Clinical trials: sponsored by Massachusetts General Hospital
Elevated Caregiver Strain, Dementia Caregiver
Leveraging Interventions for Caregiver Growth, Health, Training, Empowerment and Navigation: Comparing Group Behavioral Interventions to Improve Dementia Caregiver Strain
The goal of this clinical trial is to compare two group-based interventions for caregivers of persons with memory loss (N=450) delivered via telehealth.
- Conditions
- Elevated Caregiver Strain, Dementia Caregiver, Caregiver Stress
- Trial name
- LIGHTEN (NCT07868588)
- Testing
- Caring Together, Savvy Caregiver
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Massachusetts General Hospital
Hepatocellular Carcinoma, Resectable Hepatocellular Carcinoma
SBRT + Atezolizumab + Bevacizumab in Resectable HCC
This study is evaluating the safety and tolerability of neoadjuvant stereotactic body radiation therapy (SBRT) with atezolizumab and bevacizumab for treating resectable hepatocellular carcinoma.
- Trial name
- NCT04857684
- Testing
- Atezolizumab, Bevacizumab, Stereotactic Beam Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Nursing Home Resident, Skilled Nursing Facility
Pilot Study of a Behavioral Program for Resident Depression in Skilled Nursing Facilities
The goal of this clinical trial is to test a behavioral health program (Interventions for Stressful Transitions in Later Life, InSTILL, for Individuals) for skilled nursing facility residents.
- Conditions
- Nursing Home Resident, Skilled Nursing Facility, Depression, Feasibility Studies
- Trial name
- BRISK-I (NCT07655232)
- Testing
- Interventions for Stressful Transitions in Later Life (InSTILL) for Individuals
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Hypertension
Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of Pregnancy
The goal of this clinical trial is to determine if the medication eplerenone yields greater improvements in coronary microvascular function than chlorthalidone in women who experienced hypertension during pregnancy and…
- Trial name
- CARDAMOM (NCT07238400)
- Testing
- Eplerenone 100 mg daily, Chlorthalidone 25 mg daily, Potassium Chloride
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Prostate Cancer
Circulating Tumor Cell Analysis in Patients With Localized Prostate Cancer Undergoing Prostatectomy
This study will evaluate a method to detect tumor cells that are circulating in the blood without getting a biopsy. The investigators already know from other studies that cancer tumors shed a small number of cells into the…
- Trial name
- NCT01961713
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Schizophrenia
The Effects of Auditory Stimulation During Sleep on Brain Networks in Schizophrenia
In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights.
- Trial name
- NCT06386588
- Testing
- Closed loop auditory stimulation during sleep
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Myelodysplastic Syndromes
MBG453 in Lower Risk MDS
This research study is assessing the efficacy of MBG-453, a humanized monoclonal antibody, in treating myelodysplastic syndromes (MDS). The name of the study drug involved in this study is MBG453.
- Trial name
- NCT04823624
- Testing
- MBG453
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Prostate Cancer Metastatic
Telaglenastat + Talazoparib In Prostate Cancer
The purpose of this research is to test the effectiveness of an experimental drug combination for people with metastatic castration-resistant prostate cancer (mCRPC).
- Trial name
- NCT04824937
- Testing
- Telaglenastat, Talazoparib
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Squamous Cell Carcinoma, Head and Neck Cancer Squamous Cell Carcinoma
PDT For Induction Therapy For Head And Neck Cancer
This research study is being done to assess the safety and tolerability of toripalimab in combination with cisplatin and docetaxel (PDT) induction therapy for patients with CPS-positive locally advanced head and neck squamous…
- Conditions
- Squamous Cell Carcinoma, Head and Neck Cancer Squamous Cell Carcinoma, Head and Neck Cancer
- Trial name
- NCT07214987
- Testing
- Toripalimab-tpzi, Cisplatin, Docetaxel
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Massachusetts General Hospital
Advanced Lung Cancer, Dyspnea
Multi-site Trial of a Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer
Dyspnea, or breathlessness, is one of the most common and distressing symptoms experienced by patients with advanced lung cancer.
- Trial name
- BREEZE+ (NCT06791057)
- Testing
- Dyspnea Intervention, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 420 people
- Sponsor
- Massachusetts General Hospital
Cannabis Use Disorder, Cue-reactivity
Semaglutide for the Treatment of Cannabis Use Disorder
The goal of this pilot study is to learn about the effects of semaglutide on brain reactivity to cannabis-related cues in adults with cannabis use disorder. The main questions it aims to answer are: 1.
