Clinical trials: sponsored by McMaster University
Secondary Hyperparathyroidism, Tertiary Hyperparathyroidism
Intraoperative Parathyroid Hormone Monitoring to Guide Surgery in Renal hyperparathyroIdism
The goal of this pilot clinical is to determine the feasibility of a fully powered clinical trial to determine the effectiveness of intraoperative parathyroid hormone (IOPTH) criteria in guiding surgery for secondary and tertiary…
- Trial name
- PEREGRINE (NCT06542315)
- Testing
- Intraoperative parathyroid hormone (IOPTH) monitoring
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Microbiota
Gut Microbiota in Chronic GI Diseases
The study involves characterizing the microbiota of patients with IBS, functional diarrhea, IBD, severe motility disorders and celiac disease.
- Trial name
- ChronicGI (NCT06532110)
- Testing
- Endoscopy/Colonoscopy
- Where
- Canada
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- McMaster University
Ventral Hernia
Negative Pressure Incisional Wound Therapy for High-risk Ventral Hernia Repair
The investigators are testing the ability of vacuum dressings to improve wound healing for patients having large hernias surgically repaired who are at risk of having wound complications.
- Trial name
- N-PITH (NCT04455724)
- Testing
- Negative pressure incisional wound therapy, Standard sterile dressing
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- McMaster University
Trigger Finger
Function and Scar in Trigger Finger Release
Trigger finger is a common upper limb impairment associated with a significant decrease in quality of life, hand dexterity and strength as well as increased pain while complying daily activities of living.
- Trial name
- NCT05477290
- Testing
- Trigger Finger Release through Transverse Incision, Trigger Finger Release through Oblique Incision, Trigger Finger Release through Vertical Incision
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- McMaster University
Healthy
Supplementation of a Leucine-Enriched Dairy Protein Blend
It is well known that dietary protein is a powerful transient stimulator of the muscle protein synthetic rate (MPS) whereby changes in MPS in response to feeding may be regulated by specific downstream target proteins of…
- Trial name
- NCT03712761
- Testing
- Enriched Protein®
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McMaster University
Dietary Modification, Diet Habit
Supplementation of a Leucine-enriched Protein Blend
It is well known that dietary protein transiently stimulates muscle protein synthesis (MPS) whereby changes in MPS in response to feeding may be regulated by specific downstream target proteins of mammalian target of rapamycin…
- Trial name
- NCT03796897
- Testing
- Leucine-enriched protein, Habitual diet only
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- McMaster University
Fractures or Dislocations
INternational ORthopaedic MUlticenter Study in Fracture Care (INORMUS)
Background: Worldwide, injuries from trauma represent a major public health problem. The World Health Organization (WHO) has deemed this problem as one of the most important global priorities, calling 2011-2020 the 'Decade of…
- Trial name
- INORMUS (NCT02150980)
- Where
- 69 sites in Argentina, Botswana and 24 more
- Volunteers
- 39,797 people
- Sponsor
- McMaster University
Dementia Alzheimers
Accelerated Intermittent Theta-burst Stimulation to Modify Cognitive Function and Balance in Dementia and Memory Loss
The process of aging is accompanied by normal deterioration of body systems, leading to a decline in various functional domains including cognitive, visual, vestibular, somatosensory, and motor function.
- Trial name
- NCT06445894
- Testing
- Active Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McMaster University
Spinal Reflex Excitability, Balance
Effects of EMG-Biofeedback Balance Training on Hoffman's Reflex
The purpose of this study is to gain a further understanding of the effects of EMG-biofeedback balance training and we will be analyzing changes in spinal reflex excitability by responses from the calve muscles and data about…
- Trial name
- NCT06418503
- Testing
- Balance Training, EMG-Biofeedback Training
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- McMaster University
Asthma, Chronic Obstructive Pulmonary Disease
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease
This is a single centre exploratory study that aims to apply hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) methods and measurements in individual patients with and without lung disease to better understand…
- Conditions
- Asthma, Chronic Obstructive Pulmonary Disease, Bronchiectasis, Emphysema
- Trial name
- NCT03455686
- Testing
- Hyperpolarized 129Xe MRI
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mild Asthma
Measurements of Inflammation Induced by Allergen Inhalation Challenge in Mild Allergic Asthma
This study will measure lung function tests and examine biological samples collected before and after inhaled allergen challenges and diluent (control) challenges in participants with mild allergic asthma.
