Clinical trials: sponsored by Mahidol University
Optic Atrophy, Hereditary, Leber
A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON)
Background Leber's Hereditary Optic Neuropathy (LHON) is a maternally inherited ocular disorder associated with a mutation in mtDNA .
- Trial name
- NCT00528151
- Testing
- curcumin
- Where
- Thailand
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Dental Caries Extending Into Dentine
Digital Subtraction Radiography Evaluation of SMART Restoration With Partial Caries Removal in Primary Teeth
The objective of this study was to analyze the radiographic density of digital subtraction radiographs after SMART restoration with partial caries removal in primary molars at 6 and 12 months.
- Trial name
- DSR (NCT01749267)
- Testing
- partial caries removal only at enamel dentin junction.
- Where
- Thailand
- Volunteers
- 38 people
- Sponsor
- Mahidol University
Osteoarthritis
The Efficacy and Safety of Curcuma Domestica Extracts and Ibuprofen in Knee Osteoarthritis
Osteoarthritis of knee is common degenerative musculoskeletal diseases. Non-steroidal antiinflammatory drugs (NSAIDs) are used to decrease pain symptom but someone can not tolerate its gastrointestinal adverse effects.
- Trial name
- NCT00792818
- Testing
- Curcuma domestica extracts, Ibuprofen
- Where
- 6 sites in Thailand
- Volunteers
- 367 people
- Sponsor
- Mahidol University
Eye Drops Self-instillation
The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients
To investigate if the Eye Drop Guide more effective than carefully instructed routine technique for chronic glaucoma patients to self-instill eye drops.
- Trial name
- NCT01704248
- Testing
- Eye Drop Guide technique, Routine self-instillation technique
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Mahidol University
Psoriatic Nails
Comparison of Efficacy of Intralesional Triamcinolone Injection and Clobetasol Propionate Ointment for Psoriatic Nails
Psoriatic nails can significantly affect a quality of life of patients. Psoriasis affects both nail matrix and nail bed. Pitting, leukonychia and red spots in lunula indicate a defect in the nail matrix.
- Trial name
- NCT01703325
- Testing
- 0.1% triamcinolone , 0.05% clobetasol propionate ointment
- Where
- Thailand
- Volunteers
- 16 people
- Sponsor
- Mahidol University
Vitiligo
Comparison of Efficacy and Safety of 0.1% Tacrolimus and 0.1% Mometasone Furoate for Adult Vitiligo
Vitiligo has remained a difficult disease to treat. Previous available therapies are often ineffective. It usually takes several months or years for complete repigmentation and some areas of the body get at best only partial…
- Trial name
- NCT01333410
- Testing
- tacrolimus ointment, Mometasone furoate
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Healthy
Phase I/II Safety and Immunogenicity of Pandemic Live Attenuated Influenza Vaccine (PLAIV) Candidate Strain A/17/CA/2009/38 (H1N1) in Healthy Thais
The purpose of this study is to evaluate safety and reactogenicity of Pandemic Live Attenuated Influenza Vaccine (PLAIV) manufactured by GPO, Thailand, and to evaluate humoral immune response of the above vaccine after intranasal…
- Trial name
- NCT01666262
- Testing
- Vaccine A/17/CA/2009/38 (H1N1)
- Where
- Thailand
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Preventive Avian Flu
Phase I Safety and Immunogenicity of Live Attenuated Influenza H5 Candidate Vaccine Strain A/17/Turkey/Turkey/05/133 (H5N2) in Healthy Thai Volunteers
The purpose of this study is to evaluate safety and reactogenicity of live attenuated influenza H5 vaccine candidate strain A/17/turkey/Turkey/05/133 (H5N2) manufactured by GPO, in Thailand to previously healthy Thais.
- Trial name
- NCT01656356
- Testing
- Avian Flu Vaccine
- Where
- Thailand
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mahidol University
Other Conditions That May Be A Focus of Clinical Attention
Effectiveness of Buddhist Intergrated Group Intervention on Minefulness in Adolescents
The pupose of the study is to determine the effectiveness of the Buddhist integrated group intervention improve the mindfulness in adolescents by a randomized controlled trial.The study divede the adolescents in two groups group…
- Trial name
- NCT01605604
- Testing
- buddhist mind fullness
- Where
- Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Fibromyalgia Syndrome
Study of Indoleamine 2,3-dioxygenase Activity, Serum Levels of Cytokines, BDNF, BH4 and Mirtazapine Efficacy in Fibromyalgia Syndrome
This study aims to investigate the anti-nociceptive biogenic amine (serotonin [5-hydroxytryptamine; 5-HT], norepinephrine [NE], dopamine [DA], and their metabolites) status, and serum levels of cytokines, BDNF and BH4 in Thai…
- Trial name
- NCT00919295
- Testing
- mirtazapine
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Osteoporosis
Thai Traditional Massage Increases Biochemical Marker of Bone Formation in Postmenopausal Women
To investigate the skeletal effect of Thai traditional massage by examining the changes in biochemical markers of bone turnover.
- Trial name
- NCT01627028
- Testing
- Thai traditional massage
- Where
- Thailand
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Food (Shrimp) Allergy
The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis
The purpose of this study was to investigate the utility of serum tryptase for the confirmation of shrimp-induced anaphylaxis.
- Trial name
- NCT01619605
- Testing
- shrimp challenge
- Where
- Thailand
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Thalassemia
Effect of Antioxidant Cocktail in Beta-thalassemia/Hb E Patients
The purpose of this study is to determine the efficacy of antioxidant cocktails on the alleviation of oxidative stress and iron overload in beta-thalassemia/Hb E patients.
- Trial name
- NCT01597765
- Testing
- curcuminoids, N-acetylcysteine, deferiprone and vitamin E, Curcuminoids and alpha-tocopherol
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Dental Caries
Postoperative Pulpal Complications in Posterior Resin Composite Restorations Without Glass-ionomer Cement Lining
The purpose of this study is to observe the effects of glass-ionomer cement (GIC) lining on risk of pulpal complications in deep occlusal cavities with resin-based restorations.
- Trial name
- NCT01567514
- Testing
- Glass ionomer cement lining
- Where
- Thailand
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Solitary Mass, Lung Diseases
Comparison for Pethidine Requirement in Patients Received Spinal Morphine 0.2 and 0.3 mg for Post Lobectomy Analgesia
The purpose of the study is to evaluate the amount of total pethidine requirement during the 48 hour postoperative period after receiving spinal morphine 0.2 and 0.3 mg.
- Trial name
- pain (NCT01236495)
- Testing
- spinal morphine 0.3 mg, spinal morphine 0.2 mg
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Pain, Postoperative
A Comparison of Pain Scales in Patients With Disorder of Consciousness Following Craniotomy
This study aims to test validity, reliability and practicality of translated NCS, CNPI and FLACC in unconscious patients in 48 hour following craniotomy.
- Trial name
- NCT01547663
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Antibiotic Resistant Infection
Effectiveness and Safety of Tigecycline for Therapy of Infections Caused by Multi-Drug Resistant Acinetobacter Baumannii
30 adult hospitalized patients who have infections due to MDR Acinetobacter baumannii will be enrolled. The eligible patients will receive 100 mg of tigecycline intravenous infusion for 30 minutes followed by 50 mg every 12 hours…
- Trial name
- NCT01342731
- Testing
- Tigecycline
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Drug Safety
Ertapenem Versus Meropenem/Imipenem for ESBL+ Gram-negative Infections
Adult patients with ESBL-producing Gram negative infections are randomized to receive ertapenem or meropenem/imipenem. Clinical and microbiological responses between both groups are compared.
- Trial name
- NCT01297842
- Testing
- Ertapenem, Meropenem or Imipenem
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Mahidol University
Drug Safety
Colistin Plus Rifampicin in MDR P. Aeruginosa and A. Baumanii
In Siriraj Hospital, Colistin alone for treatment of MDR. A.baumanii or P.aeruginosa contributed to mortality 45%. In vitro studies revealed synergism of Rifampicin and Colistin. In this study, patients with documented MDR.
- Trial name
- NCT01297855
- Testing
- Colistin, Colistin plus Rifampicin
- Where
- Thailand
- Volunteers
- 130 people
- Sponsor
- Mahidol University
Drug Safety
Probiotics for Prevention of Ventilator-Associated Pneumonia (VAP)
Hospitalized patients with ventilator are randomized to receive fermented dairy product containing L. casei shirota or nothing. The main outcome is development of ventilator-associated pneumonia (VAP)
- Trial name
- VAP (NCT01301131)
- Testing
- Probiotics, control
- Where
- Thailand
- Volunteers
- 150 people
- Sponsor
- Mahidol University