Clinical trials: sponsored by Massachusetts General Hospital
Carcinoma of the Anal Canal
Concurrent Chemoradiation + 5-FU + Mitomycin-C in Anal Carcinoma
This research study is a Pilot Study. Pilot studies are conducted to see if it is practical to do this type of research ona larger scale in the future.
- Trial name
- NCT01858025
- Testing
- Pencil Beam scanning Radiation, 5-fluorouracil, Mitomycin-C
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Massachusetts General Hospital
Neisseria Gonorrhoeae Infection, Chlamydia Trachomatis Infection
Outcomes From Point-of-Care Sexually Transmitted Infection (STI) Testing in an Urban Sexual Health Clinic: A Randomized Trial
The goal of this clinical trial is to learn about the impact of a point-of-care test for gonorrhea and chlamydia in people without symptoms who are seeking sexually transmitted infection testing.
- Trial name
- NCT07399873
- Testing
- Point-of-care assay for chlamydia and gonorrhea, Laboratory-based chlamydia and gonorrhea NAAT, CRISPR-based assay
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Young Onset Dementia
Addressing Emotional Distress in Dyads of Persons With a Young Onset Dementia (YOD) and Their Care-partners
The purpose of the present investigation is to test the efficacy of a virtual, brief (6 sessions) dyadic (patient and care-partner together) intervention to prevent chronic emotional distress in dyads where one person is…
- Trial name
- NCT07018726
- Testing
- Resilient Together-YOD, Health Enhancement Program-YOD
- Where
- United States
- Volunteers
- 388 people
- Sponsor
- Massachusetts General Hospital
Aging, Preventive Care
Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2
This study consists of three aims focused on examining the feasibility of adding the Geriatric Resources and Assessment for the Care of Elders (GRACE) model to structured Annual Wellness Visits (AWVs) to improve patient and…
- Conditions
- Aging, Preventive Care, Multimorbidity, Palliative Care
- Trial name
- SPIRE2 (NCT07166861)
- Testing
- Annual Wellness Visit, Annual Wellness Visits + Geriatric Resources and Assessment for the Care of Elders (AWV + GRACE)
- Where
- 4 sites in United States
- Volunteers
- 7,140 people
- Sponsor
- Massachusetts General Hospital
Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission
Ziftomenib Maintenance Post Allo-HCT
The purpose of this study is to test the safety, effects, and recommended dose of an investigational drug, ziftomenib, in addition to the standard treatment on blood cancer with Allogeneic Hematopoietic Cell Transplantation…
- Conditions
- Acute Myeloid Leukemia, Acute Myeloid Leukemia in Remission, NPM1 Mutation, KMT2A Rearrangement
- Trial name
- NCT06440135
- Testing
- Ziftomenib
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Massachusetts General Hospital
Skin Aging
Randomized Trial of Combination Treatment With Sofwave and Sculptra
Evaluation of treatment on the upper arm with Sculptra and Sofwave on the same day versus Sofwave followed by Sculptra 1 month later.
- Trial name
- NCT07342452
- Testing
- Sofwave, Sculptra
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anxiety Disorders
Online Parent Education for Child Anxiety
The investigators are doing this research to test whether parents of children ages 2-7 can better manage their child's anxiety by completing a brief, online, self-guided parent education program.
- Trial name
- NCT07153250
- Testing
- Project EMPOWER, Being Brave Parent Education, Sharing Feelings
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
IDH1 Mutation, Acute Myeloid Leukemia (AML)
Ivosidenib as Post-HSCT Maintenance for AML
This is a Phase 2 study of the study drug, ivosidenib (a mutant IDH1 inhibitor), compared to placebo, given to patients with IDH1-mutant acute myeloid leukemia (AML) after hematopoietic stem cell transplantation (HCT).
