Clinical trials: sponsored by Massachusetts General Hospital
HIV Infections, Pregnancy Related
Adaptation of an Intervention Addressing Barriers to PrEP Use Among Pregnant Women in Zimbabwe
The purpose of this study is to develop a multi-level PrEP adherence and persistence intervention as an adaptation of the TENDAI ('grateful' in Shona) program, a problem-solving approach to reduce depression and increase HIV…
- Conditions
- HIV Infections, Pregnancy Related, Depression, Anxiety
- Trial name
- TENDAI4PrEP (NCT06226155)
- Testing
- TENDAI4PrEP, Enhanced treatment as usual
- Where
- Zimbabwe
- Volunteers
- 165 people
- Sponsor
- Massachusetts General Hospital
Depression
Researching Heat and Yoga for Mood Enhancement
This study will examine how doing heated yoga or non-heated yoga affects depression.
- Trial name
- RHYME (NCT06094088)
- Testing
- Heated Yoga, Non-Heated Yoga
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Burnout, Professional, Well-Being, Psychological
The PREGNANT (Pregnant Resident Empowerment, GuidaNce, and Advocacy iN Training) Coaching Project
This is a mixed-methods study designed to develop and evaluate an innovative coaching program for physician trainee mothers. Approximately 48 participants will be recruited from informational flyers posted in resident work areas…
- Conditions
- Burnout, Professional, Well-Being, Psychological, Imposter Phenomenon, Self Efficacy
- Trial name
- NCT07221422
- Testing
- Coaching Program
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pregnancy
Social Media Withdrawal in Pregnancy: Effects on Maternal Mental Health and Misinformation
The goal of this clinical trial is to learn if restricting social media use with a hardware device can improve mental health and well-being during pregnancy.
- Trial name
- SWIPE LEFT (NCT07812506)
- Testing
- Brick device
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression, Major Depressive Disorder
Hyperthermic Yoga for Depressive Symptoms
Study is a randomized controlled trial to assess the feasibility, acceptability, efficacy, and mechanisms of action of hyperthermic yoga versus a waitlist control for 80 medically healthy adults with mild to moderate depressive…
- Trial name
- NCT02607514
- Testing
- hyperthermic yoga
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Aging
The Wandering Nerve: Gateway to Boost Alzheimer's Disease Related Cognitive Performance
In this research study the investigators want to find out if a non-invasive electrical brain stimulation method called RAVANS (also called tVNS) can have a beneficial effect on cognition in older individuals.
- Trial name
- WALLe (NCT04908358)
- Testing
- Active transcutaneous vagus nerve stimulation respiratory-gated non-painful electrical stimulation of the auricle for 10 minute sessions
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Metastatic Colon Cancer, Stage III Colon Cancer
Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer
This research study is comparing two standard of care treatment options based on blood test results for participants who have metastatic colon cancer.
- Trial name
- NCT03803553
- Testing
- FOLFIRI Protocol, ACTIVE SURVEILLANCE, Nivolumab Protocol
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
HIV Infections, Tuberculosis
South Africa Smoking Cessation and Engagement in HIV/TB Care Care
The purpose of this study is to integrate elements from existing interventions developed by our team into a single intervention (QUIT-AD), designed to improve smoking cessation and favorable HIV/TB treatment outcomes among…
- Conditions
- HIV Infections, Tuberculosis, Smoking Cessation
- Trial name
- NCT05842161
- Testing
- QUIT-AD, Enhanced Treatment as Usual
- Where
- South Africa
- Volunteers
- 83 people
- Sponsor
- Massachusetts General Hospital
Chronic Pain, Early Cognitive Decline
Mindfulness-based Cognitive Therapy for the Chronic Pain-early Cognitive Decline Co-morbidity Among Older Black Individuals in the Community; The Feeling of Being Open Pilot
The goal of this clinical trial is to pilot an adaptation of mindfulness-based cognitive therapy for chronic pain and early cognitive decline.
