Clinical trials: sponsored by Massachusetts General Hospital
Prostate Cancer (Adenocarcinoma), Prostate Specific Antigen
Flotufolastat F 18 PET in Men With Very Low PSA Recurrence
The purpose of this study is to assess detection rate of flotufolastat F 18 positron emission tomography (PET) for low prostate specific antigen (PSA) recurrence of prostate cancer (PC) following radical prostatectomy.
- Trial name
- NCT06862856
- Testing
- Positron Emission Tomography (PET)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Prostate Cancer
Shared Decision Making in Low Risk Prostate Cancer
This study will evaluate the usefulness of an informational website designed to educate patients with prostate cancer about their options for treatment.
- Trial name
- NCT01673581
- Testing
- Survey
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Healthy, Brain Stimulation
Effects of Transcranial Electrical Stimulation on Task Performance in Healthy Adults
The objective of this randomized, double-blind, sham-controlled, crossover study is to evaluate the effects of transcranial electrical stimulation (tES) on complex cognitive task performance in healthy adult volunteers.
- Conditions
- Healthy, Brain Stimulation, Transcranial Direct Current Stimulation (tDCS), Cognition
- Trial name
- BRAIN-STIM (NCT06995560)
- Testing
- Active Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gestational Diabetes
Heterogeneity Informed Nutrition Therapy for Gestational Diabetes Mellitus
The hypothesis for this study is that women with different physiologic subtypes of gestational diabetes (GDM) (insulin secretion deficit vs.
- Trial name
- HINT-GDM (NCT04187521)
- Testing
- Meal A, Meal B
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts General Hospital
Exocrine Pancreatic Insufficiency (EPI), Pancreatitis
Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis Patients
This research aims to improve the management of exocrine pancreatic insufficiency (EPI), a condition that can develop after pancreatitis, a painful inflammation of the pancreas.
- Trial name
- NCT06691893
- Testing
- RELiZORB
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Pediatric Cancer
Video Inspired Discussions About Ethical Outcomes in Pediatrics
The goal of this clinical trial is to learn if the VIDEO-PEDS intervention works to improve Goals of Care communication between clinicians and parents of children with cancer.
- Trial name
- VIDEO-PEDS (NCT06786104)
- Testing
- VIDEO-PEDS, VIDEO-PEDS pilot, Focus Group
- Where
- 4 sites in United States
- Volunteers
- 567 people
- Sponsor
- Massachusetts General Hospital
Depression
Neurobiological Underpinnings of Placebo Response in Depression
In summary, the proposed research is novel with respect to design, technology, and its multi-level integration probing psychological and neurobiological constructs assumed to be crucially implicated in placebo response and has…
- Trial name
- NCT02562430
- Testing
- Welbutrin XL
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Massachusetts General Hospital
Orthopaedic Trauma, Chronic Opioid Use
Low-Dose Short-Term Ketorolac to Reduce Chronic Opioid Use in Orthopaedic Polytrauma Patients
The goal of this randomized clinical trial is to learn if the use of a low-dose nonsteroidal anti-inflammatory drug (NSAID), ketorolac, reduces the rate of chronic opioid use in orthopaedic trauma patients.
- Trial name
- NCT06201676
- Testing
- Ketorolac Injection, Standard of Care (SOC) Multimodal Analgesia
- Where
- 2 sites in United States
- Volunteers
- 458 people
- Sponsor
- Massachusetts General Hospital
Multiple Myeloma
Psychosocial Mobile Application (THRIVE-M) for Patients With Multiple Myeloma
This clinical trial aims to evaluate whether a psychosocial mobile application (THRIVE-M), is efficacious for improving quality of life, psychological distress, and fatigue in patients living with multiple myeloma compared to…
- Trial name
- THRIVE-M (NCT06073353)
- Testing
- THRIVE-M
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Subarachnoid Hemorrhage, Aneurysmal
Safety, Feasibility, and Efficacy of Non-invasive Vagus Nerve Stimulation (nVNS) in the Treatment of Aneurysmal Subarachnoid Hemorrhage
This is a single-site, single-arm, open-label pilot study assessing the safety, feasibility, and efficacy of non-invasive vagus nerve stimulation (nVNS), gammaCore, for the acute treatment of aneurysmal subarachnoid hemorrhage…
- Trial name
- STORM (NCT05103566)
- Testing
- gammaCore
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Colorectal Surgery, Care Transition
Optimizing Care Transition Process for Older Colorectal Surgery Patients
The goal of this study to test if a care transition intervention designed for older colorectal surgery patients would improve outcomes after discharge. It will assess the feasibility of the intervention.
