Clinical trials: sponsored by McMaster University
Surgical Site Infection
Study for Antibiotic Impregnated Calcium Sulfate Beads as Prophylaxis for Surgical Site Infection
The CDC quotes a rate of wound infection of 2-5% for inpatient surgery. Patients undergoing a vascular operation, however, are generally at an increased risk of wound infection with rates often close to 5-10%.
- Trial name
- NCT03308253
- Testing
- Stimulan Rapid Cure, Vancomycin, Tobramycin
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McMaster University
Fractures, Bone, Dislocations
Prospective Abuse and Intimate Partner Violence Surgical Evaluation
Intimate partner violence (IPV), also known as domestic abuse, is a leading cause of non-fatal injury in women worldwide. 1 in 6 women attending surgical fracture clinics have a history of IPV in the past year.
- Conditions
- Fractures, Bone, Dislocations, Spouse Abuse
- Trial name
- PRAISE-2 (NCT02529267)
- Testing
- Standard of care
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- McMaster University
Epilepsy
STEP: Enhanced Physical Activity in Children and Youth With Epilepsy
Epilepsy is common in childhood. Children with epilepsy are at increased risk of impaired health, functioning, psychological well-being, and quality of life.
- Trial name
- STEP (NCT01550874)
- Testing
- Physical activity behavior-change counselling
- Where
- 2 sites in Canada
- Volunteers
- 122 people
- Sponsor
- McMaster University
Chalazion Unspecified Eye, Unspecified Eyelid, Chalazion Left Eye, Unspecified Eyelid
Chalazion Conservative Treatment Trial
An eyelid stye, or chalazion, is the most common eyelid ailment, and is caused by the blockage of one of the oil secreting glands of the eyelid (meibomian glands).
- Conditions
- Chalazion Unspecified Eye, Unspecified Eyelid, Chalazion Left Eye, Unspecified Eyelid, Chalazion Right Eye, Unspecified Eyelid, Chalazion Both Eyes
- Trial name
- NCT01230593
- Testing
- Hot Compress plus Tobramycin Drops and Ointment, Hot compress plus Tobramycin/Dexamethasone Drops and Ointment, Hot Compresses
- Where
- 3 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- McMaster University
Multiple Sclerosis
Implementing Physical Activity Guidelines for Adults With MS
The proposed project will evaluate two methods of implementation of the new Physical Activity Guidelines (PAGs) for Adults with Multiple Sclerosis (MS) living in two Ontario communities.
- Trial name
- NCT02100020
- Testing
- Direct Referral to physical activity
- Where
- 2 sites in Canada
- Volunteers
- 94 people
- Sponsor
- McMaster University
Medication Adherence
The eDosette Pilot Study
Medication non-adherence can lead to serious health issues for older adults. This study is a four week study in older adults using a new device, the eDosette, which dispenses and records how one takes their medications, and…
- Trial name
- NCT03513224
- Testing
- eDosette
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- McMaster University
Vascular Death, Myocardial Infarction
Vascular Events In Noncardiac Surgery Patients Cohort Evaluation Study (VISION)
The investigators' study has 4 primary objectives. Among patients undergoing noncardiac surgery the investigators will determine: (1) the incidence of major perioperative vascular events; (2) the optimal clinical model to predict…
- Conditions
- Vascular Death, Myocardial Infarction, Cardiac Arrest, Stroke
- Trial name
- VISION (NCT00512109)
- Where
- 8 sites in Brazil, Canada and 5 more
- Volunteers
- 40,060 people
- Sponsor
- McMaster University
Post-mastectomy Pain Syndrome, Chronic Post-surgical Pain
Perioperative Pregabalin and Lidocaine to Reduce Chronic Breast Cancer Pain
Breast tissue and the areas surrounding the breast contain many small to medium-sized nerves. During surgery on the breast, these nerves can be inadvertently cut or damaged.
- Trial name
- PLAN (NCT02240199)
- Testing
- Intraoperative Intravenous Lidocaine Infusion, Perioperative Pregabalin
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Atherosclerotic Disease, Perioperative Bleeding
PeriOperative ISchemic Evaluation-3 Trial: A Pilot Study
A placebo-controlled, factorial trial to assess the impact of rosuvastatin and tranexamic acid (TXA) in patients undergoing noncardiac surgery who are at risk of a perioperative cardiovascular event.
- Trial name
- POISE-3 (NCT02546648)
- Testing
- Tranexamic Acid
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Postoperative Hypoxia
HI-VISION Pilot Study
A prospective cohort pilot study of non-cardiac patients to determine the feasibility of recruiting 150 patients to undergo postoperative continuous hemodynamic monitoring for up to 3 days.
