Clinical trials: sponsored by McMaster University
Genital Neoplasm Malignant Female, Surgical Procedure, Unspecified
A Trial Comparing Surgeon-administered TAP Block With Placebo After Midline Laparotomy in Gynecologic Oncology
Multimodal opioid-sparing analgesia is recommended in order to prevent post-operative complications and shorten length of stay. Administration by the surgeon of local anesthetics in the abdominal wall after surgery for a…
- Trial name
- NCT04202874
- Testing
- Surgeon-administered transversus abdominis plane (TAP)
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- McMaster University
Tuberculosis
Phase 1 Clinical Trial of the Safety and Immunogenicity of an Adenovirus-based TB Vaccine Administered by Aerosol
This is a phase 1 study, in healthy volunteers who have previously been immunized with bacilli Calmette Guerin (BCG), to evaluate the safety and immune responses that develop in the blood and lungs following the administration by…
- Trial name
- NCT02337270
- Testing
- Ad5Ag85A
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- McMaster University
Clostridium Difficile
A Prospective Trial of Frozen-and-Thawed Fecal Microbiota Transplantation for Recurrent Clostridium Difficile Infection
The primary goal of this proposal is to study the outcome of patients with recurrent Clostridium Difficile Infection (CDI) treated with frozen Fecal Microbiota Transplantation (FMT) in an open-labelled controlled trial.
- Trial name
- NCT02394275
- Testing
- Fecal Microbiota Transplant
- Where
- 2 sites in Canada
- Volunteers
- 140 people
- Sponsor
- McMaster University
Suspected Deep Vein Thrombosis
The Designer D-dimer Deep Vein Thrombosis Diagnosis (4D) Study
This is a cohort study that will assess a new diagnostic management strategy for suspected Deep Vein Thrombosis in outpatients.The new diagnostic strategy is designed to reduce the use of ultrasound testing on the day of…
- Trial name
- 4D (NCT02038530)
- Where
- 10 sites in Canada
- Volunteers
- 1,513 people
- Sponsor
- McMaster University
Obsessive-Compulsive Disorder
Probiotic Treatment in Adult Obsessive-Compulsive Disorder
This study will evaluate the effectiveness of 12-weeks of probiotic treatment in adults with primary Obsessive-Compulsive Disorder and whether this treatment will alter the microbiota composition in these patients.
- Trial name
- NCT02334644
- Testing
- Probiotic Formula (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Comorbidity, Medication Therapy Management
Effectiveness of a Medication Wallet Card
This study evaluates whether or not the use of a medication wallet card in patients over 70 taking 5 or more medications promotes self-efficacy with regards to coping with illness, understanding medications, and staying healthy.
- Conditions
- Comorbidity, Medication Therapy Management, Polypharmacy
- Trial name
- NCT02820129
- Testing
- Medication Wallet Card, Reminder Card
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
Trauma, Critical Incident
The Resilient Minds Program in Fire Departments
The purpose of the study is to assess the impact of a mental health training program in volunteer and career firefighters.
- Conditions
- Trauma, Critical Incident, Mental Illness
- Trial name
- NCT03401684
- Testing
- Resilient Minds
- Where
- 5 sites in Canada
- Volunteers
- 600 people
- Sponsor
- McMaster University
Multi-morbidity, Medication Therapy Management
Team Approach to Polypharmacy Reduction to Improve Mobility Long-Term Care
Medication side effects and interactions between medications are very common in older adults and are related to negative health outcomes, including mobility.
- Conditions
- Multi-morbidity, Medication Therapy Management, Polypharmacy
- Trial name
- NCT03202264
- Testing
- TAPER
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Constipation, Irritable Bowel Syndrome
Cognitive and Psychiatric Effects of Linaclotide on Patients With Constipation
Irritable Bowel syndrome - constipation predominant (IBS-C) is a chronic and disabling,disorder of the gut that is characterized by abdominal pain or discomfort.
