Clinical trials: sponsored by McMaster University
Postoperative Ileus, Ileus
Effect of Simethicone on Postoperative Ileus in Patients Undergoing Colorectal Surgery
Post-operative ileus is a common complication following abdominal surgery. It results in abdominal distension, nausea and vomiting as well as abdominal pain.
- Trial name
- NCT02161367
- Testing
- Simethicone, Oral Suspending Vehicle
- Where
- 2 sites in Canada
- Volunteers
- 100 people
- Sponsor
- McMaster University
Crohn's Disease
High Dose Vitamin D3 in Crohn's Disease
This is a randomized, double-blind placebo-controlled trial of high dose vitamin D3 at 10,000 International Units (IU) daily compared to low dose at 1000 IU daily in patients with Crohn's disease in remission.
- Trial name
- NCT02615288
- Testing
- Vitamin D3
- Volunteers
- 40 people
- Sponsor
- McMaster University
Venous Thromboembolism
Electronic Strategies to Enhance Venous Thromboemboli (VTE) Prophylaxis in Hospitalized Medical Patients
Venous thromboemboli (VTE) are abnormal blood clots that commonly form in the blood vessels of the legs or lungs. They can block normal blood flow, damage organs, and even cause death.
- Trial name
- E-SENTRY (NCT01401725)
- Testing
- Electronic Order Entry System + CDSS, Electronic Order Entry System Only, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 600 people
- Sponsor
- McMaster University
Cardiac Surgery
Remote Ischemic Preconditioning in Cardiac Surgery Trial
Main Research Questions: 1. Is a large trial of patients undergoing heart surgery comparing a simple procedure of temporarily stopping blood flow to the leg with a blood pressure cuff (called remote ischemic preconditioning) to a…
- Trial name
- Remote IMPACT (NCT01071265)
- Testing
- Remote Ischemic Preconditioning
- Where
- 7 sites in United States, Canada
- Volunteers
- 250 people
- Sponsor
- McMaster University
Hemodialysis, End Stage Renal Disease
Eplerenone in Hemodialysis Trial
Forty percent of patients that require dialysis for kidney failure die within three years mostly due to heart disease. Heart failure and high blood pressure are common problems in patients that require dialysis and are key causes…
- Trial name
- PHASE (NCT01650012)
- Testing
- eplerenone
- Where
- 5 sites in Canada
- Volunteers
- 158 people
- Sponsor
- McMaster University
Achalasia
A Clinical Study of Per Oral Endoscopic Myotomy (POEM) in Patients Suffering From Achalasia
This study evaluates the feasibility of endoscopic myotomy for achalasia. In achalasia, there is loss of relaxation of the lower esophageal sphincter (LES), as well as a higher baseline pressure in the LES.
- Trial name
- POEM (NCT01692106)
- Testing
- Procedure: Per Oral Endoscopic Myotomy (POEM)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
Anemia of Prematurity
Premature Infants in Need of Transfusion (PINT)
Hypothesis: That a high hemoglobin threshold for transfusion in extremely low birth weight (ELBW) infants is associated with a lower rate of survival without severe morbidity (defined as one or more of retinopathy of prematurity…
- Trial name
- NCT00182390
- Testing
- Red blood cell transfusion
- Where
- 10 sites in United States, Australia and 1 more
- Volunteers
- 424 people
- Sponsor
- McMaster University
Pain
A Randomized Trial Comparing "Push" Versus "Pull" Technology for Mobilizing Pain Evidence Into Practice Across Different Health Professions
Pain is a problem for many Canadians. Unfortunately, many doctors, nurses, therapists, and psychologists have trouble keeping up to date and applying the latest research that might help patients suffering with pain.
- Trial name
- NCT01348802
- Testing
- Push + Pull, Pull
- Where
- Canada
- Volunteers
- 675 people, healthy volunteers welcome
- Sponsor
- McMaster University
Whiplash Injuries
Manual Therapy Dosage Factorial Study
This study will determine biological responses to different dosages of neck mobilization intervention in patients, providing opportunities to identify the optimal dosage, predictors of response, outcome measures as well as the…
- Trial name
- NCT00560807
- Testing
- Mobilization
- Where
- Canada
- Sponsor
- McMaster University
Preterm Infant
Cardiorespiratory Effects of "Higher" Versus "Equivalent" CPAP Upon Extubation From High EAP in Preterm Infants
The aim of this study is to compare the cardiovascular and respiratory effects of "higher" versus "equivalent" CPAP pressures post-extubation from high endotracheal airway pressures (EAP), defined as at least 8 cm H2O (water), in…
- Trial name
- CO-PAP (NCT02528851)
- Testing
- Extubation from endotracheal mechanical ventilation to CPAP
- Volunteers
- 14 people
- Sponsor
- McMaster University
Diabetes
Community Health Assessment Program in the Philippines
The investigators are adopting an intervention which has been tested in Canada to the Philippine setting. The program will be called Community Health Assessment Program in the Philippines (CHAPP).