- Trial name
- HI-VISION (NCT02300441)
- Testing
- ECG, blood pressure and oximetry
- Where
- Canada
- Volunteers
- 133 people
- Sponsor
- McMaster University
Frail Elderly
Resistance Training to Optimize Health in Pre-frail Older Adults
Exercise programs, particularly resistance training programs using weights or resistance bands, can help improve or maintain mobility and function in older adults, preserve independent living, and improve quality of life.
- Trial name
- NCT02593084
- Testing
- Higher Intensity Resistance Training, Lower Intensity Resistance Training
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McMaster University
IBS - Irritable Bowel Syndrome
Gluten Free Diet in IBS Patients Stratified According to Their Antigliadin Status
Gluten-free diet has been shown to improve gut symptoms in patients with celiac disease and also in adult patients with diagnosis of Irritable Bowel Syndrome (Rome III criteria).
- Trial name
- GFD_IBS (NCT03492333)
- Testing
- Gluten free diet
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- McMaster University
Venous Ulcer, Foot Ulcer, Diabetic
Study of Combined Topical Growth Factor and Protease Inhibitor in Chronic Wound Healing
Leg and foot ulcers due to venous disease or diabetes are chronic wounds that can take 6 or more months to heal. Growth factors have been used to try and improve this healing, however, many such studies have failed, and that is…
- Trial name
- NCT02845466
- Testing
- Becaplermin, Promagran Dressing
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Stroke
Fit for Function: A Community Wellness Program for Persons With Stroke
The purpose of this study is to evaluate whether persons with stroke participating in a 12-week community based wellness program for persons who have had a stroke, experience improved mobility (6 Minute Walk Test), balance, (The…
- Trial name
- FFF (NCT01194102)
- Testing
- Community Based Exercise Program, Living with Stroke Education program, YMCA membership
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- McMaster University
Back Pain, Coronary Artery Disease
Detecting and Addressing Preclinical Disability
The Physical Functioning Inventory (PFI) is a standardized patient reported outcome measure that assesses preclinical disability.
- Conditions
- Back Pain, Coronary Artery Disease, Chronic Obstructive Pulmonary Disease, Diabetes
- Trial name
- NCT01979081
- Testing
- Tailored advice from a physiotherapist and/or an occupational therapist through the myOSCAR patient portal
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hypoprothrombinemia
Randomized Controlled Feasibility Trial of the Fearon Algorithm to Improve Management of Unstable Warfarin
Patients on warfarin but with unstable international normalized ratio (INR) will be recruited to a randomized trial comparing dosing based on an algorithm (Fearon algorithm, named after the mathematician Michael Fearon), which…
- Trial name
- NCT02267408
- Testing
- Warfarin adjustment using the Fearon algorithm, Warfarin adjustment using standard dosing
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- McMaster University
Wet Macular Degeneration
OZURDEX in Age Related Macular Degeneration as Adjunct to Ranibizumab
In the Western World, Age Related Macular Degeneration (ARMD) is a leading cause of blindness. This disease was once thought to be a natural part of aging, but recent research has introduced effective treatments.
- Trial name
- STAR (NCT01243086)
- Testing
- Ranibizumab, OZURDEX
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
Severe Persistent Asthma, Eosinophilic Bronchitis
Anti-Interleukin-5 (IL5) Monoclonal Antibody (MAb) in Prednisone-dependent Eosinophilic Asthma
The steroid sparing effect of anti interleukin (IL-5) monoclonal antibody has been proven, but the effectiveness of subcutaneous (SC) compared to intravenous (IV) administration of these drugs to suppress airway eosinophilia is…
- Trial name
- NCT02559791
- Testing
- Reslizumab
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
Steroid and/or Prednisone Dependent Asthma, Eosinophilic Bronchitis
Study of the Steroid Sparing Effect of Xolair (Omalizumab) in Patients With Persistent Eosinophilic Bronchitis
The purpose of this study is to investigate whether addition of Omalizumab enables a reduction in the dose of prednisone in patients with asthma and eosinophilic bronchitis.
- Trial name
- NCT02049294
- Testing
- Omalizumab (Xolair)
- Where
- 5 sites in Canada
- Volunteers
- 11 people
- Sponsor
- McMaster University
Type 2 Diabetes
Evaluating the Effect of a Diabetes Health Coach in Individuals With Type 2 Diabetes
Background: Health coaching is defined as health education, promotion and support by a professional to enhance the well-being of individuals and facilitate the achievement of their health-related goals.
- Trial name
- DiabCoach (NCT02128815)
- Testing
- Coaching
- Where
- 2 sites in Canada
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- McMaster University