Clinical trials: sponsored by Massachusetts General Hospital
Chronic Pain, Depression
Mindfulness-based Cognitive Therapy for the Chronic Pain-depression Co-morbidity Among Older Black Adults in the Community; The Quiet Focus Open Pilot
The goal of this clinical trial is to pilot an adaptation of mindfulness-based cognitive therapy for chronic pain and depression.
- Trial name
- NCT07336342
- Testing
- Mindfulness-based cognitive therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Massachusetts General Hospital
Functional Dyspepsia, Anorexia Nervosa
Identifying Multidimensional Signatures of Gastric Interoception in Functional Dyspepsia
This study is being conducted to investigate gut-brain communication in individuals with functional dyspepsia and anorexia nervosa.
- Trial name
- IMAGINE (NCT07772167)
- Testing
- Functional magnetic resonance imaging (fMRI)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Long COVID, Long COVID-19
AT1001 for the Treatment of Long COVID
The primary objective of this study is to evaluate the safety and efficacy of Larazotide (AT1001) versus placebo in children and adults 7 to ≤50 years of age who present with symptoms of Long COVID in the presence of SARS-CoV-2…
- Conditions
- Long COVID, Long COVID-19, Post Acute COVID-19 Syndrome, Post Acute Sequelae of COVID-19
- Trial name
- NCT05747534
- Testing
- Larazotide Acetate
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Massachusetts General Hospital
Deep Venous Thrombosis, Post-thrombotic Syndrome
Novel PET/CT and Treatment Strategies to Reduce PTS Following DVT
The goal of this study is to develop strategies that will improve outcomes for patients with deep vein thrombosis (DVT), using in vivo FDG-PET inflammation imaging to better predict the development of the post-thrombotic syndrome…
- Trial name
- NCT03195777
- Testing
- PET/CT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Prostate Cancer
Training on Systemic and Organ Spec. PM in PC
This research is being done to assess the impact of a supervised and structured strength and conditioning program on cardiac remodeling in participants with prostate cancer undergoing treatment with external beam radiation…
- Trial name
- NCT07768917
- Testing
- Exercise
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Melanoma, Non-small Cell Lung Cancer
Use of Serial Plasma NGS as a New Efficacy Metric to Guide Immunotherapy Treatment Discontinuation
The goal of this prospective study to investigate the use of circulating tumor DNA (ctDNA) to guide end of therapy decisions in patients with melanoma or non-small-cell lung cancer.
- Trial name
- NCT06146920
- Testing
- Evaluation of ctDNA using the F1T after 1 year of immunotherapy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Suicide, Suicide, Attempted
Pilot Study of Health System/Community Partnership for Enhanced Outreach to Prevent Suicide Attempts
The goal of this clinical trial is to test an enhanced outreach intervention (EOI) delivered by Samaritans of Boston (a community organization that provides support during mental health crises) for people after they leave an…
- Conditions
- Suicide, Suicide, Attempted, Suicidal Ideation
- Trial name
- NCT05825820
- Testing
- Enhanced Outreach Intervention (EOI) plus Care as Usual
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Cardiovascular Diseases, Coronary Artery Disease
Study to Determine the Clinical Significance of Intravascular OCT-NIRAF
There are 2 arms to this study. Arm 1: Participants undergoing coronary angiography for stable or acute coronary disease presentations and eligible for percutaneous coronary intervention (PCI) will be imaged with OCT-NIRAF at…
- Trial name
- NCT06374498
- Testing
- OCT-NIRAF, LUMISIGHT Injection, OCT-NIRAF following LUMISIGHT Injection
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Functional Gastrointestinal Disorders
Functional GI Disease Registry
The goal of this study is to establish a prospective observational cohort of individuals with functional GI disorders (functional constipation, irritable bowel syndrome, chronic nausea, functional diarrhea, and functional…
- Trial name
- FGIDR (NCT05295446)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Binge-eating Disorder
A Study of the Effects of Oxytocin in Adults With Binge-eating Disorder
This study evaluates the impact of intranasal oxytocin vs placebo in patients with binge eating disorder or episodes of binging.
- Trial name
- STROBE (NCT05664516)
- Testing
- TNX-1900 (Tonix Pharmaceuticals)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Pancreatic Cancer Metastatic
Vilastobart+Retifanlimab in BRCA or PALB2 Deficient PC
This is a single arm, open-label, non-randomized multi-institution phase II trial of a Fc enhanced CTLA4 antibody, vilastobart, in combination with PD-1 antibody, retifanlimab, in patients with BRCA1, BRCA2 or PALB2 deficient…
- Trial name
- EKLAVYA-HRD (NCT07765836)
- Testing
- vilastobart (XTX101), Retifanlimab
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Dental Diseases
MOLAR: Mapping Oral Health and Local Area Resources
The goal of this clinical trial is to test the impact of a screening and linkage intervention for adverse social determinants of health (aSDoH) on oral health linkage to care for emergency department patients.
- Trial name
- NCT05688982
- Testing
- General information provision, Geographic information provision, Navigational assistance
- Where
- United States
- Volunteers
- 2,927 people
- Sponsor
- Massachusetts General Hospital
CJD (Creutzfeldt Jakob Disease), Prion Diseases
OBSERVE: Biomarkers in Individuals at Risk for Prion Disease
We are doing this research to identify biomarkers in individuals who are at-risk for familial prion disease. We hope to use these biomarkers to predict timing of disease onset in pre-symptomatic individuals and to guide the…
- Conditions
- CJD (Creutzfeldt Jakob Disease), Prion Diseases, GSS, FFI
- Trial name
- NCT05124392
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Heart Failure, Obesity
WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise
The goal of this study is to define how treatment of obesity impacts cardiometabolic performance during exercise in patients with established HFpEF or at risk for HFpEF.
- Conditions
- Heart Failure, Obesity, Weight Loss, Heart Failure With Preserved Ejection Fraction
- Trial name
- WTLOSS-EX (NCT06576050)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts General Hospital
Relapsed Large B-cell Lymphoma, Refractory Large B-cell Lymphoma
Outpatient Epcoritamab in Large B-cell Lymphoma
The purpose of this study is to measure the efficacy of the study drug, epcoritamab, in participants with relapsed/refractory large B-cell lymphoma.
- Trial name
- NCT06811272
- Testing
- Epcoritamab, Rituximab combined with cyclophosphamide, vincristine, and prednisone, Rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisone
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder
Impact of Transcutaneous Vagal Nerve Stimulation on Stress Response in Major Depression
This study will identify the sex-dependent impact of expiratory-gated transcutaneous vagus nerve stimulation (tVNS) on the modulation of the stress response circuitry and associated physiology in major depressive disorder (MDD).
- Trial name
- tVNS_MDD_Sex (NCT04448327)
- Testing
- active tVNS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Massachusetts General Hospital
Serious Mental Illness, Psychotic Disorder
Changing Lives and Changing Outcomes-9 at Worcester Recovery Center and Hospital
People with serious mental illness (depression, bipolar, and schizophrenia spectrum disorders) have high rates of repeated criminal legal involvement and psychiatric hospitalizations.
- Conditions
- Serious Mental Illness, Psychotic Disorder, Depression, Bipolar
- Trial name
- CLCO-9 (NCT07359157)
- Testing
- Changing Lives and Changing Outcomes-9
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Postpartum Depression (PPD)
Routine vs. Early Postpartum Depression Screening: A Pragmatic Clinical Trial
After having a baby, some women develop a condition called postpartum depression, or PPD, which can cause sadness, anxiety, and difficulty bonding with their newborn.
- Trial name
- NCT07460063
- Testing
- Early PPD Screening
- Volunteers
- 428 people
- Sponsor
- Massachusetts General Hospital
Anxiety, Depression
Mobile Mental Health Stigma Reduction Intervention Among Black Adults
Major depressive and anxiety disorders are highly prevalent in the general population and are a leading cause of disability. Black adults have a high burden of depression and anxiety.
- Conditions
- Anxiety, Depression, Health Knowledge, Attitudes, Practice, Stigmatization
- Trial name
- NCT06316804
- Testing
- Video Intervention 1, Video Intervention 2, Video Intervention 3
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma (SLL)
Zanubrutinib, Obinutuzumab, Sonrotoclax (BOSon) or BGB-16673, Obinutuzumab, Sonrotoclax (DOSon) in TN CLL/SLL
The purpose of this study is to determine the proportion of participants who achieve undetectable measurable residual disease (uMRD) in previously untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
- Trial name
- NCT06849713
- Testing
- Zanubrutinib, Sonrotoclax, Obinutuzumab
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
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