Clinical trials: active, sponsored by Massachusetts General Hospital
Pregnant Women, Psychotropic Drugs
National Pregnancy Registry for Psychiatric Medications
The National Pregnancy Registry for Psychiatric Medications is dedicated to evaluating the safety of psychiatric medications such as antidepressants, ADHD medications, sedative hypnotics, and atypical antipsychotics that many…
- Trial name
- NCT01246765
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gout
Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout
The TRUST study is a randomized, controlled multicenter study to evaluate the management of gout by comparing two commonly used treatment strategies for gout (TTT vs TTASx) to determine the most beneficial for a patient-centered…
- Trial name
- TRUST (NCT04875702)
- Testing
- Allopurinol, Naproxen 250 MG, Colchicine 0.6 mg
- Where
- 7 sites in United States
- Volunteers
- 650 people
- Sponsor
- Massachusetts General Hospital
Ankle Fractures, Syndesmotic Injury
Biodegradable Magnesium Screws for Unstable Ankle Fracture Surgery
Ankle fractures are among the most common injuries that need surgery. When the broken bones make the ankle unstable, surgeons usually fix them with metal screws and plates.
- Trial name
- NCT07693933
- Testing
- RemeOs Magnesium-Based Biodegradable Screw
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Thrombosis, Arterial Occlusive Diseases
Thromboelastography With Platelet Mapping to Guide Antiplatelet Therapy After Lower Extremity Revascularization
The goal of this clinical trial is to learn if a blood clotting test called thromboelastography with platelet mapping (TEG-PM) can guide blood-thinning medication decisions in adults more than 60 years and older with peripheral…
- Conditions
- Thrombosis, Arterial Occlusive Diseases, Thromboelastography (TEG), Peripheral Arterial Disease(PAD)
- Trial name
- TARGET (NCT07597239)
- Testing
- Aspirin, Clopidogrel, Ticagrelor
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Massachusetts General Hospital
Advanced Lung Cancer, Dyspnea
Multi-site Trial of a Brief Behavioral Intervention for Dyspnea in Patients With Advanced Lung Cancer
Dyspnea, or breathlessness, is one of the most common and distressing symptoms experienced by patients with advanced lung cancer.
- Trial name
- BREEZE+ (NCT06791057)
- Testing
- Dyspnea Intervention, Enhanced Usual Care
- Where
- 2 sites in United States
- Volunteers
- 420 people
- Sponsor
- Massachusetts General Hospital
Liver Disease Chronic, End Stage Liver DIsease
LiverPAL: A Trial of Inpatient Palliative Care for Patients With Advanced Liver Disease
The goal of this clinical trial is to evaluate whether early integration of palliative care in the care of hospitalized patients with advanced liver disease (AdvLD) can improve patients' quality of life, physical symptoms, mood…
- Conditions
- Liver Disease Chronic, End Stage Liver DIsease, Cirrhosis, Cirrhosis, Liver
- Trial name
- LiverPAL (NCT05998330)
- Testing
- LiverPAL
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Massachusetts General Hospital
Obesity, Adolescent, Oxytocin
Oxytocin for Weight Loss in Adolescents
This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin in youths with obesity, ages 10-18 years old.
- Trial name
- NCT04551482
- Testing
- Oxytocin nasal spray
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Massachusetts General Hospital
Postmenopausal Osteoporosis
Romosozumab and Denosumab Combination Therapy for Osteoporosis
In this research study, the investigators want to learn more about the effect of two different FDA-approved medications in the treatment of osteoporosis.
- Trial name
- NCT07909304
- Testing
- Romosozumab, Romosozumab and Denosumab
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Myotonic Dystrophy Type 1
Metabolomic Biomarkers of Myotonic Dystrophy
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies.
- Trial name
- NCT07912983
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Fibromyalgia
Toward Biomarker-Guided Fibromyalgia Treatment With Non-Invasive Vagus Nerve Stimulation
Fibromyalgia is a syndrome with clinical symptoms that affect multiple systems of the body. Although basic science research and clinical research trials have been carried out, the cause and the mechanism of fibromyalgia are still…
- Trial name
- R61VNS (NCT07904351)
- Testing
- Transcutaneous Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Massachusetts General Hospital
Celiac Disease
Celiac Disease Genomic Environmental Microbiome and Metabolomic Study
Celiac disease (CD) is a complex disease caused by eating gluten, a protein contained in wheat, rye, and barley. It is well known that many factors contribute to the development of CD, including the genes that you have and the…
- Trial name
- CDGEMM (NCT02061306)
- Where
- 2 sites in United States, Italy
- Volunteers
- 500 people
- Sponsor
- Massachusetts General Hospital
Cardiac Surgery
Randomized Evaluation of Operating Room Extubation After Cardiac Surgery
We are studying whether waking patients up and removing the breathing tube (also known as "extubation") in the operating room after cardiac surgery improves postoperative recovery without causing harm.
- Trial name
- NCT07757880
- Testing
- OR extubation, ICU extubation
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Collagenous Gastritis
Vedolizumab for the Treatment of Collagenous Gastritis
The goal of this clinical trial is to learn about how vedolizumab may affect patients with collagenous gastritis (CG). The main questions it aims to answer are: Whether vedolizumab can reduce CG symptoms Whether vedolizumab is…
- Trial name
- NCT06317220
- Testing
- Vedolizumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Melanoma Stage III, Melanoma Stage IV
Infliximab for Treatment of Immune Checkpoint Inhibitor Colitis
The goal of this clinical trial is to compare the safety and effectiveness of infliximab compared to steroids for the treatment of immune checkpoint inhibitor-induced colitis (ICI colitis) in patients with stage III/IV skin…
- Conditions
- Melanoma Stage III, Melanoma Stage IV, Skin Cancer Stage III, Skin Cancer Stage IV
- Trial name
- NCT04305145
- Testing
- Infliximab, Methylprednisolone, Prednisone
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Massachusetts General Hospital
Myotonic Dystrophy, Duchenne Muscular Dystrophy
Biomarker Development for Muscular Dystrophies
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies.
- Conditions
- Myotonic Dystrophy, Duchenne Muscular Dystrophy, Becker Muscular Dystrophy, Facioscapulohumeral Muscular Dystrophy
- Trial name
- NCT05019625
- Where
- 5 sites in United States
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Duchenne Muscular Dystrophy
Extracellular RNA Biomarkers of Duchenne Muscular Dystrophy
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies.
- Trial name
- NCT05016908
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Myotonic Dystrophy
Extracellular RNA Biomarkers of Myotonic Dystrophy
Current methods of measuring the response to new treatments for muscular dystrophies involve the examination of small pieces of muscle tissue called biopsies.
- Trial name
- NCT05020002
- Where
- 3 sites in United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Myotonic Dystrophy Type 1
Cerebrospinal Fluid Biomarkers of Myotonic Dystrophy
Myotonic dystrophy is associated with central sleep apnea, excessive daytime sleepiness, diminished working memory, impaired visuospatial skills, and deficits in problem-solving skills.
- Trial name
- NCT06075693
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Massachusetts General Hospital
Germ Cell Tumor, Central Nervous System Germ Cell Tumor
Proton Beam Radiation Therapy for Central Nervous System (CNS) Germ Cell Tumors
The purpose of this research study is to determine if radiation using proton beam therapy will kill the germ cell tumor in the participant's central nervous system.
- Trial name
- NCT01049230
- Testing
- Proton Beam radiation
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Epilepsy
PET/MRI/EEG Imaging Study in Epilepsy
This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy.
- Trial name
- NCT06974305
- Testing
- FDG-PET/fMRI/EEG imaging
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital