Clinical trials: sponsored by McMaster University
IUD Insertion Complication, Pain, Acute
The Effectiveness of Music on Pain and Anxiety in IUD Insertion
Although intrauterine devices (IUDs) are a highly effective contraceptive method, fear of pain during insertion is one barrier to use.
- Conditions
- IUD Insertion Complication, Pain, Acute, Anxiety Acute
- Trial name
- NCT03828760
- Testing
- Music listening
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Vaccine Refusal
Assessing Knowledge, Beliefs and Attitudes Toward HPV Vaccination Among Parents in North West, Cameroon
The aim of this study is to assess knowledge, beliefs and attitudes of parents to young girls aged 9 to 14 years about HPV vaccines within some rural communities in the North West Region of Cameroon served by three hospitals in…
- Trial name
- NCT05325138
- Testing
- Interview
- Where
- Cameroon
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cardiovascular Risk Factor, Hypertension
A Web-based Platform to Conduct Trials of mHealth Apps for Hypertension
Self-management of cardiovascular (CV) risk factors is a recommended form of secondary disease prevention. There are thousands of consumer-facing mobile health (mHealth) applications (apps) intended for tracking, monitoring, and…
- Trial name
- NCT04528654
- Testing
- Mobile Health Application
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- McMaster University
COPD Exacerbation
Heated High Humidity After COPD Exacerbation
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease usually caused by exposure to tobacco smoke which leads to chronic symptoms of shortness of breath, cough, and phlegm.
- Trial name
- NCT03772626
- Testing
- Heated Humidified High-flow Nasal Cannula
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Hematoma Postoperative, Breast Cancer
Tranexamic Acid for Alloplastic Breast Reconstruction
Hematoma is a common complication of alloplastic breast reconstruction. This can lead to pain and discomfort experienced by the patient, in addition to greater use of valuable healthcare resources.
- Conditions
- Hematoma Postoperative, Breast Cancer, Tranexamic Acid
- Trial name
- NCT04918589
- Testing
- Tranexamic acid, Normal Saline
- Where
- 3 sites in Canada
- Volunteers
- 106 people
- Sponsor
- McMaster University
Dairy Products, Muscle Protein Synthesis
The Effect of Whole Milk to Improve Muscle Health in Older Women
Muscle and strength begin to noticeably decline around 50 years of age, increasing an individual's risk for disease and disability.
- Conditions
- Dairy Products, Muscle Protein Synthesis, Aging, Physical Activity
- Trial name
- NCT04981652
- Testing
- Whole Milk, Skim Milk, Almond Beverage
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hematoma Postoperative, Tranexamic Acid
Topical Tranexamic Acid for Bilateral Breast Reduction Surgery
Hematoma is a common complication of bilateral breast reduction (BBR) surgery. This can lead to pain and discomfort experienced by the patient, in addition to greater use of valuable healthcare resources.
- Trial name
- NCT04918576
- Testing
- Tranexamic acid, Normal Saline
- Where
- 3 sites in Canada
- Volunteers
- 106 people
- Sponsor
- McMaster University
Chronic Constipation
Sacral Neuromodulation as Treatment for Chronic Constipation
The objective of this study is to study if low level laser therapy will do more good than harm for patients with severe chronic refractory constipation. It is a proof of concept study without a placebo arm.
- Trial name
- NCT03819062
- Testing
- Low Level Laser Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Fecal Incontinence
Sacral Neuromodulation as Treatment for Fecal Incontinence
The objective of this study is to investigate if low level laser therapy will do more good than harm for patients with severe refractory fecal incontinence. It is a proof of concept study without a placebo arm.
- Trial name
- LLLT-FI (NCT03825575)
- Testing
- Low level laser therapy (LLLT)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McMaster University
Eating Disorders
Implementation of a Waitlist Intervention and Clinical Care Pathway for Families Awaiting at Eating Disorders Program
The COVID-19 pandemic has resulted in several challenges in service delivery for the eating disorders program at McMaster Children's Hospital.
- Trial name
- WICFAS (NCT04812899)
- Testing
- Parental guided self-help version of FBT-pre-recorded videos and readings from the book
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Postpartum Depression
Peer Administered CBT for PPD
Postpartum depression (PPD) affects up to 20% of women and has profound effects on mothers and their infants. Unfortunately, fewer than 15% of women with PPD receive evidence-based care.
