Clinical trials: sponsored by Massachusetts General Hospital
Myeloproliferative Disorders, Leukemia
I Can Move With Purpose Now! A Pilot Lifestyle Intervention Study in Myeloproliferative Neoplasm Patients
The goal of this study is to see if patients with myeloproliferative disorders are able to successfully complete the Cardiac Lifestyle Program(CLP).
- Trial name
- NCT05842603
- Testing
- Cardiac Lifestyle Program
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Obesity, Surgery
Effects of Weight Loss Surgery on Bone Health in Adolescents
The purpose of this study is to examine the impact of weight-loss surgery (Roux-en-Y gastric bypass or Vertical Sleeve Gastrectomy) on bone outcomes in girls and boys ages 13-21.
- Trial name
- NCT02557438
- Testing
- Roux-en-Y Gastric Bypass, Vertical Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Massachusetts General Hospital
Feeding Patterns, Sleep
Assessing Metabolic and Sleep Consequences of Overnight Home Parenteral Nutrition
The purpose of this study is to determine whether advancing the timing of home parenteral nutrition from overnight to daytime regimens leads to improved glucose profiles and sleep quality, and other changes in plasma metabolic…
- Conditions
- Feeding Patterns, Sleep, Glucose Intolerance, Short Bowel Syndrome
- Trial name
- NCT04743960
- Testing
- Time-of-day of parenteral nutrition provision
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Crohn's Disease
Dietary Therapy and Gut Microbiome in Crohn's Disease and Ulcerative Colitis
The study is proposed as a 2-year single site, open-label clinical trial of enteral nutrition or the specific carbohydrate diet in patients with active CD or UC.
- Trial name
- NCT02412553
- Testing
- Specific carbohydrate diet, Elemental diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Dementia, Quality of Life
Caring for Caregivers and People Living With Dementia Under Home-Based Primary Care
The goal of this clinical trial is to develop a dementia care intervention for persons receiving home-based primary care (HBPC) and living with dementia (PLWD) and their caregivers, and test the feasibility of implementing the…
- Conditions
- Dementia, Quality of Life, Caregiver Stress
- Trial name
- NCT05849259
- Testing
- Dementia Care Quality at Home
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Avoidant/Restrictive Food Intake Disorder, Dyspepsia
Exposure-Based CBT for Avoidant/Restrictive Food Intake in Functional Dyspepsia
Randomized controlled trial of an exposure-based behavioral treatment (CBT) in adults with functional dyspepsia who meet criteria for avoidant/restrictive food intake disorder (ARFID) with weight loss.
- Conditions
- Avoidant/Restrictive Food Intake Disorder, Dyspepsia, Feeding and Eating Disorders, Cognitive Behavioral Therapy
- Trial name
- NCT05587127
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
HIV, Awaiting Organ Transplant
HIV-to-HIV Transplant at MGH
HIV-infected (HIV+) individuals who agree to accept and receive a solid organ transplant from an HIV+ deceased donor will be followed to determine the safety and efficacy of this practice.
- Trial name
- NCT02750397
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Hematologic Malignancy, Refractory Lymphoma
Radiation Post-CAR T in Refractory Lymphoma
This study is evaluating the safety and efficacy of using radiotherapy in participants who have refractory lymphoma shortly after receiving CAR T cell therapy (axicel or tisacel).
- Trial name
- NCT04473937
- Testing
- Radiotherapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Massachusetts General Hospital
Urethritis, Cervicitis
Rapid Diagnostic Assay for Gonorrhea and Chlamydia
This study is a pilot randomized controlled trial evaluating the use of either a) rapid 30-minute desktop assay or b) point-of-care gram stain (current standard of care) to guide the clinical management of patients with…
- Conditions
- Urethritis, Cervicitis, Sexually Transmitted Infections
- Trial name
- NCT05564299
- Testing
- Rapid 30-minute Desktop Assay
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- Massachusetts General Hospital
Sleep Disorder, Restless Legs Syndrome
Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD
The investigators propose to test the use of pramipexole in patients being treated for Opioid Use Disorder to test its ability to reduce symptoms of both Restless Legs Syndrome and protracted opioid withdrawal and thereby promote…
- Conditions
- Sleep Disorder, Restless Legs Syndrome, Opioid-use Disorder, Opioid Withdrawal
- Trial name
- NCT04759703
- Testing
- Pramipexole
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Hiv, Cardiovascular Diseases
Mindfulness and Behavior Change to Improve Cardiovascular Health of Older People With HIV
Older people with HIV (OPWH) are disproportionately impacted by cardiovascular disease (CVD) attributable to behavioral risk factors, and chronic HIV immune dysregulation resulting inflammation.
- Trial name
- OM-OH (NCT06001814)
- Testing
- One-Mind One-Heart, Education
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Ovarian Neoplasms, Ovarian Epithelial Carcinoma
Developing a Test of Uterine Lavage for the Detection of Ovarian Cancer
The study aims to develop a test for early detection of ovarian cancer using DNA from a growth involving the ovary found in a washing of the uterus (womb), and proteins found in the blood.
- Conditions
- Ovarian Neoplasms, Ovarian Epithelial Carcinoma, Fallopian Tube Neoplasms, High Grade Ovarian Serous Adenocarcinoma
- Trial name
- NCT04794322
- Testing
- Uterine lavage, or a wash of the womb, Blood sample, Pap smear
- Where
- 6 sites in United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Head and Neck Cancer
Oral Decitabine (ASTX727) and Durvalumab in Recurrent and/or Metastatic Head and Neck Cancer Patients
This is a non-randomized, open-label, Phase Ib study to assess the safety and efficacy of a DNA methyltransferase inhibitor and immune checkpoint inhibitor(s) (durvalumab and/or tremelimumab) combination therapy in the treatment…
- Trial name
- NCT03019003
- Testing
- Oral Decitabine, Durvalumab, 5' Azacitidine
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Liver Cancer
Proton Beam Irradiation for the Treatment of Unresectable Hepatocellular Cancer and Cholangiocarcinoma
In this study the investigators will be studying the effects of proton beam radiation therapy. This is a very accurate kind of treatment that has been shown to affect less normal tissue than a photon radiation beam.
- Trial name
- NCT00976898
- Testing
- Proton Beam Irradiation
- Where
- 4 sites in United States
- Volunteers
- 83 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder, Anxiety Depression
Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV
This study will determine the effects of pregnenolone on brain function, inflammation and depressive symptoms in people with HIV who have depression.
- Conditions
- Major Depressive Disorder, Anxiety Depression, HIV
- Trial name
- SOOTHE (NCT05570812)
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Disorder of Consciousness
An Ethical Approach to Detecting Covert Consciousness
This study aims to develop an ethical approach to developing and deploying novel neurotechnologies to aid in the detection of consciousness and prediction of recovery after brain injury.
- Trial name
- DECODE (NCT05010265)
- Testing
- Clinician Questionnaire, Semi Structured Interviews
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury, Major Depressive Disorder
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive…
- Conditions
- Traumatic Brain Injury, Major Depressive Disorder, Bipolar Disorder, Schizophrenia
- Trial name
- NCT04296604
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Mental Health
Building Infrastructure for Community Capacity in Accelerating Integrated Care
Although the Affordable Care Act (ACA) expanded Medicaid eligibility, Medicaid expansions do not appear to have decreased the gap in mental health treatment between Whites and racial/ethnic or linguistic minorities.
- Trial name
- NCT04092777
- Testing
- Strong Minds, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 1,044 people
- Sponsor
- Massachusetts General Hospital
Pancreatic Cancer, Metastatic Pancreatic Cancer
Niraparib + Dostarlimab + RT in Pancreatic Cancer
This research is being done to see how the combination of dostarlimab, niraparib, and radiation therapy works in controlling metastatic pancreatic cancer.
- Trial name
- NCT04409002
- Testing
- Niraparib, Dostarlimab, Radiation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital
Brain Tumor, Medulloblastoma
Proton Beam Radiotherapy for Medulloblastoma and Pineoblastoma
There are two types of external radiation treatments (proton beam and photon beam). As part of the participant's treatment, they will receive radiation to the entire central nervous system (CNS); this is known as craniospinal…
- Conditions
- Brain Tumor, Medulloblastoma, Pineoblastoma
- Trial name
- NCT01063114
- Testing
- proton beam radiation
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
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