- Trial name
- CHAP-P (NCT02479516)
- Testing
- Community Health Assessment Program Philippines (CHAP-P)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- McMaster University
Obesity
Impact of Whey and Soy Protein Ingestion in Conjunction With Energy Restriction in Overweight/Obese Individuals
It is known that dieting (restricted energy intake) without resistance training leads to a reduced metabolic rate, and the loss of both fat and muscle mass.
- Trial name
- NCT01530646
- Testing
- Weight loss, Soy, Whey
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- McMaster University
Domestic Violence
Nurse-family Partnership (NFP) Curriculum Study
The purpose of this study is to determine whether the Intimate Partner Violence (IPV) intervention in the context of Nurse-Family Partnership (NFP) program improves women's quality of life and reduces violence relative to the NFP…
- Trial name
- NCT01372098
- Testing
- NFP + IPV intervention
- Where
- United States
- Volunteers
- 492 people
- Sponsor
- McMaster University
Overweight
Effects of High Protein Intake With Intense Exercise and Energy Deficit
A four week intervention will take place with the participants. They will undergo 6 days a week of high intensity training. They will also be at a 40% energy deficiency.
- Trial name
- RIPPED (NCT01776359)
- Testing
- High Protein, Low Protein
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Asthma
Comparison of the Methacholine PC20 Between the Trudell Aeroeclipse* II Ban Nebulizer and the Wright Nebulizer
This study will compare the methacholine PC20 of two different modern-delivery aerosol systems to determine if one may replace the other for use in clinical settings.
- Trial name
- NCT01919424
- Testing
- Methacholine Chloride, Trudell AeroEclipse*II BAN nebulizer, The English-Wright nebulizer
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- McMaster University
Traumatic Intracranial Haemorrhage
OPtimal Timing of Thromboprophylaxis in Traumatic IntraCranial Haemorrhage - Pilot Study
Victims of trauma with severe head injury who have bled into their brains are at high risk of developing blood clots in their legs.
- Trial name
- OPTTICH (NCT02260908)
- Testing
- Enoxaparin
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- McMaster University
Physicians Evidence Retrieval Skills
Multifaceted Online Interventions to Increase Clinicians Searching of Current Best Evidence to Answer Clinical Questions
Translation of new knowledge from research into evidence-informed health care is a shared obligation of the clinical and the scientific communities.
- Trial name
- MPFS (NCT02038439)
- Testing
- Intervention A - Online Clinical Questions Recorder, Intervention B - Online Evidence Retrieval Coach, Intervention C - Online Audit and Feedback
- Where
- Canada
- Volunteers
- 908 people
- Sponsor
- McMaster University
Knee Osteoarthritis
Randomized Trial in knEe Osteoarthritis Using Low Intensity Ultrasound - Evaluating Feasibility (RELIEF)
The purpose of this pilot study is to determine the feasibility of conducting a high quality clinical trial to investigate the effects of low intensity, pulsed ultrasound on knee osteoarthritis pain and physical function.
- Trial name
- RELIEF (NCT01623804)
- Testing
- low intensity, pulsed ultrasound
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- McMaster University
Preterm Birth
The GROWNDUP Study of Late Preterm Births
This pilot study will examine the feasibility of conducting a large randomized clinical trial (RCT) to examine the role of a novel, specialized follow-up clinic in preventing complications among late preterm infants (LPTB), born…
- Trial name
- GROWNDUP (NCT01747603)
- Testing
- Specialized LPTB clinic
- Where
- 2 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
Alzheimer Disease, Dementia
Supporting Caregivers of Persons With Dementia: A Pilot Study
The purpose of this study is to pilot the home Environmental Skill-Building Program (ESP) and an educational control intervention with persons with dementia and their caregivers (n=40) in preparation for a larger double-blind…
- Trial name
- NCT00908492
- Testing
- Education Control, Environmental Skill Building
- Where
- Canada
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- McMaster University