- Conditions
- IDH1 Mutation, Acute Myeloid Leukemia (AML), Hematopoietic Stem Cell Transplant (HSCT)
- Trial name
- NCT06707493
- Testing
- Ivosidenib
- Where
- 7 sites in United States
- Volunteers
- 75 people
- Sponsor
- Massachusetts General Hospital
Pediatric Patients Treated With Radiation Therapy
Proton and Photon Consortium Registry (PPCR): A Multi Center Registry of Pediatric Patients Treated With Radiation Therapy
In previous studies, Proton Beam Radiation Therapy (PBRT) has been found to show better results in treating patients with cancer, both because there is better control of where in the body the radiation is directed and because it…
- Trial name
- NCT01696721
- Testing
- No intervention
- Where
- 26 sites in United States, Australia and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Massachusetts General Hospital
Cancer, Survivorship
A Dyadic Intervention for Young Adult Patients With Cancer and Their Partner Caregivers
The purpose of this pilot study is to examine the feasibility and acceptability of a brief psychotherapy intervention to improve psychosocial coping and maintain couple relationships among young adults (aged 25-39) with cancer…
- Conditions
- Cancer, Survivorship, Caregiver Burden, Psychological Distress
- Trial name
- YAD (NCT06172907)
- Testing
- Young Adults Coping with Cancer Together Intervention
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Acute Respiratory Distress Syndrome, Ventilation Perfusion Mismatch
Vascular ARDS Recruitment After Inhaled Nitric Oxide
Acute respiratory distress syndrome (ARDS) is when a person's lungs become inflamed, which can be caused by infection, trauma, surgery, blood transfusion, or burn.
- Trial name
- NCT05801224
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Barrett's Esophagus
Surveillance and Image-Guided Biopsy of the Esophagus Using an OFDI Capsule
The purpose of this research is to test the feasibility, sensitivity, and specificity of the marking Optical Frequency Domain Imaging (OFDI) capsule for diagnosing Barrett's Esophagus (BE).
- Trial name
- NCT02422433
- Testing
- OFDI Capsule Marking
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Massachusetts General Hospital
Gastrointestinal Disease
Pilot Study for Evaluation of Cryobiopsy and Correlation With Standard Forceps Biopsy
Environmental enteric dysfunction (EED) is a poorly understood condition characterized by intestinal inflammation and loss of barrier function that is prevalent in regions of the world with inadequate sanitation and hygiene.
- Trial name
- NCT03566160
- Testing
- Cryobiopsy probe, administered to study participants
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Crohn Disease, Inflammatory Bowel Diseases
Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance
The goal of this research is to learn how a new device called the wireless thermal capsule (WTC) can collect thermal data to help see diseases that happen in the gastrointestinal (GI) tract, such as Crohn's Disease.
- Conditions
- Crohn Disease, Inflammatory Bowel Diseases, Healthy
- Trial name
- NCT07033208
- Testing
- Feasibility to obtain thermal variance measurements using a wireless thermal capsule
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Barrett Esophagus, Barretts Esophagus With Dysplasia
Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy
The goal of this research is to determine the natural history of Barrett's esophagus (BE) using tethered capsule endomicroscopy (TCE) in participants undergoing surveillance endoscopy.
- Trial name
- NCT02994693
- Testing
- OFDI capsule imaging
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Barrett Esophagus
Coordinating Center: Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy
The goal of this research is to follow Barrett's Esophagus participants for 3 years using the tethered capsule endomicroscopy device with distal scanning and a compact imaging system in a multi-site clinical study.
- Trial name
- NCT03459339
- Testing
- Tethered Capsule Endomicroscopy (TCE)
- Where
- 5 sites in United States
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Epithelial Ovarian Carcinoma, Pancreas Adenocarcinoma
Genetic Testing Decision Aid
This is a randomized trial to evaluate the effectiveness of an electronic decision aid tool versus a traditional genetic counselor session for multi-gene panel testing for people with ovarian or pancreatic cancer
- Trial name
- NCT05470920
- Testing
- Electronic Decision Aid, Pre-Test Genetic Counseling
- Where
- 2 sites in United States
- Volunteers
- 297 people
- Sponsor
- Massachusetts General Hospital
Inflammatory Disease, Permeability; Increased
Feasibility Study to Assess a Trans-nasal Intestinal Potential Difference Probe
The purpose of this study is to examine the feasibility of using a trans-nasal IPD probe as a measurement tool for gut permeability
- Conditions
- Inflammatory Disease, Permeability; Increased, Crohn Disease, Inflammatory Bowel Diseases
- Trial name
- NCT04565821
- Testing
- IPD Probe via TNIT
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Eosinophilic Esophagitis
Using Spectrally Encoded Confocal Microscopy (SECM) to Image the Esophagus
The goal of this study is to test the feasibility and the tolerability of a tethered spectrally encoded confocal microscopy (SECM) capsule and to use it to image the esophagus.
- Trial name
- NCT02202590
- Testing
- SECM Capsule
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Venetoclax-Obinutuzumab +/- Acalabrutinib in R/R CLL
This research study is studying a combination of drugs as a possible treatment for chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
- Trial name
- NCT04560322
- Testing
- Venetoclax, Obinutuzumab, Acalabrutinib
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
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