- Trial name
- PL-CBT (NCT03285139)
- Testing
- Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- McMaster University
Myotonic Dystrophy 1, Muscular Dystrophies
Myotonic Dystrophy Type 1 Aerobic Exercise Study
Myotonic dystrophy type 1 (DM1) is a genetic disease that primarily targets skeletal muscle resulting in severe weakness and muscle loss.
- Trial name
- DM1ex (NCT04187482)
- Testing
- Exercise training
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- McMaster University
Frailty
GERAS Frailty Rehabilitation at Home During COVID-19
The coronavirus disease 2019 (COVID-19) pandemic is keeping people apart, which can take a toll on physical and mental health. Many healthcare professionals are concerned vulnerable seniors may become deconditioned, which…
- Trial name
- NCT04500366
- Testing
- Socialization, Virtual Group Exercise, Nutrition Consult and Protein Supplementation
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- McMaster University
Bariatric Surgery, Chronic Kidney Diseases
Bariatric Surgery and Chronic Renal Disease
Obesity can be a major driver for the development of chronic kidney disease (CKD), which is a leading cause of death and significant loss in quality of life.
- Conditions
- Bariatric Surgery, Chronic Kidney Diseases, Obesity
- Trial name
- BARICADE (NCT05240443)
- Testing
- Bariatric Surgery + Medical Management of CKD., Medical Management for CKD
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Decision Support Techniques, GRADE Approach
Defining Decision Thresholds for Judgments on Health Benefits and Harms: Study Protocol
The objective of this study is an approach to derive and use decision-thresholds for judgments on health benefits and harms using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence to Decision…
- Trial name
- NCT05237635
- Testing
- descriptive case-scenarios
- Where
- Canada
- Volunteers
- 1,406 people, healthy volunteers welcome
- Sponsor
- McMaster University
Frail Elderly Syndrome, Chronic Disease
Implementing Advance Care Planning Conversation Tools in Family Practice
This study evaluates the use of advance care planning conversation tools with patients attending their family doctor's office. Patients complete tools about their values and wishes, and a health care provider uses a structured…
- Trial name
- NCT03508557
- Testing
- Advance care planning tools
- Where
- 4 sites in Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
HIV-1-infection, Bacterial Vaginoses
Estrogen, Probiotics and Vaginal Health to Prevent HIV Infection in ACB Women
This study will enrol African, Caribbean and Black (ACB) women who are known to have a more diverse vaginal microbiome, higher rates of bacterial vaginosis with lower numbers of protective lactobacilli, and are at increased risk…
- Trial name
- NCT03837015
- Testing
- Estring Vaginal Ring, RepHresh Pro-B
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Tuberculosis
Accessibility of the World Health Organization's eTB Catalogue of Recommendations
The World Health Organization's Global Tuberculosis Programme (WHO-GTB) issues evidence-informed guideline recommendations on tuberculosis (TB).
- Trial name
- NCT04745897
- Testing
- eTB Catalogue of Recommendations (eTB), World Health Organization Tuberculosis Website (WHO TB)
- Where
- Canada
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- McMaster University
GRADE Approach, Summary of Findings Table
New Alternative Formats vs Standard of SoF Tables. Non-inferiority Controlled Trial
The investigators will conduct a parallel two-armed, non-inferiority randomized trial comparing new alternative formats of summary of findings tables (SoF) tables with current formats.
- Conditions
- GRADE Approach, Summary of Findings Table, Cochrane Collaboration
- Trial name
- NCT02022631
- Testing
- Alternative summary of findings table format, Current summary of findings table format
- Where
- Canada
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- McMaster University
Colostomy, Hirschsprung Disease - Pull Through
Bowel Preparation in Elective Pediatric Colorectal Surgery
Infections after elective intestinal surgery remain a significant burden for patients and for the health care system. The cost of treating a single surgical site infection is estimated at approximately $27,000.
- Conditions
- Colostomy, Hirschsprung Disease - Pull Through, Necrotizing Enterocolitis, Inflammatory Bowel Diseases
- Trial name
- NCT03593252
- Testing
- Senna, Sodium Picosulfate, Magnesium Oxide and Citric Acid, Metronidazole Oral
- Volunteers
- 81 people
- Sponsor
- McMaster University