Clinical trials: sponsored by Massachusetts General Hospital
Diabetes Mellitus, Type One, Diabetes Mellitus, Type I
Repeat BCG Vaccinations for the Treatment of Established Type 1 Diabetes
This Phase II RCT using multi-dose Bacillus Calmette-Guérin (BCG) in adults with juvenile or childhood onset diabetes is based on prior clinical trials showing that even with advanced disease and little of no remaining pancreas…
- Conditions
- Diabetes Mellitus, Type One, Diabetes Mellitus, Type I, Autoimmune Diabetes, Covid19
- Trial name
- NCT02081326
- Testing
- Bacillus Calmette-Guérin, Saline injection
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Pruritus
Assessing the Efficacy and Safety of Photobiomodulation for the Treatment of Pruritus
This study is designed to evaluate the safety and effectiveness of a low-level near-infrared LED light device for relieving itch. The device is non-invasive, does not break the skin, and does not produce heat.
- Trial name
- NCT07450716
- Testing
- Light-emitting diode (LED) Photobiomodulation (PBM) device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Posttraumatic Stress Disorder (PTSD)
Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS) for Treatment of Post-Traumatic Stress Disorder (PTSD)
This study is testing a personalized form of brain stimulation called PrTMS as a treatment for post-traumatic stress disorder (PTSD) in military service members and veterans.
- Trial name
- NCT07526285
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Stress, Cancer Diagnosis
Building Resiliency Among Caregivers of Curvivors and Metavivors
The main purpose of this research study is to assess the feasibility and participants' satisfaction of the Stress Management and Resiliency - Relaxation Response Resiliency Program (SMART-3RP) and compare this treatment with…
- Conditions
- Stress, Cancer Diagnosis, Distress, Emotional
- Trial name
- ForTe (NCT05702723)
- Testing
- Smart-3RP, Enhanced Usual Care
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 2
Boosting Emotional Well-being and Happiness in Outpatients Living With Diabetes
The focus of this study is to test the efficacy of an 8-week, remotely delivered, positive-psychology-motivational interviewing (PP-MI) intervention, with additional twice weekly text messages for a total of 16 weeks (with…
- Trial name
- BEHOLD (NCT05420051)
- Testing
- Positive Psychology + Motivational Interviewing, Motivational Interviewing
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Massachusetts General Hospital
Burns, Hypertrophic Scar
Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar
Laser treatment of hypertrophic burn scars has become increasingly popular for improving scarring in burn survivors. Despite its common use, there a gap in knowledge regrading randomized control trials that demonstrate whether…
- Trial name
- NCT03692273
- Testing
- Luminis ultrapulse fractional ablative carbon dioxide laser, 0.5mm punch biopsy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Massachusetts General Hospital
Relapsed Refractory Multiple Myeloma (RRMM)
Mezigdomide and Talquetamab in Relapsed and Refractory Multiple Myeloma
This is a phase 1 study to find the recommended dose and schedule of mezigdomide and talquetamab in relapsed and refractory multiple myeloma (RRMM), and to test the effects of the drugs on cancer.
- Trial name
- MAGENTA (NCT07032714)
- Testing
- Talquetamab, Mezigdomide, Dexamethasone
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
T-Cell and NK-Cell Neoplasm
A Global Study of the PETAL Consortium
The goal of this observational study is to correlate molecular alterations with outcomes including overall survival (OS), progression-free survival (PFS), response rates for patients with a new diagnosis, primary refractory or…
- Trial name
- PETAL (NCT06067347)
- Where
- 14 sites in United States, Australia and 2 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Peanut Allergy
Food Oral Immunotherapy for Peanut Allergy
This is an open label observational single center study of clinical food oral immunotherapy outcomes with biomarker samples and participant and/or caregiver-completed questionnaires in participants between 6 months and 65 years…
- Trial name
- NCT04222491
- Testing
- Peanut oral immunotherapy
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Anesthesia, Sedation
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful.
- Conditions
- Anesthesia, Sedation, Monitored Anesthesia Care, Procedure
- Trial name
- MACS (NCT07022951)
- Testing
- Preoperative fasting
- Where
- United States
- Volunteers
- 1,200,000 people
- Sponsor
- Massachusetts General Hospital
Cholera
Vaccine- and Infection-derived Correlates of Protection for Cholera
Background: Vibrio cholerae causes millions of cholera cases and thousands of deaths annually. Vaccines are in short supply. There is no agreement on how to introduce new vaccines or evaluate their effectiveness, and the lack of…
- Trial name
- CoP (NCT06455852)
- Testing
- oral cholera vaccine or typhoid conjugate vaccine
- Where
- Bangladesh
- Volunteers
- 1,221 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hematopoietic Stem Cell Transplantation, Hematologic Diseases
Multimodal Sexual Dysfunction Intervention In HCT
This research study is evaluating the impact of an intervention to improve sexual function in stem cell transplant survivors on participants' sexual function, quality of life, and mood.
- Conditions
- Hematopoietic Stem Cell Transplantation, Hematologic Diseases, Sexual Dysfunction
- Trial name
- NCT03803696
- Testing
- Enhanced Standard Care, Multimodal Intervention to Address Sexual Dysfunction
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Massachusetts General Hospital
Chronic Graft-versus-host Disease, Chronic GVHD
Tele-Palliative Care Intervention for Patients With Chronic Graft-Versus-Host Disease
This research study is evaluating the feasibility and acceptability of implementing a telehealth palliative care intervention in patients with moderate to severe chronic graft-versus-host disease.
- Conditions
- Chronic Graft-versus-host Disease, Chronic GVHD, cGVHD
- Trial name
- cGVHDTele-PC (NCT06458127)
- Testing
- Tele-palliative care visit
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer, Myocardial Fibrosis
Losartan in Prevention of Radiation-Induced Heart Failure
This study is being done to see if losartan affects the chances of developing radiation-induced heart failure in patients who are receiving radiation therapy as part of standard of care treatment for breast cancer.
- Conditions
- Breast Cancer, Myocardial Fibrosis, Radiation-Induced Fibrosis
- Trial name
- NCT05607017
- Testing
- Losartan, Radiation Therapy
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
A Pilot Study of Tomographic Optical Breast Imaging (DBT-TOBI) to Monitor Response to Neoadjuvant Therapy
This research study is evaluating whether the use of digital breast tomosynthesis and near-infrared tomographic optical breast imaging (DBT-TOBI) scans can predict the response of triple negative or HER2+ breast cancer to…
- Trial name
- NCT03822312
- Testing
- DBT-TOBI, MRI-TOBI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Acute Myeloid Leukemia, Myelodysplastic Syndromes
A Collaborative Palliative and Leukemia Care Model for Patients With AML and MDS Receiving Non-Intensive Therapy
This research study is evaluating the impact a collaborative palliative care and oncology team will have on end-of-life outcomes, quality of end-of-life care, and the quality of life, symptoms, and mood of patients with acute…
- Trial name
- NCT03310918
- Testing
- Palliative Care, Standard Leukemia care
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Massachusetts General Hospital
Scars, Scleroderma
Laser Treatment for the Improvement of Scars and Scleroderma
In this study, the investigators seek to evaluate the effects of a laser treatment on the redistribution/regeneration of collagen on the clinical, microscopic, and molecular profiles of hypertrophic scars and scleroderma.
- Trial name
- NCT04567537
- Testing
- Laser Treatment
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Preeclampsia, Gestational Hypertension
Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories
The hypertensive disorders of pregnancy (preeclampsia and gestational hypertension) are associated with increased long-term maternal risk of developing cardiovascular disease.
- Trial name
- IMPACT-HT (NCT07041281)
- Testing
- spironolactone 25 mg orally once daily
- Where
- 3 sites in United States
- Volunteers
- 204 people
- Sponsor
- Massachusetts General Hospital
Achilles Tendon Rupture, Blood Flow Restriction Therapy
Project Tendura: The Impact of Blood Flow Restriction Resistance Training (BFR-RT) in Patients With Achilles Tendon Rupture (ATR) Repair
The goal of this clinical trial is to determine whether blood flow restriction resistance training (BFR-RT) improves postoperative muscle recovery and functional outcomes following primary surgical repair of acute Achilles tendon…
- Conditions
- Achilles Tendon Rupture, Blood Flow Restriction Therapy, Achilles Tendon Repairs/Reconstructions, Dynamic Blood Flow Restriction
- Trial name
- NCT07498166
- Testing
- Blood Flow Restriction Resistance Training (BFR-RT), Standard Physical Therapy
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Logopenic Variant Primary Progressive Aphasia, Non-fluent Variant Primary Progressive Aphasia
TMS for the Treatment of Primary Progressive Aphasia
Primary Progressive Aphasia (PPA) is a progressive syndrome in the family of Alzheimer's disease and related disorders involving devastating language impairments caused by selective neurodegeneration of the brain's language…
- Conditions
- Logopenic Variant Primary Progressive Aphasia, Non-fluent Variant Primary Progressive Aphasia, Semantic Variant Primary Progressive Aphasia
- Trial name
- NCT04188067
- Testing
- Active rTMS
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
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