Clinical trials: sponsored by McMaster University
Knee Arthroplasty, Total, Partial Knee Arthroplasty
Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee
Knee replacements are the second most common surgery in Canada. Most patients recover very well but research consistently shows that 1 in 5 patients still have pain many months after surgery.
- Conditions
- Knee Arthroplasty, Total, Partial Knee Arthroplasty, Chronic Pain, Postoperative, Osteoarthritis (OA) of the Knee
- Trial name
- OREOS-K (NCT07895472)
- Testing
- Standard care, Multicomponent opioid reduction and pain management pathway
- Volunteers
- 170 people
- Sponsor
- McMaster University
Cancer
Partner4Exercise Study
Background: As Canada's population ages, the number of older adults facing cancer is on the rise. By 2030, 23% of Canadians will be over 65, and two in five will be diagnosed with cancer in their lifetime.
- Trial name
- P4E RCT (NCT07408128)
- Testing
- Peer matching, Quailfied Exercise Professional (QEP) Support
- Where
- Canada
- Volunteers
- 183 people
- Sponsor
- McMaster University
Obesity (Disorder)
Mechanisms of Weight Loss: Tirzepatide vs Semaglutide
The goal of this clinical trial is to determine if there are differences in the effect of 12 weeks of tirzepatide versus semaglutide on energy balance in adults with obesity and without known diabetes.
- Trial name
- JOULE3 (NCT07900074)
- Testing
- Tirzepatide, Semaglutide
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Glucose Homeostasis
Postprandial Glucose Handing in Contraceptive and IUD Users
Goals: The long-term use of hormonal birth control has been shown to effect glucose handling, or blood sugar regulation, and potentially lead to insulin resistance which increases a person's risk for metabolic diseases such as…
- Trial name
- HCPG (NCT07169591)
- Testing
- Oral Glucose Tolerance test (75g 2-hour)
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Ketamine Sedation in the ICU (KANINE) RCT
Sedation is given to intensive care unit (ICU) patients to treat discomfort, anxiety, agitation, and to help facilitate care, particularly when they require a breathing tube.
- Trial name
- KANINE (NCT06767358)
- Testing
- ketamine hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 54 people
- Sponsor
- McMaster University
Knee Osteoarthritis
Cannabinoids vs. Placebo on Persistent Post-surgical Pain Following TKA: A Pilot RCT
Each year, approximately 75,000 Canadians undergo knee replacement surgery, and up to 25% develop persistent post-surgical pain.
- Trial name
- NCT03825965
- Testing
- MPL-001 (CBD: THC 25:1)
- Where
- 2 sites in Canada
- Volunteers
- 39 people
- Sponsor
- McMaster University
Diabetic Macular Edema
Mean Visual Acuity Changes Following Five Injections of Aflibercept
Diabetic Macular Edema is a serious ocular consequence of poorly controlled diabetes. Even though significant research has been done to clarify the pathogenesis of DME, a clear causal pathway of the complication is of yet…
- Trial name
- NCT02645266
- Testing
- Aflibercept Injection [Eylea]
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cough, Refractory Chronic Cough
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough
The FORTITUDE trial will provide head-to-head evidence on the benefits and harms of two commonly prescribed neuromodulators (low-dose morphine and pregabalin), the effectiveness of a virtual cough control therapy, exploratory…
- Conditions
- Cough, Refractory Chronic Cough, Unexplained Chronic Cough, Cough Hypersensitivity Syndrome
- Trial name
- FORTITUDE (NCT07288528)
- Testing
- Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin
- Where
- 5 sites in Canada
- Volunteers
- 124 people
- Sponsor
- McMaster University
Cancer
The IMPACT Implementation-Effectiveness Trial
More Canadians are surviving cancer, however, individuals with cancer live with side effects for years after treatments have ended.
- Trial name
- IMPACT (NCT06323707)
- Testing
- Exercise, Self-management e-module
- Where
- 3 sites in Canada
- Volunteers
- 129 people
- Sponsor
- McMaster University
Type 2 Diabetes, Mental Health
Technology-Enabled Collaborative Care for Diabetes and Mental Health
Managing both type 2 diabetes and mental health challenges can be difficult, and many people do not receive care that supports both.
