Clinical trials: sponsored by McMaster University
Cardiovascular Disease, Diabetes Mellitus
Community Paramedicine at Home
Community Paramedicine @Home (CP@Home) is a novel community paramedicine health assessment program for high users of Emergency Medical Services (EMS).
- Conditions
- Cardiovascular Disease, Diabetes Mellitus, Accidental Falls, Social Isolation
- Trial name
- CP@Home (NCT02835989)
- Testing
- CP@Home
- Where
- Canada
- Volunteers
- 2,826 people
- Sponsor
- McMaster University
Eating Disorders
A Virtual Parent-led Support Group for Parents of Children and Youth With Eating Disorders: A Mixed Methods Feasibility Study Examining Acceptability, Cost and Parent Outcomes
There is a gap in the literature about the feasibility and implementation of parent-led support groups for parents who have children or adolescents with eating disorders.
- Trial name
- NCT04686864
- Testing
- Support Group for Caregivers
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Eating Disorders, Eating Disorders in Adolescence
Assessing the Feasibility of an Intervention for Youth and Parents Transitioning to Adult Eating Disorder Services
Teenagers with eating disorders often experience a disruption in care upon turning 18. At this age, they are no longer eligible to receive pediatric treatment but are also not yet set up with the appropriate adult services.
- Trial name
- NCT04888273
- Testing
- Transition Intervention
- Where
- Canada
- Volunteers
- 19 people
- Sponsor
- McMaster University
Breast Reconstruction, Patient Education
Educational Session To Optimize Patient's Breast Reconstruction Experience at McMaster
This pilot study uses a randomized controlled trial design to introduce an educational session for breast reconstruction patients. Participants will be randomly assigned to the (1) control group or the (2) experimental group.
- Trial name
- RESTORE (NCT03743753)
- Testing
- Experimental
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Laryngeal Edema
Cuff Leak Test and Airway Obstruction in Mechanically Ventilated ICU
Introduction: Endotracheal intubation and mechanical ventilation are lifesaving interventions that are commonly done in the intensive care unit (ICU).
- Trial name
- COMIC (NCT03372707)
- Testing
- Cuff Leak Test
- Where
- 3 sites in Canada, Poland and 1 more
- Volunteers
- 100 people
- Sponsor
- McMaster University
Epiphora, Ptosis
Bupivacaine Epiphora Trial
The objective of this study is to investigate quantitative improvement in excessive tearing after administration of Bupivacaine, a local anesthetic, into the affected eyelids.
- Trial name
- NCT03266081
- Testing
- 0.75% bupivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Child
Post-exercise Protein Intake for Active Children
Today, there is an important lack of knowledge on the effects of dietary protein on protein metabolism after physical activity in children.
- Trial name
- NCT01598935
- Testing
- nutrition
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy Volunteer
OrthoEvidence Trial Assessing Japanese Knowledge Updates
The purpose of this randomized controlled trial is to clarify whether providing translated evidence summary (Advanced Clinical Evidence (ACE) reports from OrthoEvidence) will increase the access to the summary compared to…
- Trial name
- OTAKU (NCT05250622)
- Testing
- Japanese-translated evidence summaries (Advanced Clinical Evidence report from OrthoEvidence), English evidence summaries (Advanced Clinical Evidence report from OrthoEvidence)
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postpartum Depression
Online PHN CBT for PPD
The primary objective of this study is to determine if online group CBT for PPD delivered by public health nurses is superior to postnatal care as usual in: a) acutely treating PPD, b) reducing relapse and recurrence, c)…
- Trial name
- NCT04928742
- Testing
- Group Cognitive Behavioural Therapy (CBT)
- Where
- Canada
- Volunteers
- 159 people
- Sponsor
- McMaster University
Cubital Tunnel Syndrome
Health-Related Quality of Life in Cases of Cubital Tunnel Syndrome
This study aims to determine the Health Related Quality of life (HRQOL) (the physical, mental, emotional and social functioning) of patients with cubital tunnel syndrome following anterior intramuscular transposition, after one…
- Trial name
- NCT02995382
- Testing
- Anterior Intramuscular Transposition
- Sponsor
- McMaster University
Exercise
The Effect of Brief Bodyweight Exercise on Acute Glycemic Control in Healthy Inactive Adults
This study will investigate whether an 11-minute bodyweight exercise session can improve short-term glycemic control. Glycemic control refers to the process of how the body regulates blood sugar.
