Clinical trials: sponsored by McMaster University
Spinal Cord Injury
The Effects of Anti-oxidants on Clinical Outcomes and Radiological Features of Chronic Spinal Cord Injury: A Pilot Study
This study will enroll 10 adults with a chronic spinal cord injury. The investigators will image their damaged motor tracts using MRI tractography scanning, and the investigators will formally assess their ASIA motor level at the…
- Trial name
- NCT01904591
- Testing
- Selenium, Vitamin E
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- McMaster University
Diabetes Mellitus, Type 2
Interprofessional Community-Based Diabetes Intervention for Older Adults
This study will examine the feasibility and acceptability of a 6-month interprofessional community-based health promotion program, and explore its effects on older adults' self-management of Type 2 Diabetes (T2DM).
- Trial name
- NCT01880476
- Testing
- Home visits and group program
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- McMaster University
Cardiovascular Diseases, Diabetes
South Asian HeArt Risk Assessment Project - Pilot
People who originate from the Indian subcontinent known as South Asians are the fastest growing group of non-white Canadians. They suffer an excess prevalence of abdominal obesity, type 2 diabetes and heart disease.
- Conditions
- Cardiovascular Diseases, Diabetes, Abdominal Obesity
- Trial name
- SAHARA-Pilot (NCT01577719)
- Testing
- Multimedia Lifestyle Improvement, Usual Care
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cardiovascular Diseases, Diabetes
South Asian HeArt Risk Assessment Project - Trial (SAHARA-Trial)
People who originate from the Indian subcontinent known as South Asians are the fastest growing group of non-white Canadians. They suffer an excess prevalence of abdominal obesity, type 2 diabetes and heart disease.
- Conditions
- Cardiovascular Diseases, Diabetes, Abdominal Obesity
- Trial name
- SAHARA (NCT01841398)
- Testing
- Multimedia Lifestyle Improvement, Usual Care
- Where
- Canada
- Volunteers
- 343 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cardiovascular Diseases, Inflammation
Diet Intervention and GEnetic STudy (DIGEST-Pilot)
Genetic factors contribute to risk factors for cardiovascular disease, such as blood lipids, blood pressure, obesity, diabetes, and may also influence dietary choices, physical activity, and responses to stress.
- Conditions
- Cardiovascular Diseases, Inflammation, Dyslipidemias, Blood Pressure
- Trial name
- DIGEST (NCT01658137)
- Testing
- Prudent Diet, Typical Western Diet
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- McMaster University
Shoulder Pain, Rotator Cuff Tear
All-Arthroscopic Versus Mini-Open Repair of Small or Moderate Rotator Cuff Tears
This study will compare two different surgical techniques for repairing a tear in the muscles of the shoulder (rotator cuff). The investigators will determine whether an arthroscopic or mini-open technique provides better quality…
- Trial name
- NCT00128076
- Testing
- All-Arthroscopic repair, Mini-open repair
- Where
- 9 sites in Canada
- Volunteers
- 275 people
- Sponsor
- McMaster University
Cardiovascular Diseases, Diabetes Mellitus
Pilot Project: Community Health Assessment Program Through Emergency Medical Services
Older adults living in subsidized housing report poorer health. Their low income and age make it harder for them to use community services.
- Trial name
- CHAP-EMS (NCT02772263)
- Testing
- CHAP-EMS
- Where
- Canada
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- McMaster University
Intensive Care Unit Acquired Weakness, Critical Care
TryCYCLE: A Pilot Study of Early In-bed Leg Cycle Ergometry in Mechanically Ventilated Patients
Background: Patients in the intensive care unit (ICU) are the sickest in hospital, and need advanced life-support. Survivors of critical illness are very vulnerable to weakness and disability.
- Conditions
- Intensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory Failure
- Trial name
- TryCYCLE (NCT01885442)
- Testing
- In-bed leg cycle ergometry
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- McMaster University
Cardiac Arrhythmias, Hemorrhage
Tapered Warfarin or Interrupted Warfarin With Heparin Bridging for Pacemaker or Defibrillator Implantation
Approximately 2 million patients in North America are currently treated with the blood thinner warfarin. These patients have every year more than 200,000 invasive procedures, for which warfarin must be stopped to avoid bleeding…
- Conditions
- Cardiac Arrhythmias, Hemorrhage, Thromboembolism
- Trial name
- PACEBRIDGE (NCT02094157)
- Testing
- Tapered warfarin regimen, Bridged regimen Low-molecular-weight heparin
- Where
- 2 sites in Canada
- Volunteers
- 173 people
- Sponsor
- McMaster University
Atrial Fibrillation, Venous Thromboembolism
Reinitiation of Anticoagulation After Temporary Withdrawal of Vitamin K Antagonist
It is not known how to best restart warfarin after temporary withdrawal. Participants will be randomized to two groups. Group 1 will restart warfarin at their usual maintenance dose, group 2 will restart warfarin at double their…
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Heart Valve Disease, Surgery
- Trial name
- DOSIDO (NCT01348074)
- Testing
- Double dose
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- McMaster University
Heparin-induced Thrombocytopenia
Rivaroxaban for Treatment of Patients With Suspected or Confirmed Heparin-Induced Thrombocytopenia
Heparin is an anticoagulant (blood thinner) that is commonly used to treat patients with heart attacks and patients with blood clots in their legs or lungs (venous thrombosis).
