Clinical trials: sponsored by McMaster University
Celiac Disease, Nutrient Deficiency
Zinc Deficiency Treatment in Celiac Disease: Supplementation Versus Diet
Micronutrient deficiencies are common amongst celiac disease (CeD) patients due to consumption of a restrictive and nutritionally unbalanced gluten-free diet (GFD) in addition to slow intestinal villi healing.
- Trial name
- NCT05782257
- Testing
- Zinc Supplementation, Zn-Optimized Diet
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Hip Osteoarthritis, Knee Osteoarthritis
Fit-Joints: Getting Fit for Hip or Knee Replacement
Osteoarthritis leads to reduced independence and quality of life. Total hip replacement is a successful and cost-effective surgical intervention to relieve pain and improve functioning in patients with osteoarthritis.
- Trial name
- Fit-Joints (NCT02885337)
- Testing
- Multi-Modal Frailty Intervention, Usual Care
- Where
- 2 sites in Canada
- Volunteers
- 41 people
- Sponsor
- McMaster University
Hemophilia A, Hemophilia B
Personalized Medicine for Canadians With Hemophilia
Performing an individual pharmacokinetic (PK) estimate is only the first step in implementing tailored prophylaxis, which requires using the PK profile information to design a personalized treatment regimen matching the treatment…
- Trial name
- PMCH (NCT03615053)
- Testing
- Implementation of WAPPS-Hemo personalized dosing regimen
- Where
- 7 sites in Canada
- Volunteers
- 600 people
- Sponsor
- McMaster University
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Randomized Controlled Trial of Citizen-targeted Evidence-based Resources
The purpose of this study is to determine whether an online resource developed to aid health consumers in making health decisions and better support them to seek quality evidence before other evidence is effective in the context…
- Trial name
- NCT04693780
- Testing
- Structured guide, List
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- McMaster University
Death, Communication, Multidisciplinary
Preserving Compassionate End of Life Care in the Pandemic
Compassionate and humanistic care for patients dying in the hospital has been especially challenging during the pandemic. Family presence is restricted, maximal barrier precautions are advised, and personal protective equipment…
- Conditions
- Death, Communication, Multidisciplinary, Empathy, Compassion
- Trial name
- NCT04602520
- Testing
- 3 Wishes Project
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- McMaster University
Blood Transfusion
Pilot Study of Sex-matched vs. Sex-mismatched Red Blood Cell Transfusion
Blood transfusion is common for patients in hospital, especially for those in intensive care. Patients receive blood that is matched to them based on their blood group (A, B, AB, O), but not based on sex.
- Trial name
- NCT04814264
- Testing
- Red blood cells
- Where
- 5 sites in Canada
- Volunteers
- 270 people
- Sponsor
- McMaster University
Mild Cognitive Impairment
The Effects of Exercise on Synaptic Plasticity in Individuals With Mild Cognitive Impairment and in Healthy Aging.
The research is focused on ameliorating cognitive decline in aging and in individuals diagnosed with Mild Cognitive Impairment (MCI).
- Trial name
- NCT05663918
- Testing
- Self- determined Intensity Interval Training
- Where
- 6 sites in Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hypospadias
Caudal vs Local Anesthesia in Hypospadias
Hypospadias is one of the most common congenital malformations of the genitalia in boys, and is typically managed by surgical intervention.
- Trial name
- CLASH (NCT02512887)
- Testing
- Caudal Block Anesthesia, Dorsal Penile Block Anesthesia
- Where
- 4 sites in Canada
- Volunteers
- 224 people
- Sponsor
- McMaster University
Inguinal Surgery
Ibuprofen Compared to Morphine as a Pediatric Postoperative Pain Management Tool Following Inguinal Surgery
Morphine is now the most commonly used opioid in children for pain management even though the safety of morphine use in children is a primary concern for parents as it is perceived to have more associated risks.
- Trial name
- NCT02603848
- Testing
- Ibuprofen, Morphine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Hemophilia A, Hemophilia B
Web Accessible Population Pharmacokinetics Service - Hemophilia: Sources of Variability
Using anonymized patient data collected as part of the WAPPS-Hemo project to explore the sources of variability in individual pharmacokinetics (PK); use the sources of variability to improve the performance of the WAPPS-Hemo…
- Trial name
- WAPPS-Hemo (NCT03533504)
- Testing
- Variability in individual PK
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- McMaster University
Cardiovascular Diseases, Cardiovascular Risk Factor
Cardiovascular Health Awareness Program (CHAP) in Subsidized Social Housing
This project aims to improve the cardiovascular health of seniors living in subsidized housing by implementing the successful community-based Cardiovascular Health Awareness Program (CHAP).