- Trial name
- NCT05144490
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- McMaster University
Mental Health Issue, Mental Stress
"OnCall": Implementation Study of M-Health for Canadian Public Safety Personnel
First Responders, or Public Safety Personnel (PSP), play a key role in protecting the health and safety of Canadians, yet this important work can take a toll on their mental health, leading to an elevated risk of post-traumatic…
- Conditions
- Mental Health Issue, Mental Stress, Post Traumatic Stress Disorder
- Trial name
- OnCall (NCT05255419)
- Testing
- OnCall mobile health peer support app
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cough
The Effects of Salbutamol on Mannitol Induced Cough Responses in Healthy Controls
The study aim is to investigate if changes in osmolarity using mannitol challenge can evoke coughing healthy controls with no evidence of bronchoconstriction (PC20>16mg/ml or mannitol PD15 > 635 mg, or < 10% incremental fall in…
- Trial name
- COMA (NCT04565847)
- Testing
- Salbutamol 5mg/mL, Sodium Chloride 0.9% Inhl 3Ml
- Where
- 2 sites in Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postpartum Depression
1-Day CBT Workshops for PPD
Postpartum depression (PPD) affects up to 20% of women and has profound effects on women and their families. Clinical practice guidelines recommend that the majority of women with PPD receive psychotherapy.
- Trial name
- NCT03654261
- Testing
- Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 461 people
- Sponsor
- McMaster University
Muscle Disuse Atrophy, Nutrition, Healthy
Effect of a Natural Source Supplementation on Muscle Mass
Periods of muscle disuse are commonly experienced in young and elderly individuals as a result of short-term hospitalization or leg casting after injury.
- Trial name
- NCT05369026
- Testing
- Single leg immobilization
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Septic Shock
SQUEEZE Trial: A Trial to Determine Whether Septic Shock Reversal is Quicker in Pediatric Patients Randomized to an Early Goal Directed Fluid Sparing Strategy vs. Usual Care
The purpose of the SQUEEZE Trial is to determine which fluid resuscitation strategy results in the best outcomes for children treated for suspected or confirmed septic shock.
- Trial name
- SQUEEZE (NCT03080038)
- Testing
- Fluid Sparing Resuscitation Strategy
- Where
- 8 sites in Canada
- Volunteers
- 406 people
- Sponsor
- McMaster University
Neoplasms Malignant, Surgery
Improved Adherence With Extended Venous Thromboembolism Prophylaxis After Major Cancer Surgery
This is a prospective, twin-center, cohort study in patients discharged from the hospital after major abdominal or pelvic cancer surgery for cancer.
- Conditions
- Neoplasms Malignant, Surgery, Venous Thromboembolism, Prophylaxis
- Trial name
- NCT04479579
- Testing
- Apixaban 2.5 milligram
- Where
- 2 sites in Canada
- Volunteers
- 53 people
- Sponsor
- McMaster University
Substance Use Disorders, Prenatal Care
Routine Pregnancy Screening for Women on Opioid Substitution Therapy
Women who take opioid substitution therapy have higher rates of unintended pregnancy, more pregnancies, and a higher risk of pregnancy complications than the general population.
- Conditions
- Substance Use Disorders, Prenatal Care, Pregnancy Outcome
- Trial name
- PREG-O (NCT03489174)
- Testing
- Monthly Pregnancy Screening, Usual Care
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- McMaster University
Postpartum Depression
Peer Administered Online CBT for PPD
Postpartum depression (PPD) affects up to one in five of women and has profound effects on mothers and their infants. Unfortunately, fewer than 15% of women with PPD receive evidence-based care.
- Trial name
- PL-OCBT (NCT04913584)
- Testing
- Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- McMaster University
End-stage Renal Disease, Thrombocytopathy
Cohort Study Comparing Short Daily Hemodialysis (HD) With Conventional HD
This study is examining the effects of short daily hemodialysis on platelet function, fluid volume control, arterial stiffness and patient quality of life, as compared to conventional hemodialysis.
- Conditions
- End-stage Renal Disease, Thrombocytopathy, Cardiovascular Diseases
- Trial name
- NCT00182156
- Where
- Canada
- Sponsor
- McMaster University