Clinical trials: sponsored by Massachusetts General Hospital
Depression Disorders, Depression - Major Depressive Disorder
Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
This project explores whether heated yoga, sauna, and a mindfulness app reduce depressive symptoms
- Conditions
- Depression Disorders, Depression - Major Depressive Disorder, Depression Disorder, Depression Chronic
- Trial name
- SHINE (NCT07082998)
- Testing
- heated yoga, sauna, mindfulness app
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Family History of Lung Cancer
LEGACY: Lung Cancer Screening in Individuals With a Lung Cancer Family History-Protocol A
This research is being done to determine if an image-based deep learning model (Sybil) can accurately predict the likelihood of future lung cancer based on chest computed tomography (CT) imaging from individuals.
- Trial name
- NCT07685028
- Testing
- CT scan, Sybil
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Body Dysmorphic Disorder, Somatoform Disorders
Treatment Study Investigating New Cognitive Behavioral Therapy Treatment Manual for Body Dysmorphic Disorder
In an earlier phase of this study, a cognitive behavioral therapy (CBT) manual to treat body dysmorphic disorder (BDD) symptoms was developed.
- Trial name
- NCT00106223
- Testing
- Cognitive behavioral therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Healthy
The Brain Metabolism of Unpredictable Signals
The investigators will be studying brain glucose and oxygen metabolism using hybrid PET/fMRI imaging to better understand how decoupling between brain glucose and oxygen metabolism relates to the processing of unpredictable…
- Trial name
- NCT05756335
- Testing
- (Un)predictable and (un)attended stimuli
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Irritable Bowel Syndrome, Inflammatory Bowel Disease
Effects of Relaxation Response Mind-body Intervention in Patients With IBS and IBD
In this pilot study, the investigators examined whether a relaxation response mind-body intervention could be effectively delivered to mixed groups of IBS and IBD patients and determined the effects of the intervention on quality…
- Trial name
- NCT02136745
- Testing
- Relaxation Response Mind-Body Intervention
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Massachusetts General Hospital
Social Anxiety Disorder
Waitlist-Control Trial of Smartphone (App-based) CBT for Social Anxiety Disorder (SAD), Withdrawn
The investigators are testing the efficacy of Smartphone-delivered cognitive behavioral therapy (CBT) treatment for social anxiety disorder (SAD).
- Trial name
- NCT04622930
- Testing
- Smartphone-delivered CBT for SAD
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Adrenoleukodystrophy, Restless Legs Syndrome
Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy
The investigators recently observed that up to 25% of women with X-linked adrenoleukodystrophy (ALD) have moderate to severe Restless Leg Syndrome (RLS).
- Trial name
- NCT05003648
- Testing
- Pramipexole
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Treatment Resistant Depression, Inflammation
Specialized Pro-resolving Lipid Mediators and Treatment Resistant Depression
The goal of this clinical trial is to determine the impact of omega-3 fatty acids on the production of anti-inflammatory effects and clinical improvement in people with depression who have not responded well to standard…
- Conditions
- Treatment Resistant Depression, Inflammation, Overweight
- Trial name
- NCT05774665
- Testing
- Omega 3
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
Cue-reactivity, Cannabis Use Disorder
Evaluation of Suvorexant for Reduction of Brain Reactivity in Patients With Cannabis Use Disorder (Pilot Study)
The goal of this study is to observe the impact of suvorexant, sold as BELSOMRA, on brain activity of people who frequently use cannabis. Suvorexant is an FDA-approved medication to treat insomnia.
- Conditions
- Cue-reactivity, Cannabis Use Disorder, Functional MRI, Orexin Antagonist
- Trial name
- NCT06584942
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Fecal Incontinence, Irritable Bowel Syndrome With Diarrhea
The Role of Fiber in the Prevention and Treatment of Fecal Incontinence
The purpose of this study is to determine the effect of fiber supplementation on the fecal metagenome and metabolome in relation to symptoms and anorectal physiology in post-menopausal women with irritable bowel syndrome with…
- Trial name
- NCT04806386
- Testing
- Psyllium
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Massachusetts General Hospital
Amyotrophic Lateral Sclerosis, Alzheimer Disease
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial
This is an open-label, biomarker-driven basket trial of baricitinib in people with subjective cognitive disorder, mild cognitive impairment, Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS), or asymptomatic carriers…
- Conditions
- Amyotrophic Lateral Sclerosis, Alzheimer Disease, Mild Cognitive Impairment
- Trial name
- NADALS (NCT05189106)
- Testing
- Baricitinib
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Surgery, Cardiac, Atrial Fibrillation
Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery
Postoperative atrial fibrillation is quite common after cardiac surgery with up to 1 in 3 patients experiencing this abnormal heart rhythm.