- Trial name
- NCT01598168
- Testing
- Rivaroxaban
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McMaster University
Age Related Macular Degeneration
Evaluation of Wet Age-Related Macular Degeneration (AMD) Genetic Profile Interactions With Ranibizumab Treatment Outcomes
Age Related Macular Degeneration (AMD) is the leading cause of blindness in North America. This condition causes a progressive loss of central vision, the part of your vision that allows you to read, drive and see images in sharp…
- Trial name
- NCT01363570
- Testing
- Ranibizumab
- Where
- 2 sites in Canada
- Volunteers
- 70 people
- Sponsor
- McMaster University
Feeding Intolerance in Premature Infants
Glycerin Suppositories Used Prophylactically in Premature Infants (SUPP): a Pilot Randomized Placebo-controlled Trial
All premature babies have problems with feeding and nutrition. Some can develop a life-threatening bowel infection necrotizing enterocolitis.
- Trial name
- NCT02153606
- Testing
- Glycerin Suppository
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- McMaster University
Mental Health Impairment
Impact Study of Workplace Mental Health Education on Early Intervention for Healthcare Workers With Mental Health Issues
The purpose of this study is to compare the impact of a new workplace-based mental health peer education program with standardized mental health literacy training on early intervention and support for healthcare employees with…
- Trial name
- NCT02158871
- Testing
- Beyond Silence, Mental Health First Aid (MHFA)
- Where
- 2 sites in Canada
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cardiovascular Disease, Sudden Cardiac Death
Feasibility Testing of Decision Support for Patients Who Are Candidates for an Implantable Defibrillator
Sudden cardiac death (SCD) due to a ventricular arrhythmia is a serious cause of cardiovascular death in Canada. The implantable cardioverter defibrillator (ICD) offers high-risk patients a treatment option to reduce the…
- Trial name
- NCT01876173
- Testing
- Patient Decision Aid for an ICD (primary prevention, non-CRT)
- Where
- Canada
- Volunteers
- 82 people
- Sponsor
- McMaster University
Aging, Sarcopenia
Leucine Co-ingestion and Myofibrillar Protein Synthesis in Older Adults
The loss of muscle mass with aging is associated with a dysregulation of muscle protein synthesis (MPS) that is generally characterized by a suppressed MPS response to protein ingestion.
- Trial name
- NCT02371278
- Testing
- Leucine
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hemodynamically Stable, Critical Illness
Comparing USCOM and Echocardiographic Hemodynamic Measurements in Children (CUE Study)
The primary objective of this study is to evaluate the agreement between hemodynamic measurements obtained using the Ultrasound Cardiac Output Monitor (USCOM®; USCOM Ltd., Sydney, Australia), and reference standards as determined…
- Trial name
- NCT02083172
- Testing
- Ultrasound Cardiac Output Monitor and 2 D-Echo
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- McMaster University
Obesity
Effects of Short-term Energy Deficit on Muscle Protein Turnover
Weight loss through energy restriction results in the loss of both fat and muscle mass. Muscle mass is important for mobility, strength, glucose control and energy expenditure, and therefore the retention of muscle mass during…
- Trial name
- NCT02406040
- Testing
- Energy Restriction
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity
Laparoscopic Single-Anastomosis Duodenal-Jejunal Bypass With Sleeve Gastrectomy vs Laparoscopic Duodenal Switch
Will a laparoscopic Single-Anastomosis Duodenal-ileal Bypass with Sleeve Gastrectomy produce similar or superior results when compared to a laparoscopic Duodenal Switch, as a primary surgical procedure for weight loss in…
- Trial name
- DSvsSADI (NCT02692469)
- Testing
- Duodenal Switch, Duodenal-ileal Bypass with Sleeve Gastrectomy
- Volunteers
- 140 people
- Sponsor
- McMaster University
Stress Ulcer Prophylaxis
Re-Evaluating the Inhibition of Stress Erosions: Gastrointestinal Bleeding Prophylaxis In ICU
The purpose of the this Pilot Trial is to determine the feasibility of conducting a large randomized controlled trial (RCT), that aims to examine the efficacy and safety of using pantoprazole compared to placebo for stress ulcer…
- Trial name
- REVISE (NCT02290327)
- Testing
- Pantoprazole
- Where
- 10 sites in Australia, Canada and 1 more
- Volunteers
- 91 people
- Sponsor
- McMaster University