Clinical trials: sponsored by Mansoura University
Peridontitis
Effectiveness of Epigallocatechin-3-Gallate (Green Tea Extract) as Adjunctive Locally Delivered Nanotherapeutic in the Treatment of Stage II Periodontitis
The main objective of the current study is to clinically and biochemically evaluate the effectiveness of epigallocatechin-3-gallate-loaded chitosan nanoparticulate gel as a local drug delivery system, when used in conjunction…
- Trial name
- NCT07754253
- Testing
- Ten patients with stage II periodontitis will receive epigallocatechin-3-gallate (EGCG)-loaded chitosan nanoparticulate gel injected into the periodontal pockets, chitosan nanoparticulate gel (CTN gel), scaling and root planing (SRP) only.
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
TMJ Internal Derangement
Correlation Between MRI Findings and Clinical Improvement Following TMJ Injection With Hyaluronic Acid and Platelet-Rich Plasma
Temporomandibular joint (TMJ) disorders can cause jaw pain, clicking sounds, and difficulty opening the mouth, affecting daily activities such as eating and speaking.
- Trial name
- MRI TMJ (NCT07750522)
- Testing
- intra-articular Injection of Hyaluronic Acid Combined with Platelet-Rich Plasma
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Intrabony Periodontal Defect, Periodontal Disease
Evaluation of NIPSA Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in theTreatment of Intrabony Defects
Sixty patients will be selected from the outpatient clinic in the Oral Medicine and Periodontology Department, Faculty of Dentistry, Mansoura University, Egypt, according to preoperative clinical and radiographic data that will…
- Trial name
- RCT (NCT07737678)
- Testing
- allopastic bone graft, cross-linked hyaluronic acid, Non-Incised Papillae Surgical Approach
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Burns, Pain, Procedural
Virtual Reality for Pain and Fear in Children With Burns
Burn injuries are very painful for children, especially during dressing changes when the wound is cleaned and re-bandaged. This procedure, while necessary, can cause pain, fear, and distress that may make children afraid of…
- Conditions
- Burns, Pain, Procedural, Pain, Acute, Fear
- Trial name
- VR-PFB (NCT07740980)
- Testing
- Virtual Reality (VR) Distraction, Standard Burn Dressing Care
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Modified Thoracoabdominal Nerve Block (M-TAPA), Analgesic Technique
Bilateral Modified Thoracoabdominal Nerve Block as an Analgesic Technique in Comparison With Bilateral Thoracic Erector Spinae Plane Block in Abdominoplasty Operations
This study aimed to compare the analgesic effect of bilateral ultrasound-guided modified thoracoabdominal nerve block with bilateral ultrasound-guided erector spinae plane block in abdominoplasty surgery.
- Conditions
- Modified Thoracoabdominal Nerve Block (M-TAPA), Analgesic Technique, Thoracic Erector Spinae Plane Block, Abdominoplasty
- Trial name
- NCT07738900
- Testing
- General Anaesthesia using intravenous propofol, fentanyl intravenous, and atracurium besylate, Modified thoracoabdominal nerve block using 25 mL of bupivacaine 0.25%, Erector spinae plane block using 25 mL of bupivacaine 0.25%
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Mansoura University
Hashimoto Thyroiditis, Subacute Thyroiditis
Colchicine for Autoimmune and Subacute Thyroiditis
Thyroiditis includes inflammatory thyroid disorders such as Hashimoto's thyroiditis and subacute thyroiditis. These conditions may cause thyroid pain, neck tenderness, elevated inflammatory markers, thyroid dysfunction, fatigue…
- Conditions
- Hashimoto Thyroiditis, Subacute Thyroiditis, Thyroiditis
- Trial name
- COLTHYR (NCT07571681)
- Testing
- colchicine, Prednisolone, NSAID
- Where
- 2 sites in Egypt, Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- Mansoura University
Renal Stones
PCNL Versus RIRS for Management of Stones in Solitary Kidney
Few studies compared PCNL and RIRS for stones in solitary kidney. Current guidelines do not provide clear recommendations concerning the management of renal stones in patients with solitary kidney.
- Trial name
- NCT07730892
- Testing
- retrograde intra renal surgery (RIRS), percutaneous nephrolithotomy (PCNL)
- Where
- Egypt
- Volunteers
- 83 people
- Sponsor
- Mansoura University
Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Oxygen
Topical Oxygen Therapy for BRONJ
A randomized clinical trial comparing Blue®m oral gel and autologous PRF membrane as adjuncts to surgical debridement in BRONJ/MRONJ patients.
- Conditions
- Bisphosphonate Related Osteonecrosis of the Jaws (BRONJ), Oxygen, Topical Administration, Wound Healing
- Trial name
- OXY-BRONJ Tria (NCT07725107)
- Testing
- Topical Blue®m application, PRF membrane placement
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Mansoura University
Tooth Extraction
Evaluation of Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials
Thirty two healthy patients will be selected from the outpatient clinic of the oral and maxillofacial surgery department, faculty of dentistry, Mansoura university, to be included in this study with non restorable teeth in the…
- Trial name
- NCT07725029
- Testing
- Demineralized dentin matrix grafting material, Demineralized dentin matrix with injectable platelet rich fibrin
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Obstructive Sleep Apnea
DISE vs Muller's Maneuver in OSA Assessment
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder caused by recurrent upper airway collapse during sleep.