- Trial name
- NCT03342287
- Testing
- questionnaires, cognitive evaluation, Blood
- Where
- Canada
- Sponsor
- McMaster University
Breast Cancer
ciNPT in Autologous Abdominal Tissue Breast Reconstruction
In women who undergo mastectomy for the treatment of breast cancer, autologous reconstruction using the deep inferior epigastric perforator (DIEP) flap is a common surgical procedure that aims to restore both the appearance and…
- Trial name
- NCT04985552
- Testing
- DIEP Breast Reconstruction, ciNPT, Conventional Tape Dressings
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Aging
Health TAPESTRY Ontario
The Health Teams Advancing Patient Experience: Strengthening Quality (Health TAPESTRY) is a community-based program led by primary care teams, that creates connections between trained community volunteers, interprofessional…
- Trial name
- NCT03397836
- Testing
- Health TAPESTRY Intervention, Usual Care
- Where
- Canada
- Volunteers
- 599 people, healthy volunteers welcome
- Sponsor
- McMaster University
Clostridium Difficile Infection
Multi-Centre Trial of Fresh vs. Frozen-and-Thawed FMT for Recurrent CDI
The goal of this study is to determine the outcome of patients with recurrent CDI treated with fresh FMT versus frozen-and-thawed FMT in a randomized controlled trial.
- Trial name
- NCT01398969
- Testing
- Fresh FMT, Frozen-and-Thawed FMT
- Where
- 4 sites in Canada
- Volunteers
- 232 people
- Sponsor
- McMaster University
Long-term Care, Polypharmacy
Team Approach to Polypharmacy Evaluation and Reduction in a Long-Term Care Setting
Medication side effects and interactions between medications are very common in older adults and are related to negative health outcomes.
- Conditions
- Long-term Care, Polypharmacy, Frailty
- Trial name
- TAPER-LTC (NCT04055896)
- Testing
- Medication Reduction
- Where
- 2 sites in Canada
- Volunteers
- 15 people
- Sponsor
- McMaster University
Vaccine Preventable Disease
COVID-19 Vaccine For Indirect Protection
The primary objective of this study is to test whether vaccinating adults ≥18 years in Hutterite colonies with mRNA-1273 (Moderna COVID-19) vaccine as compared to control (usual care) can prevent RT-PCR confirmed COVID-19 in…
- Trial name
- NCT04818736
- Testing
- COVID-19 Vaccination, Usual care
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Health Promotion, Health Education
The Future of Viral Communications: Video-Based Health Promotion Strategies for COVID-19 Vaccinations
The investigators aim to study whether education, in the form of three two-minute educational videos about COVID-19 vaccine development and dissemination, reduces vaccine hesitancy and increases intent to vaccinate.
- Conditions
- Health Promotion, Health Education, COVID-19 Vaccines
- Trial name
- NCT04876885
- Testing
- Educational video
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
SARS-CoV-2 Infection, Covid19
Breath Analysis of Patients Diagnosed With COVID-19 Using Infrared Spectroscopy
To analyze Volatile Organic Compounds (VOCs) in the breath of patients with SARS-CoV-2 and controls in SARS-CoV-2 breath specimens.
- Trial name
- BREATH (NCT04867213)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- McMaster University
Depression, Postpartum
Group CBT for PPD in the Public Health Setting
Postpartum depression (PPD) affects over 14,000 women in Ontario each year and can have profound effects on mothers, their children, and their families.
- Trial name
- NCT03039530
- Testing
- Group Cognitive Behavioral Therapy, Postnatal Care As Usual
- Where
- Canada
- Volunteers
- 141 people
- Sponsor
- McMaster University
Anxiety, Depression
CBT for Young Mothers
Approximately 1 in 4 adolescent mothers will develop depression after delivering a child, though some studies suggest that as many as 53% will develop postpartum depression.
- Conditions
- Anxiety, Depression, Emotion Regulation
- Trial name
- CBTYM (NCT03329144)
- Testing
- Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- McMaster University
Skin Cancer, Basal Cell Skin Cancer Skin Cancer, Non-Melanoma Skin Cancers - Squamous Cell Carcinoma Patient Satisfaction
FACE-Q in Facial Reconstructive Surgery: A Prospective Database
The primary objective is to establish a prospective database of clinical information, FACE-Q scores, and patient photographs (as appropriate) to enhance the understanding and practice of facial plastic and reconstructive surgery.
- Trial name
- NCT04842279
- Testing
- FACE-Q scale
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- McMaster University
Anxiety, Depression
Evaluating a Primary-Care Group-based Mindfulness Program
The study evaluates the effectiveness of a group-based mindfulness program conducted in a primary care setting. This study also aims to identify any scale-up and implementation considerations for the program.
- Conditions
- Anxiety, Depression, Sleep Initiation and Maintenance Disorders, Social Isolation
- Trial name
- NCT03662581
- Testing
- Mindfulness Group Program
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University