- Conditions
- Colorectal Surgery, Care Transition, Older Adults (65 Years and Older)
- Trial name
- NCT06752031
- Testing
- OSCAR-S Care Transition Model
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Non-MSI-H or pMMR Colorectal Cancer With Liver Metastasis
Botensilimab, Balstilimab, and SBRT in Colorectal Cancer
This is a single-arm pilot feasibility study evaluating the combination of Botensilimab and Balstilimab with Radiation Therapy (RT) in Non-Microsatellite Instability High (MSI-H) or Proficient Mismatch Repair (pMMR)…
- Trial name
- NCT07128355
- Testing
- Stereotactic Body Radiation Therapy (SBRT), Botensilimab, Balstilimab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Massachusetts General Hospital
Hemodialysis Access Failure
Collateral Ligation in Failing Fistulas
Arteriovenous fistulas (AVFs) for hemodialysis often fail to become usable due to failure to mature (FTM). The most common cause is narrowing of the artery or vein (stenosis).
- Trial name
- CLiFF (NCT03365089)
- Testing
- Collateral vein ligation
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Brain Tumors, Non-CNS Malignancies
Prospective Assessment of Quality of Life (QOL) in Pediatric Patients Treated With Radiation Therapy for Brain Tumors and Non-central Nervous System (Non-CNS) Malignancies
In recent years, remarkable advances in medical oncology, surgery, and radiology have allowed for increasing cure rates for childhood malignancies.
- Trial name
- NCT01115777
- Testing
- Quality of Life surveys completed at specified timepoints
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Massachusetts General Hospital
Schizophrenia
Effects of Auditory Stimulation on Sleep and Memory in Schizophrenia
The investigators will test the hypothesis that auditory stimulation (playing quiet sounds during sleep) can normalize brain activity during sleep and improve memory in patients with schizophrenia.
- Trial name
- NCT04783571
- Testing
- Auditory Stimulation
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acute Myeloid Leukemia
Venetoclax + Azacitidine vs. Induction Chemotherapy in AML
This research is being done to assess the therapeutic activity of a promising combination (azacitidine and venetoclax) versus conventional cytotoxic chemotherapy in induction-eligible patients with acute myeloid leukemia.
- Trial name
- NCT04801797
- Testing
- Cytarabine, Idarubicin, Daunorubicin
- Where
- 9 sites in United States
- Volunteers
- 172 people
- Sponsor
- Massachusetts General Hospital
Mood Disorders, Anxiety Disorders
Reconnecting to Ourselves and Others in Virtual Meetings (ROOM)
This study aimed to determine the feasibility and acceptability of delivering Resilience Training in multi-user virtual reality.
- Conditions
- Mood Disorders, Anxiety Disorders, Psychotic Disorders
- Trial name
- NCT06360562
- Testing
- Resilience Training
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Lung Cancer, Health Screening
Deep Learning Using Chest X-Rays to Identify High Risk Patients for Lung Cancer Screening CT
The goal of this clinical trial is to evaluate whether an AI tool that alerts providers to patients at high 6-year risk of lung cancer based on their chest x-ray images will improve lung cancer screening CT participation.
- Conditions
- Lung Cancer, Health Screening, Early Cancer Detection, Deep Learning
- Trial name
- NCT06910956
- Testing
- CXR-LC
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Massachusetts General Hospital
Obesity, Childhood, Overweight and Obesity
First Heroes: Engaging Fathers in the First 1000 Days
The First Heroes study plans to influence weight and health trajectories, modify disease risk, and improve health care services for mother-father-infant triads from racial/ethnic minority and health disparity populations.
- Conditions
- Obesity, Childhood, Overweight and Obesity, Social Determinants of Health, Physical Activity
- Trial name
- First Heroes (NCT04477577)
- Testing
- New Parent Intervention, Safety Control
- Where
- United States
- Volunteers
- 657 people
- Sponsor
- Massachusetts General Hospital
Psychotic Disorders, Mood Disorders
A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences
This is a randomized controlled trial testing the efficacy of Resilience Training in college students with elevated transdiagnostic risk for developing a serious mental illness.
- Conditions
- Psychotic Disorders, Mood Disorders, Anxiety Disorders
- Trial name
- NCT06929442
- Testing
- Resilience Training (RT), Life Skills Training (LST)
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Massachusetts General Hospital
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