- Trial name
- PATRONUS (NCT05543278)
- Testing
- Amiodarone
- Volunteers
- 242 people
- Sponsor
- Massachusetts General Hospital
Healthy Control
Auditory Stimulation Effect on Brain Oscillations and Sleep Dependent Learning
The investigators are testing the impact of quiet sounds played during sleep on brain oscillations and memory.
- Trial name
- NCT06688526
- Testing
- Quiet Sounds
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hyperhidrosis
Image Guided Targeted Photoablation for the Treatment of Localized Hyperhidrosis
Hyperhidrosis is a condition in which sweating is in excess of that required for normal regulation of body temperature. Commonly affected areas in primary hyperhidrosis include axillae, palms and soles.
- Trial name
- NCT04178161
- Testing
- Laser treatment
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 1, Diabetes type1
Repeat BCG Vaccinations For The Treatment Of Pediatric Type 1 Diabetes
The purpose of this study is to investigate if repeat bacillus Calmette-Guérin (BCG) vaccinations can confer a beneficial immune and metabolic effect on pediatric Type 1 diabetes.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes type1, Autoimmune Diabetes
- Trial name
- NCT05180591
- Testing
- Bacillus Calmette-Guérin, Saline Injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 1 Diabetes
Repeat BCG Vaccinations for the Treatment of New Onset Type 1 Diabetes in Children Age 8-<18 Years
The purpose of this study is to investigate if repeat bacillus Calmette-Guérin (BCG) vaccinations can confer a beneficial immune and metabolic effect in new onset pediatric Type 1 diabetes.
- Conditions
- Diabetes Mellitus, Type 1 Diabetes, Diabetes type1, Autoimmune Diabetes
- Trial name
- NCT05866536
- Testing
- Bacillus Calmette-Guérin, Saline Injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Multiple Myeloma
Sotatercept (ACE-011) With Lenalidomide or Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma
It is possible that the combination of lenalidomide, dexamethasone and ACE 011 may reduce or prevent the growth of cancer cells along with improving anemia and bone lesions that sometimes occur in people with multiple myeloma.
- Trial name
- NCT01562405
- Testing
- ACE-011, Lenalidomide, Dexamethasone
- Where
- 4 sites in United States
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Gastroparesis
Central and Peripheral Effects of Cognitive Behavioral Therapy on Brain-Gut Axis Signaling in Gastroparetic Patients
This is a single-center pilot study to be conducted at Massachusetts General Hospital. The purpose of this study is to examine the non-pharmacological impact of Cognitive Behavioral Therapy (CBT) on gastroparesis symptoms and…
- Trial name
- NCT03531450
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Orthopaedic Related Pain (Musculoskeletal Pain), Opioid
Two Post-Operative Pain Protocols at Discharge for Orthopaedic Patients
This is a single-center, pilot randomized controlled trial designed to evaluate the feasibility of a definitive trial comparing opioid-free discharge prescriptions to usual care (which includes opioids) in patients undergoing…
- Conditions
- Orthopaedic Related Pain (Musculoskeletal Pain), Opioid, Pain, Pilot Study
- Trial name
- NCT07265557
- Testing
- Discharge pain medication prescription
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Post-hemorrhagic Hydrocephalus (PHH)
Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain Hemorrhage
Hydrocephalus is a serious condition in which fluid builds up inside the brain, often requiring lifelong surgical placement of a shunt to drain excess cerebrospinal fluid (CSF).
- Trial name
- VENTURE-PHH (NCT07662174)
- Testing
- Sirolimus (Rapamune®)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital