Clinical trials: sponsored by McMaster University
Obesity, Morbid, Obesity
Omega-3 vs Very Low Calorie Diet for Liver Size Reduction
A recent review demonstrated that Non-alcoholic fatty liver disease (NAFLD) affects 10-35% of the adult population worldwide, with the prevalence approaching 85-100% in obese populations.
- Conditions
- Obesity, Morbid, Obesity, NAFLD, NASH - Nonalcoholic Steatohepatitis
- Trial name
- NCT03132662
- Testing
- Omega-3, Very Low Calorie Diet
- Volunteers
- 60 people
- Sponsor
- McMaster University
Respiratory Insufficiency of Prematurity
Canadian Oxygen Trial (COT)
Study Question: In infants who are born at gestational ages of 23 0/7 to 27 6/7 weeks, does lowering the concentration of supplemental oxygen to target an arterial oxygen saturation by pulse oximetry (SpO2)of 85-89% compared with…
- Trial name
- COT (NCT00637169)
- Testing
- Titration of oxygen therapy
- Where
- 23 sites in United States, Argentina and 4 more
- Volunteers
- 1,201 people
- Sponsor
- McMaster University
Aging, Muscle Loss
Protein Intake and Step Reduction in Older Adults
Sarcopenia, the loss in muscle mass with age, is associated with several negative health outcomes including cancer, stroke, cardiovascular disease and diabetes.
- Trial name
- DRI (NCT03285737)
- Testing
- Whey, Collagen
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- McMaster University
Traumatic Intracranial Haemorrhage
OPtimal Timing of Thromboprophylaxis in Traumatic IntraCranial Haemorrhage (OPTTTICH Feasibility Study)
Victims of trauma with severe head injury who have bled into their brains are at high risk of developing blood clots in their legs. These blood clots can break off and travel through the bloodstream to the lungs causing death.
- Trial name
- OPTTTICH (NCT01589393)
- Testing
- Enoxaparin
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- McMaster University
Osteoarthritis, Knee, Osteoarthritis, Hip
Resilience for Older Workers With OA Through Exercise
Exercise is effective at reducing pain while improving physical function. However we do not know if exercise can boost resilience in the workplace, to allow people with osteoarthritis to work as long as they desire.
- Trial name
- NCT02609672
- Testing
- Exercise, No Exercise
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Cataracts
Comparison of the Effectiveness of Povidone-iodine in Reducing Conjunctival Bacterial Load Prior to Cataract Surgery in Patients Treated With a Lidocaine Gel Dilating Formulation Versus Eye Drops: A Randomized Controlled Trial
The eye contains a lens that focuses light. A clouding of the lens is known as a cataract. Cataracts decrease vision. The treatment for cataracts is cataract surgery.
- Trial name
- NCT01898728
- Testing
- topical povidone-iodine after premedication with topical liquid eye drops, topical povidone-iodine after premedication with topical gel
- Where
- Canada
- Volunteers
- 101 people
- Sponsor
- McMaster University
Apnea of Prematurity
Caffeine for Apnea of Prematurity (CAP)
At least 5 of every 1000 live-born babies are very premature and weigh only 500 to 1250 grams at birth. Approximately 30-40% of these high-risk infants either die or survive with lasting disabilities.
- Trial name
- NCT00182312
- Testing
- Caffeine citrate injection
- Where
- 34 sites in United States, Australia and 7 more
- Volunteers
- 2,000 people
- Sponsor
- McMaster University
Muscle Atrophy
n3 PUFA and Muscle-disuse Atrophy in Young Women
This study will examine the influence of n3 PUFA supplementation on the rate of muscle atrophy in women undergoing 2 weeks of unilateral limb immobilization.
- Trial name
- NCT03059836
- Testing
- n3 PUFA-enriched fish oil
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Breast Neoplasm
Giving Information on the Risks and Limitations of Mammography Screening (GIRLS)
To trial the provision of full information on the benefits and risks of mammography in women that are eligible for breast screening.
- Trial name
- GIRLS (NCT02914197)
- Testing
- Full information
- Where
- Canada
- Volunteers
- 608 people, healthy volunteers welcome
- Sponsor
- McMaster University
Celiac Disease, Barrett Esophagus
Gluten Related Disorders in Barrett's Esophagus
In a small group of people gluten, a storage protein commonly in wheat and other grains, can cause gut inflammation and symptoms like diarrhea and abdominal pain.
- Conditions
- Celiac Disease, Barrett Esophagus, Gluten Sensitivity, GERD
- Trial name
- NCT03329534
- Testing
- Gluten free diet
- Volunteers
- 40 people
- Sponsor
- McMaster University
Skeletal Muscle Hypertrophy, Muscle Weakness
The Effects of Lifting Light or Heavy Weights on Muscle Growth and Strength in Trained Young Men
When practicing weightlifting regularly the body makes new proteins within the muscle. These new proteins can increase the size of the cells within the muscle to make them larger, a process called hypertrophy.
- Trial name
- NCT02139865
- Testing
- 30% 1RM, 80% 1RM
- Where
- 2 sites in Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McMaster University
Peripheral Artery Disease
Online Support for Outpatient Peripheral Arterial Disease Self-management
This study looks to examine whether an online patient tool to monitor factors affecting patients peripheral artery disease can lead to improvements in patients' disease and slow its progression.
- Trial name
- NCT03464006
- Testing
- Online Support Module, Standard of Care
- Volunteers
- 200 people
- Sponsor
- McMaster University
Nonneurogenic Lower Urinary Tract Dysfunction, Dysfunctional Elimination Syndrome
The Effectiveness of a Bladder Training Video for Management of Lower Urinary Tract Symptoms.
Children with non-neurogenic lower urinary tract dysfunction (NLUTD) represent a significant subgroup of pediatric urology patients, comprising up to 30 percent of some out-patient clinics.
- Trial name
- NCT01915004
- Testing
- Educational Intervention
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- McMaster University
Pleural Effusion, Pleural Effusion Malignant
The Effect of Non-Steroidal Anti-Inflammatory Drug Naproxen on Pleural Effusion Formation After Lung Resection
Following a lung resection procedure, patients have their pleural space drained of fluid that accumulates due to the severing of proximal vessels like lymph nodes.
- Trial name
- NCT01612975
- Testing
- Naproxen
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- McMaster University
Dietary Modification
Testing of Micellar Casein, Blended Micellar Casein and Native Whey
The importance of protein in nutrition is momentous to ones health. Dietary proteins are essentially nutritional because they contain amino acids, which the body uses to build its own proteins, as well as other molecules that are…
- Trial name
- NCT03021694
- Testing
- Testing of micellar casein, blended micellar casein and native whey, versus native whey to determine post-ingestion aminoacidemia, glycemia, and insulinemia in young adult men
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University
Lung Neoplasms, Lung Diseases
EBUS Score Validation for Malignancy
Surgical removal of a tumour in the lung offers the best chance for survival in early stage lung cancers. One main criteria of surgical eligibility is the absence of cancer spread to the lymph nodes; rendering the staging process…
- Trial name
- NCT02793713
- Testing
- Endobronchial Ultrasound
- Where
- 2 sites in Canada
- Volunteers
- 300 people
- Sponsor
- McMaster University
Lung Neoplasms, Benign Lung Disease
Incentive Spirometry Added to Physiotherapy to Reduce Postoperative Pulmonary Complications After Lung Surgery
After any surgery, there is a chance of complications. After lung surgery to remove tumours, there is a particularly high chance of a person developing an infection or needing help breathing, called post operative pulmonary…
- Trial name
- NCT02146092
- Testing
- Incentive spirometry, Physiotherapy
- Where
- Canada
- Volunteers
- 389 people
- Sponsor
- McMaster University
Endothelial Dysfunction
Artery Function Responses to Changes in Blood Flow
The purpose of this study is to determine if different blood flow patterns change artery function. We hypothesize that the temporary induction of an oscillatory blood flow pattern will result in an immediate improvement in artery…
- Trial name
- ASPEN (NCT02982044)
- Testing
- Suprasystolic (300 mmHg) cuff compressions, Handgrip exercise, Passive heat stress
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University
Aging
A Randomized Controlled Trial Using the Health TAPESTRY Approach to Care for Older Adults
Health TAPESTRY is a delayed intervention pragmatic randomized control trial promoting interprofessional team collaboration, facilitating connection to the community through system navigation and trained community volunteers…
- Trial name
- HealthTAPESTRY (NCT02283723)
- Testing
- Health TAPESTRY Intervention, Usual care
- Where
- 2 sites in Canada
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- McMaster University
Osteoporosis
The Effect of Theory Menu-Based Intervention on Vitamin D Adherence in People With Osteoporosis-Pilot Study
This pilot study evaluates the effect of theory menu-based mini-videos on vitamin D adherence in older adult with osteoporosis. Half of participants will watch the videos while the other half will receive usual care (treating…
- Trial name
- NCT02358590
- Testing
- HAPA menu-based mini-video, Standard care
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- McMaster University