therapist and Nurse in Stroke Patients
This study aimed to develop and implement an interdisciplinary team model with integration of all the relevant expertise and to establish powerful collaboration and communication among the team.
- Trial name
- NCT02361307
- Testing
- Seamless ADL training, Conventional ADL training
- Where
- Thailand
- Volunteers
- 36 people
- Sponsor
- Mahidol University
Dental Implant
PROMs Comparing Digital & Conventional Workflows
This randomized controlled trial (RCT) analyzed monolithic single-unit implant restorations out of lithium disilicate (LS2) or polymer-infiltrated ceramic networks (PICN) in a chairside digital workflow (Test) and a conventional…
- Trial name
- NCT04986761
- Testing
- Treatment of implant single crown
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Dental Implantation, Postoperative Pain
Patient-reported Outcome Measures Comparing Static Computer-aided Implant Surgery and Conventional Implant Surgery
The aim of this randomized controlled trial was to compare PROMs in patients receiving single tooth replacement in posterior sites by s-CAIS and CIS.
- Conditions
- Dental Implantation, Postoperative Pain, Computer-assisted Surgery, Patient Outcome Assessment
- Trial name
- NCT04950491
- Testing
- Modified Dental Anxiety Score (MDAS) questionnaire, Pain questionnaire, Oral Health-Related Quality of Life (OHRQoL) questionnaire
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Cannabis
The Study of Pharmacological Treatment Pattern for Cannabis-induced Psychosis
A cross-sectional and retrospective chart review study was conducted at the Princess Mother National Institute on Drug Abuse Treatment (PMNIDAT), Thailand.
- Trial name
- NCT04945031
- Testing
- cannabis
- Where
- Thailand
- Volunteers
- 317 people
- Sponsor
- Mahidol University