Clinical trials: sponsored by Massachusetts General Hospital
Stage IV Non-small Cell Lung Cancer, Targeted Therapy
Patient-centered, Optimal Integration of Survivorship and Palliative Care
The goal of this study is to develop and test the feasibility of a supportive care model (POISE) for patients with metastatic Non-small Cell Lung Cancer (NSCLC).
- Conditions
- Stage IV Non-small Cell Lung Cancer, Targeted Therapy, Nonsmall Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT04900935
- Testing
- POISE
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Thumb Osteoarthritis, First Dorsal Interosseous Strengthening
Strengthening of the First Dorsal Interosseous for Thumb Carpometacarpal Osteoarthritis
To determine the effect of first dorsal interosseus (FDI) strengthening in patients with thumb carpometacarpal (CMC) osteoarthritis.
- Trial name
- NCT03177577
- Testing
- Splint, Splint with strengthening exercises
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Massachusetts General Hospital
Non-traumatic and Traumatic Orthopaedic Issues
Orthopaedic Hand and Upper Extremity Data Repository
The purpose of this research is to investigate multiple facets of non-traumatic and traumatic orthopaedic health issues. Studies under this protocol will investigate a variety of research questions concerning traumatic and…
- Trial name
- NCT03177642
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Lung Cancer, Lung Diseases
Lung Cancer Risk and Early Detection in Firefighters
This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify…
- Trial name
- NCT04614129
- Testing
- Low Dose CT
- Where
- United States
- Volunteers
- 734 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Neurofibromatosis 1
Efficacy of Skin Cooling in Reducing Pain Associated With Non-invasive Treatments of Neurofibromatosis Type 1 Cutaneous Neurofibromas
This study will evaluate the effectiveness of skin cooling in increasing tolerability of four treatments in Neurofibromatosis Type 1 Cutaneous Neurofibromas.
- Trial name
- NCT06132165
- Testing
- Deoxycholic Acid, Polidocanol, 1064nm Nd:YAG laser
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Adjacent Segment Disease
Decompression Versus Decompression and Fusion
Adjacent segment disease (ASD) in the lumbar spine is a well-known sequela of lumbar fusion surgery. The annual incidence of adjacent level re-operation is approximately 3% with a ten-year prevalence of 20-30%.
- Trial name
- NCT04542720
- Testing
- Observational: Decompression, Observational: Extension Fusion
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Surgery, Colostomy Stoma
Communication Intervention for Fecal Ostomy Surgery
In this study the investigators will evaluate the acceptability of a communication intervention for fecal ostomy surgery (CI-oSurg) to address the needs of adults who are undergoing fecal ostomy surgery.
- Conditions
- Surgery, Colostomy Stoma, Ileostomy - Stoma
- Trial name
- CI-oSurg (NCT06320002)
- Testing
- Communication Intervention for fecal ostomy surgery
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Non-Alcoholic Fatty Liver Disease, Obesity
Growth Hormone Releasing Hormone Analog to Improve Nonalcoholic Fatty Liver Disease and Associated Cardiovascular Risk
Nonalcoholic fatty liver disease (NAFLD) is common in individuals with obesity and is a significant threat to public health, because it can lead to impaired liver function and liver failure.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Obesity, Obesity, Abdominal, Liver Fat
- Trial name
- NCT03375788
- Testing
- Tesamorelin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Massachusetts General Hospital
Asphyxia Neonatorum, Birth Asphyxia
Augmented Infant Resuscitator (AIR): Transitioning a Novel Behavior Change Innovation to Drive Newborn Ventilation Skills Enhancement
Augmented Infant Resuscitator (AIR) is an inexpensive add-on, compatible with nearly every existing bag-valve mask and many types of ventilation equipment.
- Conditions
- Asphyxia Neonatorum, Birth Asphyxia, Perinatal Asphyxia
- Trial name
- NCT05349175
- Testing
- Augmented Infant Resuscitator (AIR)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Metastatic Breast Cancer
Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer
Many people living with metastatic breast cancer face challenging symptoms and frequent medical visits. At the same time, conversations about personal goals, values, and preferences for care may not always happen as early or as…
- Trial name
- TARGET-PC (NCT06795529)
- Testing
- Palliative Care Intervention, "TARGET-PC", Enhanced Usual Care
- Where
- 3 sites in United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
Chronic Pain, Musculoskeletal Pain
Improving Health for Older Adults With Pain Through Engagement
The goal of this project is to conduct a randomized, hybrid type 1 effectiveness-implementation trial (N=200) to evaluate the effectiveness and implementation of a 10-week mind-body and walking program (GetActive+) vs treatment…
- Trial name
- iHOPE (NCT06119698)
- Testing
- GetActive+
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Overweight, Childhood, Obesity, Childhood
Comparative-effectiveness of a Healthy Lifestyle and Asthma Management Program, In-person vs. ONline
The goal of this study is to evaluate the effectiveness of CHAMPION ("Comparative-effectiveness of a Healthy lifestyle and Asthma Management Program, In-person vs ONline"), a primary care-based intervention to address childhood…
- Conditions
- Overweight, Childhood, Obesity, Childhood, Asthma in Children
- Trial name
- CHAMPION (NCT06432790)
- Testing
- CHAMPION
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Obesity, Abdominal, Anesthesia Morbidity
CPAP in Patients With Severe Obesity After Anesthesia
The goal of this study is to compare two continuous positive airway pressure (CPAP) settings on heart and lung function in patients with severe obesity after anesthesia. The main questions it aims to answer are: 1.
- Conditions
- Obesity, Abdominal, Anesthesia Morbidity, Apnea, Obstructive Sleep, Atelectases, Postoperative Pulmonary
- Trial name
- NCT06287632
- Testing
- Recruitment/ITP-CPAP (Intervention A), Standard CPAP (Intervention B), Atmospheric Pressure
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Bone Marrow Transplant Complications, Hematologic Malignancy
Mobile CARE-App to Promote Coping for Caregivers of Patients Receiving Stem Cell Transplant
The goal of this research study is to determine whether a self-administered, psychosocial mobile application (CARE app) is effective at improving the quality of life and experience of caregivers of patients receiving…
- Trial name
- NCT05709912
- Testing
- CARE Application, Usual Care
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Cancer Colorectal, Cancer Cervix
Building Connections
Building Connections seeks to address health and healthcare inequities in socially vulnerable communities. The project will be conducted in collaboration with clinical practices across Massachusetts, serving a diverse population…
- Conditions
- Cancer Colorectal, Cancer Cervix, Depression, Anxiety, Obesity
- Trial name
- NCT07091032
- Testing
- Treatment as Usual, Building Connections Intervention
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- Massachusetts General Hospital
Epilepsy
Auditory Stimulation Effects on Sleep and Memory in Patients With Epilepsy
This study will investigate the role of coordinated brain rhythms during sleep in memory consolidation and determine whether playing precisely timed brief bursts of noise can enhance these rhythms and improve memory in epilepsy…
- Trial name
- NCT04788628
- Testing
- Baseline, Motor procedural memory task, Motor procedural memory task plus auditory stimulation
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Amyotrophic Lateral Sclerosis (ALS), Emotional Distress
Resiliency Intervention for Patients With ALS and Their Care-Partners
The purpose of this study is to pilot a resiliency and coping intervention for persons recently diagnosed with Amyotrophic Lateral Sclerosis (ALS) and their primary informal caregivers.
- Trial name
- RT-ALS (NCT06968468)
- Testing
- Resilient Together ALS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Leptomeningeal Carcinomatosis
Ipilimumab and Nivolumab in Leptomeningeal Metastases
This research study is studying a combination of two drugs as a possible treatment for Leptomeningeal Metastases. The names of the study interventions involved in this study are: Ipilimumab Nivolumab
- Trial name
- NCT02939300
- Testing
- Nivolumab, Ipilimumab
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital
Colo-rectal Cancer
Eliminating Barriers to Colorectal Cancer Screening Using Rapid Cycle Testing: A Pilot Study
The investigators will use a mixed methods study i.e. focus groups involving CHC staff as well as quantitative study which involves analyzing data that is available from the EHR and DRVS population management platform.
- Trial name
- NCT05524428
- Testing
- Implementation Science Strategy
- Where
- 4 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Autism
Effectiveness of Atomoxetine in Treating ADHD Symptoms in Children and Adolescents With Autism
This study will evaluate the effectiveness of atomoxetine in treating children with attention deficit hyperactivity disorder symptoms associated with autistic disorder, Asperger's syndrome, and pervasive developmental disorder…
- Trial name
- NCT00498173
- Testing
- Atomoxetine
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
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