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Diabetes Mellitus
- Trial name
- NCT03549845
- Testing
- Cardiovascular Health Awareness Program
- Where
- Canada
- Volunteers
- 2,742 people, healthy volunteers welcome
- Sponsor
- McMaster University
Multi-morbidity, Medication Therapy Management
Team Approach to Polypharmacy Evaluation and Reduction (Pharmacy)
In an aging population, most seniors suffer from multiple chronic conditions. When the number of medications taken is ≥5 (polypharmacy), the burden of taking multiple concurrent medications can do more harm than good.
- Conditions
- Multi-morbidity, Medication Therapy Management, Polypharmacy
- Trial name
- NCT03557944
- Testing
- Medication reduction
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Hypertrophy
D2O Dosing Strategies to Assess Muscle Protein Synthesis
Skeletal muscle mass is regulated by the balance of muscle protein synthesis (MPS) and muscle protein breakdown (MPB). MPS is sensitive to exogenous stimuli, particularly exercise and protein ingestion.
- Trial name
- D2O-MPS (NCT04256343)
- Testing
- Deuterium Oxide (D2O) Dose
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Aging
The Eggs and actiVity in hEalth agiNg Pilot (EVEN-P) Trial in Older Persons
Two of the most effective lifestyle-based approaches to reduce the risk of adverse health events and enhance quality of life with aging are exercise and a healthy diet.
- Trial name
- EVEN-P (NCT04264013)
- Testing
- Exercise, Exercise plus diet (egg)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Aging
OT Directed Services in Long-term Care in Ontario
In long-term care, staff provide help to residents with bathing, dressing, eating, walking, toileting, transferring, and moving in bed. Some residents can do more for themselves than others.
- Trial name
- OTLTC (NCT05527028)
- Testing
- Occupational Therapy Services
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postpartum Depression
1 Day Workshops for Preventing PPD: A Pilot Study
The aim of this pilot study is to (1) develop a treatment manual for a 1-Day CBT-Based Workshop for preventing postpartum depression that is acceptable to women; (2) recruit 15 women into a pilot workshop and seek their feedback…
- Trial name
- NCT05040581
- Testing
- 1-Day CBT-Based Workshop for Preventing PPD
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postpartum Depression
Online Peer-Delivered 1-Day CBT Workshops for PPD
A parallel group RCT with experimental (immediate workshop) and waitlist control (treatment 12 weeks later) groups will address our objectives.
- Trial name
- NCT04934488
- Testing
- Online Peer-Delivered 1-Day CBT-Based Workshop
- Where
- Canada
- Volunteers
- 404 people
- Sponsor
- McMaster University
Asthma, Allergic
Tezepelumab and Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma
Asthma is a condition where small inhaled particles can cause inflammation in the lung leading to constriction of airways and wheeze.
- Trial name
- NCT05740748
- Testing
- Tezepelumab
- Where
- 2 sites in Canada
- Volunteers
- 34 people
- Sponsor
- McMaster University
Generalized Anxiety Disorder, Social Anxiety Disorder
Cannabidiol for the Treatment of Anxiety Disorders: An 8-Week Pilot Study
This proposed study aims to evaluate the efficacy of daily Cannabidiol (CBD) Oil Capsules in treating symptoms of DSM-5 anxiety disorders, using a two-arm, 8-week randomized, placebo-controlled trial in adults aged 21-65 years.
- Conditions
- Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia
- Trial name
- NCT03549819
- Testing
- Cannabidiol (CBD) Oil Capsules, Sunflower Lecithin Oil in Capsule
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
COVID-19 Pandemic
Investigating Development of Autoimmunity in Post-Acute COVID-19 Syndrome (PACS)
The coronavirus pandemic has severely affected healthcare systems and changed life as everyone know it, globally. Apart from the acute phase disease complications, it is now apparent that a significant proportion (15%) of…
- Trial name
- NCT05459506
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- McMaster University