- Trial name
- S-CUD (NCT07879612)
- Testing
- semaglutide
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Chronic Post-surgical Pain
Psychophysical and Neural Mechanisms Contributing to Chronic Post-Surgical Pain in Adolescents and Adults
The current project will (1) enhance our understanding of the neurobiology of chronic post-surgical pain (CPSP); (2) provide a metric to follow patients with CPSP in the clinic; (3) provide a metric for those who will chronify…
- Trial name
- NCT05304286
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Massachusetts General Hospital
Autism Spectrum Disorder, Anxiety
Heart Rate Variability Biofeedback for Anxiety in Autistic Youth
Heart rate variability biofeedback (HRVB) is a breathing-based intervention that reduces anxiety in a range of populations. Second-generation wearable HRVB devices not only deliver scheduled biofeedback practice sessions but also…
- Trial name
- NCT07812233
- Testing
- Lief Smart Patch
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Eating Disorders, Body Dissatisfaction
Preventing Disordered Eating and Body Dissatisfaction Among High-risk Pregnant Individuals
The investigators aim to conduct a feasibility randomized controlled trial (RCT) of an eating disorder prevention program (The Body Project, adapted for pregnancy) versus a health education control among pregnant individuals with…
- Trial name
- NCT06659354
- Testing
- Pregnant Body Project (PBP), Pregnancy Health Education (PHE)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Ventilated Patient in Intensive Care
Weighted Blanket to Improve Sedation and Comfort During Ventilator Weaning
Patients in the ICU who are being taken off of a breathing machine (ventilator weaning) commonly experience anxiety, agitation, sleep disruption, and physiologic stress.
- Trial name
- NCT07710469
- Testing
- Weighted blanket, Standard hospital linens
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Massachusetts General Hospital
Bacterial Vaginosis
A Study to Test New Investigational Drugs (LCFA-01and LC103) for Bacterial Vaginosis (BV) Treatment
This Phase 1b study will evaluate different combinations of LCFA-01, LC103, and the antibiotic metronidazole in women with bacterial vaginosis (BV).
- Trial name
- NCT07875673
- Testing
- metronidazole (MTZ)+ LC103+ LCFA-01, LCFA-01 + LC103
- Where
- 6 sites in Australia, South Africa
- Volunteers
- 280 people
- Sponsor
- Massachusetts General Hospital
Lymphoma, B-Cell, Relapsed Cancer
Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)
Participants are invited to take part in this research study because they have relapsed (cancer has come back) or refractory (cancer has not responded to treatment) B-cell Lymphoma and will be undergoing CAR T-cell Therapy.
- Conditions
- Lymphoma, B-Cell, Relapsed Cancer, Refractory Lymphoma, Diffuse Large B Cell Lymphoma
- Trial name
- NCT06004167
- Testing
- Adaptive Bridging Radiation Therapy (ABRT)
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Back Pain, Depressive Symptoms
Cannabidiol for Reduction of Brain Neuroinflammation
This study will investigate whether cannabidiol (CBD), the primary centrally and peripherally active non-intoxicating compound in the cannabis plant, exerts anti-neuroinflammatory effects in patients with chronic low back pain…
- Trial name
- CBD (NCT05066308)
- Testing
- CBD
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Massachusetts General Hospital
Vascular Inflammation, ASCVD
Effects of IL-1 Beta Inhibition on Vascular Inflammation in TET2 Clonal Hematopoiesis
The primary goal of this clinical trial is to test the hypothesis that the drug canakinumab (anti-IL-1B monoclonal antibody) decreases vascular inflammation when used by people with a history of coronary artery disease, including…
- Conditions
- Vascular Inflammation, ASCVD, ASCVD Management
- Trial name
- TECTONIC (NCT06691217)
- Testing
- CANAKINUMAB (ILARIS®)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Kidney Failure Chronic, Stem Cell Transplant
Addition of Venetoclax to Combined Hematopoietic Stem Cell and Kidney Transplantation
The primary objective is to assess the safety of the addition of venetoclax to reduced intensity conditioning for HLA-matched and haploidentical combined HSC and kidney transplantation as measured by stable full donor…
- Conditions
- Kidney Failure Chronic, Stem Cell Transplant, Stem Cell Transplant Complications, Tolerance
- Trial name
- NCT07358195
- Testing
- Venetoclax, Hematopoietic Cell Transplantation Conditioning Regimen, Kidney Transplant
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital