Clinical trials: sponsored by Massachusetts General Hospital
Heart Failure
STOP-CA (Statins TO Prevent the Cardiotoxicity From Anthracyclines)
This research study will test whether atorvastatin, a drug commonly prescribed for reducing cholesterol levels, can protect the heart during chemotherapy with doxorubicin.
- Trial name
- NCT02943590
- Testing
- Atorvastatin
- Where
- 4 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Chronic Pain, Musculoskeletal Pain
Improving Health for Older Adults With Pain Through Engagement (Open-pilot)
The goal of this project is to conduct an open-pilot (N=30) to evaluate the feasibility, acceptability, and fidelity of a mind-body and activity program (GetActive+) with older adults with chronic pain.
- Trial name
- iHOPE (NCT05782231)
- Testing
- GetActive+
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Massachusetts General Hospital
Stroke, Ischemic
Stroke Motor Rehabilitation and Recovery Study
SMaHRT (Stroke Motor reHabiliation and Recovery sTudy) is a longitudinal study aimed at understanding the natural history of upper extremity motor recovery after ischemic and hemorrhagic stroke.
- Trial name
- SMaHRT (NCT03485040)
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Massachusetts General Hospital
Non-Small Cell Lung Cancer (NSCLC)
Phase I/II Trial of Alectinib and Bevacizumab in Patients With Advanced, Anaplastic Lymphoma Kinase (ALK)-Positive, Non-Small Cell Lung Cancer
This research study is evaluating two drugs, alectinib and bevacizumab, as possible treatments for Advanced Non-Small Cell Lung Cancer (NSCLC).
- Trial name
- NCT02521051
- Testing
- Alectinib, Bevacizumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Cancer
Living Well With Serious Illness "Wicokuje Sica Tuha Akisniya Wiconi": Wawokiya Health Advocate Intervention
Informed by a Community Advisory Board (CAB) and community assessments performed in the first phase of work funded through R01CA240080, this study will test a wawokiya (one who helps) health advocate (WHA)-based palliative care…
- Trial name
- NCT05208606
- Testing
- Wawokiya Health Advocate
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Depression
Preconception and Pregnancy Obesity Treatment and Prevention Among Women With a History of Depression
The purpose of the Preconception and Pregnancy Obesity Treatment and Prevention Among Women with A History of Depression preliminary study is to provide a lifestyle intervention for women with a history of depression who are…
- Trial name
- NCT03053323
- Testing
- Lifestyle Intervention
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Inflammatory Bowel Diseases, Crohn Disease
Effect of a Probiotic Mixture on the Gut Microbiome and Fatigue in Patients With Quiescent Inflammatory Bowel Disease
The study is proposed as a single-site randomized double-blind placebo-controlled trial requiring 4 study visits, where two of the visits are combined with their appointment for routine clinical care.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT03266484
- Testing
- Probiotic Mixture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Multisystemic Smooth Muscle Dysfunction Syndrome, ACTA2
A Retrospective and Prospective Natural History of Genetic Vasculopathies
This study will combine retrospective review of medical records from patients with ACTA2 and ongoing collection of clinical data using standardized instruments and intervals on an observational basis from patients with ACTA2.
- Trial name
- NCT06552052
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Hemorrhagic Stroke
Precision Clinical and Genetic Tools for Brain Health in Hemorrhagic Stroke
The overall goal of this study is to increase health care provider awareness for common risk factors and comorbidities in patients with hemorrhagic stroke that are related to impaired brain health, to ultimately improve patients…
- Trial name
- NCT05643001
- Testing
- In-patient and out-patient electronic health record alert
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Massachusetts General Hospital
Cutaneous Squamous Cell Carcinoma, Actinic Keratoses
Immunotherapy Before Transplantation for Skin Cancer Prevention in Organ Transplant Recipients
This clinical trial aims to investigate the efficacy of Calcipotriol ointment combined with 5-fluorouracil cream as an immunotherapy for actinic keratosis in Organ Transplant Recipients (OTRs) before transplantation and determine…
- Conditions
- Cutaneous Squamous Cell Carcinoma, Actinic Keratoses, Skin Cancer, Organ Transplant Recipients
- Trial name
- NCT04329221
- Testing
- Calcipotriol Only Product in Cutaneous Dose Form, Vaseline, Topical 5FU
- Where
- 2 sites in United States
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Topical Calcipotriene Treatment for Breast Cancer Immunoprevention
This research study is studying a topical ointment called calcipotriene to see if it can stimulate the immune cells against the breast lesion in ways that would prevent its recurrence after surgical removal
- Trial name
- NCT03596073
- Testing
- Topical Calcipotriene Ointment, Topical Vaseline
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Massachusetts General Hospital
Immunotherapy, Cutaneous Squamous Cell Carcinoma
Immunotherapy After Transplantation for Skin Cancer Prevention in Organ Transplant Recipients
This clinical trial aims to investigate the efficacy of Calcipotriol ointment combined with 5-FU cream in Organ Transplant Recipients (OTRs) to determine if it can stimulate the immune cells against actinic keratoses precancerous…
- Conditions
- Immunotherapy, Cutaneous Squamous Cell Carcinoma, Actinic Keratoses, Organ Transplant Recipients
- Trial name
- NCT04642287
- Testing
- Calcipotriol Only Product in Cutaneous Dose Form, Vaseline, Topical 5FU
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Atrial Fibrillation, Ischemic Stroke
Precision Medicine in Ischemic Stroke and Atrial Fibrillation
The overall goal of this study is to minimize morbidity due to Atrial Fibrillation (AF). The specific objective is to develop and implement a rational and personalized approach to AF risk estimation that can inform management…
- Trial name
- PreMISe-AF (NCT04637087)
- Testing
- Atrial fibrillation risk electronic health record alert
- Where
- United States
- Volunteers
- 805 people
- Sponsor
- Massachusetts General Hospital
Neuromyelitis Optica
High Frequency Impulse Therapy for Neuropathic Pain in NMOSD
The aim of this study is to determine whether self-administered, at-home use of a transcutaneous electrical nerve stimulating device is an effective, acceptable and feasible method of relief from neuropathic pain among patients…
- Trial name
- NCT04614454
- Testing
- High Frequency Impulse Therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Massachusetts General Hospital
Vaping, Nicotine Dependence
Varenicline for Nicotine Vaping Cessation in Adolescents
The study will test the hypothesis that varenicline, when added to behavioral and texting support for vaping cessation, will improve vaping abstinence rates in adolescents dependent on vaped nicotine over placebo plus behavioral…
- Trial name
- ViVA (NCT05367492)
- Testing
- Double Blind Varenicline, QuitVaping, This Is Quitting
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Massachusetts General Hospital
Uterine Bleeding, Uterine Fibroid
Pain Reduction and Ovarian Perfusion Following Uterine Fibroid Embolization
The goal of this study is to assess of Pressure-Enabled Drug Delivery on fibroid treatment in patients undergoing UFE.
- Trial name
- PEDD-UFE (NCT06106633)
- Testing
- TriNaV
- Where
- 2 sites in United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Heart Failure，Congestive
Implementing a Digitally-enabled Community Health Worker Intervention for Patients With Heart Failure
The purpose of this study is to assess the acceptability, feasibility, and preliminary effectiveness of implementing a 30-day digitally-enabled community health worker intervention compared to usual care with a community health…
- Trial name
- NCT05130008
- Testing
- Digitally-enabled CHW Care, Usual CHW Care
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Bariatric Surgery, Metabolic Surgery
Comparative Effectiveness of Metabolic and Bariatric Surgery With PROMs
This long-term, nationwide observational data collection repository will obtain patient-reported outcomes from metabolic and bariatric surgery patients.
- Conditions
- Bariatric Surgery, Metabolic Surgery, Weight Reduction
- Trial name
- MBSAQIP-PROM (NCT02749305)
- Testing
- Collection of patient-reported outcome measures
- Where
- United States
- Volunteers
- 11,146 people
- Sponsor
- Massachusetts General Hospital
Tobacco Smoking, Second Hand Tobacco Smoke
eCEASE to Support Treatment for Parental Tobacco Use
The proposed project aims to develop an innovative and disseminable electronic health record (iEHR)-based approach that supports optimal primary care workflows to routinely screen families for tobacco and e-cigarette use, address…
- Conditions
- Tobacco Smoking, Second Hand Tobacco Smoke, Smoking Cessation
- Trial name
- eCEASE (NCT04974736)
- Testing
- iEHR + Navigator
- Where
- United States
- Volunteers
- 817 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pediatric Obesity
Pediatric Healthy Weight Clinic
The overall goal of this study is to increase access to and adoption of the Healthy Weight Clinic package in primary care settings serving low income families in the United States who have a disproportionately high prevalence of…
- Trial name
- CORD (NCT05020314)
- Testing
- Healthy Weight Clinic
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Massachusetts General Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.