Clinical trials: sponsored by McMaster University
Gastro Intestinal Bleeding, Patient Engagement
Patient Important Gastrointestinal Bleeding in the ICU
This study will engage patients and families to create a definition of what matters most to them about upper gastrointestinal (GI) bleeding.
- Conditions
- Gastro Intestinal Bleeding, Patient Engagement, Family Members
- Trial name
- PIB (NCT05506150)
- Testing
- Interviews
- Where
- Canada
- Volunteers
- 51 people
- Sponsor
- McMaster University
Arthritis, Health Related Quality of Life
A Case Series Comparing T+LRTI to Partial Trapeziectomy for Thumb Osteoarthritis
The purpose of this study was to measure the differences in Health Related Quality of Life (HRQOL) and functional measurements between two groups of patients with Carpometacarpal Osteoarthritis of the thumb.
- Conditions
- Arthritis, Health Related Quality of Life, Osteoarthritis
- Trial name
- NCT03392454
- Testing
- T+LRTI, PT+TI
- Volunteers
- 20 people
- Sponsor
- McMaster University
Asthma
Effect of Sex Hormone During the Menstrual Cycle on Capsaicin Evoked Cough Responses
The study aim is to investigate if changes in sex hormones during the menstrual cycle affects cough sensitivity in females and males with mild allergic asthma.
- Trial name
- CASH (NCT04233762)
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- McMaster University
Sarcopenia
Mixed Exercise Training and Novel Multi-Nutrient Supplementation in Young Adults
This study aims to elucidate the effects of 12 weeks of novel multi-nutrient supplementation combined with mixed aerobic/resistance exercise training on skeletal muscle function in young adults.
- Trial name
- NCT06231069
- Testing
- Multi-nutrient supplement, Exercise
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Asthma; Eosinophilic
Efficacy of Reslizumab Dose Escalation in Patients With Severe Asthma
Dose escalation of reslizumab can ameliorate sputum eosinophilia in severe asthmatics who have persistent sputum eosinophilia despite treatment with reslizumab at the standard dose.
- Trial name
- NCT04710134
- Testing
- Reslizumab
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
Hip Fractures
HIP Fracture Accelerated Surgical TreaTment And Care tracK (HIP ATTACK) Trial
HIP ATTACK is an international randomized controlled trial of 3000 patients with a hip fracture that requires a surgical intervention.
- Trial name
- HIP ATTACK (NCT02027896)
- Testing
- Accelerated medical clearance and surgery
- Where
- 69 sites in United States, Belgium and 15 more
- Volunteers
- 3,001 people
- Sponsor
- McMaster University
Women's Health, Brain Plasticity
Effects of Probiotics on Synaptic Plasticity During the Menstrual Cycle
Modulation of our gut microbiota through probiotics, can improve our emotional state, decrease pain sensitivity, improve cognitive processes, increase neurotransmitter levels and alter functional connectivity.
- Trial name
- NCT06213428
- Testing
- Progressive Perfect Probiotic
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Lung Cancer
Ventilation Heterogeneity Prior to Lung Resection
This is a single centre prospective six-week observational study to understand the prevalence and clinical relevance of abnormal ventilation of the lung (assessed by Technegas ventilation single photon emission computed…
- Trial name
- NCT04191174
- Testing
- Hyperpolarized 129Xe MRI, Technegas V SPECT, Sputum Induction
- Where
- Canada
- Volunteers
- 115 people
- Sponsor
- McMaster University
IBD, Venous Thromboembolism
Postoperative Extended Venous Thromboprophylaxis in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a relatively common disease that effects all age groups and carries significant morbidity and mortality.
- Conditions
- IBD, Venous Thromboembolism, Crohn Disease, Ulcerative Colitis
- Trial name
- EXPAND (NCT03935451)
- Testing
- Apixaban 2.5 milligram
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity, Non-Bariatric Surgery
PReoperative Very Low Energy Diets for Obese PAtients Undergoing Non-bariatric Surgery
The PREPARE Pilot randomized controlled trial (RCT) is a multi-center, parallel, blinded RCT that aims to assess the feasibility of a full RCT comparing preoperative very low energy diets (VLEDs) to standard of care prior to…
- Conditions
- Obesity, Non-Bariatric Surgery, Preoperative Weight Loss, Preoperative Optimization
- Trial name
- PREPARE (NCT05918471)
- Testing
- Very Low Energy Diet with Liquid Supplementation
- Where
- 4 sites in Canada
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- McMaster University
Rectal Cancer, Obesity
Preoperative Very Low Energy Diet for Obese Rectal Cancer Patients
This pilot study will aim to determine the feasibility, safety, and cost associated with a preoperative VLED for obese rectal cancer patients.