- Conditions
- Type 2 Diabetes, Mental Health, Diabetes Distress
- Trial name
- TECC-DM (NCT07181863)
- Testing
- Health coaching, Educational emails
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- McMaster University
Female, Premenopausal
The Influence of Plan B® on Cardiovascular Health.
The goal of this double-blind randomized controlled trial is to learn about the impacts of a single dose of Plan B® on the cardiovascular system in young, health, premenopausal females.
- Trial name
- LEVOH (NCT07759635)
- Testing
- Plan B (Levonorgestrel)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Disease, Aging
Compassionate Communities Neighbourhood Program
This study will evaluate a Compassionate Communities-based intervention aimed at reducing social isolation by mobilizing individuals to act on their health and social needs individually, and in collaboration with fellow members…
- Trial name
- WECCC-NHB (NCT03634163)
- Testing
- Neighbourhood exchange, Quality of Life Assessment
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Back Pain
The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study
The investigators will conduct a pilot cluster randomized controlled trial (RCT) of chiropractic care added to usual medical care, versus usual medical care alone, for adult patients prescribed opioid therapy for chronic…
- Trial name
- ACCESS-DC (NCT06160947)
- Testing
- Usual Medical Care, Usual Medical Care + Chiropractic Care
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Irritable Bowel Syndrome (IBS)
Personalized Probiotic Treatments for Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is characterized by stomach pain and altered bowel habits. It affects about 5 million people in Canada. Doctors don't fully understand what causes IBS, so treatments often don't work well.
- Trial name
- NCT07872514
- Testing
- Probiotic containing B longum, Probiotic Lactobacillus
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Inflammatory Bowel Disease
Investigating Serotonin Signalling in IBD Patients
Alterations in normal serotonin (5-hydroxytryptamine;5-HT) signaling have been reported in ulcerative colitis (UC) and Crohn's disease (CD).
- Trial name
- IBD (NCT01650311)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Stroke, Stroke (CVA) or Transient Ischemic Attack
Optimized Recruitment to Drive Equitable Research in Stroke, Empowering Decision-making (ORDERed)
Stroke is a major health issue, especially for women, who are more likely than men to have worse outcomes and lower quality of life after a stroke.
- Trial name
- ORDERed (NCT07576647)
- Testing
- Supported, women-centred and aphasia-friendly recruitment process (ORDERed), Traditional recruitment processes (TRADITIONAL)
- Where
- 3 sites in Canada
- Volunteers
- 1,600 people
- Sponsor
- McMaster University
Intensive Care Unit Acquired Weakness, Critical Care
CYCLE: A Randomized Clinical Trial of Early In-bed Cycling for Mechanically Ventilated Patients
Patients who survive critical illness usually experience long-lasting physical and psychological impairments, which are often debilitating. Rehabilitation interventions started in the ICU may reduce this morbidity.
- Conditions
- Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
- Trial name
- CYCLE (NCT03471247)
- Testing
- In-Bed Cycle Ergometer, Routine PT
- Where
- 16 sites in United States, Australia and 1 more
- Volunteers
- 363 people
- Sponsor
- McMaster University
Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC)
Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis
This clinical trial tests if oral vancomycin can safely treat active ulcerative colitis (UC) in adults who also have primary sclerosing cholangitis (PSC), a liver condition.
- Trial name
- DRIVE-UP (NCT07341282)
- Testing
- Vancomycin (blinded), Vancomycin (open-label extension)
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- McMaster University
Sacro-iliac Joint Pain
Ketorolac Versus Corticosteroid Injections for Sacroiliac Joint Pain
This study will contribute to the current literature that have compared joint injections with steroid versus ketorolac providing evidence for the use of ketorolac for SI joint pain.
- Trial name
- NCT06081101
- Testing
- Methylprednisolone Injection, Ketorolac Injection
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Myelodysplastic Syndrome
Revisiting the Universal Donor: Does Exposure to O Blood Products Affect Patient Outcomes?
In a recent analysis of a large transfusion database (Transfusion Research Utilization, Surveillance and Tracking database [TRUST]), the investigators found that the transfusion of ABO non-identical RBCs to group A individual was…
- Trial name
- UD (NCT04859218)
- Testing
- RBC transfusion
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- McMaster University