- Trial name
- MATT (NCT06411886)
- Testing
- Allergen challenge, Saline challenge
- Where
- 2 sites in Canada
- Volunteers
- 12 people
- Sponsor
- McMaster University
Identification of Home Fall Hazards
Comparison of Home-based Video, Paper/Print Checklist and Professional Home Assessment in Detection of Fall Hazards at Home
The purpose of this study is to assess the feasibility and potential impact of video analysis of footage taken with a GoPro camera video in comparison to a homeowner checklist or gold standard home assessment as a means of…
- Trial name
- NCT02775604
- Testing
- Video based/Therapists' rating of comprehensive-home-fall-hazard-checklist (vt-CHFHC), Paper based/Patient self-rating of comprehensive-home-fall-hazard-checklist (pp-CHFHC)
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mobility Limitation, Health Related Quality of Life
A Community-based Program That Supports Physical Activity, Healthy Eating, Social Participation and System Navigation in Older Adults
Physical mobility and social participation are needed to maintain independence and quality of life for adults over 55 years of age.
- Conditions
- Mobility Limitation, Health Related Quality of Life, Healthy Aging, Health Inequity
- Trial name
- EMBOLDEN (NCT05008159)
- Testing
- 3 month community-based mobility and health intervention
- Where
- 2 sites in Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- McMaster University
Palliative Care
Building CAPACITI for Community-Based Palliative Care
The purpose of this cluster randomized controlled trial is to assess the efficacy of a quality improvement intervention called CAPACITI intended to increase competency among primary care teams to deliver early palliative care.
- Trial name
- CAPACITI (NCT05120154)
- Testing
- Online educational materials, Facilitated online webinars
- Where
- Canada
- Volunteers
- 566 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postpartum Depression
Online Peer-Delivered Group CBT for PPD
Mothers and birthing parents (hereafter referred to as mothers) who have recovered from Postpartum Depression and are well now, receive training to teach a 9 week Cognitive Behavioural Therapy (CBT) treatment to mothers who are…
- Trial name
- NCT05044455
- Testing
- Cognitive Behavioural Therapy (CBT)
- Where
- Canada
- Volunteers
- 191 people
- Sponsor
- McMaster University
Pregnancy Related
How do Perceptions of Coronavirus Disease (COVID-19) Risk Influence Health Decisions in Pregnancy?
Pregnant people have a higher risk of severe COVID-19 disease. Pregnant people have been disproportionately impacted by COVID-19 infection control policies, which have resulted in higher rates of intimate partner violence, mental…
- Trial name
- NCT05663762
- Where
- 2 sites in Canada
- Volunteers
- 136,500 people, healthy volunteers welcome
- Sponsor
- McMaster University
Celiac Disease, Gluten Sensitivity
RCT: Effect of Late vs Early Introduction of Gluten-free Oats on Patients With Newly Diagnosed Celiac Disease.
The investigators are conducting a pilot study to investigate the impact of late compared to early introduction of gluten-free oats on gut symptoms, nutrition status, celiac activity and quality of life in patients with a recent…
- Conditions
- Celiac Disease, Gluten Sensitivity, Gluten Allergy, Gluten Enteropathy
- Trial name
- NCT05803408
- Testing
- gluten-free oats
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Gastro Intestinal Bleeding, Patient Engagement
Patient Important Gastrointestinal Bleeding in the ICU
This study will engage patients and families to create a definition of what matters most to them about upper gastrointestinal (GI) bleeding.
- Conditions
- Gastro Intestinal Bleeding, Patient Engagement, Family Members
- Trial name
- PIB (NCT05506150)
- Testing
- Interviews
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- McMaster University
Benign Paroxysmal Positional Vertigo
Canalith Repositioning Procedure for BPPV in Primary Care
The purpose of this study is to see whether family doctors can treat benign paroxysmal positional vertigo (BPPV), or dizziness, using a procedure in the office.
- Trial name
- NCT00182273
- Testing
- Canalith repositioning maneuver (CRM)
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Neck Pain
Augmented Reality Sensorimotor Training to Treat Chronic Neck
The goal of this research is to investigate whether 2-4 weeks of augmented reality sensorimotor training induces positive changes so as to effect pain relief in patients with chronic neck pain.
- Trial name
- NCT05880511
- Testing
- Repetitive transcranial magnetic stimulation, Augmented Reality Sensorimotor Training
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University