- Trial name
- NCT04379830
- Testing
- Very Low Energy Diet
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Peer Support, Injection-related Infections
The Injection-Related InfectionS (IRIS) Program
People who inject drugs are at risk of injection-related infections, like abscesses or infective endocarditis. The Injection-Related InfectionS (IRIS) program hopes to improve treatment for participants by providing a…
- Conditions
- Peer Support, Injection-related Infections, Infections, People Who Infect Drugs (PWID)
- Trial name
- IRIS (NCT06169553)
- Testing
- Holistic injection-related injection treatment
- Where
- 2 sites in Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Cerebrovascular Function, Cognition
Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity
People who report subjective memory complaints have a greater risk of developing dementia. Memory issues may be an early warning sign of dysfunctional cerebral glucose metabolism and cerebral blood flow.
- Trial name
- NCT05992571
- Testing
- β-OHB
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Myocardial Infarction, STEMI
A Smartphone APPlication for the Transmission of ECGs in the Management of Patients Presenting With Suspected Heart Attacks in the Hamilton, Niagara, Haldimand, and Brant Area
The delivery of timely and appropriate care is crucial for patients with heart attacks. Blocked arteries need immediate intervention to restore blood flow.
- Trial name
- NCT05290389
- Testing
- SMART AMI APPLICATION
- Where
- 17 sites in Canada
- Volunteers
- 260 people
- Sponsor
- McMaster University
Pompe Disease, Muscle Loss
Nutritional Therapy in Late-onset Pompe Disease
RATIONALE: Pompe disease (PD) is a recessive genetic disorder wherein the body cannot break down glycogen due to a mutation in the acid alpha glucosidase (GAA) gene, which encodes for acid alpha-glucosidase.
- Conditions
- Pompe Disease, Muscle Loss, Obesity, Nutrition Poor
- Trial name
- PDT-MIS (NCT06130228)
- Testing
- Multi-ingredient supplement (PDT-MIS)
- Volunteers
- 28 people
- Sponsor
- McMaster University
Heart Failure, Diastolic Dysfunction
Diastology-Guided Management of Decompensated Heart Failure
More than 30% of people hospitalized with decompensated heart failure return to the hospital within 90 days. Emerging evidence suggests that hemodynamic monitoring with guided management may enhance prognosis and management.
- Trial name
- DYNAMIC (NCT06131008)
- Testing
- Diastology, Diastology-Guided Diuresis, Usual Care
- Volunteers
- 30 people
- Sponsor
- McMaster University
Adult ADHD
Recollect the Game: A Novel Treatment for Executive Functioning Deficits in Adults With ADHD
Adults who have attention deficit hyperactivity disorder (ADHD) suffer from significant occupational, academic and social problems, many of which are believed to be a result of problems with executive functioning.
- Trial name
- NCT03437993
- Testing
- Recollect, the game, Tetris
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Attention Deficit Hyperactivity Disorder, Generalized Anxiety Disorder
A 14 Week, Randomized, Placebo-Controlled Cross-Over Study of Methylphenidate Hydrochloride Controlled Release Capsules in Adult ADHD With and Without Anxiety Disorder Comorbidity
Other psychiatric disorders, including anxiety, often co-occur with adult ADHD; with 85% of ADHD patients having at least one other psychiatric condition.
- Conditions
- Attention Deficit Hyperactivity Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT03785223
- Testing
- Methylphenidate Hydrochloride Controlled-Release Capsules
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Ulcerative Colitis Acute
Tofacitinib for Hospitalized Acute Severe Ulcerative Colitis Management
The TRIUMPH study was designed to build on the existing literature by studying the efficacy of tofacitinib in hospitalized patients with acute severe ulcerative colitis.
- Trial name
- TRIUMPH (NCT04925973)
- Testing
- Tofacitinib 10 MG [Xeljanz]
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Oxidative Stress, DNA Damage, Radiation Induced
Multi-Nutrient Supplement for Radio-Protection
Exposure to radiation, such as during routine CTs, bone scans, or X-rays, causes oxidative stress which can damage the DNA (your genetic material) within your white blood cells.
- Conditions
- Oxidative Stress, DNA Damage, Radiation Induced, Radiation Exposure
- Trial name
- MNSRP (NCT04781868)
- Testing
- Multi-nutrient supplement
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University