- Trial name
- NCT07723417
- Testing
- Drug-Induced Sleep Endoscopy (DISE)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Unilateral Cleft Lip
Botulinum Toxin Injection in Reducing Scar Following Cheilorrhaphy.
the aim of the study will be directed to evaluate clinically the effect of botulinum toxin type A injection on reducing the scar following cleft lip surgical repair.
- Trial name
- NCT07137234
- Testing
- Modified Millard rotation advancement flap technique, botulinum toxin injection (BTX A) before surgical intervention
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Mansoura University
Cesarean Section
Enhanced Recovery Protocol After Cesarean Section
This study aims to evaluate the effectiveness of implementing the Enhanced Recovery After Cesarean (ERAC) protocol on maternal and neonatal outcomes.
- Trial name
- ERAC (NCT07720986)
- Testing
- Enhanced Recovery after Cesarean protocol of Care, Routine hospital care
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Chronic Disease, Memory Impairment
Impact of a Mobile Application-Based Medication Reminder on Treatment Adherence Among Patients With Chronic Diseases and Memory Impairment: A Nursing Leadership Perspective
This study aims to evaluate the impact of using a mobile application-based medication reminder on medication adherence among patients diagnosed with chronic diseases and memory impairment.
- Trial name
- NCT07718334
- Testing
- Mobile Application-Based Medication Reminder
- Where
- 2 sites in Egypt
- Volunteers
- 193 people
- Sponsor
- Mansoura University
Initial Dental Caries
Remineralizing Effect of Nano-eggshell, Casein Phosphopeptide Amorphous Calcium Phosphate (CPP-ACP), and Sodium Fluoride on Initial Enamel Caries
This randomized controlled clinical trial aims to evaluate and compare the remineralizing effect of nano-eggshell varnish, CPP-ACP paste (GC Tooth Mousse), and sodium fluoride varnish on initial enamel caries among adolescents…
- Trial name
- CPP-ACP (NCT07711132)
- Testing
- nano-eggshell varnish, Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP)Dental Paste, Sodium Fluoride Varnish (5%)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University
Partial Edentulism, Partial Edentulism Class 1
Surface Wear of PEEK Clasp Against Zirconia Full-Coverage Restored Abutments in Distal Extension Removable Partial Dentures
This prospective clinical comparative study will evaluate the surface wear of BioHPP (modified polyetheretherketone) clasps opposing either natural tooth abutments or zirconia full-coverage abutments in mandibular bilateral…
- Trial name
- PEEKWear (NCT07708558)
- Testing
- PEEK Removable Partial Denture Framework with Natural Tooth Abutments, PEEK Removable Partial Denture Framework with Zirconia Abutments
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Mansoura University
TMJ Disc Displacement With Reduction
Hyaluronic Acid and I-PRF Mixture for TMJ Disc Displacement Management
The aim of this study is to evaluate the efficacy of hyaluronic acid and I-PRF mixture for intra-articular injection following arthrocentesis in the management of TMJ reducible disc displacement.
- Trial name
- NCT07683650
- Testing
- 18 joints that receive arthrocentesis using 100 ml of ringer lactate solution, Arthrocentesis followed by hyaluronic acid injection, Arthrocentesis followed by injection of hyaluronic acid and betamethasone mixture
- Where
- Egypt
- Volunteers
- 72 people
- Sponsor
- Mansoura University
Tooth Loss, Surface Treatment
Effect of Different Loading Protocols on Photofunctionalized Implants in the Posterior Maxilla
This randomized clinical trial evaluates different loading protocols for UV-photofunctionalized dental implants in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow
- Conditions
- Tooth Loss, Surface Treatment, Immediate Dental Implant Loading, Implant Loading
- Trial name
- PHOTOLOAD (NCT07700914)
- Testing
- Immediate loading of UV-photofunctionalized dental implants, Early loading of UV-photofunctionalized dental implants, Conventional loading of UV-photofunctionalized dental implants
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Skeletal Class III Malocclusion
Skeletal and Dentoalveolar Effects of Functional Clear Aligner Therapy in Growing Patient With Skeletal Class III Malocclusion
The purpose of this study is to evaluate the skeletal, dentoalveolar \& soft tissue effects of functional clear aligner therapy in growing patient with Skeletal class III malocclusion.
- Trial name
- NCT07703007
- Testing
- Functional Clear Aligner
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University
Complete Edentulism, All-on-4
OT-Bridge System Versus Multiunit Abutment for Mandibular All On-4 Screw Retained Prostheses.
This study aims to compare two different prosthetic systems used in mandibular full-arch implant-supported fixed prostheses (All-on-4).
- Conditions
- Complete Edentulism, All-on-4, Implant Supported Prosthesis, Multiunnit Abutments
- Trial name
- NCT07701200
- Testing
- OT-Bridge, Multiunit
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Tooth Loss, Surface Treatment
Photofunctionalization and Hyaluronic Acid for Posterior Maxillary Implants
This randomized clinical trial evaluates the effect of UV photofunctionalization and hyaluronic acid on dental implants placed in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow-up
- Conditions
- Tooth Loss, Surface Treatment, Delayed Implant, Implant Placement
- Trial name
- PHOTOHA (NCT07700732)
- Testing
- Delayed dental implant placement without photofunctionalization., Delayed dental Implant photofunctionalization before placement, Delayed dental Implant photofunctionalization and hyaluronic acid application before placement.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
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