- Trial name
- NCT07210398
- Testing
- Mindfulness-based cognitive therapy
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
HIV Infections
Intervention Development for Syndemics Among PWH in SA
In South Africa, the country with the highest HIV prevalence (19%), co-occurring problems such as depression, post-traumatic stress, and food insecurity interact to enhance one another (i.e., syndemic problems) and are associated…
- Trial name
- NCT06152003
- Testing
- Cognitive Behavioral Therapy for Syndemics and Adherence (CBT-SA)
- Where
- South Africa
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Colorectal Cancer (Diagnosis), Anal Cancer
Mind-Body Sexual Well-Being Program for Female GI Cancer Survivors
This record describes two distinct study phases: 1) A small open pilot trial including up to 10 participants, intended to generate descriptive feedback on regarding perceived benefits and areas for improvement for a group-based…
- Conditions
- Colorectal Cancer (Diagnosis), Anal Cancer, Sexual Dysfunction Female
- Trial name
- NCT07795801
- Testing
- Mind-Body Group Intervention, Enhanced Usual Care Control (EUCC)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Sarcoma
Bevacizumab/Doxorubicin/Radiation for Sarcoma
The main purpose of this study is to test the safety, tolerability, maximum tolerated dose, and effectiveness of bevacizumab in combination with chemotherapy and radiation therapy.
- Trial name
- NCT01746238
- Testing
- Bevacizumab, Doxorubicin, Radiation Therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
Voice Disorders, Vocal Fold Polyp
Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction
Vocal hyperfunction (VH) is the most commonly treated class of voice disorders by speech-language pathologists and voice therapy is the primary curative treatment.
- Conditions
- Voice Disorders, Vocal Fold Polyp, Vocal Nodules in Adults, Muscle Tension Dysphonia
- Trial name
- NCT05970562
- Testing
- Ambulatory Voice Monitoring with Biofeedback (AVM-B), Conversation Training Therapy
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Primary Ovarian Insufficiency, Premature Menopause
Effects of Estrogen on Heart Health in Women With Primary Ovarian Insufficiency
The goal of this observational study is to study the effects of treating women with Primary Ovarian Insufficiency (POI) with estrogen replacement therapy to bolster the evidence backing cardiometabolic preventive care in women…
- Conditions
- Primary Ovarian Insufficiency, Premature Menopause, Metabolic Complications, Endothelial Function (FMD)
- Trial name
- ENCODE (NCT06866119)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
HIV-1-infection, Coronary Microvascular Dysfunction
Improving Coronary Vascular Health in Women
Women with HIV have an increased risk of having a myocardial infarction (heart attack) as compared to women without HIV. One of the mechanisms underlying the increased risk of myocardial infarction among women with HIV may…
- Conditions
- HIV-1-infection, Coronary Microvascular Dysfunction, Metabolic Disease
- Trial name
- INFORM_2 (NCT06843902)
- Testing
- Health Education, Subspecialty clinic referral
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Opoid Managment, Pain Management
Effect of Opioid-Sparing Anesthesia on Postoperative Opioid Consumption and Pain in Elderly Patients Undergoing Spine Surgery
The goal of this clinical trial is to learn if an anesthesia management strategy called opioid-sparing anesthesia could help reduce postoperative opioid consumption, pain intensity and enhance recovery in elderly patients…
- Trial name
- NCT07588802
- Testing
- Opioid-Sparing Protocol, Routine anesthesia protocol
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Diabetes
Genetically Informed Screening for Early-Stage Type 1 Diabetes
This study is a test to find out if genetic information can be used to help healthcare providers identify diseases. Specifically, the investigators want to find out how genetic information can help healthcare providers identify…
- Trial name
- PATHS-T1D (NCT07802496)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obsessive-Compulsive Disorder
Transcranial Direct Current Stimulation Potentiation of Fear Extinction in OCD
The investigators want to learn more about how human beings learn not to fear and the impact of changing the fear network in the brain using transcranial Direct Current Stimulation (tDCS) in individuals with obsessive compulsive…
- Trial name
- NCT05521074
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Massachusetts General Hospital
Iron-deficiency, Heart Failure With Preserved Ejection Fraction
Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF)
The primary objective of this study is to determine if the correction of functional iron deficiency by administering a single dose of intravenous iron (ferric derimaltose or Monoferric®) in participants with heart failure with…
- Trial name
- IRONMETHFpEF (NCT04945707)
- Testing
- Ferric Derisomaltose 1000 Mg in 100 mL INTRAVENOUS SOLUTION [Monoferric]
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Drug Allergy, Cephalosporin Allergy
Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing
Cephalosporin antibiotics are commonly used but can result in allergic reactions and anaphylaxis. There is no clear diagnostic approach for cephalosporin-allergic patients, and guidance for the use of other antibiotics in…
- Conditions
- Drug Allergy, Cephalosporin Allergy, Drug Hypersensitivity, Antibiotic Allergy
- Trial name
- DACAT (NCT06406114)
- Testing
- Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing
- Where
- 6 sites in United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
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